Data Development
Resume:
Shankar Lanke
**** ****** ********** **, *******, GA 30341
Ph: 678-***-**** Fax: 678-***-****
Email: ************@*****.***
EDUCATION
PhD Candidate (Expected Graduation: Sep’09), Pharmaceutical Sciences, Mercer University, Atlanta.
Dissertation: Oral and Transdermal Delivery of Low Molecular Weight Heparin
Advisors: Dr. James G. Strom and Dr. Ajay K. Banga
B. Pharmacy (1999-2003), Jawaharlal Nehru Technology University, Guntur, India.
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RESEARCH AND DEVELOPMENT EXPERIENCE
Summer intern – Biopharmaceutics, Novartis Pharmaceuticals (May’09 - Present)
• Primary project – Development of a database consisting of biopharmaceutical data of Novartis-
NCEs that are/were in the clinical phase of development.
A collaborative project between Pharmaceutical Analytical Development (PHAD) and
Drug Metabolism Pharmacokinetics (DMPK) departments.
Application of GastroPlus™ (G+) and ISIS chem Draw tools to simulate
biopharmaceutical data for the drugs compiled in the database and to compare the
simulated and observed results.
Other projects
•
To develop a database of marketed pediatric formulations (drug, dosage form and age
relevant data).
Designing an optimal in vivo experiment to characterize buccal delivery of a NCE.
To support the formulation scientists in preparing the solid oral dosage forms in the
Clinical Manufacturing Unit (CMU) [hands on work with blending, granulating, drying
and compression techniques].
Novartis Sponsored Trainings
•
In vitro-in vivo correlation (IVIVC) model building and application.
GastroPlus™ Modeling to predict the human gastrointestinal absorption and IVIVC
correlations.
Formulation Development and Analytical techniques:
Size exclusion chromatography- evaluated and validated the size of LMWH.
•
Dynamic light scattering- analyzed the LMWH microspheres particle size.
•
Scanning electron microscopy- studied the surface morphology of microspheres.
•
Zeta potential- examined the colloidal stability and/or suspendability.
•
Determined in vitro drug release and encapsulation efficiency of microsphere formulations.
•
UV-visible spectrophotometry- colorimetric assays were used to quantify the LMWH in plasma
•
samples.
Differential scanning calorimetry- identified the LMWH compatibility with excipients.
•
Fourier transform infra red spectroscopy data evaluated and interpreted.
•
Spray drying- prepared microspheres using Buchi-191mini spray dryer
•
Capsule Coating- developed coated capsules using pan coating.
•
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Shankar Lanke
Oral and Transdermal formulations of low molecular weight heparin (LMWH)
• Oral delivery: Developed and characterized biodegradable microsphere formulations to enhance
the oral bioavailability of LMWH.
• Developed an optimized process to prepare microparticulate formulations of LMWH
containing mucolytic agents through the characterization of formulation properties such as
particle size, shape, charge and encapsulation efficiency.
• Characterization of LMWH transport across intestinal tissue using Ussing chamber and
modified Doluisio techniques.
• Assessment of oral bioavailability and pharmacokinetics of LMWH in Sprague Dawley rats.
• Transdermal systems: Development of iontophoretic, ultrasound and microneedle assisted
techniques for the transdermal delivery of LMWH.
• Determination of LMWH transport across skin tissue in in vitro studies using Franz diffusion
cells.
• Investigation of LMWH delivery across skin using passive, iontophoresis, ultrasound,
metallic and soluble maltose microneedles.
• Assessment of drug disposition and drug permeation through the skin layers using Laser
Scanning Confocal Microscopy (LSM510) studies and histological studies, respectively.
• Characterization of in vivo transdermal delivery of LMWH in male CD hairless rats
Data analysis techniques:
Non compartmental pharmacokinetic data analysis using WinNonlin® software (Version 5.2.1).
•
Statistical analysis and graphical representation of data (Statistix-7)®.
•
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JOB EXPERIENCE
Research Assistantship (2005- 2008), Mercer University, GA
o Reviewed the research proposal for submission to Georgia Research Alliance grant.
o Reviewed the AAPS abstracts for submission (2005-2008).
o Supervised laboratory personnel to initiate, manage and execute the research projects.
o Evaluation of data protocols and SOP’s
• Animal Vivarium Supervisor (2005-2007), Mercer University, GA
o Maintenance and care of vivarium
o Managed vivarium supplies through appropriate documentation.
• Graduate Student Mentor (2006-2008), Mercer University, GA
o Mentoring first year graduate students with research techniques and experimental design.
• Teaching Assistantship (2005-2007), Mercer University, GA
o Taught undergraduate students in Pharmaceutics and Biopharmaceutics.
o Prepared and supervised undergraduate pharmaceutics laboratories.
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RESEARCH PUBLICATIONS
S.S.S. Lanke, S. G. Gayakwad, J.G Strom and M. J. D’Souza, “Oral delivery of low molecular weight
heparin microspheres prepared using biodegradable polymer matrix system,” Journal of
Microencapsulation, 2008.
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Shankar Lanke
S.S.S. Lanke, C.S. Kolli, J.G. Strom and A. K. Banga, “Enhanced Transdermal Delivery of Low
Molecular Weight Heparin by Barrier Perturbation,” International Journal of Pharmaceutics, 2008.
S.S.S. Lanke, J.G Strom and M. J. D’Souza, “Microsphere Formulations to Enhance the Oral
Bioavailability of Heparin,” (Under Peer Review for submission to Critical Reviews in Therapeutics
and Drug Delivery Systems).
L. L. Marshall, A. Allison, D. Nykamp and S.S.S. Lanke, “Perceived Stress and Quality of Life Profile of
Doctor of Pharmacy Students: A Pilot Study,” American Journal of Pharmaceutical Education, 2008.
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RESEARCH PRESENTATIONS (Presented at National and International Scientific Meetings)
S.S.S. Lanke, S.G. Gayakwad, A. Siddig, J.G Strom and M.J. D’Souza, “Microencapsulation of Low
Molecular Weight Heparin into a Biodegradable Polymer for Oral Delivery.” To be presented at Annual
Meeting of American Association of Pharmaceutical Scientists 2008, Georgia.
S.S.S. Lanke, S.G. Gayakwad, J.G Strom and M.J. D’Souza. “Efficacy of Mucolytic Agent for Oral
Delivery of Low Molecular Weight Heparin.” Presented at the Annual Meeting of Georgia Life Sciences
2008, Georgia.
S.S.S. Lanke, S.G. Gayakwad, J.G Strom and M.J. D’Souza..“Mucolytic Agent for the Oral Delivery of
Low Molecular Weight Heparin.” Presented at the Annual Meeting of Graduate Research Association of
Students in Pharmacy 2008, Florida.
S.S.S. Lanke, C.S. Kolli, G. Li, J.G. Strom and A. K. Banga.“Transdermal Delivery of Low Molecular
Weight Heparin Using Combination of Microneedles and Iontophoresis.” Presented at the Annual
Meeting of American Association of Pharmaceutical Scientists 2007, California.
S.S.S. Lanke, C.S. Kolli, G. Li, J.G. Strom and A. K. Banga. “Transdermal Delivery of Low Molecular
Weight Heparin Using Combination of Microneedles and Iontophoresis.” Presented at the Annual
Meeting of Graduate Research Association of Students in Pharmacy 2007, New Jersey.
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WORKSHOPS ATTENDED
AAPS Workshop on Evolving Science and Technology in Physical Pharmacy and Biopharmaceutics,
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June 2009.
AAPS workshop on Scientific and Technological Advances in the Use of Lipid-based Drug Delivery
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Systems for Bioavailability Enhancement and Tissue Targeting, March 2009.
REFERENCES: References will be provided upon request.
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