Development Maintenance

Charles A. Gilson III

**** *** *** ******, *** Diego, CA 92107 ( 858-***-**** (

********@*****.***

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OBJECTIVE

I am seeking a full-time chemistry related career that can make use of my

8+ years of industrial experience synthesizing and characterizing small

molecules for use in drug discovery. I am presently employed with Biogen

Idec here in San Diego, but my current position is being relocated to

Boston, Mass. at the end of this year.

SKILLS

. Over seven years of industrial experience involving the multi-step

synthesis and characterization of small, novel heterocyclic compounds

for use in early stage drug discovery.

. One year of small molecule preformulation experience performing

physical and chemical evaluation of early-to-late stage drug

development candidates.

. Proven success record of academic and professional experience working

on a variety of exploratory projects involving route development, hit-

to-lead identification, and scale-up projects from microscale to the

multi-gram level.

. Extensive experience with small molecule isolation and

characterization utilizing preparatory/analytical HPLC, 1 and 2-D NMR,

LCMS, IR, GCMS, microwave synthesis and numerous automated

chromatography instruments.

. Conducted experiments to evaluate the pharmaceutical properties of

drug development candidates using DSC, TGA, XRPD, microscopy, moisture

sorption, FTIR, RAMAN, HPLC (Empower software) and dissolution

analysis.

. Crystallization and solid state characterization for salt and

polymorph selection of clinical candidates.

. Extensive use of Beilstein, Scifinder and ChemGate database systems.

. NMR maintenance including weekly nitrogen fills and periodic helium

fills.

. Responsible for the maintenance and upkeep of numerous instrument

systems including Waters Deltaprep HPLC's, CEM microwave synthesizers,

PAR hydrogenators, ect.

. Past experience working as a Highway Patrolman for the State of

Virginia

PROFESSIONAL EXPERIENCE

Biogen-Idec Inc, San Diego, CA

Associate Scientist II - 10/2008 to present

. Conducted preformulation experiments to evaluate the solid state

pharmaceutical properties including solubility, stability,

crystallinity, hygroscopicity, ect. of small molecule drug development

candidates.

. Performed crystallization/characterization of freebase and salt forms

of small molecule drug candidates for the purpose of salt and

polymorph selection.

Biogen-Idec/Conforma Therapeutics Corporation, San Diego, CA

Associate Scientist II - 03/2004 to 10/2008

. Worked at the bench with small molecules as a synthetic organic

chemist.

. Generated new heterocyclic scaffolds targeting various kinase binding

sites which demonstrate anti-tumor activity.

. Designed and conducted experiments for small molecule route

development and lead optimization projects.

. Utilized knowledge of literature and patent searches to aid in target

identification and explore synthetic methodology design.

. Performed the stereospecific synthesis of a complex natural product

fragment as part of an on-going oncology research effort and published

its results.

. Generated libraries of compounds and provided sufficient

characterization data for inclusion in numerous patents.

Arena Pharmaceuticals Inc., San Diego, CA

Research Associate - 09/2001 to 01/ 2004

. Worked as a team member whose responsibility was the small-scale

synthesis and characterization of novel heterocyclic molecules serving

as 5HT2C agonists.

. Performed multi-gram synthesis of key compounds on the mole scale.

. Worked extensively with air-sensitive reagents, cross-coupling

organometallics and microwave chemistry while generating proprietary

seratonin agonists.

EDUCATION

The Pennsylvania State University, University Park, Pa.

MS, Organic Chemistry - 05/2001.

. Worked as a teaching assistant in an undergraduate organic chemistry

instrumentation laboratory.

. 9-month synthetic chemistry practicum with ViroPharma Inc., Exton, Pa.

. Instructed three semesters of undergraduate organic chemistry

laboratory (Chem 35) students, 20 students per lab section.

. 5 Semesters of graduate research experience with Dr. P. Maslak where I

synthesized novel spiroconjugated charge transfer dyes possessing

interesting optical properties

. 1 Semester of natural product research in the lab of Steven Weinreb.

The University of Alaska Fairbanks, Fairbanks, AK

BS, Natural Resources Management - 05/1992

PUBLICATIONS

[My paper]Brian Smith, Jeffrey Smith, James Tsai, Jeffrey Schultz, Charles

Gilson, Scott Estrada, Rita Chen, Douglas Park, Emily Prieto, Charlemagne

Gallardo, Dipanjan Sengupta, Peter Dosa, Jon Covel, Albert Ren, Robert

Webb, Nigel Beeley, Michael Martin, Michael Morgan, Stephen Espitia, Hazel

Saldana, Christina Bjenning, Kevin Whelan, Andrew Grottick, Frederique

Menzaghi, William Thomsen; "Discovery and Structure-Activity Relationship

of (1R)-8-Chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine (Lorcaserin),

a Selective Serotinin 5-HT2C Receptor Agonist for the treatment of

Obesity"; Journal of Medicinal Cehmistry, (2008), 51 (2), 305-313.

Gilson III, C.A.; Le Brazidec, J.Y.; Zang, H.; Yang, C.; Burrows, F.;

Boehm, M.; "Stereoselective Synthesis of the C1-C13 Fragment of 2,3-Dihydro-

dorrigocin A"; Journal of Organic Chemistry (2005), 70(20), 8212-8215.

Gilson III, C.A.; Le Brazidec, J.Y.; Zang, H.; Yang, C.; Burrows, F.;

Boehm, M.; First synthesis of the C1-C13 fragment of dorrigocin A.

Abstract of Papers, 229th ACS National Meeting, San Diego, CA, March 13-17,

2005.

Smith, Brian M.; Smith, Jeffrey; Tsai, James H.; Schultz, Jeffrey A.;

Gilson, Charles; Chen, Rita; Estrada, Scott; Park, Douglas; Prieto, Emily;

Sengupta, Dipanjan; Saldana, Hazel; Thomsen, William; Kevin, Whelan;

Creehan, Kevin; Gonzalez, Lena; Menzaghi, Frederique; Bjenning, Christina;

Beeley, Nigel; Webb, Robert R.; Behan, Dominic. Discovery, SAR and

biology of 5-HT2C receptors for the treatment of obesity. Abstracts of

Papers, 229th ACS National Meeting, San Diego, CA, United States, March 13-

17, 2005 (2005),

Tsai, James H.; Smith, Brian M.; Chen, Rita; Prieto, Emily; Park, Douglas;

Smith, Jeffrey; Schultz, Jeffrey A.; Gallardo, Charlemagne; Estrada, Scott;

Fang, Sherry; Gilson, Charles; Thomsen, William; Saldana, Hazel; Bjenning,

Christina; Creehan, Kevin; Gonzalez, Lena; Whelan, Kevin; Webb, Robert R.;

Beeley, Nigel. Evaluation of selective 5-HT2C phenylpiperazine agonists

for the treatment of obesity. Abstracts of Papers, 229th ACS National

Meeting, San Diego, CA, United States, March 13-17, 2005 (2005),

Burbaum, Beverly W.; Gilson, Charles A., III; Aytes, Shelley; Estrada,

Scott A.; Sengupta, Dipanjan; Smith, Brian; Rey, Max; Weigl, Ulrich.

Processes for preparing 3-benzazepines. PCT Int. Appl. (2005), 143

pp. CODEN: PIXXD2 WO 200-***-**** A2 20050303 CAN 142:280072 AN

2005:182631

Schultz, Jeffrey A.; Smith, Brian M.; Smith, Jeffrey; Tsai, James H.;

Gilson, Charles; Estrada, Scott; Chen, Rita; Park, Douglas; Prieto, Emily;

Gallardo, Charlemagne; Sengupta, Dipanjan; Thomsen, William; Saldana,

Hazel; Bjenning, Christina; Creehan, Kevin; Gonzalez, Lena; Whelan, Kevin;

Webb, Robert R.; Beeley, Nigel. Synthesis and SAR of substituted

benzazepines as selective 5-HT2C agonists. Abstracts of Papers, 229th

ACS National Meeting, San Diego, CA, United States, March 13-17, 2005

(2005)

Smith, B.; Gilson III, C.A.; Schultz, J.; Smith, J.; "Benzazepine

Derivatives Useful for the Treatment of 5HC2C Receptor Associated

Diseases". International patent publication WO 2005/003096 (01/13/05).

Smith, B.; Schultz, J.; Gilson III, C.A.; Estrada, S.; "Benzazepine

Derivatives and Methods of Prophylaxis or Treatment of 5HC2C Receptor

Associated Diseases". International patent publication WO 2005/042490

(05/12/2005).

Smith, B.; Schultz, J.; Gilson III, C.A.; Estrada, S.; "Benzazepine

Derivatives and Methods of Prophylaxis or Treatment of 5HC2C Receptor

Associated Diseases". International patent publication WO 2005/042491

(05/12/2005).

Smith, B.; Smith, J.; Tsai, J.; Schultz, J; Gilson,C.A.; Estrada, S.; Chen,

R.; Park, D.M.; Prieto, E.; Gallardo, C.; "Discovery and SAR of New

Benzazepines as Potent and Selective 5HT2C Receptor Agonists for the

Treatment of Obesity".; Bioorganic & Medicinal Chemistry Letters; 2005; 15

(5); 1467-1470.

Smith, Brian; Gilson, Charles, III; Schultz, Jeffrey; Smith, Jeffrey. A

preparation of benzazepine derivatives, useful as 5HT2C receptor

modulators. PCT Int. Appl. (2005), 71 pp. CODEN: PIXXD2 WO

200-***-**** A1 20050113 CAN 142:134482 AN 2005:29313

Smith, Brian; Smith, Jeffrey; Chen, Rita; Covel, Jon; Dosa, Peter; Estrada,

Scott; Gilson, Charles; Park, Douglas; Prieto, Emily; Schultz, Jeffrey;

Tsai, James; Webb, Rob; Aytes, Shelley; Burbaum, Beverly; Fritch, John;

Sengupta, Dipanjan; Henshilwood, James; Reyes Saldana, Hazel; Thomsen,

William; Whelan, Kevin; Menzaghi, Frederique; Bjenning, Christina; Martin,

Michael; Chapman, Dennis; Maffuid, Paul; Beeley, Nigel; Chalmers, Derek;

Behan, Dominic. Discovery of APD356: A potent and selective 5-HT2C

receptor agonist for the treatment of obesity. Abstracts of Papers,

227th ACS National Meeting, Anaheim, CA, United States, March 28-April 1,

2004 (2004)

References are available upon request.

Hobbies

I am an avid outdoorsman and someone who possesses more than the average

amount of mechanical aptitude. I have a restored Boston Whaler fishing

boat which I currently use for marlin and tuna fishing. I also enjoy

riding and working on my Harley Davidson motorcycle.

Contact this candidate