Research Management

Philippe Taupin, Ph.D.

Professor, Scientific Director - Expert in Stem Cell Biology

Field of Expertise: Neurosciences

Philippe Taupin

***** ****** *****, *** *****, CA 92127

Mob. [1] 858-***-****

Email: ******@****.***

Career Objectives _________________________________________

- I am aiming to join the pharmaceutical and biotechnology sector as

an entrepreneur, or in a senior management position in a pharmaceutical or

biotechnology company, to contribute to its effort to develop treatments

and cures for neurological disorders and injuries.

- I am aiming to bring to the pharmaceutical and biotechnology sector

the expertise, know-how and technologies that I have acquired and developed

in the field of adult neurogenesis and neural stem cells, to develop new

treatments and cures for neurological disorders and injuries.

Expertise _____________________________________________________

- Expert in adult neurogenesis and neural stem cell research with over 15

years of research experience and over 6 years of experience, as head of

laboratory and research management.

- Strong expertise in all aspects of scientific research, validated by a

successful track record of grants funding, scientific publications and

patents granted.

- Expertise spans from research vision and orientation, team building and

management, employees teaching and training, setting up and developing new

protocols, techniques and facilities, devising strategies to meet goals and

deadlines, writing scientific grant proposals, manuscripts and patent

applications, giving lecture & seminars

- Extensive and broad technical and practical expertise in molecular

biology, biochemistry, cell culture, histochemistry and surgery on small

animals. Ability to develop and troubleshoot new protocols and techniques.

- Fields of expertise: neurosciences, drug discovery & regenerative

medicine for the treatment of neurological diseases, disorders and

injuries.

Professional Profile______________________________________________

March 2009-Present: Entrepreneur

- File patent applications, prepare & compile a business plan

- Prospect & interview with capital venture firms, angel investors and

pharma/biotech companies

- I have identified potential secondary investors

April 2008-February 2009: Scientific Director & Professor

- Fighting Blindness Vision Research Institute & Dublin City University,

Dublin, Ireland

- Set up the statute of the institute, defined and set up research

programs, hired employees for first & second research teams

- Research involved a doubled-pronged approach for treating and curing

blindness. The strategy involves a dual approach between the retina, a non

neurogenic area, and the hippocampus, a neurogenic area. The research is

based on adult neural stem cells and projects that were developped in

Singapore

- Wrote grant applications, published several manuscripts, gave lectures &

seminars at various venues, edited 3 books

October 2008-March 2009: Editor in Chief-Research

- Journal of Neuroregeneration and Regeneration, Weston, MA, USA.

- Worked with the editor to launch the journal, contributed to the journal

revival, growth & endeavor. The journal is now in its third issue

- Completed the writing of several manuscripts, filed one patent

application, wrote 2 books & edited 4 others

September 2003-September 2008: Head of Laboratory & Associate Professor

- National Neuroscience Institute, National University of Singapore,

Nanyang Technological University, Singapore, Singapore

- Set up laboratory, hired & trained employees, initiated and completed own

research program in adult neurogenesis and neural stem cells, managed a

team of 4 employees, including students and research assistants

- Research involved developing new models to study adult neurogenesis

pharmacology, to derive primate cell lines & to generate genetically

modified transgenic mice. Particularly, we identified, characterized,

isolated and purified the synapses of newly generated neuronal cells of

adult rodent brains.

- Wrote several manuscripts and grant proposals that were successful

-including grant funding from the USA- for a budget of over 1 million USD,

gave lectures & seminars at various venues

- Set up a facility for cell analysis and cell sorting

- Performed teaching duties at universities

February 1994-August 2003: Post-Doctoral Fellow & Staff Scientist

- Laboratory of Genetics, Pr. F.H. Gage, Salk Institute for Biological

Studies, La Jolla, CA, USA

- Research involved the discovery and characterization of a neural stem

cell factor, its receptor & mechanism of action. The neural stem cell

factor stimulates the proliferation of neural stem cells in vitro, from

single cells, and adult neurogenesis in vivo. It is a result of this study

that we have been able to isolate and characterize neural progenitor and

stem cells from human biopsies and post-mortem tissues. These works have

been the subject of patent applications that are published & granted

- Wrote several manuscripts, and wrote and contributed to the writing of

several grant proposals, including NIH-RO1, that were successful, gave

lectures & seminars at various venues

September 1989-January1994: Pre-Doctoral Fellow

- Unit de Physiopathologie du Developpement, Dr. Y. Ben-Ari, Institut

National de la Sant et de la Recherche M dicale U29, Paris, France

- Research involved the development of a model to study and characterized

neurotransmitters and factors involved in epilepsy. I isolated and purified

the synapses of hippocampal granule cells, as synapstosomes, from adult rat

control and after neo-natal irradiation. As a result of this study, I

showed that an excitatory and an inhibitory neurotransmitter could be

released by the same synapse

- I passed my thesis with highest honor and felicitation of the jury

committee. I was the first student of that program to pass my thesis

Education_____________________________________________________

1993. "Th se de Doctorat d'Universit "/Ph.D., Neurosciences. Universit

Pierre et Marie

Curie

1990. "Dipl me Etude Approfondies", Neurosciences. Universit Pierre et

Marie Curie

1989. "Maitrise"/M.Sc., Biochemistry. Universit Pierre et Marie Curie

1988. "License"/B.Sc., Biochemistry. Universit Pierre et Marie Curie,

Paris, France

Awards & Grants (selected from over 13)____________________________________

2005-2008. BioMedical Research Council, Principal investigator grant

2004-2006. BioMedical Research Council-Juvenile Diabetes Research

Foundation,

Principal investigator grant

2002. Pasarow Scholar, Award

1998-2003. NIH-NIA, Grant RO-1, Co-principal investigator grant

1997-2000. Cancer Center NIH, NRSA grants

1994. France Parkinson, Award

1989-1993. Groupe Servier, Research fellowship

Selected Intellectual Properties____________________________________

U.S. Patent pending filed January 7, 2008, entitled "Methods of

Purification of

Neurogenic Structures and Uses Thereof"

U.S. Patent No. 6,436,389 B1 issued August 20, 2002, entitled "Stem Cell

Glycostatin C

and Methods of Use Thereof", foreign filing No. 99/29533, published

PCT

Application WO/2000/33791

Publications (selected from over

60)_________________________________________

Scientific Manuscripts

Taupin P. Characterization and isolation of synapses of newly generated

neuronal cells of

the adult hippocampus at early stages of neurogenesis. Journal of

Neurodegeneration and Regeneration. In press

Taupin P. Adult neurogenesis, neural stem cells and Alzheimer's disease:

developments,

limitations, problems and promises. Current Alzheimer Research. In

press

Taupin P. A simple direct pre-embedding technique for characterizing the

ultrastructure

of scarce biological specimens. Biotechnic and Histochemistry. 2008;

83(5):253-

257.

Taupin P. Adult neurogenesis pharmacology in neurological diseases and

disorders.

Expert Review of Neurotherapeutics. 2008; 8(2):311-320.

Taupin P. Stem cells engineering for cell-based therapy. Journal of Neural

Engineering.

2007; 4(3):R59-R63.

Taupin P. BrdU Immunohistochemistry for Studying Adult Neurogenesis:

paradigms,

pitfalls, limitations, and validation. Brain Research Reviews. 2007,

53(1):198-

214.

Taupin P. Adult neural stem cells, neurogenic niches and cellular therapy.

Stem Cell

Reviews. 2006, 2(3): 213-19.

Taupin P. Neurogenesis in the adult central nervous system. C R Biol. 2006

Jul;329(7):465-75.

Chin VI, Taupin P, Sanga S, Scheel J, Gage FH, Bhatia SN. Microfabricated

platform for

studying stem cell fates. Biotechnol Bioeng. 2004 Nov 5;88(3):399-415.

Shi Y, Chichung Lie D, Taupin P, Nakashima K, Ray J, Yu RT, Gage FH, Evans

RM.

Expression and function of orphan nuclear receptor TLX in adult neural

stem

cells. Nature. 2004 Jan 1;427(6969):78-83.

Taupin P, Gage FH. Adult neurogenesis and neural stem cells of the central

nervous

system in mammals. J Neurosci Res. 2002 Sep 15;69(6):745-9.

Palmer TD, Schwartz PH, Taupin P, Kaspar B, Stein SA, Gage FH. Cell

culture.

Progenitor cells from human brain after death. Nature. 2001 May

3;411(6833):42-3.

Taupin P, Ray J, Fischer WH, Suhr ST, Hakansson K, Grubb A, Gage FH. FGF-2-

responsive neural stem cell proliferation requires CCg, a novel

autocrine/paracrine cofactor. Neuron. 2000 Nov;28(2):385-97.

Taupin P, Ben-Ari Y, Roisin MP. Subcellular fractionation on Percoll

gradient of mossy

fiber synaptosomes: evoked release of glutamate, GABA, aspartate and

glutamate decarboxylase activity in control and degranulated rat

hippocampus. Brain Res. 1994 May 2;644(2):313-21.

Books

Taupin P. Stem Cells & Regenerative Medicine. Vol. 5. Patents and Clinical

Trials. Nova

Science Publishers. 12 chapters. ISBN: 978-60741-782-8. Pub. Date:

2009, 4th

quarter

Taupin P. The hippocampus - Neurotransmission and Plasticity in the nervous

system.

Nova Science Publishers. Monograph 12 chapters. ISBN: 1-60021-914-4.

Pub.

Date: 2008

Taupin P. Adult neurogenesis and neural stem cells in mammals. Nova Science

Publishers. Monograph 15 chapters. ISBN: 1-59454-856-0. Pub. Date:

2006

Personal Profile_________________________________________________

Nationalities: French, American, Singapore permanent resident

Languages: french native langage, english fluent, german basic

understanding

Residence in the United States: 16393 Alipaz court, San Diego, CA 92127.

Mob. [1] (858) 254 - 5569

Residence in France: Residence Oceanic, 124 Boulevard de la Corniche, 17110

Saint Georges de Didonne. Tel. [33] (0)5 46 06 22 52

Activity: english boxing.

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