Vice President Development

Hong Woo Kim

Address: *** *** ******, *********, **

02141

Phone: 858-***-**** (home), 949-***-**** (cell)

*************@*****.***

Immigration Status: Permanent resident card holder

Experience:

Genosco Inc.: Senior Scientist (July 2009- present):

-Working on kinase inhibitors (anti-cancer/anti-inflammation); discovered

hit compounds with single-digit or nanomolar potency for targeted kinase as

well as cells. (two provisional patents were submitted).

- Practicing molecular modeling using ligand editor (Molsoft), and Glide

(Schrodinger):

Ardea Biosciences Inc.: Principal Scientist (January 2007- Mar 2008):

- Working on discovery and SAR (Structure and Activity Relationship) of 2nd

generation of MEK project (anti cancer)

- Worked on SAR of Novel HCV protease (peptidomimetic chemistry)

- Working on discovery and SAR of HIV intergrase inhibitors which is in

preclinical stage

Valeant Research & Development (formerly ICN): Associate Principal

Scientist (March 2003-December 2006):

- SAR of the novel imidazole series as NNRTI inhibitor independently

-One of the inventors of Rdea NNRTI currently in clinical trial Phase II

(Rdea 806)

-Worked on HCV inhibitors (NS5B)

-Invented kg large-scale synthesis of MEK inhibitor (anti-cancer) compound

in clinical trial Phase I

-Managed 3 MS and BS researchers

Ribapharm Inc. (Senior Scientist II, May 2002- March 2003):

- Hit to lead optimization of NNRTI

University of California, Irvine: Postdoctoral Researcher (May 2000- May

2002):

- Advisor - James S. Nowick

- Research area - "Synthesis of multiple stranded oligo-urea on solid

support, and (-strand mimics incorporating an unnatural amino acid".

LG (Research Scientist, Feb 1991- July 1995):

- Discovery and development of rice-herbicide (Pyanchor) which is

commercialized in southern Asia, Latin America as well as Korea

Military Service (Nov 1988 - Feb 1991)

- Korean Army

Education:

University of Nebraska, Lincoln: Ph. D. - Organic Chemistry (1995- 2000):

- Dissertation Advisor - Stephen G. DiMagno

- Dissertation Title - "Heavily Fluorinated Carbohydrate and Nucleoside

Analogues".

Korea University, Seoul, Korea: MSc - Organic Chemistry (1986-1988):

- Thesis Advisor - Bong Rae Cho

- Thesis Title - "Asymmetric Synthesis of Chiral Base Using Aspartic Acid"

Korea University, Seoul, Korea: BSc. - Chemistry (1982-1986):

Research Interests:

- Design, synthesis, and optimization of biologically active molecules such

as peptidomimetic, heterocyclic compounds for the discovery, and

development of antivial and anti-cancer drugs.

- Non-covalent interactions between biomolecules and biological system

which could be applied for innovative biomedical applications such as

antibody drug conjugates.

Publications:

1) Yan, Shunqi; Appleby, Todd; Gunic, Esmir; Shim, Jae Hoon; Tasu, Tania;

Kim, Hongwoo; Rong, Frank; Chen, Huaming; Hamatake, Robert; Wu, Jim Z.;

Hong, Zhi; Yao, Nanhua. Isothiazoles as active-site inhibitors of HCV NS5B

polymerase. Bioorganic & Medicinal Chemistry Letters (2007), 17(1), 28-33

2) Tri-Substituted Triazoles as Potent Non-Nucleoside Inhibitors of the HIV

Reverse Transcriptase submitted to Bioorganic Medinical Chemistry Letters

(2006), 16, 4444-4449. De La Rosa, M. ; Kim, H.W.; Gunic, E.; Jenket, C.;

Boyle, U.; Koh, Y.-H.; Korboukh, I.; Allan, M.; Zhang, W.; Chen, H.; Xu,

W.; Nilar, S.; Yao, N.; Hamatake, R.; Lang, S.; Hong, Z.; Zhang, Z.;

Girardet, J.-L.

3) Tri-Substituted Imidazoles as Potent Non-Nucleoside Inhibitors of the

HIV Reverse Transcriptase manuscript in preparation to Bioorganic Medinical

Chemistry Letters; Kim, H. W.; Girardet, J.-L.

4) The polar hydrophobicity of fluorinated compounds; Biffinger, Justin C.;

Kim, H. W.; DiMagno, S. G. ChemBioChem 2004, 622-627.

5) Nowick, J. S.; Lam, K. S.; Gothard, C. M.; Huon, J. K.; Kemnitzer, W.

E.; Khasanova, T.; Kim, H. W.; Liu, R.; Maitra, S.; Mee, H. T.; Stigers, K.

D. Peptides: The Wave of the Future: Lebl, M.; Houghten, R. A., Ed.;

American Peptide Society: San Diego, 2001: p 572-574.

6) Structure, and transport properties of a novel heavily fluorinated

carbohydrate analogue, Kim, H. W.; Rossi, P.; Shoemaker, R. K.; S. G.

DiMagno, J. Am. Chem. Soc.1998, 9082-9083.

Presentations:

1) Korea University, July, Seoul, Korea, "The Discovery of RDEA806 - A Non-

Nucleoside Reverse Transcriptase Inhibitor Currently in Phase II" (Invited)

2) Kolon Life Sciences, June, Korea, "The Discovery of RDEA806 - A Non-

Nucleoside Reverse Transcriptase Inhibitor Currently in Phase II" (Invited)

3) Oscotec, June, Korea, "The Discovery of RDEA806 - A Non-Nucleoside

Reverse Transcriptase Inhibitor Currently in Phase II" (Invited)

4) ACS National Meeting, April 2001, San Diego, "Molecular recognition

between (-sheets in proteins and in model systems" Nowick, J. S.; Cary, J.

M.; Chung, D. M. ; Gothard, C. M.; Huon, J. K.; Kemnitzer, W. E.;

Khasanova, T. ; Kim, H. W.; Maitra, S.; Mee, H. T.; Russu, W. A.; Stigers,

K. D..

5) ACS National Meeting, March 2000, San Francisco, "Anomeric activation of

heavily fluorinated carbohydrate analogues" Kim, H. W.; DiMagno, S. G.

6) ACS National Meeting, August 1998, Boston, "Synthesis, structure and

transport properties of a novel heavily fluorinated carbohydrate analogue"

Kim, H. W.; Shoemaker, R. K.; DiMagno, S. G..

7) ACS National Meeting, August 1998, Boston "Fluorinated porphyrins and

carbohydrates for fluorous phase synthesis", DiMagno, S. G.; Dussault, P.;

Smirnov, V. V.; Kim, H. W.; Schultz, J..

8) ACS National Meeting, April 1997, San Francisco "Heavily fluorinated

nucleoside derivatives", DiMagno, S. G.; Kim, H. W.

Selected Patents:

1) Preparation of S-triazolyl ?-mercaptoacetanilides as inhibitors of HIV

reverse transcriptase. Girardet, Jean-Luc; Koh, Yung-Hyo; De la Rosa,

Martha; Gunic, Esmir; Hong, Zhi; Lang, Stanley; Kim, Hong Woo. PCT Int.

Appl. (2006), 74 pp. WO 200-***-**** A2 20060309

2) Girardet, Jean Luc; Koh, Yung-Hyo; Shaw, Stephanie; Kin, Hong Woo.

Preparation of purines, azapurines, and deazapurines as non-nucleoside

reverse transcriptase inhibitors for treatment of HIV infection. PCT Int.

Appl. (2006), 109 pp. CODEN: PIXXD2 WO 200-***-**** A2 20061116

3) Non-nucleoside reverse transcriptase inhibitors for use in treatment of

HIV infection.

Girardet, J.-L.; Zhang, Z.; Hamatake, R.; de la Rosa, M.; Gunic, E.; Hong

Z.; Kim, H. W.; Koh, Y.-H.; Nilar, S.; Shaw, S.; Yao, N. PCT Int. Appl.

(2004), 70 pp. WO 200-***-**** A2 20040415

4) Herbicidal composition (Preparation of pyridinylphenoxy propionate

derivatives as herbicides), Lee, B. B.; Hur, C. W.; Kim, H. W.; Kim, J. S.

KR 133146 B1 1998

5) Novel 6-Chloro-2-(4,4-Dimethyoxypyrimidin-2-yl)oxybenzoic acid imino

ester derivatives process for preparing thereof and its use as herbicide,

Kim, H. W.; Cho, J. H.; Lee, H. S.; Kim, J. S.; Lee, S. J. KR9706240, 1997

6) 2-Phenoxy pyrimidin derivatives having tetrahydropyranyl redical and

method of preparing them, Hur, C. W.; Lee, H. S.; Lim, J. S.; Cho, J. H.;

Hong, S. M.; Kim, H. W.; Kim, J. S.; Yu, S. G. KR9600049, 1996

7) 6-Chloro-2-(4,6-dimethoxypryrimidin-2-yl)oxybenzoic acid imino ester

derivatives, processes for their production and a method for their

application as herbicides, Hur, C. H.; Cho, J. H.: Lee, H. S.; Yoo, S. K.;

Hong, S. M.; Kim, H. W.; Rim, J. S.; Bae, Y. T.; Chae, S. H.; Kim, J. S.;

Lee, B. B.; Oh, H. S.; Choi, W. B. U. S. Patent 5 494 888, 1996.

8) Herbicidal pyrimidine derivatives, process for preparation thereof and

their use as herbicide, Hur, C. H.; Cho, J. H.: Lee, H. S.; Yoo, S. K.;

Hong, S. M.; Kim, H. W.; Rim, J. S.; Bae, Y. T.; Chae, S. H.; Kim, J. S.;

Lee, B. B.; Oh, H. S.; Choi, W. B. U. S. Patent 5 521 146, 1996.

9) Novel 6-Chloro-2-(4, 6-dimethoxypyrimidin-2-yl) oxybenzoic acid ester

derivatives, processes for their production as a method for their

application as herbicides, EP 608862, 1994.

10) Pyrimidine derivatives, process for their preparation and their use as

herbicide, EP 658549, 1994.

Affiliations:

American Chemical Society (1995-present)

Phi Lambda Upsilon, Honorary Chemical Society (1998-present)

References:

1) Jean-Luc Girardet, vice president, Ardea Biosciences

4939 Directors Place, San Diego, CA 92121

Tel) 858-***-****, Fax: 858-***-****, **********@********.***

2) James S. Nowick, professor, department of chemistry

1102 natural Sciences 2 University of California, Irvine, CA 92697

Tel) 949-***-****, ********@***.***

3) Stephen G. DiMagno, professor, department of chemistry

Hamilton Hall 818C, University of Nebraska-Lincoln,

Lincoln, NE 68588

Tel) 402-***-****, *******@********.***.***

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