Assistant University

SHEJIN ZHU

** **** ******, *******, ** *****

Cell: 617-***-****; Email: ********@*******.***

OBJECTIVE

Seeking a research position as a medicinal or organic chemist in biotech

and pharmaceutical industry.

SUMMERY

. Seven years of medicinal chemistry experience in infection disease and

oncology areas.

. Expertise in synthetic method development and reaction optimization.

. Skilled in multi-step syntheses, separation/purification (HPLC,

Biotage and Isco) and characterization (NMR, MS and IR) of

biologically active molecules.

. Extensive medicinal chemistry knowledge in design, lead generation and

optimization of molecules to improve PK/PD profile.

. Extensive experience in small scale and large scale-up synthesis.

. Self-motivated, result-oriented, excellent work ethic with solid

organization skill, excellent team player with strong communication

skills.

EDUCATION

. M. S., Medicinal Chemistry, Rutgers University, New Brunswick, NJ,

2004. GPA 3.98.

. M. S., Organic chemistry, Beijing Forestry University, China, 2000.

GPA 4.00.

. B. S., Organic chemistry, Beijing Forestry University, China, 1997.

GPA 3.67.

PROFESSIONAL EXPERIENCE

2005-Current, Scientific Associate II, Novartis Institutes for

Biomedical Research, Boston, MA

. Provided medicinal chemistry supports in the therapeutic area of

infectious disease with different projects.

. Knowledgeable in basic screening cascade. Independently designed

analogues with SAR information to resolve critical issues and

contribute to lead compounds for multiple projects.

. Coordinated projects with scientists from different disciplines.

. Rotated in biological department and gained biological skills such as

how to test MIC. Etc.

2003-2005, Graduate Research, Rutgers University. Adviser: Dr. Edmond

J. LaVoie

. Synthesized non-camptothecin topoisomerase I-targeting agents (M.S.

thesis).

. Synthesized derivatives of 8, 9-methylenedioxy-2, 3-

dimethoxybenzo[i]phenanthridine-12-caboxylic acid targeting

topoisomerase I enzymes.

. Synthesized 6-substituted 6H-dibenzo[c,h][2,6]naphthyridin-5-ones,

reversed lactam analogues of ARC-111, topovale .

2002 Fall semester, Graduate Research, University at Albany, Albany, NY

. Developed new methods to prepare asymmetric compounds by using

Peterson reaction.

1997-2000, Graduate Research, Beijing Forestry University, Beijing, China

. Synthesized rosin glucoside non-ionic surfactant by phase-transfer and

solid catalysts (M.S. thesis).

HONORS/ACTIVITIES

. 2007 Novartis spot award for above beyond analytical support to

project team.

. 1997 Outstanding Undergraduate Student, Beijing Forestry University,

Beijing, China.

. Member, organic division, American Chemical Society.

TEACHING EXPERIENCE

.

2003-2004, Teaching Assistant, Rutgers University, New Brunswick, NJ

. Taught Medicinal Chemistry in a recitation group of 5-10 students

each semester.

. Supervised two graduate students on their scale-up projects.

2002 Fall semester, Teaching assistant, SUNY at Albany, Albany, NY

. Taught Organic Chemistry Techniques in a lab of 20-30 students.

2002 Spring semester, Teaching assistant, City University of New York,

New York, NY

. Taught Organic Chemistry Techniques in a lab of 20-30 students.

PUBLICATIONS AND ABSTRACTS

1. Xiaoling Puyang, Danielle L. Poulin,[pic] Joanna E. Mathy, Leah J.

Anderson, Sue Ma, Zheng Fang, Shejin Zhu, Kai Lin, Roger Fujimoto,

Teresa Compton, and Brigitte Wiedmann Mechanism of Resistance of

Hepatitis C Virus Replicons to Structurally Distinct Cyclophilin

Inhibitors Antimicrobial Agents and Chemotherapy, 54(5), 1981-1987,

2010

2. Shejin Zhu, Alexander L. Ruchemlman, Nai Zhou, Angela Liu, Leroy F.

Liu, and Edmond J.LaVoie 6-Substituted 6H-

Dibenzo[c,h][2,6]naphthyridin-5-ones: Reversed Lactam Analogues of ARC-

111 with Potent Topoisomerase I-targeting Activity and Cytotoxicity

Bioorg Med. Chem. 14, 3131-3143, 2006

3. Shejin Zhu, Alexander L. Ruchemlman, Nai Zhou, Angela Liu, Leroy F.

Liu, and Edmond J.LaVoie Esters and amides of 2,3-dimethoxy-8,9-

Methylenedioxy-benzo[i]phenanthridine-12-carboxylic acid: Potent

Cytotoxic and topoisomerase I-targeting agents. Bioorg Med. Chem.

13(24), 6782-6794, 2005

4. Alexander L. Ruchelman, Shejin Zhu, Nai Zhou, Angelia Liu, Leroy

F.Liu, and Edmond J. LaVoie Dimethoxybenzo[i] phenanthridine-12-

carboxylic acid Derivatives and 6H-Dibenzo[c,h][2,6]naphthyridin-5-

ones with Potent Topoisomerase I-targeting Activity and Cytotoxicity

Bioorg Med. Chem. Lett., 14(22), 5585-5589, 2004

5. Alexander L. Ruchelman, Shejin Zhu, Nai Zhou, Angelia Liu, Leroy

F.Liu, and Edmond J. LaVoie Benzo[i] phenanthridines and 6H-

Dibenzo[c,h][2,6]naphthyridin-5-ones with Potent Topoisomerase I-

targeting Activity and Cytotoxicity. Abstracts of Papers. The 2004

Annual American Chemical Society Meeting, Philadelphia, PA, August 22,

2004

REFERENCES AVAILABLE UPON REQUEST

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