Manager Assistant
Resume:
Suganthy Yoganathan
E-mail: *********@*****.***
Clinton NJ 08809
EDUCATION
*/**** ************** ********* &Research Institute, Inc (PERI)
Certificate: Concepts in Good Clinical Practices for
the clinical Research
5/ 2000 MS (Chemistry), Washington State University, Pullman,
WA.
8/ 1997 BS (Biological science), Ohio State University,
Columbus, OH.
PROFESSIONAL EXPERIENCE
10/2001-present: Research Scientist - Bristol-Myers Squibb -Hopewell NJ
. Key player for the clinical Pharmacogenomic and Pharmacodynamic
biomarkers to assist in the clinical development of several
investigational oncology compounds in early and late stage clinical
trials: First in human (development) through Phase IV (commercial)
. Incorporated biomarker Strategies and writing in to Clinical
Protocols where applicable. Contribute specific sections to protocols
and participate in Clinical operational team meetings, discussions
and update the biomarker data in the CSR as in the protocol and Keep
tract the cost within oncology late stage products.
. Worked closely with clinical Monitor, protocol manager and other
operational clinical teams on protocol development by implementing
the biomarkers in the study and providing recent scientific updates,
novel technology applications, and guidance of cost regarding the
genomics/genetics and biomarker assay development for biomarkers.
. Explored new opportunities for technology development/expansion and
Point of contact for collaborators from other companies developing
supportive technologies.
. Remained current with literature and novel and new technologies and
share
knowledge with discovery, clinical and commercial colleagues
through
presentations and written reports
. Responsible for examining biomarkers for oncology drugs and identify
for new indications
. Assisted the drug discovery group in use of biomarkers for lead
therapeutic candidates to develop pharmacogenomic and pharmacodynamic
assays.
. Performed extensive data and statistical analysis from gene
expression data to identify genomic markers predictive of drug
response and identification of new drug targets in different cancer
by treatments comparison, classification algorithms, hierarchal
clustering, gene pathway and clinical data analysis.
. Generated expression profiles from preclinical and clinical
diagnostic tumor specimens using Affymetrix gene chips. Performed RNA
isolation, RT-PCR,
. Performed cells based assay with cancer cell lines for biomarker
discovery.
. Tailored screening strategies using siRNA, Phospho- ELISA, FACS and
immunoblot and immuno-precipitation techniques to study the protein
expression with drug in cancer cell lines.
. Project leader for preclinical studies to discover potential
biomarkers that could be used differentiate our VEGFR-2 inhibitor
from the competition and better understand the mechanism of action
(MOA). This work lead to initiate the phase II clinical study and
several collaborations internally and out side the BMS including with
Dr.Hanahan at UCSF to study our VEGFR-2 inhibitor in a VGFR-2
resistant preclinical model and better understand the pathways
involved with VEGF and FGF signaling and publications.
12/ 2000-9/ 2001: Scientist, Roche Molecular Systems, Belleville, NJ.
. Developed and optimized methods of purification and analyses.
. Purified and analyzed oligonucleotides by HPLC.
. Maintained and trouble shooted HPLC instruments.
. Responsible for writing and editing standard operating procedures
(SOPs) used in the R&D group.
6/ 2000-12/2000: Research Scientist, Roche Vitamins, Inc., Nutley, NJ.
. Maintained cell lines and performed stable cell transfections.
. Selected stable cell lines using FACS, immuno-fluorescence microscopy
and immuno-precipitation.
. Designed and performed assays and implemented high throughput
screening protocols to recover targeted natural products.
3/ 2000-6/ 2000: Scientist CELGRO Corp (Intern), North Brunswick, NJ.
. Designed and implemented enrichment, isolation, and high throughput
screening protocols to recover targeted enzymes.
. Conducted biochemical studies to assess the productivity of
recombinant fermentation processes of microorganisms.
. Operated and maintained lab-scale fermentors.
. Contributed to the scale-up of recombinant fermentation processes
8/1998-3/2000: Research Assistant, Department of Chemistry, Washington
State University.
. Investigated the immuno-response of macrophages by studying the
reactive oxidants produced by activated murine macrophages.
. Cultured primary and transfected cell lines.
. Activated the cells and analyzed products by uv-vis spectrophotometry,
liquid scintillation counting, and HPLC and fluorescence
spectrophotometry.
. Synthesized polyacrylamide beads as mimic bacteria and observed
phagocytosis.
. Used scanning electron microscope and fluorescence microscope to
characterize polyacrylamide beads.
1997-1998: Teaching Assistant, Undergraduate Organic Chemistry, Washington
State University.
. Planned and led help sessions and recitations in organic chemistry.
. Conducted lab sessions and graded lab reports.
LAB SKILLS:
. Cloning and subcloning, RT-PCR techniques, siRNA screening,
Microarray, cDNA and genomic library construction and screening,
protein expression.
. Animal tissue culture, isolation of specific cell using FACS,
immunofluorescent assay and isolation of white blood cells.
. High throughput screening:
. Used TECAN, Beckman multimeck automated 96-channel pipetter, Platemate
automated pipetter, Titertek automated pipetter and Topcounter
scintillator.
COMPUTER SKILLS:
. MS Excel, MS Power Point, MS Word, programming in Basic, Gene cluster,
spotfire, Waters Millenium software, FACTS, GEMINI, multimekpro, cybio
control, softmax, image pro plus, cell quest, Origin, and Graphpad .
. Experience with assessing and searching scientific databases and
sequence analysis software
COMPLETED TRAINING COURSE
. Attended the class Affymetrix expression array analysis held by
Affymetrix in New York 2004
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