Assistant Project

Dennis Law, Ph.D.

*** *. ****** ***. 626-***-****

La Puente, Ca. 91744 ***********@*****.***

Experience:

Postdoctoral research at City of Hope working of molecular dynamics

simulations, April 2010-July 2010

Postdoctoral research at ORNL working on modeling and simulation,

June 2008-Feb 2009

Postdoctoral research at IBM Almaden Research center working

on the Blue Gene project, June 2006 - June 2008

Dissertation Title: Combining Experimental Information and Computational

Methods to Produce Testable Models for Macromolecular Complexes

Education

Ph.D., Physical Chemistry

University of California, San Diego (UCSD), March 2005

B.S., Chemistry

University of California, Irvine, 1998

Research Experience

Graduate Student Researcher, Computational Chemistry, UCSD, 1998 -

2005

- Mastered various techniques for understanding molecular

interactions.

Lab Instructor, General Chemistry, UCSD, 1998

- Taught methods for doing lab experiments and maintained

safety in the lab

Teaching Assistant, UCSD, 1998-1999

- Presented the fundamentals of general chemistry and physical

chemistry

Tutor, UCSD, 1999-2005

- Tutored several students in chemistry and biochemistry

Selected Skills and Techniques

Bioinformatics & Biophysics methods

- Protein-protein docking tools - Protein-molecule

interaction tools

- binding free energy calculation - Molecular

dynamics simulations

- Monte-Carlo methods - free energy

calculations

- Extensive use of Protein Data - 3D modeling &

visualization

Bank (PDB) - homology

modeling

Computational Biophysics Programs

- AMBER, Insight II, Pymol, VMD, Rasmol, Molscript, UHBD,

DELPHI, TINKER, DOT, MSMS, and many others

Experimental Techniques

- MALDI-TOF H/D exchange mass spectrometry

Computer Skills (4+ years)

- designing algorithms - testing programs

- writing code - debugging code

- word processing - spreadsheets

- MPI - design

- managed jobs on 2 Bluegene racks (16k processors)

Computer Languages (4+ years)

- ANSI C, C++, FORTRAN, Perl, Unix

Leadership: Strong communication, organizational, public speaking and

mentoring skills

Language: Bilingual English/Spanish

Publications:

Law, D. S., Ten Eyck, F. L., Katzenelson, O., Tsigelny, I., Roberts, V. A.,

Pique, M. E. & Mitchell, J. C. (2003). Finding

needles in haystacks: Re-ranking DOT results using complementarity,

cluster analysis and biological information.

Proteins, Struct. Funct. Genet. 52, 33-40.

Anand, G. S., Law, D., Mandell, J. G., Snead, A. N., Tsigelny. I,,

Taylor S. S., Ten Eyck, L. F. & Komives E. A.

(2003). Identification of the protein kinase A regulatory RI(alpha)-

catalytic subunit interface by amide H/2H

exchange and protein docking. Proc. Nat. Acad. Sci. USA 100, 13264-

13269.

Law, D., Hotchko, M., Ten Eyck, F. L. (2005). Progress in Computation and

Amide Hydrogen Exchange for Prediction of

Protein - Protein Complexes. Proteins, Struct. Funct. Genetics. 60, 302-

307.

Fellowships and Grants:

1999-2002 GAANN Fellow

2003-2004 Molecular Biophysics Training Grant

2006-2008 CPIMA postdoc

References:

William T. Heller Oak Ridge National Lab

********@****.*** 865-***-****

Jed W. Pitera IBM Research, Macromolecular

Simulation and Modeling

******@**.***.*** 408-***-****

Lynn F. Ten Eyck San Diego Supercomputer Center,

(Ph.D. Advisor) Pharmacology

********@****.*** 858-***-****

J. Andrew McCammon UC San Diego

(Ph.D. co-advisor) 858-***-****

*********@****.***

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