Assistant Data Entry

Kelli M. Jones

*** *. ******** **, ********, CT *6504 . 203-***-**** .

*****.*****@***.***

Education

Master of Science in Neuroscience

University of Hartford, Hartford, CT

Expected graduation December 2010

Bachelor of Science in Biology, Minor in Chemistry, May 2002

Quinnipiac University, Hamden CT

Professional Experience

Research Scientist I, 2009 - present

Bristol Myers Squibb Co., Department of Neuroscience - Wallingford,

CT

Associate Research Scientist II, 2006 - 2009

Bristol Myers Squibb Co., Department of Neuroscience - Wallingford,

CT

. Developed an attentional set-shifting task, used to measure

executive function in rats. Demonstrated a stable MK-801

deficit in the task and reversal with known anti-psychotics

as well as in-house compounds. The assay became a key part of

the screening tier for a full phase program in schizophrenia

and was used to identify ECNs for clinical trials.

. Developed deficit models of working memory using scopolamine

and MK-801 to acutely disrupt performance in the delayed non-

match to position task for rats

. Surgical implantation of ICV cannulae in rats and analysis of

working memory after ICV infusion of neuropeptides

. Drug preparation

. Data analysis and presentation of data at working group

meetings

Associate Research Scientist I, June 2004-2006

Bristol Myers Squibb Co., Department of Neuroscience - Wallingford,

CT

. Assessed various neurodevelopmental rodent models of

schizophrenia for cognitive deficits, duties included

creating the models (neonatal ventral hippocampal lesioned

rats, neonatal rats treated with PCP, and pre-natal rats

treated with a mitosis inhibitor on gestational day 17),

testing the models in 5-Choice serial reaction time task and

the set-shifting maze task, and histological validation of

the models

. Behavioral test experience includes: radial arm maze, 5-

Choice serial reaction time task, set-shifting maze task,

latent inhibition (lick suppression), fear conditioning,

delayed non-match to position

. Provided in-vivo support for AD program, duties included

dosing (IP, SC, IV and PO), taking blood samples (retro-

orbital bleeds and cardiac puncture), CSF collection, harvest

of tissues (brain, duodenum, ileum etc.), and brain

dissection in rats and mice. Experience with dogs includes

catheterization, dosing (capsule and oral gavage), saphenous

vein bleeds and restraint

. Drug preparation

. Data entry/analysis

Research Assistant, October 2003 - May 2004

University of Pittsburgh, Department of Neuroscience -

Pittsburgh, PA

Moghaddam Lab

. Stereotaxic brain surgery on rats, placement of microdialysis

probes into the prefrontal cortex and amygdala

. Construction of microdialysis probes

. Used HPLC to determine the amount of dopamine being released

from different areas of the brain

. Preparation of buffers and solutions

. Ran maze-bazed behavioral assessments, primarily set-

shifting

. Responsible for routine upkeep of laboratory including

compliance with lab safety regulations

. Assisted moving the laboratory to a new place

Kelli M. Jones

132 N. Chestnut St, Branford, CT 06504 . 203-***-**** .

*****.*****@***.***

Research Assistant, September 2002 - October 2003

Yale University, School of Medicine, Department of Psychiatry -

New Haven, CT

Moghaddam Lab

. Stereotaxic brain surgery on rats, chronic bilateral

cannulation of prefrontal cortex, obitofrontal cortex and

anterior cingulated cortex

. Ran operant and maze-based behavioral assessments,

including set-shifting, T-maze, open field activity and

spontaneous alternation

. Dosing of rats (microinjection and IP)

. Histology, including animal perfusion, tissue

sectioning, slide mounting and staining

. Data entry

Research Assistant, summers of 2001 and 2002

Connecticut Agricultural Experiment Station, Mosquito Management -

New Haven, CT

. Identified adult and larvae mosquitoes to species

using diagnostic keys

. Maintenance of mosquito colonies

. Field work, collecting egg rafts and setting CDC

light traps at different locations throughout the

state

Independent Study Project, January 2002 - May 2002

Quinnipiac University, Department of Biology - Hamden, CT

. Investigated the effects of diet (high saturated fat versus

low saturated fat) on the phospholipid composition of

pulmonary surfactant in mice

. Performed surgical techniques on mice to extract lung

surfactant, which was later analyzed by HPLC

. Care of laboratory animals

Computer Skills

. Microsoft Office (Excel, PowerPoint, Outlook, Word, Access)

. Sigmaplot

. SAS

. SPSS

. Endnote

. Graphic State

Awards

. PRI Star Award, 12/2009, for innovative contributions towards

the development of novel neuro-developmental models of

schizophrenia

. Crystal Award, 6/2009, for exceptional demonstration of a Core BMS

Behavior (driving performance)

. PRI Star Award, 1/2007, for excellence and achievement in driving

the Lexicon collaboration

. PRI Star Award, 12/2004, for role in conducting the first

terminal dog study for the gamma secretase program

Publications

Hodges, DB Jr, Lindner MD, Hogan JB, Jones KM, Markus EJ,

"Scopolamine induced deficits in a battery of rat cognitive tests:

comparisons of sensitivity and specificity," Behavioural Pharmacology,

2009, 20(3) 237-51.

Meredith, JE. Jr, Thompson LA, Toyn JH, Marcin L, Barten DM,

Marcinkeviciene J, Kopcho L, Kim Y, Lin A, Guss V, Burton C, Iben L,

Polson C, Cantone J, Ford M, Drexler D, Fiedler T, Lentz KA, Grace JE

Jr, Kolb J, Corsa J, Pierdomenico M, Jones K, Olsen RE, Macor JE,

Albright CF, "P-glycoprotein efflux and other factors limit brain

amyloid beta reduction by beta-site amyloid precursor protein-cleaving

enzyme 1 inhibitors in mice." Journal of Pharmacology and

Experimental Therapeutics, 2008, 326(2): 502-13.

Lindner MD, Hogan JB, Hodges DB Jr., Orie AF, Chen P, Corsa JA, Leet

JE, Gillman KW, Rose GM, Jones KM, Gribkoff VK, "Donepezil primarily

attenuates scopolamine-induced deficits in psychomotor function, with

moderate effects on simple conditioning and attention, and small

effects on working memory and spatial mapping", Psychopharmacology,

2006, 188(4) 629-40.

Kelli M. Jones

132 N. Chestnut St, Branford, CT 06504 . 203-***-**** .

*****.*****@***.***

Jones KM, Hogan JB, Chen P, Hodges, DB Jr., Lindner MD. "Preclinical

models of psychosis and behavioral assessments of deficits in

clinically-relevant cognitive domains." Lawrenceville, NJ: Bristol-

Myers Squibb Poster Session, 2005.

Stefani MR, Jones K, Groth K, Moghaddam B. "Comparison of systemic

and Intra-prefrontal cortical NMDA receptor blockade on task

acquisition and set-shifting abilities in rats." Program No. 940.13.

2003 Neuroscience Meeting Planner. New Orleans, LA: Society for

Neuroscience, 2003. Online.

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