Assistant Manager

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OBJECTIVE

R&D position that utilizes my initiative and creativity in analytical

problem-solving.

SUMMARY OF QUALIFICATIONS

. 8 years of experience in research laboratory.

. PhD in Analytical Chemistry with expertise in chromatography and mass

spectrometry.

. Extremely solid skills in operation and maintenance of GC, LC, ICP-MS and

ESI-MS.

. Deep mastery of trace elemental analysis.

. Experience of LC-MS/MS based proteomics.

. Experience of material characterization with FT-IR, NMR, DSC, TGA, etc.

. Experience of polymer synthesis and characterization.

. Outstanding written and verbal communication.

EDUCATION

. PhD in Analytical Chemistry University of Cincinnati 2006-2010

GPA=3.9/4.0

Dissertation title: Elemental speciation of biometals with LC-ICP-MS and

LC-MS/MS; Adviser: Joseph A. Caruso

. MS in Polymer Chemistry&Physics Nankai University 2003-2006

GPA=3.8/4.0

. BS in Chemistry Nankai University 1999-2003

GPA=3.8/4.0

PROFESSIONAL EXPERIENCE

Graduate Assistant, University of Cincinnati, Cincinnati, OH 2006.9-

present

. Developed ICP-MS methods for measuring trace elements in various

materials.

. Developed HPLC methods for IC, RP, SEC at conventional, capillary and

nano flows.

. Developed GC and SPME methods for GC-ICP-MS and GC-TOF-MS.

. Used microwave in acid digestion for ICP-MS analysis and tryptic

digestion for LC-MS/MS.

. Developed LC-MS/MS methods for peptide mapping.

. Developed post-column isotope dilution methods for LC-ICPMS online

quantification.

. Determined the structures of organic compounds with ESI-MS/MS.

. Gained extensive experience in data analysis and interpretation.

. Initiated the study of metals in mouse macrophage cells during pathogen

infection. Established a novel analytical approach for studying

intracellular metal regulation and for the first time, discovered zinc's

fundamental role in pathogen growth.

. Designed experiments for characterizing selenium metabolites in plants,

qualitatively and quantitatively. Elucidated the structures of volatile

selenium gas, inorganic selenium, organic selenium and Se-containing

proteins.

. Evaluated heavy metal contamination by measuring metal concentrations in

wild lichens.

. Investigated the role of metals in hypertension by monitoring the metals

in mouse organs.

. Determined the organometals in crude oil.

Graduate Assistant, University of Cincinnati, Cincinnati, OH 2006.9-

present (Continued)

. Managed testing services for clients and wrote reports.

. Managed waste disposal for the research group based on the EPA

regulations.

. Supervised undergraduate researches.

. Trained new group members on instrumentation and data analysis.

. Taught undergraduate students for four years.

. Led a group of 20 undergraduate students for projects.

. Collaborated with researchers from various disciplines.

Graduate student, Nankai University, Tianjin, China 2002.9-2006.6

. Characterized materials with NMR, FT-IR, DSC, TGA and XPS.

. Synthesized polymers using ATRP and suspension polymerization.

. Synthesized and characterized a few novel compounds of cholesteric liquid

crystals.

. Fabricated microchips for immunoassay by controlled surface modification.

. Explored lab-on-a-chip techniques, including soft-lithography and micro-

contact printing.

ACHIEVEMENTS, HONORS, AWARDS & AFFILIATIONS

. Published 2 patents and 18 peer-reviewed papers plus 3 in preparation.

. Presented 3 invited lectures, 5 other talks and 10 posters.

. Awarded 2010 URC Graduate Student Research Fellowship (winner of the

graduate student research proposal contest).

. Awarded the Scholarship of Nankai University for 4 times.

. Member of ACS and ASMS.

REFERENCES

. Dr. Joseph A. Caruso, Professor of Chemistry

Department of Chemistry, University of Cincinnati, Cincinnati, OH

513-***-**** ******.******@**.***

. Dr. Patrick A. Limbach, Professor of Chemistry

Department of Chemistry, University of Cincinnati, Cincinnati, OH

513-***-**** ***.*******@**.***

. Dr. Michael S. Winters, Research Assistant Professor of Infectious

Diseases

Division of Infectious Diseases, University of Cincinnati College of

Medicine, Cincinnati, OH

513-***-**** ********@*****.***

. Dr. Peter A. Padolik, Manager of Freshman Laboratories

Department of Chemistry, University of Cincinnati, Cincinnati, OH

513-***-**** *****.*******@**.***

PUBLICATIONS, PRESENTATIONS & PATENTS (See attached)

Peer-reviewed publications

1. Q. Chan, S.E. Afton and J.A. Caruso, "Investigation of selenium

metabolites in Se-enriched kale, Brassica oleracea A, via HPLC-ICPMS and

nanoESI-ITMS," Journal of Analytical Atomic Spectrometry, 2010, 25, 186-

192.

2. Q. Chan, S.E. Afton and J.A. Caruso, "Selenium speciation profiles in

selenite-enriched soybean (Glycine Max) by HPLC-ICPMS and ESI-ITMS,"

Metallomics, 2010, 2, 147-153.

3. M.S. Winters, Q. Chan, J.A. Caruso and G.S. Deepe, "Metallomic analysis

of macrophages infected with histoplasma capsulatum reveals a fundamental

role for Zn in host defenses," Journal of Infectious Diseases, 2010, 202,

1136-1145.

4. Q. Chan and J.A. Caruso, "GC or LC with ICPMS detection," Analytical and

Bioanalytical Chemistry, submitted in August 2010. (An invited review)

5. R.N. Easter, Q. Chan, B. Lai, E.L. Ritman, J.A. Caruso and Z. Qin,

"Vascular metallomics: copper in the vasculature," Vascular Medicine,

2010, 15(1), 61-69.

6. K. Wrobel, C.R. Flores, Q. Chan and K. Wrobel, "Ribonucleoside labeling

with Os(VI)-a methodological approach to evaluation of RNA methylation by

HPLC-ICP-MS," Metallomics, 2010, 2, 140-146.

7. K.H. Won, Q. Chan, S.E. Afton, M. Ashraf, J.A. Caruso, B. Lai, N.L.

Weintraub and Z. Qin, "Human macrophage ATP7A localizes in the trans-

Golgi apparatus, controls intracellular copper levels, and mediates

macrophage responses to dermal wounds," Journal of Vascular Research,

July 2010. (submitted)

8. Y. Fang, Y. Zhang, B. Catron, Q. Chan, Q. Hu and J.A. Caruso,

"Identification of Se compounds in regular rice and Se-enriched rice by

foliar application: HPLC-ICPMS and Nano-ESI-ITMS for detection," Journal

of Analytical Atomic Spectrometry, 2009, 24, 1657-1664.

9. M.S. Winters, D.S. Spellman, Q. Chan, F.J. Gomez, M. Hernandez, B.

Catron, A.G. Smulian, T.A. Neubert and G.S. Deepe, "Histoplasma

capsulatum proteome response to decreased iron availability," Proteome

Science, 2008, 6, 36.

10. Hou, S; Feng, X; Wang, L; Chan, Q. Microcontact printing of

multiproteins on the GA modified glass substrate and its application in

the research of immunoassays. Solid State Phenomena, 2007, 121-123, 721.

11. Y. Yang, Q. Chan, X. Ma, K. Deng, Y. Shen, X. Feng and C. Wang,

"Electrical conformational bistability of dimesogen molecules with a

molecular chord structure," Angewandte Chemie International Edition,

2006, 45, 6889.

12. L. Wang, X. Feng, S. Hou, Q. Chan and M. Qin, "Microcontact printing of

multiproteins on the modified mica substrate and the research of

immunoassays," Surface and Interface Analysis, 2006, 38, 44.

13. Y. Shen, Y. Yao, Q. Chan and X. Feng, "Comparative research of

supermolecular self-assemble dimesogenic cholesteric liquid crystals,"

Chinese Journal of Liquid Crystals and Displays, 2005, 21, 599.

14. Q. Chan, X. Feng, Y. Shen and X. Peng, "Study of preparation and

properties of novel dimesogenic cholesteric liquid crystalline with long

flexible spacers," Chinese Journal of Liquid Crystals and Displays, 2005,

20, 361-364.

15. Y. Shen, X. Feng, Q. Chan and X. Peng, "Supramolecular liquid

crystalline architechtures by hierarchical self-assembly. Chemical

Journal on Internet, 2005, 7, 30.

16. Q. Chan and X. Feng, "Cholesteric liquid crystals application in color

display technology," Advanced Display, 2004, 5, 17.

17. X. Feng, S. Hou, Q. Chan and L. Wang, "Microcontact printing techniques

in bioscience," Chem. Res. Chinese Univ., 2004, 20, 826.

18. X. Feng, S. Hou, L. Wang, Q. Chan and P. Han, "Microfluidic networks

techniques in biosciences," Chemical Journal on Internet, 2004, 6, 62.

Presentations

1. Q. Chan, M.S. Winters, G.S. Deepe and J.A. Caruso, "Investigation of

intracellular metal regulation in macrophages upon infection utilizing

ICP-MS and isotope dilution." Central Regional Meeting of ACS (CeRMACS),

Dayton, OH, June 2010. (Poster)

2. Q. Chan, M.S. Winters, G.S. Deepe and J.A. Caruso, "Investigation of Zn

and Zn-binding proteins in macrophage by LC-ICPMS and LC-MS/MS," Ohio

Mass Spectrometry Symposium, Columbus, OH, April 2010. (Talk)

3. Q. Chan, M.S. Winters, G.S. Deepe and J.A. Caruso, "Metalloprotein

regulation employed by macrophages as a host defense mechanism against

Histoplasma capsulatum," Winter Conference on Plasma Spectrochemistry,

Fort Myers, FL, January 2010. (Talk)

4. Q. Chan, "Applications of metallomics approaches in biology," National

Research Center for Geoanalysis, Beijing, China, December 2009. (Invited

lecture)

5. Q. Chan and J.A. Caruso, "Selenium speciation in Se-enriched plants by

HPLC-ICPMS and ESI-ITMS," Beijing Conference and Exhibition on

Instrumental Analysis (BCEIA), Beijing, CHINA, November 2009. (Invited

lecture)

6. Q. Chan and J.A. Caruso, "Metallomics approaches for biological issues,"

Agilent Advanced ICP-MS Applications Seminar, Beijing, China, November

2009. (Invited lecture)

7. Q. Chan, M.S. Winters, G.S. Deepe and J.A. Caruso, "Applying metallomics

to immunology: a study of metal regulation in macrophage infected with

Histoplasma capsulatum," Beijing Conference and Exhibition on

Instrumental Analysis (BCEIA), Beijing, China, November 2009. (Talk)

8. K. Wright, Q. Chan and J.A. Caruso, "Monitoring environmental

contamination via measuring metals in lichens using ICPMS," NSF-REU

Poster Session, Cincinnati, OH, August 2009. (Poster)

9. Q. Chan, S.E. Afton and J.A. Caruso, "Characterization of selenium

metabolites in Se-enriched kale (Brissica oleracea) via ion-pairing

reversed phase chromatography with ICPMS and ESI-IT-MS detection," ASMS

Conference on Mass Spectrometry, Philadelphia, PA, June 2009. (Talk)

10. Q. Chan, S.E. Afton and J.A. Caruso, "The investigation of selenium

metabolites in soybean (Glycine Max) via ion-pairing reversed phase

chromatography with ICPMS and ESI-IT-MS," International Symposium on

Metallomics, Cincinnati, OH, June 2009. (Talk)

11. M.S. Winters, Q. Chan, J.A. Caruso and G.S. Deepe, "Zn limitation as a

host defense mechanism against Histoplasma capsulatum," International

Symposium on Metallomics, Cincinnati, OH, June 2009. (Poster)

12. Y. Fang, Y. Zhang, Q. Chan, Q. Hu and J.A. Caruso, "The Investigation

Selenium Speciation in Se-enriched Rice and Green Tea Using Ion Pairing

RP-HPLC-ICPMS and nanoESI-MS," Ohio Mass Spectrometry Symposium,

Columbus, OH, June 2009. (Poster)

13. Y. Fang, Y. Zhang, Q. Chan, Q. Hu and J.A. Caruso, "Identification of

Selenium Compounds in Se-enriched Rice by Foliar Application Using HPLC-

ICP-MS and Chip-based NanoESI-ITMS," International Symposium on

Metallomics, Cincinnati, OH, June, 2009. (Poster)

14. Q. Chan, S.E. Afton and J.A. Caruso, "The investigation of selenium

metabolites in kale (Brassica oleracea acephala) utilizing HPLC with

ICPMS detection," 40th Central Regional Meeting of the American Chemical

Society (CERMACS), Columbus, OH, June 2008. (Poster)

15. Q. Chan, S.E. Afton and J.A. Caruso, "The investigation of selenium

metabolites in kale utilizing HPLC-ICPMS and HPLC-ESI-MS," Winter

Conference on Plasma Spectrochemistry, Temecula, CA, January 2008.

(Poster)

16. Q. Chan, S.E. Afton and J.A. Caruso, "The investigation of selenium

metabolites in soybean utilizing multi-dimensional HPLC-ICPMS," Ralph and

Helen Oesper Symposium, Cincinnati, OH, October 2008. (Poster)

17. Q. Chan, S.E. Afton and J.A. Caruso, "The investigation of selenium

metabolites in kale utilizing HPLC-ICP-MS," UC Graduate Poster Forum,

Cincinnati, OH, March 2008. (Poster)

18. Q. Chan, S.E. Afton and J.A. Caruso, "The investigation of selenium

metabolites in kale utilizing HPLC-ICP-MS," Ralph and Helen Oesper

Symposium, Cincinnati, OH, October 2007. (Poster)

Patents

1. Q. Chan and X. Feng, "Dual mesogenic unit cholesteric liquid crystal:

its synthesis method and application," CN 1632056, 2005.

2. X. Feng, S. Hou, L. Wang, Q. Chan and P. Han, "Method for preparing

multicomponent biological microarray chip," CN 1588070, 2005.

Qilin (Charlie) Chan

*****.****@*****.***; 513-***-****

2971 Deckebach Ave APT 35

Cincinnati, OH 45220

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