Design Engineer Medical

Harleviene J. Gu

** ******* ****, ******* ** **791 . 516-***-**** . ******@*****.***

EDUCATION

B.S. MASSACHUSETTS INSTITUTE OF TECHNOLOGY

(9/03- 6/07)

Dual Degree in Materials Science & Engineering, Physics; Minor in

Writing (GPA: 4.45/5.0)

UNIVERSITY OF PENNSYLVANIA

(9/10- 6/11)

Liberal and Professional Studies

OBJECTIVES- To obtain a position as a Medical Writer using my broad

and comprehensive technical and medical backgrounds. To obtain a

position in New York, NY due to its proximity to my family on Long

Island

SKILLS

.Computer Skills: MS Windows OS, Windows XP, Mac OS, Microsoft Office

Tools (Excel, Word, Outlook, etc), Photoshop, MAT-LAB, AutoCAD 2008,

Pro-E, Solidworks, MathCAD, etc.

.Languages: Fluent in English, Chinese, Mandarin and Shanghai

dialect. Literate in Latin.

.Instruments: SEM, TEM, STEM, Scanning Confocal Electron Microscope,

Nanoscope Multiprobe, AFM, NSOM, spectroscopic tools, gas

chromatograph, DSC, Electron Beam Deposition, PCR, electrophoresis,

ELISA analysis.

EXPERIENCES

Children's Hospital of Philadelphia (CHOP)

Researcher--- Department of Neurology

5/11- Present

. Analyze EEGs of patients to determine how specific waveforms

generate seizures. Research molecular methods to downregulate

epileptic reoccurrences and duration.

. Research the effect of CREB transcription factor in the development

of epilepsy in order to understand the molecular mechanisms involved

in epilepsy which is helpful in developing novel epilepsy therapeutic

target.

. Study the role of CREB in epileptogenesis using a genetically

modified mouse model (CREB? mice) which lack part of the CREB

protein.

Children's Hospital of Philadelphia (CHOP)

Academic Research Associate--- Emergency Department

1/11- 5/11

. Worked with the ED staff to screen, consent, and enroll young

patients for clinical research. The studies included: seizure

medication, occult/abdominal trauma, therapeutic hypothermia,

nebulized hypertonic saline for acute bronchiolitis, dextrose IVF in

treatment of acute dehydration, biosignature identification of

bacterial infections in febrile patients, ALTE (Apparent Life-

Threatening Event), NCOSS Child Injury reports, concussion, PID

(Pelvic Inflammatory Disease) Biosignature, and MRSA.

Hospital of the University of Pennsylvania (HUP)

Academic Research Associate--- Emergency Department

9/10- 12/10

. Screened, consented, and enrolled patients for clinical research

projects which included: Early diagnosis of Acute Coronary Syndrome

(ACS), early diagnosis of sepsis, domestic violence, early diagnosis

of stroke, cocaine related heart disease, pregnancy-related

complications, emotional consequences of traumatic injury, and

community wide interventions to decrease the relapse rate in

asthmatics. I also helped out the staff in the ED department when

needed.

DREXEL UNIVERSITY COLLEGE OF MEDICINE

Research Specialist II--- Department of Biochemistry and Molecular

Biology 4/09- 8/10

. Produced and validated a covalently linked HNG-gp120 complex using

photo labeled HNG derivative to determine attachment site of peptide

to protein. Determined changes in immunogenic landscape immunizations

with unliganded protein and covalent complex and detecting antibody

. Determined surface changes and other parameters of the complex as

compared to unliganded gp120 by binding assays with a panel of

antibodies sensitive to specific conformations and assays for

stabilization, secondary structure composition and solvent

accessibility.

COOK MEDICAL, INC.

Research and Design Engineer --- R&D

Department 09/07-

3/09

.Designed and implemented production of endoscopic devices,

including Biliary/Pancreatic, Endoscopic Ultrasound, and

Esophageal/Gastric/Colonic product families for procedural efficiency.

.Generated new ideas for devices through working with experts in

field of knowledge and incorporating customer and design control

requirements into product specs.

.Developed prototypes and test methods for concept feasibility,

established comprehensive project plans for development of devices in

accordance with design control requirements.

.Produced detailed design documentation by creating component and

assembly drawings, generating SOPs, outlining BOM, performing

engineering evaluation / analysis of designs.

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Lab Researcher -- Biomolecular Materials

Group 11/03-

06/07

.Synthesized polymer and viral nanofibers with genetically

controllable and functionalizable surface proteins using filamentous

phage virus. Identified mechanical properties of phage fibers.

.Fabricated electrospun polymer-blend (PVP and PEO) and phage-based

virus nanofibers (both blends and core- sheath structures) with gold

core. Researched effect of electric field on crystallinity.

Demonstrated DNA extraction from phage fibers.

Teaching Assistant -- MIT Physics

Department

02/05-06/06

.Taught and tutored "Electricity and Magnetism" and "Classical

Mechanics" courses.

.Prepared recitation notes, tutored students, and held problem set

help sessions.

.Tested, demonstrated, and assisted students with laboratory

experiments.

STATE UNIVERSITY OF NEW YORK AT STONY BROOK

Research Assistant

06/06-08/06

.Investigated viability, proliferation, and mineralization of MC3T3-

E1 osteoblast-like cells on biocompatible substrates. Collected data

in preparation for studies of osteoporosis.

.Developed microfluidic device to investigate effect of fluid flow

on bone cell growth and bone remodeling process.

HARVARD/MIT HEALTH SCIENCE AND TECHNOLOGY LAB

Lab

Researcher

05/05-09/05

.Designed nanoparticles and nanoporous materials that can home to a

tumor, sense changes in tissues, enhance imaging, and trigger release

of a therapeutic payload.

PUBLICATIONS

. "Stability and Potency Evaluation of Dual Antagonist HIV-1 gp120-

Targeting Peptidomimetic Entry Inhibitors for AIDS Microbicides," IPM-

USAID Project (July 2009).

. "Immunological Landscape in HIV-1 Env Induced by Allosteric Dual

Antagonists", Center for HIV/AIDS Vaccine Immunology (CHAVI) (May

2009).

. "Weaving Genetically Engineered Functionality into Mechanically

Robust Virus Fibers", Featured on Cover of Advanced Materials, (March

2007).

. "Effect of Substrate Surface Modification on Biomineralization of

Osteoblasts", Materials Research Society (December 2006).

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