Project Quality Control

RAMYA SUDHA MUTTAVARAPU

****, *** *******, ***#**, Fairfax, Virginia 22031

E mail: *********@*****.**.**

Phone: 216-***-****

To pursue a career in an esteemed organization holding a responsible position which would enhance my skills

to work in a competitive environment and carve a winning edge for the organization.

ACADEMIC CREDENTIALS:

Master of Science in Chemistry

GPA 3.6

2012

Cleveland State University, Cleveland, Ohio

GPA 4.0

Bachelor of Science in Pharmaceutical Sciences 2010

Acharya Nagarjuna University, India

PROFESSIONAL EXPERIENCE:

Teaching Assistant, Department of Chemistry

(Spring 2012)

Cleveland State University

Responsibilities Included:

• Maintained a schedule for teaching and lab work

• Created assignments and workshops for students

• Prepared the Reagents required for the lab work

• Assisted the professor in preparing the tests and grading the answer sheets

• Regularly attended the Career and Research workshops for the students of Department of Chemistry

Tutor, Tutoring and Academic Success Centre

(Fall 2011 –Fall 2012)

Cleveland State University

• Conducted review sessions in Biology and Chemistry for the freshmen classes.

• Engaged in academic activities with students either one on one or in small groups.

• Collaborated with the academic advisor to best address the student needs.

Quality control chemist (Feb 2013 Present)

Chantilly biopharma, Virginia

As a part of the job,

• Analysed samples

• Kept a track of documentation

• Prepared and updated activity sheets for QC lab

• Worked with UV spectrophotometer, FTIR, disintegration, dissolution apparatus, friability apparatus, centrifuge,

KF titrimeter, Potentiometer, Blenders, Granulators etc.

• Documented experiments and prepared release sheets for analysed samples.

• Functioned as Stability coordinator.

RESEARCH EXPERIENCE:

Thesis, Master of Science program

Polymer Bio Implants PLLA Implants for bones

Dr. John F Turner, Asst. Professor, Dept of Chemistry, Cleveland State University.

Bone related disorders like Osteoporosis, Arthritis have been menacing problems for a very long time now. With so many

advancements in the treatment, growing an artificial bone under laboratory conditions was perceived as a positive venture.

As a part of the project,

• Obtained Poly L Lactic Acid pellets from Birmingham Polymers, Birmingham, AL.

• Studied the profile of Poly L Lactic Acid (PLLA) its physical and optical properties and DSC and XRD studies.

• Compression moulding of PLLA beads into 5cm x 5cm plaques.

• Developed a visual C++ program which controls the stepper motor. The stepper motor is used to stretch the polymer

plaques to different draw ratios from 1 to 5.5.

• Obtained Raman images of the polymer stretched to different draw ratios.

• Production of an osteoclast like cell line on the stretched polymer surface under laboratory conditions.

Instrumentation Handled:

• Raman Spectroscopy

• Scanning Electron Microscopy (SEM)

• PCR, RT PCR

2012 Summer Internship

Biosynthesis of O linked glycans

Dr. Thomas Gerken, Professor, Biomedical Research, Case Western Reserve University

Glycoproteins containing heavily o glycosylated, mucin like domains play an important role in all bioprocesses. The goal of

the project was to develop a detailed understanding of biosynthetic processes that regulate the unique glycosylation

process of these o glycosylated domains. Wild type mice and MUC2 knockout mice are used for studies.

The project included,

• Tissue extraction from the mice and homogenisation

• Centrifugation to separate soluble protein and lipid from the insoluble components

• Reduction and Carboxymethylation

• Dialysis

• Lyophilisation

• Analysis of dried solid protein using SDS PAGE, Protein mass comparison, Size exclusion chromatography

techniques.

Instrumentation Handled:

• Column chromatography

• Homogeniser

• Lyophilizer

Thesis/Project, Bachelor of Science program

Design, Development and Evaluation of sustained release dosage forms of Diclofenac

Diclofenac is an NSAID that is highly effective and widely employed in the treatment of inflammation. But the half life is

only 2.4 hours, which necessitates frequent administration. But, frequent administration causes adverse effects like gastric

upset and hence, it is better to administer as Microspheres and Microcapsules.

As a part of the project,

• Studied various disease profiles, symptoms, diagnosis, treatments and pathophysiologies.

• Made an extensive study about various drug profiles, their syntheses, administration, adverse effects,

contraindications, and advancements.

• Collected the drug in pure form and evaluated its physical properties like melting point, dissolution, bioavailability and

disintegration.

• Used the most efficient technique (solvent evaporation) to convert the drug into micro particles.

• Evaluated the drug for its properties like dissolution, disintegration and bioavailability using disintegration apparatus

and UV Spectrophotometer.

• Tested the shape of microspheres using Scanning Electron Microscopy (SEM).

Instrumentation Handled:

UV/ Visible Spectrophotometer

Potentiometer

KF Titrator

Dissolution Disintegration apparatus

Friability

Hardness

Density

Viscometers

Tablet press

Stability chambers

EXTRA CURRICULAR ACTIVITIES

• 2012 Presented a poster about Advanced Polymer Chemistry at PINO Conference at Case Western University.

• 2012 Part of Freshmen Orientation Committee at Cleveland State University.

• 2010 Winner of Summer Research Fellowship at Baba Atomic Research Centre (BARC), Mumbai, India.

• 2009 Won the Poster session (Breast Cancer) at National Seminar, held at Acharya Nagarjuna University

• 2009 Won the Elocution competition at National Pharmacy Week celebrations

• 2009 Appreciated for Poster session about Cervical Cancer during Indo American Pharmaceutical Regulatory

Symposium

• 2007 – Won two inter college debating events.

• Winner of many Classical Dance competitions.

• Event organiser and Student Cultural Representative in high school and undergraduate program.

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