Scientist

Resume SURESH GADDE PhD

Green card holder (EB*)

email: ******@****.***.*******.***, ******@***.***

mobile: 316-***-**** address: 9 Devotion st, Apt 2L, Brookline MA 02446

SUMMARY

Skilled organic/polymer chemist and drug formulation specialist, with an outstanding publication record

Extensive work experience in design, synthesis and the development of nanomedicines for oncology and

cardiovascular applications

Self-motivated team player, independent thinker, highly analytical and experienced in a broad range of laboratory

techniques. Interested in the design and development of novel biomaterials and small molecules for therapeutic

applications

Currently seeking employment where I can apply my multidisciplinary skills for addressing problems related to

human health

EDUCATION

Ph.D. Organic/Analytical Chemistry, Wichita State University, Wichita, KS, USA 2001-2006

M.Sc. Chemistry. University of Hyderabad, Hyderabad, India 1998-2000

SKILLS AND TECHNICAL ABILITIES

Outstanding capabilities in experimental design, optimization, troubleshooting and data analysis

Qualified in bench to bedside translation with regards to design, synthesis, and development of nanotherapeutics

Able to adapt effectively to new environments, forward thinking and responsible team player

Able to think creatively in problem solving and develop innovative solutions based on strong theoretical and

scientific arguments

Excellent leadership and mentoring skills; mentored numerous students, at all education levels, providing them

with the opportunity to publish high impact papers

Excellent oral and written communication skills

Driven, self-starter with capability to work independently and closely with project team.

Comfortable working on both academic and industrial projects especially in a high pressure start-up environment

Cell culture techniques, cytotoxicity assays

Zetasizer, Two-Photon/Confocal/Fluorescence Microscopy, Flow Cytometry, TEM, SEM, and TGA

NMR (COSY, NOESY, and DOSY), FT-IR, GC-MS, HPLC, Fluorescence, Electrochemistry (CV, SWV, and DPV)

Computational methods: DFT, ONIOM, AM1 and PM3

Experienced in Microsoft Office applications

WORK EXPERIENCE

Post-Doctoral Fellow Advisor: Professor Omid Farokhzad MD Dec 2009-Present

Brigham and Women’s Hospital, Harvard Medical School Boston, MA

Designed, and led several polymer-drug conjugates, di block, and tri block polymer synthesis projects for developing

novel targeted polymeric nanoparticle drug delivery systems for the treatment of cancer and cardiovascular

diseases

Synthesized and nanoengineered a library of LXR agonist containing nanoparticles and tested in vitro and in vivo for

anti-inflammatory effects. Developed highly novel statin containing nanoparticles for anti -atherosclerosis therapy

Synthesized and nanoengineered phenanthriplatin containing nanoparticles, and in vitro cytotoxicity evaluated on

several cancer cell lines, and in vivo efficacy studies were performed on prostate cancer xenograft models

Designed and synthesized novel biodegradable biomaterials for protein delivery and RNAi therapeutics

Led the labs efforts in the synthesis of several platinum based drug-polymer conjugates. Evaluated synergistic

cytotoxic effects between Platin based anticancer agents and anti-angiogenesis agents. Developed novel

nanotherapeutics containing multiple agents for combination chemotherapy

Developed, optimized and introduced to the group the use of drug combination and drug synergy calculation

software

Developed polymer and/or lipid-polymer hybrid multifunctional nanoparticle systems which contain two-photon

fluorescence imaging polymer, MRI imaging agent, and targeting ligand for targeted drug delivery and dual imaging

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SURESH GADDE PhD

Post-Doctoral Associate Advisor: Professor Angel E. Kaifer Ph.D Dec 2006-Nov 2009

Department of Chemistry, University of Miami Coral Gable, FL

Synthesized several photo- and electro-active and/or electron paramagnetic resonance active moieties and

studied host-guest mechanisms with different host molecules with a aim of constructing novel analytical

methodologies for molecular switches, molecular rotors, and sensors

Synthesized of deep cavity host molecule octa acid. Different electro- and photoactive guest molecules were

encapsulated in dimeric octa acid capsules and studied electrochemical and photochemical process

Studied the controlled formation of H- and J-aggregates via host-guest complexation using cucurbituril hosts and

driving the formation of H- and J-aggregates with different polyelectrolytes and surfactants

Explored electronic communication between identical photo- and electro-active units via multiple H-bonding

Graduate Research Assistant Advisor: Professor Francis D’Souza, Ph.D Aug 2001-Nov 2006

Department of Chemistry, Wichita State University Wichita, KS

Designed, synthesized and performed spectroscopic, electrochemical, computational and photochemical studies

on different covalently and non-covalently linked porphyrin fullerene dyads

Studied applications in building artificial photosynthetic systems mimics

Performed studies on intra- and intermolecular photo-induced electron transfer processes. Promoted multi-step

electron and/or energy transfer processes in well-defined redox gradients

Worked as teaching assistant in organic and analytical chemistry

CONSULTING

Blend Therapeutics, Scientific Consultant 2012-present

Member of Harvard Graduate Consulting Club, Boston 2013-present

Semifinalist in 2013 Harvard vs. MIT Case Competition

FELLOWSHIPS AND AWARDS

Dora Wallace Hodgson Outstanding Doctoral Dissertation Award: Wichita State University 200 7

Parker Fellowship: Wichita State University 2002

PATENTS

Compositions and Methods for the Treatment of Cancer. Stephen J. Lippard, Ga young Park, Timothy Johnstone,

Omid C. Farokhzad, Suresh Gadde. 2012. WO2012177935

PUBLICATIONS

Published more than 40 articles in different high impact journals, resulting in more than 1000 citations

Manuscripts under preparation and recent publications are listed below

Suresh Gadde, Orli Even-Or, Nazila Kamaly, Apoorva Hasija1, Philippe G. Gagnon1, Krishna Harsha Adusumilli1, Andrea

Erakovic, Edward A. Fisher, Omid C. Farokhzad. Development of therapeutic polymeric nanoparticles containing the LXR

agonist GW3965 for the resolution of inflammation. ( Manuscript under preparation)

Ga Young Park, Suresh Gadde, Timothy C. Johnstone, Apoorva Hasija, Philippe G. Gagnon, Anoop K Pal, Omid C. Farokhzad,

Stephen J. Lippard. In vitro and in vivo studies of the delivery of a monofunctional platinum anticancer agent,

phenanthriplatin, for more effective prostate cancer therapy. ( Manuscript under preparation)

Nazila Kamaly, Gabrielle Fredman, Manikandan Subramanian, Suresh Gadde, Alekasandar Pesic, Louis Cheung, Zahi A. Fayad,

Robert Langer, Ira Tabas, Omid C. Farokhzad. Development and in vivo efficacy of targeted polymeric inflammation-resolving

nanoparticles. Proc. Natl. Acad. Sci. USA 2013, 110, 6506-6511

Pedro M. Valencia, Eric M. Pridgen, Brian Perea, Suresh Gadde, Christopher Sweeney, Philip W. Kantoff, Stephen J. Lippard,

Robert Langer, Rohit Karnik, Omid C. Farokhzad. Synergistic Cytotoxicity of Irinotecan and Cisplatin in Dual-Drug PSMA-

Targeted Polymeric Nanoparticles. Nanomedicine 2013, 8, 687-698

Full list of publications can be accessed at: http://scholar.google.com/citations?user=M183VwwAAAAJ&hl=en&oi=ao

REFERENCES

Available upon request

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