PROFILE

Research Scientist with more than * years of Industrial research experience in, multi-step synthesis, synthetic route scouting, process optimization, purification techniques, crystallizations, and characterization of organic molecules. Currently with Ricerca Biosciences, 2+ years at Albany Molecular Research Inc. in NY, and 3 years at Dr. Reddy’s Laboratories, in India and a summer-2007 intern at Vertex Pharmaceuticals in Cambridge, MA.

Research experience in total synthesis of natural products, nucleotides, heterocycles, metal-catalyzed reactions and organometallic compounds.

Proved to be a good and creative problem solver for chemical synthesis.

Sound knowledge on the principles of medicinal chemistry, ADME, and drug development process.

Instrumentation experience in NMR, MS, GC, HPLC, IR, UV, DSC, TGA.

Excellent skills in report writing, proposal writing, oral communication, project management, interaction with multidisciplinary team with leadership, independent decision-making and a good team player.

EDUCATION

University of Delaware, Newark, DE

Ph.D., Organic Chemistry (GPA 3.79/4). 2002 - 2007

Sri Sathya Sai Institute of Higher Learning, Puttaparthi, India.

M.Sc. (GPA 4.5/5) and B.Sc. Honor’s (GPA 4.16/5) in Chemistry. 1992-1997

RESEARCH EXPERIENCE

Ricerca Biosciences, Concord, OH. Scientist, Synthetic Chemical Services Sep’ 2010-Current

Process optimization and synthesis of API’s (β-lactams) in kilo lab, with cGMP controls.

Preparation of batch records, reviewing SOP’s, managing technicians in the kilo lab.

Route scouting and process development of novel anti-HCV nucleotide molecules.

Succeeded in synthesis of radio labeled compounds with cGMP controls.

Successfully synthesized novel derivatives of Retinol and Rapamycin.

Designing and synthesizing novel molecules for cystic fibrosis.

Albany Molecular Research Inc., Albany, NY. Senior Research Scientist, Mar’ 2008-May’ 2010

Succeeded in route designing and synthesis of novel scaffold targets for various therapeutic areas in a CRO environment.

Independently developed the synthesis of 20 novel scaffolds which involved considerable route scouting and methodology development.

Successfully developed synthetic route for spirocyclic lactams as CCR2 inhibitors.

Successful synthesis and process optimization of an important benzofuran scaffold led to the extension of a contract project up to 6 months.

Successfully developed easy route for thiophene based tricyclic cores, imidazoles, as anti-HCV targets, (with molecular weight up to 900, with amide coupling reactions as terminal steps).

Established, optimized reaction conditions for ring closing metathesis on anti-HCV target scaffolds.

Performed up to 400 reactions per year, established the processes for reactions on scale up to 200g.

Involved with training Bachelor level associates.

Vertex Pharmaceuticals Inc., Cambridge, MA. Summer Internship. Summer’ 2007

Chemical Development: Worked on route designing and synthesizing lead molecules for anti-HCV.

University of Delaware, Doctoral Research. 2002 - 2007

“Cycloaddition reactions of Cyclopropenes.” The overarching theme of my dissertation research has been to use the intrinsic reactivity of high strain molecules to drive difficult cycloaddition reactions. Pauson-Khand (PK) Reactions and Inverse Electron Demand Diels-Alder Reactions of Cyclopropenes:

Discovered that chiral substituted cyclopropenes are remarkably reactive substrates for inter- and intramolecular PK reactions. The diastereo- and regioselectivities of these reactions are excellent.

Successfully proved that the use of cyclopropenes overcomes fundamental limitations in PK chemistry.

Successfully transformed the cyclopropene PK products in to cyclopentanones that are substituted by chiral, quaternary centers.

Successfully accomplished for the first time a concise enantio selective total synthesis of -pentalenene, a structural signature of strained angular triquinanes with antibiotic properties - via intramolecular PK reaction methodology.

Successful synthesis of -pentalenene was achieved in 15 steps with an overall yield of 9%.

Demonstrated that chiral cyclopropenes are exceptionally good dienophiles for Inverse Electron Demand Diels-Alder Reactions.

Proved that Cyclopropenes efficiently react with aza-dienes to give substituted tetrahydro pyridines, again with remarkable regio- and diastereocontrol.

Dr. Reddy’s Research Foundation, Hyderabad, India. Senior Chemist. 1997-2000

The secondary metabolites, labdane diterpenes viz Andrographolide, limonoids viz Azadirone, and tri terpene acids viz Bassic Acid were isolated in pilot plant in multi gram (100gm) quantities starting from 10-40 kilos of plant material.

Effectively isolated and identified biologically active compounds from medicinal plants by bioassay guided fractionation of the selected plant extracts.

Supervised 2-3 technicians in the pilot plant.

Efficiently Prepared via semi-synthesis, Novel Chemical Entities (NCE’s) to derive Structure Activity Relationships (SAR’s) towards anti tumor and anti diabetic activities.

Demonstrated ability to work in a multidisciplinary environment for SAR’s and metabolite studies.

Efficiently Synthesized heterocycles having antitumour activity, indenoisoqinolines, isoquinolinoquinolines, benzopyranoisoquinolines, imidzoisoquinolines and CDK inhibitors, butyrolactones, flavopyridol. Some of the selected molecules were synthesized in multi gram scale (50 gm) for preclinical studies.

LABORATORY RESEARCH SKILLS

Extensive experience in route scouting, process development, multi-step synthesis, purification techniques, crystallizations, and characterization of complex organic molecules.

Performed NMR experiments on Bruker 500/400 MHz, 1HNMR, 13CNMR, 2D NMR- COSY, NOESY, HSQC, and HMBC.

Experience with (Varian/HP) GC, GCMS, HPLC, IR, UV, DSC and TGA.

Databases; ISIS, Beilstien, Sci-finder.

PUBLIATIONS

“Co-Complexes Derived from Alkene Insertion to Alkyne-Dicobaltpentacarbonyl Complexes: Insight into the Regioselectivity of Pauson Khand Reactions of Cyclopropenes.” Pallerla, Mahesh K.; Yap, G. P. A.; Fox, Joseph M, J. Org. Chem., 2008, 73, 16, 6137-6141.

“Synthesis of Stable Derivatives of Cycloprop-2-ene Carboxylic Acid.” Yan, Ni; Liu, Xiaozhong; Pallerla, Mahesh K.; Fox, Joseph M, J. Org. Chem., 2008, 73, 11, 4283-4286.

“Enantioselective synthesis of -pentalenene.” Pallerla, Mahesh K.; Fox, Joseph M, Organic Letters, 2007, 9, 26, 5625-5628.

“Diastereoselective Intermolecular Pauson-Khand Reactions of Chiral Cyclopropenes.” Pallerla, Mahesh K.; Fox, Joseph M, Organic Letters, 2005, 7, 16, 3593-3595.

“Synthesis and structure-activity relationships of andrographolide analogues as novel cytotoxic agents.” Nanduri, S; Nyavanandi, VK; Sanjeeva RTS; Kasu, S; Pallerla, Mahesh K; Sai Ram, P.; Rajagopal, S; Ajaya KR.; Ramanujam, R; Moses Babu, J.; Vyas, K; Sivalakshmi DA; Om Reddy, G.; Akella, V. Bioorganic & Medicinal Chemistry Letters, 2004, 14, 18, 4711-4717.

“Biological investigation and structure - Activity relationship studies on azadirone from Azadirachta indica A. Juss.” Nanduri S, Thunuguntla SSR, Nyavanandi VK, Kasu S, Pallerla Mahesh K, Ram PS, Rajagopal S, Kumar RA, Deevi DS, Rajagopalan R, Venkateswarlu A Bioorganic & Medicinal Chemistry Letters, 2003, 13, 22, 4111-4115.

Contributed towards 3 US patents (WO0157026A; WO0185709A; WO0185710A) filed on Andrographolide derivatives at Dr. Reddy’s Research Foundation. (Much of the work was proprietary).

PRESENTATIONS

“Intermolecular and intramolecular Pauson-Khand reactions of cyclopropenes.” Pallerla, Mahesh K.; Fox, Joseph M. Abstracts of Papers, 228th ACS National Meeting, Philadelphia, PA, United States, August 22-26, 2004.

“Synthesis and SAR studies of C12-substituted andrographolide analogs as novel anticancer agents.” Nanduri, S; Sanjeeva RTS; Nyavanandi, VK; Kasu, S; Pallerla, Mahesh K; Rajagopal, S; Deevi, DS; Ajay RK; Ramanujam, R; Akella, V. Abstracts of Papers, 225th ACS National Meeting, New Orleans, LA, United States, March 23-27, 2003.

“Polymer-Supported Catalysts for the Enantioselective Addition of Diethyl zinc to Aldehydes.” Malhotra, Sanjay V.; Lee, Juny; Pallerla, Mahesh K. Abstracts of Papers, 223rd ACS National Meeting, Orlando, FL, United States, April 7-11, 2002.

REFERENCES

Prof. Joseph M. Fox, Dept of Chemistry and Biochemistry, University of Delaware, Newark, DE-19716. Email: zll7t7@r.postjobfree.com, Ph: 302-***-****.

Prof. Douglass F. Taber, Dept of Chemistry and Biochemistry, University of Delaware, Newark, DE-19716. Email: zll7t7@r.postjobfree.com, Ph: 302-***-****.

Dr. Krishna Yalamareddy, Albany Molecular Research Inc., Albany, NY-12212. Email: zll7t7@r.postjobfree.com, Ph: 414-***-****.

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