David R. Adams BSc, PhD, CChem, MRSC

A recognized professional with hands-on experience in all aspects of the drug discovery process from lead finding to the clinic with a background in academia, large pharmaceutical, medium/small biotech and CRO industries. Key skills include people and project management, scientific leadership, organisation and a hands-on approach to problem solving.

CONTACT DETAILS

Address 32 The Spinney,

Marlow Hill,

High Wycombe,

Bucks. HP11 1QE. UK

Telephone/email T: 013********

M: 079**-******

E: ygdjo8@r.postjobfree.com

SUMMARY OF EDUCATION AND EXPERIENCE

• Consultant in Medicinal Chemistry, 2007,ongoing

• Group Leader, Sygnature Chemical Services, 2007-2010

• Founder and Director of Alsace Chemistry Services, France, 2007-2009

• Head of Chemistry, Neuro3d, France: 2005 - 2007

• TechDry(UK) Ltd., Director, 2004, ongoing

• Vernalis Research Ltd., Director of Medicinal Chemistry, 1995 – 2004

• Wyeth Research (UK) Ltd, Principal Research Scientist and Project Leader, 1991 – 1995

• Salford Ultrafine Chemicals and Research Ltd, Project Leader, Research and Development, 1990 -1991

• Central University of Venezuela, Faculty of Pharmacy, Associate Professor, 1979 -1990

• Beecham Pharmaceuticals Research Division, Harlow, Essex; Principal Scientific Officer, 1974 - 1979

• University of Southampton, Postdoctoral Research Fellow (Supervisor, Professor R. C. Cookson, FRS), 1972 – 1974

• King's College, University of London, Ph.D. Organic Chemistry (Supervisor, Professor D. I. Davies), 1969 – 1972

• Leicester University, B.Sc. Hons. Chemistry, 1966 - 1969

Publications in the areas of synthetic, mechanistic, natural product and medicinal chemistry with additional work covered in a number of patents, patent applications and presentations/lectures (a list is available).

TRACK RECORD

• Consultant, Medicinal Chemistry R&D

o Adviser on IP strategy and patenting issues

o Critical assessor of R&D projects

• Founder and Director of Alsace Chemistry Services

o Chemistry services including custom synthesis, medicinal chemistry, patents, formulation and assistance in regulatory affairs

• Group Leader, Sygnature Chemical Services

o Project manager with responsibility for the medicinal chemistry, synthetic chemistry and molecular modelling input into client project collaborations e.g. Alzheimer’s disease, HCV (patents and publications pending)

o Resource management and core competency responsibilities

• Head of Chemistry, Neuro3d, France.

o CMC and chemistry IMPD/IND documentation for ongoing development compounds (e.g. ocaperidone Phase II)

o Significant input into the formulation, manufacturing processes and analytical methodology and controls of development compounds

o Timely delivery of drug substance and drug product for manufacturing, clinical and pre-clinical trials through efficient interaction with consultants and CROs

o Directed lead finding and lead optimisation efforts of the main (PDE, Dopamine) and exploratory projects, introducing computational tools for predicting drug-like properties and a rational, focused approach to drug design

o Responsible for the IP portfolio in liaison with the nominated patent agents

o Due diligence and competency in the successful sale of assets on closure

• TechDry(UK) Ltd

o Set-up in July 2004 for the development and distribution of novel water-based hydrophobic admixtures and related materials for the construction industry and to exploit natural products of biological importance

• Director of Medicinal Chemistry, Vernalis Research Ltd (formerly Cerebrus Ltd).

o Provided the expertise and leadership for medicinal chemistry programmes (CNS, e.g. 5-HT2C, A2A, CB1) leading to the selection of a number of clinical candidates

o Worked closely with the Senior Director of Chemistry in the set-up of the Cerebrus Chemistry Research laboratories

o Set-up and managed the core competencies of IT, Informatics and Databases; Parallel Chemistry; Molecular Modelling; Screening Services (including extensive hands-on contributions as a DBA, in Unix administration, and in computational chemistry)

o Directed the exploratory project programmes

o Responsible for the introduction of modified GLPs for compound handling and selection

• Wyeth Research (UK) Ltd.

o Project Leader '5-HT1D Agonists for the treatment of Migraine'

o Management and appraisal of research staff

o Drug design and synthesis (including molecular modelling)

o Multipurpose computer skills using Macs, PCs and Silicon Graphics workstations

• Salford Ultrafine Chemicals and Research Ltd.

o Project Leader, Research and Development

o Management of Research and Development Staff

o Project evaluation and custom synthesis with efficient time management

• Central University, Caracas, Venezuela

o Associate Professor, Faculty of Pharmacy

o Research interests included Natural Products (e.g. Prostaglandins, isolation and synthesis) and the synthesis of heterocycles with antiparasitic, antiviral and anti-inflammatory activities

o Director/Coordinator of Postgraduate studies in Medicinal Chemistry

o Planning and responsibility for course content

o Teaching of the Medicinal Chemistry courses

o Responsible for Medicinal Chemistry Research

o Fund raising for research and teaching

• Beecham Pharmaceuticals Research Division, Harlow, Essex

o Bench chemist with two promotions in four years

o Synthesis of heterocyclic prostaglandin analogues as bronchodilators

OTHER RELEVANT EXPERIENCE

Institution CfPA (The Center for Professional Advancement), Amsterdam, The Netherlands.

Course CMC Submissions in CTD Format

Date 24-25 April, 2006

Institution Learning Tree International,

Euston, London

Certified Professional in Unix Systems and Unix Systems Administration, 2003.

Institution Microtech, London

Course 'Oracle';

Date June - October, 1995

Institution Wyeth Research (UK) Ltd

Dates August – December, 1994

Course Leadership Skills Development;

(Front -Line Leadership; Zenger-Miller Inc.)

Institution Cambridge Centre for Molecular Recognition

Date 14th - 17th March, 1994

Course Understanding Molecular Modelling

Institution Department of Pharmacology,

University of Cambridge,

Tennis Court Road,

Cambridge CB2 1QJ. U.K.

Date Nov, 1989 – May, 1990

Status Visiting Fellow, Darwin College. (Darwin Fellowship)

Supervisor/Co-ordinator Dr. P. M. Dean

Project Computer assisted analysis of protein similarity

Institution Astbury Dept. of Biophysics,

University of Leeds, Leeds, UK

Date July, 1987 - Dec, 1987

Status Visiting scholar (Royal Society Fellowship)

Supervisor/Co-ordinator Dr. A. J. Geddes

Project Computer assisted design of novel DHFR inhibitors

LANGUAGES English, Spanish, French (basic understanding)

MEMBERSHIP OF SCIENTIFIC SOCIETIES

The Royal Society of Chemistry, UK

The American Chemical Society, USA

Society of Chemistry Industry, UK (ex-Member of Executive Council)

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