Resume

Dr. Amit Srivastava

Principal Scientist

Pharmaceutical Process Development

Roche Pharmaceuticals

**** *. *** ****** *******

Bldg. 801

Florence SC 29506

yf5swl@r.postjobfree.com

Employment History

Principal Scientist Chemical Development at Roche Pharmaceuticals October 2007 - present

Education

Ph.D. (Synthetic Organic Chemistry) Purdue University West Lafayette IN USA December 2007 in H. C. Brown (Nobel Laureate Chemistry 1979) Center for Borane Research

M.S. (5 years integrated Chemistry) Indian Institute of Technology (IIT) Kanpur India 1997-2002

Awards and Achievements

Received Special Recognition Award by Roche management team for significant contributions to various Roche projects involving process development to manufacture the investigational drug candidates

Best Poster Presentation in H. C. Brown Symposium 2006 Purdue University

Ranked in top 2% in India among about 1 50 000 students appeared in the Joint Entrance Examination (JEE-1997) for admissions into Indian Institutes of Technology

Awarded National Scholarship in school

Awarded Merit Scholarship IIT Kanpur

Research Experience

October 2007 Present Principal Scientist Roche Pharmaceuticals. Served as a lead chemist on the development of several Roche IND (Investigational New Drug) candidates that cure cancer cardiovascular diseases depression rheumatoid arthritis etc.

Fall 2002 Fall 2007 Doctoral Student Herbert C. Brown Center for Borane Research Department of Chemistry Purdue University West Lafayette IN USA (Advisor: Prof. P. V. Ramachandran). Thesis title:

Total Synthesis of Potential Antitumor Agent (-)-Dictyostatin

Summer 2001: Worked as a summer intern at Laboratoire de Chimie Organique Biologique CNRS-UMR 6052 ENSCR 35700 Rennes France (Advisor: Prof. Rene Gree)

Synthesis of the Stereoisomers of Bicyclo[6.1.0]nonan-2-ol and their Fluorination Studies

Summer 2000: summer project at Department of Chemistry IIT Kanpur (Advisor: Prof. P. K. Bharadwaj)

Summer 1999: summer project at Department of Chemistry IIT Kanpur (Advisor: Prof. P. K. Bharadwaj)

Research Interests

Pharmaceutical process development

Discovery and development of new synthetic methods and reagents

Scale-up of chemical processes

Instrumental Techniques: Multi-probe Nuclear Magnetic Resonance (NMR) Spectroscopy Fourier Transform-Infra Red (FT-IR) Spectroscopy Ultra Violet-Visible (UV-VIS) Spectroscopy Gas Chromatography-Mass Spectroscopy (GC-MS) High Performance Liquid Chromatography (HPLC) Gas Chromatography (GC) Analytical preparatory capillary and chiral) Ozonizer Polarimeter

Computer Skills: Microsoft Word Excel Power Point Netscape Chemdraw Scifinder Scholar Beilstein Commander Web of Science

List of Publications in Peer-Reviewed Research Journals

Amit Srivastava Jason Yang Baoshu Zhao Yong Jiang Wade Blackmon and Bernd Kraemer A Highly Efficient and Scalable Process for Demethylation of 6-(2 4-Dimethoxybenzoyl)chromen-2-one and Other Aryl Methyl Ethers Syn Comm 2010 40 1765-1771. (Main Aurthor)

P. V. Ramachandran Amit Srivastava Debasis Hazra Total Synthesis of Potential Antitumor Agent (-)-Dictyostatin Org. Lett. 200*-*-***-***.

P. V. Ramachandran Debarshi Pratihar Debajan Biswas Amit Srivastava M. V. R. Reddy Novel Functionalized Trisubstituted Allylboronates via Hosomi-Miyaura Borylation of Functionalized Allyl Acetate Org. Lett. 200*-*-***-***.

Manuscripts Ready for Publication

P. V. Ramachandran Kamlesh Padiya Amit Srivastava Highly Enantio- and diastereoselective Crotylations of Aldehydes and Ketones using Ate Complexes

P. V. Ramachandran H. C. Brown Guisheng Li Amit Srivastava Diastereo- and Enantioselective Synthesis of syn-β-Trifluoromethyl Homoallylic Alcohols by Tandem Hydroboration/Allylboration

Invited Lectures and Presentations

Invited Lecture IIT Kanpur Chemistry Department Total Synthesis of (-)-Dictyostatin January 2007

Presented a paper Synthesis of fluorinated allylboranes and the progress towards the preparation of fluoro-analogs of C1-C9 and C18-C23 subunits of (-)-dictyostatin at the ACS National Meeting San Francisco CA USA September 2006

Poster Presentation Total Synthesis of (-)-Dictyostatin at Herbert C. Brown Lectures in Organic Chemistry Department of Chemistry Purdue University April 2006; Awarded Best Poster Award.

Invitation to Review a Research Paper

Served as a referee to review a number of research papers published in various international journals including Tetrahedron Letters Tetrahedron Bioorganic & Medicinal Chemistry Letters etc.

References

Dr. Jason Yang

Sr. Principal Scientist

Roche Carolina Inc.

6173 E. Old Marion Highway

Florence SC 29506

yf5swl@r.postjobfree.com 843-***-****

Dr. Tom Cleary

Manager Chemical Development

Roche Carolina Inc.

6173 E. Old Marion Highway

Florence SC 29506

yf5swl@r.postjobfree.com 843-***-****

Prof. Dr. P. V. Ramachandran

Department of Chemistry Purdue University

560 Oval Drive

West Lafayette IN 47907

yf5swl@r.postjobfree.com 765-***-****

Prof. Dr. N. Sathyamurthy

Director Indian Institute of Science Education and Research

Sector 26 Chandigarh 160 019

yf5swl@r.postjobfree.com

Contact this candidate