Yumei Dai

Postdoctoral Research Associate

Chemical Engineering,

University of Massachusetts, Amherst

*** *. ******** **., *** Goessmann Lab, Amherst, MA 01003

413-***-**** (Tel), 413-***-**** (Fax)

Email: yd04ym@r.postjobfree.com

Professional Experience

Apr.2009-Present Postdoctoral Research Associate, Tumor Therapeutic and Bioengineering

Laboratory, Chemical Engineering Department, University of

Massachusetts, Amherst

Mar.2007-Apr.2009 Postdoctoral Research Associate, Food Biophysics & Nanotechnology

Laboratory, Department of Food Science, University of Massachusetts,

Amherst

Jul.2004-Mar.2007 Postdoctoral Research Associate, Molecular Microbiology Laboratory,

Institute of Plant Physiology & Ecology, Shanghai Institutes for Biological

Sciences, Chinese Academy of Sciences

Education

2004 Ph.D. in Microbiology Shenyang Institute of Applied Ecology

Chinese Academy of Sciences, P. R. China

2001 M.S. in Zoology Shenyang Normal University, P. R. China

1998 B.S. in Biology Shenyang Normal University, P. R. China

Other Professional Activities

Journal Review Journal of Clinical Microbiology; Food Biotechnology

2008-Present Professional Member Institute of Food Technologist (IFT)

2008-Present Regular Member International Association for Food Protection (IAFP)

2009-Present Associate Member American Association for Cancer Research (AACR)

Grants and Protocols

Forbes N. (PI), Dai Y. (Co-PI), Amplified, persistent drug production in Salmonella enterica

serovar Typhimurium as a delivery system for breast cancer therapy, 2010, Rays of Hope.

(Funded, $20,000)

Dai Y., Forbes N. (PI), Arenas R. Anticancer drug transport and apoptosis-inducing dynamics in

tumor microenvironment gradient mimicking microfluidic device, 2010, Interdisciplinary

Postdoctoral Fellowship in the Center of Excellence in Apoptosis Research. (Funded,

$60,000)

Forbes N. (PI), Dai Y. (Co-investigator), St. Jean A, Swoffold C. and Toley B. Animal

protocol: Intratumal drug delivery by genetic engineered Salmonella typhimurium in a

mouse model. 2010, Baystate Medical Center Institutional Animal Care and Use

Committee. (Approved).

Fellowships and Awards

2010 The Center of Excellence in Apoptosis Research (CEAR) Interdisciplinary

Postdoctoral Fellowship

1998 Outstanding Graduate Student Award. Educational Department of Liaoning

Province, P. R. China

1995-1997 Outstanding Undergraduate Student Award, Shenyang Normal University, P. R

China.

1994-1998 Outstanding Undergraduate Student Scholarship (competitive, received each year

for a total of 4 times), Shenyang Normal University, P. R China.

Research Interests

Intratumoral Therapeutic Delivery: to create genetically modified bacteria that target the

therapeutically resistant regions of tumors and secrete cancer-killing compounds.

Anticancer Drug Transport and Apoptosis-inducing Dynamics in Tumor

Microenvironment Gradient Mimicking Microfluidic Device.

Development of a Novel Antimicrobial Hurdle Technology to Improve Microbial

Stability of Carbonated and Noncarbonated Beverages.

Encapsulation and Activity of Naturally-Occurring Food Antimicrobials In Beverage

Applications

Assessment of The Role of Sequential Addition of Food Antimicrobials on Their

Inhibitory Activities

The Diversity of Linear and Circle Plasmids of Streptomyces Isolated from Extreme

Environments.

Characterization of Telomeres of Streptomyces Linear Plasmids

Genetic Diversity and Coevolution between Nitrogen-Fixating Frankia and Its Symbiotic

Host Plant, Alnus.

Publications (17, 4 in preparation)

Dai Y., Toley B, Swoffold C and Forbes N. (2011) Integrated quorum sensing system amplified

gene expression in Salmonella accumulated in tumors. (In preparation)

Dai Y., Normand M. Weiss J. and Peleg M. (2010) Modeling of efficacy of triplet antimicrobial

combinations: yeast suppression by lauric arginate, cinnamic acid, and sodium benzoate or

potassium sorbate as a case study. Journal of Food Protection, 73: 515–523

Dai Y., McLandsborough L, Weiss J, and Peleg M. (2010) Concentration and application order

effects of sodium benzoate and eugenol mixtures on the growth inhibition of

Saccharomyces cerevisiae and Zygosaccharomyces bailii. Journal of Food Science, 75:

M482-488

Yang Y., Dai Y., Chen Z., Qin Z (2010) Cloning and analysis of the telomeres of five

Streptomyces linear plasmids. Acta Microbiologica Sinica, 58(8):1008-103

Dai Y., Peleg M. and Weiss J. (2009) Antimicrobial activity of triple combinations of lauric

arginate, cinnamic acid, and sodium benzoate or potassium sorbate against spoilage yeasts.

(In preparation)

Dai Y., Prachaiyo P. and Weiss J. (2009) Inhibition activities of lauric arginate and its

combination with sodium benzoate or potassium sorbate against Escherichia coli O157:H7

and Listeria monocytogenes. (In preparation)

Dai Y., Yang Y., Fan Y., Shen M., Zhou M, Cai X. and Qin Z. (2009) Abundance of plasmids

among Streptomyces strains from the Tibet plateau of China. Applied and Environmental

Microbiology. (In preparation)

Dai Y., Zhou M. and Qin Z. (2008) Detection of linear and circular plasmids among

actinomycetes isolated from acid and alkaline soils. Acta Microbiologica Sinica. 48(2):

244-246

Xiong Z., Tang X., Dai Y., Zhang C., Zhang Z. and Xu L.(2006) Genetic Diversity of Frankia

Strains in Alnus nepalensis Nodules in Yunnan Revealed by rep-PCR. Chinese Journal of

Applied Ecology. 12(5): 623-627

Dai Y., Zhang C., Xiong Z and Zhang Z. (2005) Correlations between the ages of Alnus host

species and the genetic diversities of associated endosymbiotic Frankia strains from

nodules. Science in China Ser. C Life Sciences. 48 Supp. I: 76-81.

Dai Y., He X., Zhang C. and Zhang Z. (2004) Characterization of genetic diversity of Frankia

strains in nodules of Alnus nepalensis (D. Don) from the Hengduan Mountains on the basis

of PCR-RFLP analysis of the nifD-nifK IGS. Plant and Soil. 267: 207-212.

Dai Y., Cao J., Tang X. and Zhang C. (2004) Diversity of Frankia in nodules of Alnus

Nepalensis in Gaoligong Mountains revealed by IGS PCR-RFLP analysis. Chinese

Journal of Applied Ecology. 15(2): 186-190.

Dai Y., Han S., Tang X. and Zhang C. (2003) Genetic diversity of Frankia in nodules of Alnus in

Changbai Mountain. Chinese Journal of Northeast Forestry University. 13(6): 6-8.

Tang X., Dai Y., Xiong Z. and Cao J. (2004) Genetic diversity analysis of Frankia strains in

nodules of three Alnus species from Changbai Mountain by REP fingerprinting. Chinese

Journal of Ecology. 23(4):68-71

Tang X., Dai Y., Xiong Z., Zhang Z. and Zhang C. (2003) Effect of natural stress on genetic

diversity of Frankia in nodules of Alnus. Chinese Journal of Applied Ecology. 14(10):

1734 -1746.

Wan D. and Dai Y. (2002) Investigation of water-birds in Liaoning Province. Liaoning Forestry

Science and Technology. (4): 21-23.

Dai Y. and Liu M. (2001) Investigation of wintering water-birds in Liaoning Province. Journal

of Shenyang Normal University(Natural Science Edition). 19(2): 52-55.

Conference Proceedings (8)

Sep. 2010 Toley B., Dai Y., Forbes N. Micron-Scale Oxygen Delivery Prevents the Onset of

Necrosis in Tumors. AACR Metastasis and the Tumor Microenvironment, Philadelphia,

PA (poster)

Nov. 2009 Dai Y., Forbes N. Chemotherapy Molecule Delivered by Tumor-Targeted

Salmonella enteric serovar Typhimurium under the Control of Integrated Modular AND

Gate. AACR Molecular Targets and Cancer Therapeutics. Boston, MA (poster)

Jun. 2009 Dai Y., McLandsborough L, Weiss J, and Peleg M. Quantifying the Concentration

and Application Order Effect of Sodium Benzoate and Eugenol Mixtures on the Growth

Suppression and Retardation of Two Yeasts. 2009 IFT Annual Meeting & Food Expo.

Anaheim, LA (poster)

Aug. 2008 Dai Y., Peleg M. and Weiss J. Modeling of Activity of Triple Combinations of

Antimicrobials, Using Lauric Arginate, Cinnamic Acid, and Sodium Benzoate or

Potassium Sorbate as a Case Study. 95th Annual meeting International Association for Food

Protection. Columbus, OH (oral presentation)

Jul. 2008 Dai Y., Peleg M. and Weiss J. Antimicrobial Activity of Triple Combinations of

Lauric Arginate, Cinnamic Acid, and Sodium Benzoate or Potassium Sorbate against

Spoilage Yeasts. 2008 IFT Annual Meeting & Food Expo. New Orleans, LA (poster)

Jul. 2008 Dai Y. and Weiss J. Antimicrobial Activity of Combinations of Saponin and

Potassium Sorbate against Spoilage Yeasts. 2008 IFT Annual Meeting & Food Expo. New

Orleans, LA (poster)

Feb. 2006 Dai Y. Xiong Z. and Zhang C.G. Ecology and Co-Evolution between Alnus Species

and Their Microsymbiont Frankia. Annual meeting of biological nitrogen fixation project

supported by National Key Basic Research Support Foundation (NKBRSF) of China.

Xiamen, P. R. China. (oral presentation)

Apr. 2004 Dai Y. and Zhang C.G. Genetic Diversity of Frankia Strains in the Nodules from

Alnus Species. Annual meeting of biological nitrogen fixation project supported by the

National Key Basic Research Support Foundation (NKBRSF) of China. Beijing, P. R.

China. (oral presentation)

Extracurricular Activities

Mar.2009 A lecture on Food Pathogen Salmonella, University of Massachusetts, Amherst.

Fall 2002 Lecturer in Zoology, Liaoning University, P. R China.

Fall 2002 Lecturer in Entomology, Shenyang Normal University, P. R China.

1997 Internship, Taught 8th grade on Human Biology and Health

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