Eric G. Suchanek Resume
Resume:
Eric G. Suchanek, Ph.D.
Contact Information
Eric G. Suchanek
Liberty Township, OH 45011
********@***.***
Summary
Talented PhD in Biophysics with an emphasis on molecular modeling and computational chemistry seeks challenging, rewarding position in the pharmaceuticaql/biotechnology arenas. I have real-world industrial expertise in small molecule drug design methods and QSAR. Experienced in methods for conformer analysis and optimization, de novo drug design, pharmacophore modeling, molecular mechanics, quantum mechanics, and virtual screening. I have done extensive computer application development and have good competency in C, C++, Lisp, Fortran and Perl. I have an aptitude and desire to learn, develop and apply new computer-based techniques to real-world problems. I possess good knowledge of medicinal chemistry and biology. I believe and evidence the personal attributes of integrity, creativity, problem solving, and have a strong work ethic. Strong ability to work independently and as a member of a team. I have an industrial track record of success and possess the ability to work effectively with higher levels of company management.
Objective
To obtain a rewarding and challenging position in the biotechnology or pharmaceutical industries that can capitalize on my unique skillset within computational chemistry, biology and molecular modeling arenas.
Education
Washington University in St Louis Saint Louis, Missouri, United States. B.S. Biology Graduated: 6/30/1982
Johns Hopkins Medical School Baltimore, Maryland, United States Ph.D. Biochemistry/biophysics Graduated: 6/1/1987
Achievements
• Developed one of the first real-time molecular visualization programs deployed on a personal computer.
• Developed early computer-aided rapid screening algorithm for disulfide bond stabilization in proteins of known structure.
• Developed algorithms for rapid creation of photo-realistic lenticular and holographic images with an emphasis on scientific visualization.
• Built high-resolution model of Parathyroid Hormone 1-34 from ab initio modeling, subsequently verified with solution NMR.
• Built first model of 7 trans-membrane G-protein Coupled Receptors within P&G; subsequently used for several internal drug development programs.
• Developed several high-potency small molecular candidates for the kinase family, used in osteoporosis therapy. Applied high throughput screening techniques to prune large (millions) of candidates to viable subsets useful in în-vitro screen programs.
• Architected, deployed and managed a high-performance multi-processor supercomputer center for use within P&G Pharmaceuticals. This became the backbone for our computational chemistry and biology system. Managed all aspects of the system from software acquisition, vendor interactions, maintenance, etc.
• Managed a multi-national modeling and simulation community of practice within the P&G Research and Development division.
• Led the Research Computing and Informatics group at P&G Pharmaceuticals. Managed external interfaces with software vendors including Accelerys, Tripos, SGI and MDL. Deployed unique in-house cheminformatics data solutions across the division. Managed all budget aspects of the group including capital, expense, personnel.
Publications
Theoretical and Practical Considerations in Virtual Screening: A Beaten Field? Maria Kontoyianni, Prakash Madhav, Eric Suchanek and William Seibel Current Med Chem 15:107-116 2008.
Design and Synthesis of 13,14-Dihydro Prostaglandin F1α Analogues as Potent and Selective Ligands for the Human FP Receptor Yili Wang, John A. Wos,* Michelle J. Dirr, David L. Soper, Mitchell A. deLong, Glen E. Mieling, Biswanath De, Jack S. Amburgey, Eric G. Suchanek, and Cynthia J. Taylor J. Med Chem 43 (5), pp 945–952 2000 Peer reviewed journal
An engineered intersubunit disulfide enhances the stability and DNA binding of the N-terminal domain of .lambda repressor R. T. Sauer, K. Hehir, R. S. Stearman, M. A. Weiss, A. Jeitler-Nilsson, E. G. Suchanek, C. O. Pabo Biochemistry 25 (20), pp 5992–599 1986.
Computer-aided model-building strategies for protein design C.O. Pabo and Eric G. Suchanek Biochemistry 25 (20), pp 5987–599 1986.
Introduction of Intersubunit Disulfide Bonds In the Membrane-Distal Region of the Influenza Hemagglutinin Abolishes Membrane Fusion Activity. Godley, L., Pfeifer, J., Steinhauer, D., Ely, B., Shaw, G., Kaufmann, R., Suchanek, E., Pabo, C., Skehel, J.J., Wiley, D.C. & Wharton, S. Cell 68:635-645 1992.
The development of novel 1,2-dihydro-pyrimido[4,5-c]pyridazine based inhibitors of lymphocyte specific kinase (Lck). Sabat, Mark (M); Vanrens, John C (JC); Brugel, Todd A (TA); Maier, Jennifer (J); Laufersweiler, Matthew J (MJ); Golebiowski, Adam (A); De, Biswanath (B); Easwaran, Vijayasurian (V); Hsieh, Lily C (LC); Rosegen, Jeff (J); Berberich, Steve (S); Suchanek, Eric (E); Janusz, Michael J (MJ) Bioorg Med Chem Letters (16):4257-61 2006.
Associations
American Chemical Society
Phi Beta Kappa
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