patent agent

Douglas Tan

**** ******** **

San Diego CA *****

Tel 858-***-**** (h) 858-***-****(cell)

Email: ***********@*****.***

ADMISSIONS

• Registered with the U.S. Patent and Trademark Office (Reg. No. 62,927)

Education

University of Illinois at Champaign-Urbana

M.S., Microbiology, May 1996

• Admitted as a PhD fellowship student, passed preliminary, however, left program upon opportunities at Pfizer

Rensselaer Polytechnic Institute, Troy, NY

M.S., Computer Science, December 2002

Indiana University at Bloomington

B.S. Chemistry, December 1992

• Honor and pre-Med student

Professional Experience

Pfizer Global R&D 1996-present

Legal Department, San Diego CA May 2007-present

Registered Patent Agent

• Drafted and prosecuted non-provisional U.S. and PCT patent applications related to chemical compounds and

• Generated office responses to domestic and international patent authorities.

• Carried out literature and patent search using WestLaw, LexisNexis, PatBase, MicroPatent, SciFind, Beilstein, RGate, CAS.

• Participated in due diligence discussions.

Department of Molecular Biology, San Diego CA Jan 2004 to present

Senior Associate Scientist

• Developed high throughput protein expression technology to support the effort of Structure-Based Drug Design using molecular biology, biochemistry and protein chemistry technology;

• Carried out parallel protein expression, purification and crystallization to acquire protein structures and protein–compound co-structures;

• Participate in project strategy discussions involving compound designs.

Exploratory Medicinal Science, Groton CT June 1996 – Dec. 2003

Assistant to Associate Scientist

• Expressed native and tagged target proteins using bacteria, baculo, yeast, drosophila, and mammalian expression systems and in vitro cell free expression system;

• Developed and optimized protein expression/purification systems for structure (crystallography), NMR and therapeutic screening;

• Engineered proteins and construct-designed for activity, stability and solubility;

• Tested protein activity with protein assays, ELISA and enzyme specific assays;

• Carried out Seleno-Met, N15, C13 and Deuterium protein labeling for NMR studies;

• Contributed to solve several protein structures.

University of Illinois at Champaign-Urbana, Urbana IL Sept 1993 – May 1996

Department of Genetics, PhD Graduate Research Assistant

• Clostridia Genetics, vector construction and plasmid characterization.

Yale University, New Haven CT Jan. 1993 – June 1993

Department of Cell Biology, Research Assistant

• Mitochondria Genetics and Biochemistry research using hybridoma cells.

Indiana University at Bloomington, Bloomington, IN Sept. 1991 - Dec. 1992

Department of Cell Biology, Research Assistant

• Technical assistance on Interferon Biochemical research.

Indiana University at Bloomington, Bloomington IN Sept. 1990- Jun 1991

Department of Biology, Research Assistant

• Genetic study of yeast budding genes.

Albert Einstein Medical College, Bronx, NY Summers 1991 and 1992

Department of Neuroscience, Summer student

• NGF gene cloning, tissue culture and deficient Herpes Virus packaging.

Honors and Activities

• April, 2006, Performance Achievement Award, Pfizer PGRD

• Sept. 1994 - present, The American Association for the Advancement of Science

• June 1995 – present, American Society for Microbiology

• Jan. 2000 – April 2006, United Way Volunteer

• May 1997- December 2003, Volunteer, Groton Social Services

• Summer 1991, Honor Undergraduate Research Program, Albert Einstein Medical College

• Feb. 1991 - Dec. 1992, Chemistry Club, Indiana University

Publications

• Hoth, L. R., Tan, D. H., Wang, I.-K., Wengender, P. A., Thompson, M. A., Kamath, A. V., and Geoghegan, K. F. , Expression and protein chemistry yielding crystallization of the catalytic domain of ADAM17 complexed with a hydroxamate inhibitor Protein Expr. Purif (2007) 52, 313-319.

• Nakayama G, Bingham P, Tan D, Magley K. A fluorescence assay for screening inhibitors against RNase acitivity of HIV-I reverse transcriptase, Analy BioChem, 2006 Feb 19, 351(2006), p260-65

• McClure KF, Abramov YA, Laird ER, Barberia JT, Cai W, Carty TJ, Danley DE, Elliott NC, Gabel CA, Han S, Hynes TR, Lemotte PK, Mansour MN, Marr ES, Letavic MA, Pandit J, Sweeney FJ, Tan D, Tao Y.Theoretical and Experimental Design of Atypical Kinase Inhibitors: Application to p38 MAP Kinase, J Med Chem. 2005 Sep 8;48(18):5728-37

• K. Stutzman-Engwall, D. Tan, F. Rajamohan, K. McGrath, H. Zhao,S. Hawrylik, J. Brown, R. Marala, C. Wielis, and B.Posner Cell Lines Over-Expressing The bcl-2 GENE Are More Resistant To Apoptosis Protein Expression in Animal Cells (PEACe) Conference Sept. 18-22, 2005 in Crete, Greece.

• D. Tan, Towards Efficient OLAP Caching in Web Environment, 18th Annual RPI Computer Science Conference, Hartford, April 2002

• K. F. Geoghegan,* L. R. Hoth, D. Tan, K. Borzilleri, J. Withka and J G. Boyd. Cyclization of N-Terminal S-Carbamoylmethylcysteine Causing Loss of 17 Da from Peptides and Extra Peaks in Peptide Maps, J. Proteome Res. (2002) Vol1, Number 2, p181-7

• M. A. Letavic, T. J. Carty, A. V. Kamath, J. Pandit, L. Reeves, F. J. Sweeney, D. H. Tan and etc.,Synthesis and Biological Activity of Selective Pipecolic Acid-Based TNF-_ Converting Enzyme (TACE) Inhibitors Bioorganic & Medicinal Chemistry Letters 12 (2002) 1387–1390

• D Tan; Y Li; HP Blaschek Moleccular charaterization and utilization of the CAKs filamentous viruslike particle derived from Clostridium beijerinckii Bioengineering and biotechnology 28(2):118-***-****

• D.Tan Genetic Characterization and Profiling of the filamentous viruslike particle CAK1 in Clostridium acetobutylicum NICB 8052. MS thesis, Aug, 1996

• D. Tan and H.P. Blaschek. Examination of the ds and ss Replication Origins of the Filamentous Viruslike particle CAK1 in Clostridium acetobutylicum NICB 8052 Using deletion analysis. 96th ASM General Meeting, New Orleans, May 1996.

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