Analytical chemist

OBJECTIVE

To seek an R&D scientist position with emphasis in analytical chemistry

PROFESSIONAL SUMMARY

Assistance in filing a US patent as a co-author and applying for a NIH grant

Hands-on experience in the operation, maintenance and trouble-shooting of MS, LC-MS and NMR instruments and related data analysis, experience with implementing GC-MS, UV/Vis, SEM, TEM, XRD

Background in leading a 6-person team to develop a non-invasive diagnostic approach for esophageal diseases

Experience in collaborating with over 30 professionals with different communication styles and personalities from hospitals, pharmaceutical companies, instrument manufacturers, colleges and institutes

Strong communication skills and good peer-reviewed publication record

In-depth knowledge of statistical programming using Matlab and R software packages

EDUCATION

Purdue University, West Lafayette, IN, US

Ph. D. in Analytical Chemistry, Department of Chemistry December 2011

Nankai University, Tianjin, China

M. S. in Polymer Chemistry and Physics, Institute of Polymer Chemistry June 2006

B. S. in Materials Chemistry, Department of Chemistry June 2003

RESEARCH EXPERIENCE

Research Assistant for Professor Daniel Raftery, Purdue University, West Lafayette, IN, US October 2006~present

Development of LC-MS and NMR-based metabolomics techniques

Innovated and wrote experimental protocols for metabolic profiling of biofluids

Implemented pattern recognition techniques to process experimental data for metabolite detection and disease diagnosis

Early detection of human esophageal diseases and canine urinary bladder cancer using metabolic profiling approach

Identified a set of 20 serum metabolites as biomarkers for early human esophageal cancer detection using LC-QTOF MS and NMR

Developed an efficient statistical prediction model to distinguish esophageal cancer patients from healthy controls, and applied it to detect high risk esophageal diseases such as Barrett’s Esophagus and High Grade Dysplasia

Discovered 6 biomarkers in canine urine for early urinary bladder cancer detection using NMR

Evaluated the biological significance and altered metabolic pathways based on the identified biomarker candidates

Research Assistant for Professor Chenxi Li, Nankai University, Tianjin, China September 2003~June 2006

Designed and prepared novel small molecule hydrogelators

Studied the mechanism of nanomaterials (silver, gold, polyaniline) controlled growth at microenvironment in hydrogel

Fabricated honeycomb structure porous thin polymeric films using poly(styrene-co-acrylonitrile), polycarbonate and poly(L-lactide)

INDUSTRIAL EXPERIENCE

Safety Assessment Intern, Merck Research Laboratories, West Point, PA, US June 2011~August 2011

Profiled metabolites of in vitro hepG2 cells treated with mitochondrial toxicants using UPLC-FT ICR MS and NMR

Explored the mode of action for therapeutic drugs and investigated potential drug toxicities by studying the pathway inhibition

Organic Chemistry Intern, Hemay Bio-Tech Co. Ltd., Tianjin, China September 2002~June 2003

Optimized protocols to reduce a synthetic method from seven steps to five steps

Synthesized and purified two novel low reactive irreversible small molecule drugs against cancer for in vitro and in vivo tests

PATENT

Daniel Raftery, Jian Zhang, and Zane Hammoud. “Metabolite Biomarkers for the Detection of Esophageal Cancer Using NMR”, pending.

CERTIFICATION

Q-TOF LC/MS Techniques and Operations, Agilent Technologies (2010)

HONORS

Travel Award to American Society of Mass Spectrometry Annual Conference, Purdue Graduate Student Government (2011)

Student Travel Award, Experimental Nuclear Magnetic Resonance Conference (2011)

Graduate Assistantship, Purdue University (2006~present)

He Binglin Award for Outstanding Graduate Student, Nankai University (2006)

Graduate Scholarship, Nankai University (2003~2006)

Outstanding Undergraduate Student, Nankai University (2002)

National Scholarship of China (2002~2003)

Undergraduate Scholarship, Nankai University (2000~2003)

TEACHING EXPERIENCE

Teaching Assistant of General Chemistry, Purdue University, IN, US August 2006~December 2009

Closely supervised undergraduates, evaluated skills of general laboratory techniques and helped achieve goals in the subject

Conducted recitation sessions, graded students, and held office hours

PUBLICATIONS

Jian Zhang, Lingyan Liu, Jeremiah Bowers, Siwei Wei, G.A. Nagana Gowda, Zane Hammoud, and Daniel Raftery, “Serum Metabolic Profiling of Human Esophageal Cancer and Other Esophageal Disease Onsets Using LC-QTOF MS”, submitted.

Jian Zhang, G.A. Nagana Gowda, and Daniel Raftery, “Metabolic Profiling of Dog Urinary Bladder Cancer”, in preparation.

Siwei Wei, Lingyan Liu, Jian Zhang, Shanaiah Murthy, Nagana Gowda, Harald Seeger, Tanja Fehm, Hans J. Neubauer, and Daniel Raftery, “Metabolomics Approach for Predicting Response to Neoadjuvant Chemotherapy for Breast Cancer”, in preparation.

Siwei Wei, Jian Zhang, Lingyan Liu, Tao Ye, G.A. Nagana Gowda, Fariba Tayyari, and Daniel Raftery. “Ratio Analysis NMR Spectroscopy (RANSY) for Selective Metabolite Identification in Complex Samples”, Analytical Chemistry, in press.

Lingyan Liu, Siwei Wei, Jian Zhang, G.A. Nagana Gowda, Murthy Shanaiah, Heather Heiligstedt, Burns Matthew, E. Gabriela Chiorean, Michael Chior, and Daniel Raftery, “Metabolic Study of Human Colorectal Cancer Using 1H Magnetic Resonance Spectroscopy”, submitted.

Jian Zhang, Lingyan Liu, Siwei Wei, G.A. Nagana Gowda, Zane Hammoud, Kenneth Kesler, and Daniel Raftery, “Metabolomics Study of Esophageal Adenocarcinoma”, The Journal of Thoracic and Cardiovascular Surgery, 2011, 141, 469.

Baohui Zhao, Jian Zhang, Hongying Wu, Xudong Wang, and Chenxi Li, “Fabrication of Honeycomb Ordered Polycarbonate Films Using Water Droplets as Template”, Thin Solid Films, 2007, 515, 3629.

Jian Zhang, Baohui Zhao, Linghui Meng, Hongying Wu, Xudong Wang, and Chenxi Li, “Controlled Synthesis of Gold Nanospheres and Single Crystals in hydrogel”, Journal of Nanoparticle Research, 2007, 9, 1167.

Linghui Meng, Yan Lu, Xudong Wang, Jian Zhang, Yueqin Duan, and Chenxi Li, “Facile Synthesis of Straight Polyaniline Nanostick in Hydrogel”, Macromolecules, 2007, 40, 2981.

Jian Zhang, Xudong Wang, Baohui Zhao, and Chenxi Li, “Facile Synthesis of Narrowly Dispersed Silver Nanoparticles in Hydrogel”, Chemistry Letters, 2006, 35, 40.

Baohui Zhao, Jian Zhang, Xudong Wang, and Chenxi Li, “Water-Assisted Fabrication of Honeycomb Structure Porous Film from Poly(L-lactide)”, Journal of Materials Chemistry, 2006, 16, 509.

Hongying Wu, Zelin Liu, Xudong Wang, Baohui Zhao, Jian Zhang, and Chenxi Li, “Preparation of Hollow Capsule-Stabilized Gold Nanoparticles through the Encapsulation of the Dendrimer”, Journal of Colloid and Interface Science, 2006, 302, 142.

Baohui Zhao, Chenxi Li, Yan Lu, Xudong Wang, Zelin Liu, and Jian Zhang, “Formation of Ordered Macroporous Membranes from Random Copolymers by the Breath Figure Method”, Polymer, 2005, 46, 9508.

CONFERENCE PRESENTATIONS

Jian Zhang, Lingyan Liu, Siwei Wei, G.A.Nagana Gowda, Jeremiah Bowers, Zane Hammoud, and Daniel Raftery, “Detection of Metabolic-based Serum Biomarkers for Human Esophageal Cancer using LC-MS”, American Society of Mass Spectrometry, Denver, CO, 2011.

Jian Zhang, Lingyan Liu, Siwei Wei, G.A. Nagana Gowda, Jeremiah Bowers, Zane Hammoud, and Daniel Raftery, “Detection of Metabolic-based Biomarkers for Human Esophageal Cancer Combining NMR and LC-MS”, Experimental Nuclear Magentic Resonance Conference, Pacific Grove, CA, 2011.

Lingyan Liu, Siwei Wei, Jian Zhang, G.A. Nagana Gowda, Murthy Shanaiah, Heather Heiligstedt, Burns Matthew, E. Gabriela Chiorean, Michael Chior, and Daniel Raftery, “Metabolic Study of Human Colorectal Cancer Using 1H Magnetic Resonance Spectroscopy”, Pittsburg Conference of Analytical Chemistry, Atlanta, GA, 2011.

Jian Zhang, Lingyan Liu, Siwei Wei, G.A. Nagana Gowda, Zane Hammoud, and Daniel Raftery, “Metabolomics-based Early Detection of Esophageal Adenocarcinoma”, Pittsburg Conference of Analytical Chemistry, Atlanta, GA, 2011.

Siwei Wei, Jian Zhang, Lingyan Liu, Tao Ye, G.A. Fariba Tayyari, Nagana Gowda, and Daniel Raftery. “Identification of Metabolites in Complex NMR Spectra Using Ratio Analysis of Peak Integrals”, Pittsburg Conference of Analytical Chemistry, Atlanta, GA, 2011.

Jian Zhang, Lingyan Liu, Siwei Wei, G.A. Nagana Gowda, Zane Hammoud, and Daniel Raftery, “1H NMR-based Metabolomics Study of Esophageal Cancer”, Pittsburg Conference of Analytical Chemistry, Orlando, FL, 2010.

Jian Zhang, Lingyan Liu, Siwei Wei, G.A. Nagana Gowda, Zane Hammoud, and Daniel Raftery, “1H NMR-based Metabolomics Study of Esophageal Adenocarcinoma and Other Esophageal Disease Onsets”, Purdue Cancer Center Annual Scientific Retreat, West Lafayette, IN, 2010.

Haiwei Gu, Hongling Han, Yanping Sun, Zhengzheng Pan, Jian Zhang, Scott A. McLuckey, and Daniel Raftery, “Application of Nano-Electrospray Tandem Mass Spectrometry for Direct Fingerprinting of Rat Urine in Metabolomics”, American Society of Mass Spectrometry, Denver, CO, 2008.

Linghui Meng, Jian Zhang, Xudong Wang, and Chenxi Li, “Facile Synthesis of Straight Polyaniline Nanorods in Hydrogel”, Proceedings of International Forum on Green Chemical Science & Engineering and Process Systems Engineering, Tianjin, China, 2006.

Baohui Zhao, Jian Zhang, Chenxi Li, and Xudong Wang, “Water-assisted Fabrication of Honeycomb Ordered Porous Films from poly(ε-caprolactone)”, National Meeting on Polymer Science, Chinese Chemical Society, Beijing, China, 2005.

Jian Zhang, Xudong Wang, Baohui Zhao, and Chenxi Li, “UV-induced Synthesis of Silver Nanoparticles in Hydrogel”, National Meeting on Polymer Science, Chinese Chemical Society, Beijing, China, 2005.

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