Software Analyst

RADHE RAMAN SINGH

Email:

Mobile: 090******** *******************@*****.**.**

Career Summary & Objectives:

Willing to work as a key player in exigent & innovative environment. I would use my analytical and technical skills to meet prevailing standards and deadlines.

Academic Profile:

M.Sc ICA (2005-2007)

Specialization: Instrumentation

Jiwaji University Gwalior M.P

Aggregate: 72.0%

M.Sc (2003-2005)

Specialization: Organic Chemistry

Purvanchal University Jaunpur U.P

Aggregate: 67%

Industrial Experience:

Previous Experience:

Company : Jubilant Biosys Ltd Bangalore

Year : 3.4

Department: DMPK

Current Experience:

I am working with LGC Promochem India Pvt. Ltd in DMPK department from Apr 2011 to till date.

Job Profile:

Carrying out PK studies of new chemical entities in animals (Rodents).

Preparation of formulation of NCE’s. (For Oral, IV and SC).

Brain tissue binding, microsomal binding and blood plasma ratio study.

Operation, maintenance and trouble shooting of LC-MS/MS and HPLC systems.

LC-MS/MS and HPLC Method development of NCE’s.

Analysis and quantification of metabolic stability assay, protein binding assay, aqueous solubility assay, CaCo2, tissue distribution and pharmacokinetic study samples of NCE’s by LC-MS/MS and HPLC.

Cocktail sample analysis of CYP sample.

Performing invitro assays: viz aqueous solubility assays, metabolic stability assays, CYP inhibition assays, Plasma protein Binding assays.

Tuning of compounds.

Performing Full method validation of NCE’ and generic drugs.

Training & Project :

I have done the 3-month’s summer training in ADL Department of Zydus Cadila Healthcare Ltd. Ahemedadad.

Non Surgical Techniques:

Blood sampling in rats and mice by retro orbital plexus, cardiac puncture, tail vein.

Well versed with different routes of drug administration like intravenous, intra-peritoneal, oral, subcutaneous, and intramuscular in rodents.

Instrumental Skills:

Expertise in handling various sophisticated instruments like

LC-MS/MS (API-4000, API-4000 Q trap, Thermo Ultra).

HPLC (Waters).

Summary of Expertise:

Method development of new chemical entities (NCE’s) for their solubility, metabolic stability, permeability assays, protein binding and pharmacokinetic profile study analysis by LCMS-MS (analyst), HPLC.

Metabolite profiling (Phase I & II) and identification by using LC-MS/MS.

Familiar with using WinNonlin software for calculations of pharmacokinetic parameters.

Considerable expertise and knowledge of extraction of new chemical entities from biological fractions (Plasma, serum, whole blood, tissues, urine, tumor, etc) by SPE, LLE and protein precipitation methods.

Considerable expertise and extensive knowledge of the scientific literature. Well versed in using Science Direct, Scopus, Scirus and other scientific databases.

Capable of doing independent and collaborative research.

Achievements:

Two Publications

LC-MS/MS-ESI method for simultaneous quantitation for the endocannabinoids: AEA, OEA and PEA. Application for rat pharmacokinetic study.

Highly sensitive method for the determination of adenosine by LC-MS/MS-ESI: Method validation and scope of application to a pharmacokinetic/ pharmacodynamic study.

Computer Skills:

Skilled in the use of WINDOWS 2000 & XP, MS-DOS, MS-OFFICE, and Internet.

Analyst 5.1 for LC-MS/MS (API 4000).

Empower 2 for waters HPLC.

Knowledge of Chem. - sketch for drawing chemical structure.

Considerable expertise and extensive knowledge of winNonlin software’s, Light Site Software’s for metabolite identification and Graphpad prism.

Strengths:

Positive attitude.

Hard working.

Time management.

References:

Dr. Rajeev Jain (Head of Chemistry/MICA/EC) Jiwaji University, Gwalior

Contact No. - H. - 0751- 2340216, O. -075*-*******

Declaration

I hereby declared that the above-furnished information is true and correct to the best of my knowledge.

Radheraman Singh

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