Engineer Assistant

Xiangjun Linda Zheng

**** * ***** **. ***. ***, Tucson, AZ, 85719, Cell: 520-***-****,

Email: ********@*****.***, ******@*****.*******.***

OBJECTIVE

Engineer or researcher in areas related to MicroElectroMechanical Systems (MEMS), Microfluidics or biomedical applications of MEMS technologies.

EDUCATION

Ph.D. in Mechanical Engineering, University of Arizona, 2007.08 - 2011.12. GPA: 3.64

project: ‘Selective isolation of circulating tumor cells from blood using microfluidic technology’.

Minor in Physics, University of Arizona, 2007.08 - 2011.12 (expect).

M.S. in Environmental Science, Tianjin University, China, 2002.09 - 2005.04. GPA: 3.81

B.E. in Environmental Engineering, Tianjin University, China, 1998.09 - 2002.07. GPA: 3.84

EXPERTISE

Scientific & Laboratory skills:

• Expert in MEMS design and mask layout using AutoCAD.

• Rich hands-on experience in class 100 clean room, processing such as lithography, thermal oxidation, thin film characterization, polymer micro-device fabrication, integration of microfuidic systems, etc.

• Strong background in MEMS & microfluidics simulation in Matlab and COMSOL

• Extensive experience in complex microfluidic experiments with Circulating Tumor Cells.

Professional Software:

Matlab, AutoCAD, SolidWorks, COMSOL, ImageJ, SketchUp, C, and Microsoft Office, etc.

Languages: Fluent in Chinese Mandarin (reading, writing and speaking)

EXPERIENCE

Research Experience:

University of Arizona, Research Assistant, 2007.08 - present

• Design and fabricate a set of microfluidic devices to detect very rare tumor cells in blood. Different devices made from silicon wet etching, DIRE etching, SU-8, PDMS have been fabricated.

• Optimize the device design and simulate the flow field in COMSOL.

• Build a modeling system in Matlab to analyze the cell motion in shear flow, combining cell adhesive dynamics and Stokesian dynamics in the model.

• Utilizing microfluidic technologies, design a unique low-to-high flow field pattern and 98.5% of the non-target cells were cleaned out while 100% of the target cells were recovered.

• Immobilize proper antibodies to the device surface to isolate the EpCAM+ cancer cells or Cadherin+ cancer cells.

Industrial Experience:

Tianjin China OTIS Elevator Co., Ltd., EH&S Engineer, 05/2005–01/2007

• Manage the safety in workshop

• Supervise to establish a healthy and environment friendly working place

Teaching Experience:

University of Arizona, Teaching Assistant, 2007.08-2009.05

• Teach the students to operate equipments, analyze data, design & perform mechanical experiments and write the experiment reports.

• Tutor the students Thermodynamics, teach the students to solve typical problems, hold office hours for students to seek for help in their study

PUBLICATIONS

Journal publications:

1 X. Zheng, et al., A high-performance microsystem for isolating circulating tumor cells. Lab Chip, vol. 11, pp. 3269-3276, 2011, 2011.

2 X. Zheng, et al., Cell receptor and surface ligand density effects on dynamic states of adhering circulating tumor cells. Lab Chip, DOI:10.1039/C1LC20455F, 2011.

3 L. S. L. Cheung, X. Zheng, et al., Detachment of captured cancer cells under flow acceleration in a bio-functionalized microchannel. Lab Chip, vol. 9, pp. 1721-1731, 2009.

4 L. S. L. Cheung, X. Zheng, et al., Adhesion dynamics of circulating tumor cells under shear flow in a bio-functionalized microchannel. J. Micromech. Microeng., vol. 21, 054033 , 2011.

5 L. S. L. Cheung, X. Zheng, et al., Kinematics of specifically captured circulating tumor cells in bio-functionalized Microchannels. J. Microelectromech. Syst., vol. 19, pp. 752-763, 2010.

Conference presentations and publications:

1 X. Zheng, et al., Proc. Transducers’11, pp. 1614-1617, 2011.

2 X. Zheng, et al., Proc. MEMS’11, pp. 849-852, 2011.

3 X. Zheng, et al., Proc. MEMS’10, pp. 939-942, 2010.

4 X. Zheng, et al., Proc. ASME’09 IMECE2009-13217, 2009.

5 X. Zheng, et al., Sixth Era of Hope Conference, BC061859, 2011.

6 L. S. L. Cheung, X. Zheng, et al., Proc. MEMS’09, pp. 431-434, 2009.

7 L. S. L. Cheung, X. Zheng, et al., Proc. microTAS’ 08, pp. 1159-1161, 2008.

8 L. S. L. Cheung, X. Zheng, et al., Fifth Era of Hope Conference, BC061859, 2008.

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