Feng Gao, Ph.D

** ****** *****, ******, ** ****3

Email: t2xh32@r.postjobfree.com

Phone: (Work) 518-***-****; (Home) 518-***-****; (Cell) 518-***-****

o A high energy, self-motivated, goal focusing organic chemist with advanced organic synthetic skill and a polymer material science background

o Proven track record problem solver with through experience in chemical process improvement, development, optimization, and safety

o Expertise in organic synthesis, synthetic route design, experiment design (DOE), catalyst design and preparation, polymer process, polymorph control, analytical method development, process safety assessment (RC1, DSC, TSU), and chemical hazard assessment, etc.

o Excellent communication skill with solid experience of customer interaction and project management

o Co-authored and published 20 peer-reviewed scientific papers, two patents, and 10 presentations.

o Invited referee for scientific journals including Organic Process Research and Development (OPRD), Tetrahedron, Tetrahedron Letters, and etc.

WORK EXPERIENCES

2007, 03 - present Senior Research Scientist, Chemical Development, Albany Molecular Research, Inc. (AMRI), Albany, NY

• As a leading chemist, successfully improved a problematic process into a highly robust and cost-effective one that reduced overall 5 steps to 2 steps, reducing operation time by 75%, saving over one million dollars for 2 100 kg campaign.

• Completed a high profile project from a major biotech pharmaceutical company that demands process development, optimization, and essentially to manufacture multi-kilograms of high potency API under cGMP conditions within an extremely compelling time line. The improved process was much more reliable and the overall yield (4 steps) was increased from 50% to 62%.

• Excelled multiple challenging projects that often transferred from customers from a first time customer that requires preparing an impurity, which originally was synthesized on mg scale through 7 steps involving tedious multiple chromatography purification. Again by applying my solid synthetic skill and expertise, I redesigned the synthetic route, completely removed chromatography, increased the overall yield by 22 fold, and delivered 10 times quantity of the product. As a result, the customer was won over and came back to AMRI with a 1.5 million dollars contract.

• Completed a highly challenging project that a competitor failed to deliver. The project urgently demanded to deliver 100 g product that was originally synthesized via 10 synthetic steps, one of which involved a carbonylation of a poor substrate under supercritical CO2 conditions. By applying my solid organic synthesis skill I revised the synthetic route (shortened the 10 steps synthesis to 6 steps) and finished route scouting, scale-up and achieved to deliver the product within 2 months.

• Developed from scratch robust processes for production of multiple challenging polymer-API conjugates used for targeted drug delivery system, through which established a solid business relationship with the customer and generated 3 million dollars revenue.

• Increasing responsibilities over the years including supervising junior chemists, management of projects, and communication within company and among customers

• Good documentation skill including writing bids, batch records, and SOPs

2003, 01 – 2007, 2 Research Assistant, Ph.D. candidate, McGill University, Chemistry Department, Montréal, QC, Canada

• Highly independent researcher directed and developed my own research program including rational design of bioactive molecules, synthetic route design and scouting, execution of multiple-step synthesis

• Honored with 5 university and departmental awards for excellence in research of my Ph.D program

• Teaching organic chemistry laboratories for three consecutive years with excellent feed-back and recognition from the course directors and students

• Supervised the overall research and instrumental training of all the newly incoming students [HPLC (Agilent 1100), Labconco® liophilizer, UV spectrometer (Agilent 8453) and Jasco®, J-810 spectropolarimeter (CD)]

1999, 07 -- 2002, 05 Research Associate, Ohio State University, Dentistry College, Columbus, OH

• Initiated and wrote proposals for industrial collaborators including 3M corporation (St. Paul, MN) and Kerr Corporation (a subsidiary of Syborn Specialties, OC, CA)

• Completed 3 projects sponsored both by NIH and industrial collaborators: (1) Design and synthesis of oligomeric oxazolines and their application for high performance thermoplastics; (2) Photo-polymerizable polyhedral oligomeric silsesquioxane (POSS) nanocomposites for biomedical applications; (3) Hyperbranched/dendritic polyester-derived visible-light-cured (VLC) composites for dental restoration

1995, 09 -- 1999, 06 Research Scientist, Southern China University of Technology, Guangzhou, China

• Developed a novel polymer composite based on micro phase separation and aggregation [Polystyrene/poly(methyl methacrylate)] for LCD backlight application (awarded a patent).

• Synthesized a thermos-sensitive hydrogel for controlled release of APIs.

• Synthesized a series of polyeletrolytes labeled with fluorescence probes (pyene and dansyl) for studying polyelectrolyte phase behavior.

• Awarded (as PI) 2 research grants sponsored by the National Natural Science Foundation of China and the Natural Science Foundation of Guangdong Province (RMB 290,000 total)

1992, 09 -- 1995, 07 Graduate Research Assistant, Zhongshan University, Guangzhou, China

• Successfully developed a novel Ti-supported Ziegler-Natta catalyst for copolymerization of styrene and 1-olefin; Awarded a Chinese patent

1987, 07 -- 1992, 06 Chemist, Anyang Fine Chemical Factory, Henan Province, China

• Formulated and marketed waterborne coatings for household applications

• Supervised a group of lab technicians for routine production

• Provided technique and safety training for new employees

• Wrote SOPs and supervised their implementation

EDUCATION

2003, 01 -- 2007, 2 Ph. D. Organic Chemistry, McGill University (Montréal, QC, Canada)

1992, 09 -- 1995, 07 M. Sc. Polymer Chemistry, Zhongshan University (Guangzhou, China)

1983, 09 -- 1987, 07 B. Sc. Chemistry, Wuhan University (Wuhan, China)

HONORS/AWARDS

Pall Dissertation Award ($3,000, 2006), for excellent research accomplishments achieved by a graduate student in the Department of Chemistry, McGill University, Montréal, QC, Canada

Canadian Institute of Health Research Scholarship ($35,000, 2005 and 2004) for excellent research performance in chemical biology program, McGill University, Montréal, QC, Canada

Canadian Society for Chemistry – Graduate Award ($1,000, 2006) awarded to cover the travel cost for presenting in a national or international conference, McGill University, Montréal, QC, Canada

Udho, Parsini and Diwan Award ($300, 2005) for best research paper published in the calendar year 2005 by a graduate student in chemistry department, McGill University

Chemical Biology (McGill) Travel Award ($750, 2006), for presenting excellent chemical biology research results at a major conference, McGill University

Outstanding Staff of the year ($500, 2001) for excellent research performance, Ohio State University, College of Dentistry, Columbus, OH

OTHER SKILLS/EXPERIENCES

• Expert in MS-Office, Sci-Finder search, raw material procurement, and batch record.

• Broad knowledge of polymer science, biology, enzymology, experienced with formulation, enzymatic essays, chemo-enzymatic transformation, fermentation, and computer assisted drug design (CAD), pharmacology, and ADMK.

PUBLICATIONS

1. Gao, F.; Yan, X. X.; Auclair, K. “Synthesis of a Phosphonate-linked Aminoglycoside-Coenzyme A Bisubstrate and Use in Mechanistic Studies of an Enzyme Involved in Aminoglycoside Resistance” Chemistry – A European Journal, 2009, 15(9), 2064-2070.

2. Magalhaes, M.L.B.; Vetting, M.W.; Gao, F.; Freiburger, L.; Auclair, K.; Blanchard, J.S.; “Kinetic and structural analysis of bisubstrate inhibition of the Salmonella enterica aminoglycoside 6 -N-acetyltransferase” Biochemistry, 2008, 47(2), 579-584.

3. Gao, F.; Yan, X. X.; Zahr, o.; Larsen, A.; Vong, K.; Auclair, K. “Synthesis and use of sulfonamide-, sulfoxide-, or sulfone-containing aminoglycoside-Coenzyme A bisubstrates as mechanistic probes for aminoglycoside N-6 -acetyltransferase” Bioorg. & Med. Chem. Lett., 2008, 18(20), 5518-5522.

4. Yan, X. X.; Gao, F.; Yotophan, S.; Auclair, K. “Design of aminoglycoside derivatives not modified by the resistance-causing aminoglycoside 6’-N-acetyltransferases” Bioorg. & Med. Chem. 2007, 15(8), 2944-2951.

5. Gao, F.; Yan, X. X.; Ait-Mohand-Brunet, S.; Shakya, T. ; Wright, G. D.; Auclair, K. “Synthesis and structure-activity relationship of truncated bisubstrate inhibitors of aminoglycoside 6’-N-acetyltransferases.” J. Med. Chem. 2006, 49, 5273-5281.

6. Gao, F.; Auclair, K. “Highly efficient P(III)-to-P(V) oxidative rearrangement.” Phosphorus, sulfur, and silicon and the related elements. 2006, 181, 159-165.

7. Gao, F.; Yan, X. X.; Baettig, O. M.; Berghuis, A. M.; Auclair, K. “Regio- and chemo-selective 6’-N-derivatization of aminoglycosides: bisubstrate inhibitors as probes to study aminoglycoside 6’-N-acetyltransferase.” Angew. Chem. Int. Ed. 2005, 44, 6859-6862.

8. U.S. Pat. Appl. Publ. (2006), US 200-***-**** A1 20060921, entitled “Inhibitors of aminoglycoside 6'-N-acetyltransferases, compositions and uses thereof” Auclair, K.; Gao, F.; Yan, X. / inventors, filed February 21, 2006.

9. U.S. provisional patent application No. 60/653,979; entitled “Aminoglycoside-CoA conjugates compositions and uses thereof.” Auclair, K.; Gao, F.; / inventors, filed February 18, 2005.

10. Gao, F.; Tong, Y.; Schricker, S. R.; Culbertson, B. M. “Hyperbranched polyester with mixed methacryloyl and aliphatic ester terminal groups: Synthesis, characterization and application in dental restorative formulations.” J. Macromol. Sci., Pure. Appl. Chem., 2002, 39(4), 267-278.

11. Gao, F.; Tong, Y.; Schricker, S. R.; Culbertson, B. M. “Novel trimethacrylates: synthesis, characterization and evaluation for improved dental restoratives.” J. Macromol. Sci., Pure. Appl. Chem., 2002, 39(4), 251-265.

12. Gao, F.; Tong, Y.; Schricker, S. R.; Culbertson, B. M. "Evaluation of neat resins based on methacrylates modified with methacryl-POSS, as potential organic-inorganic hybrids for formulating dental restoratives." Polymers for advanced technologies, 2001, 12, 355-360.

13. Tong, Y.; Gao, F.; Huang, Y., Schricker, S. R.; Culbertson, B. M. “Synthesis of ether-linked bisoxazolines and their use in step-growth polymerization reactions with phenolics.” Polymers for advanced technologies, 2001, 12, 1-9.

14. Ren B.; Tong, Z.; Gao, F.; Liu, X. “Fluorescence and X-ray diffraction studies on binding and complexes of surfactants and dansylated polyelectrolytes with sulfonate groups.” Polymer 2001, 42(17), 7291-7298

15. Ren, B.; Tong, Z.; Gao, F. "Charge density effects on the fluorescence behavior of dansyl labels to strong polyelectrolytes." Polymer, 2001, 42(5), 2001-2006

16. Tong, Z.; Gao, F.; Ren, B. "Dual behavior of polyelectrolyte and ionomer for an ionizable polymer containing sulfonate groups in DMSO/THF mixtures." Polymer, 2001, 42(1), 143-149

17. Ren, B.; Gao, F.; Tong, Z. “Solvent polarity scale on the fluorescence spectra of a dansyl monomer copolymerizable in aqueous media.” Chemical Physics Letters, 1999, 307, 55-61

18. Gao, F.; Xu, Y. W. “Polymeric pseudo-crown ethers resin bearing azo- and azothia-crown ethers: synthesis and adsorption for metal ions.” J. Appl. Polym. Sci. 1997, 65, 931-937

19. Gao, F.; Lin S. A. “Synthesis of the Block Copolymer of Styrene and 1-Butene with a Novel Supported Ti-Catalyst.” J. Polym. Sci. Part A: Polym. Chem. 1996, 34, 2909-2914.

20. Gao, F.; Lin S. A. “Copolymerization of styrene and 1-butene with a novel MgCl2-supported Ti catalyst.” Macromol. Chem. Phys. 1996, 197, 4225-4236.

PRESENTATIONS

1. Gao, F.*; Yan, X.; Auclair, K. Expedite discovery of inhibitors of antibiotic resistance via regioselective derivatization of unprotected aminoglycosides International Symposium on Green Chemical Processes for Pharmaceutical and Fine Chemicals McGill University, Montreal, QC, Canada. Oct. 20-22, 2006. (poster)

2. Gao, F.*; Yan, X.; Auclair, K. Synthesis and Structure-activity Relationship Study of Truncated Bisubstrate Analog Inhibitors of 89th Conference of The Canadian Society for Chemistry, Halifax, NS, Canada. May 31st, 2006. (presentation)

3. Gao, F.*; Yan, X.; Baettig, O. M.; Berghuis, A. M.; Auclair, K. Combating Aminoglycoside Resistance The 16th Quebec-Ontario Minisymposium in Synthetic and Bioorganic Chemistry (QOMSBOC), St. Adele, Quebec, Canada, Nov. 13th, 2005. (poster)

4. Gao, F.*; Auclair, K. Synthesis of inhibitors of aminoglycoside 6’-N-acetyltransferase Ii – towards inhibition of aminoglycoside resistance 88th Conference of The Canadian Society for Chemistry, Saskatoon, SK, Canada, Jun. 1st, 2005. (presentation)

5. Gao, F.*; Yan, X.; Auclair, K. Synthesis of inhibitors for AAC6’: derivatization of unprotected aminoglycosides The 15th QOMSBOC, Ottawa, ON, Canada, Nov. 15th, 2004. (presentation)

6. Gao, F.*; Schricker, S. R. Hyperbranched multimethacrylate with modulated shell chemistry for dental composite 30th AADR/25th CADR, Chicago, IL, USA. March 8th, 2001. (poster)

7. Gao, F.*; Culbertson, B. M. Novel self-initiating keto (meth)acrylate monomers for improved dental composites 219th ACS national meeting, San Francisco, CA, USA. March 28th, 2000. (poster)

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