Manager Project

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K.MURUGESH, M.PHARM, Ph.D

No.**, First Floor, Ganesh Residency,

First Cross, Model Colony,

Yeswanthpur,

Bangalore - 560 022.

Mobile no +91-966*******.

Email: ********@*****.***.

OBJECTIVE

To work in a creative environment where my research skills can be utilized to

become a scientist in leading research organisation in a project discipline that leverages

the growth of the organisation.

INDUSTRIAL RESEARCH EXPERIENCE

Currently working as Sr.Research Scientist in DMPK LAB in Jubilant Biosys ltd,

Bangalore, India (May 2009 to till date).

Worked as Research Scientist I in Bio analytical department in Lambda therapeutics

Ltd, Ahmedabad, India (October 2008 to April 2009).

Worked as Sr.Scientist in Bio analytical department in CRBio, Hyderabad, India (Jan

2008 to September 2008).

Worked as Asst.Professor in R.V.S.College of Pharmacy, Sulur, India (Dec 2002 to

Dec 2003).

EDUCATIONAL PROFILE

Ph. D (Pharmacy) December 2007, Jadavpur University, Calcutta, West Bengal,

India.

M.Pharm March 2002, The Tamilnadu Dr.M.G.R. Medical University,

(Pharmaceutical Chennai, Tamilnadu. India. - First Class.

Chemistry)

B. Pharm April 1999, The Tamilnadu Dr.M.G.R. Medical University,

Chennai, Tamilnadu. India. - First Class.

MANAGERIAL RESPONSIBILITIES

Lead and participate in an active laboratory program, designing and executing

appropriate DMPK strategies and assays.

Lead and participate in ADMET with a sound understanding of its significance to

project decision making and small molecule drug design, with an ability to solve the

more complex ADMET problems which arise.

Expertise in all aspects of DMPK and be able to effectively communicate with

medicinal chemists, in vitro biologists, in vivo pharmacologists and the

technical experts of clients and collaborators.

Provide leadership/management within the various department locations through a

structured process of objective setting, performance appraisal, and individual

development. As such, responsible for improving overall productivity and efficiency.

Able to sustain a high performance culture and effectively resolve performance

issues.

Provide regular and open communication to keep staff, program and project teams,

and R&D management informed of direction, progress and strategic developments in

supporting and meeting R&D objectives. Actively participates in departmental

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committees/meetings as an advisor in scientific, administrative and regulatory areas.

Recommends to management the purchase or modification of equipment, facility

renovations, and allocation of resources to meet strategic pharmacokinetic and R&D

objectives.

Writes expert opinions, reports and regulatory submissions to meet marketing

registration needs for products. Stays fully informed of advancements in biologics

research and development and regulatory positions to advise and adjust research

direction to ensure products will meet R&D objectives for regulatory and medical

needs.

SCIENTIFIC SKILLS AND ABILITIES

Invitro and invivo metabolism studies

Conducting microsomal and hepatocyte stability, intrinsic clearance and CYP

inhibition studies.

In-house preparation of rat liver microsomes.

Transport studies using Caco-2 - Maintenance of culture cells, conducting cell

permeability and efflux studies.

Pharmacokinetic (PK) studies in Rodents and Non- rodents.

Routine In vivo PK screening of NCE’s.

Conducting bioavailability and dose proportionality studies.

Conducting protein binding and tissue distribution.

Surgical skills: Jugular and bile duct cannulations.

Preformulation experience on NCE’s.

Prediction of PK parameters, interpretation and report preparation.

Experienced in non-compartmental and compartmental pharmacokinetic analysis.

Allometry scaling to predict human clearance and volume of distribution.

Conducting Radio label mass balance and tissue distribution studies.

Bioanalysis using HPLC and LC-MS/MS.

Bioanalytical method development and Validation of bioanalytical methods to support

regulatory studies. Experience in analyzing and reporting human PK from clinical

trials.

To conduct bioanalysis to fulfill pharmacokinetic, pharmacodynamic, toxicodynamic,

and local drug delivery initiatives for NCEs.

Metabolite identification using LC-MS/MS Q-trap.

INSTRUMENT KNOWLEDGE

LC-MS/MS API-3200, 4000, Sciex Applied Bio-Systems, Canada.

LC-MS/MS THERMO DISCOVERY MAX & Ultra - USA

HPLC, Shimadzu Prominence, Japan.

FT-IR spectrometer, Perkin Elmer, USA.

UV-Vis Spectrophotometer, Jasco, India.

SOFTWARE KNOWLEDGE

Analyst Software 1.5 version – Sciex software.

LC Quan 2.5.6 - Thermo Software.

Proficient knowledge in winnonlin software.

ACADEMIC CREDENTIALS

Qualified Graduate Aptitude Test in Engineering (GATE-2000), particular in

Pharmaceutical Sciences securing 77.22 percentile.

GRE qualified during Dec 2002.

College second during B.Pharm.

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College second during first year M.Pharm.

Awarded distinction in Diploma in Computer Application (DCA).

LIST OF PUBLICATIONS

Highly sensitive LC-MS/MS-ESI method for simultaneous quantitation of albendazole

and ricobendazole in rat plasma.Kuldeep Sharma,Murugesh.Kandasamy,Sanjeev

Giri,Sriram Rajagopal & Ramesh Mullangi.Bio med chromatography – In Press.-2011

LC-MS/MS - ESI method for simultaneous quantification of the three

endocannabinoids: AEA, OEA and PEA. Application to a rat pharmacokinetics

study.Kuldeep Sharma, Radhae Raman Singh,Murugesh.Kandasamy,Chandan

Mithra,Sanjeev Giri,Sriram Rajagopal & Ramesh Mullangi.Bioanalysis,3(2),2011,181-

196.

Development and validation of a highly sensitive LC-MS/MS method for

simultaneous quantification of acetyl-CoA and malonyl – CoA in animal tissues.

Ramesh Mullangi,Gilibili ravindra,Murugesh Kandasamy, Kuldeep Sharma,

Sanjeev Giri,Sriram Rajagopal.Biomedical chromatography – Manuscript ID : BMC-

10-0519.

"Evaluation of Antidiabetic and Antihyperlipidemic Activity of Luffa tuberosa (Roxb.)

Fruits in Streptozotocin induced Diabetic Rats ".Veerendra C.Yeligar, Murugesh

K, Deepak Kumar Dash, Siva Shankar Nayak, B. C. Maiti and Tapan K.

Maity.Natural Product Sciences (Korea) 13 (1) 2007, 17-22.

"Antineoplastic Activity of Crude Saponin mixture from the Roots of Luffa tuberosa

(Roxb.) in Ehrlich Ascites carcinoma Bearing mice".Veerendra C.Yeligar, Murugesh

K, Deepak Dash, Siva S. Nayak, Bhim C. Maiti and Tapan K. Maity . Natural

Product Sciences (Korea) 12 (4) 2006, 247-253.

” Antidiabetic, Antioxidant and Antihyperlipidemic Status of Heliotropium zeylanicum

Extract on Streptozotocin-Induced Diabetes in Rats”.K. Murugesh, V. Yeligar, D. K.

Dash, P. Sengupta, B. C. Maiti, and T. K. Maity Biological and Pharmaceutical

Bulletin,Vol 29,No.11,Dec-2006,2202.

”Effect of Berberis tinctoria Leaf (Berberidaceae) Extract on Antidiabetic,

Antihyperlipidemic and Antioxidant Status in Streptozotocin Induced Diabetes in

Rats”.K.Murugesh, Veerendra C Yeligar, B.C.Maiti, T.K.Maity. Oriental Pharmacy

and Experimental Medicine Vol 6, No. 4, Dec 2006.244-253.

“Hepato Protective and Antioxidant Role of Berberis tinctoria Lesch Leaves on

Paracetamol Induced Hepatic Damage in Rats”.K.Murugesh, Veerendra C Yeligar,

B.C.Maiti, T.K.Maity. Iranian Journal of Pharmacology and Therapeutics.Vol 4,

No.1, Jan 2006, 64-69.

“Synthesis and antimicrobial activity of new 3-amino sulphonyl [3’-chloro-4’-

(substituted phenyl) 2’-oxo azetidine] indole”. K.Murugesh, V.S.Saravanan,

J.Thomas Leonard and G.Sonia. Asian J of Chem.Vol.17, No.2 (2005), 980-984.

“Synthesis and Pharmacological activities of 2, 3,4,10 tetrahydro 3, 10 dioxo 2-

(substituted phenyl)[1,2,4] triazino [4,3-a] indoles”. K.Murugesh, V.S.Saravanan,

J.Thomas Leonard and G.Sonia“Asian J of Chem.Vol.17, No.3 (2005), 1641-1645.

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PRESENTATIONS – NATIONAL / INTERNATIONAL CONFERENCES

Poster presentation of paper in XVII International Botanical Congress held at

Austria, July-2005.”Hepato Protective and Antioxidant Role of Berberis tinctoria

Lesch Leaves on Paracetamol Induced Hepatic Damage in Rats”. T.K.Maity,

B.C.Maiti, K.Murugesh, Veerendra C Yeligar, Deepak Dash.

Poster presentation of paper in 37th Annual Conference of Indian

Pharmacological Society held at Kolkata-2005, Studies on Leishmanicidal

Potential of Berberis tinctoria Lesch Leaves (Berberidaceae)”Murugesh.K,

Veerendra C.Yeligar, Bidhan C.Khan, Deepak. Dash, Sudipta Saha, Maity.T.K.

Poster presentation of paper in International conference on “Promotion and

Development of Botanicals with International Coordination: Exploring quality, safety,

efficacy and regulations held at Kolkata-2005 “Studies on Leishmanicidal Potential of

Luffa tuberosa Roots” Veerendra.C.Yeligar, Murugesh.K, Bidhan. C.Khan, Deepak.

Dash, Sudipta Saha, Maity.T.K.

REFERENCES

Dr.T.K.Maity, Dr.T.Sen,

Professor, Professor,

Dept.of pharmaceutical chemistry, Dept of pharmacology,

Dept. of Pharmaceutical Technology, Dept.of Pharmaceutical Technology,

Jadavpur University, Jadavpur University,

Kolkata – 700 032, India. Kolkata – 700032, India.

Email – *********@*****.*** Email – *****@*******.***

Phone – 919********* Mobile – 098********.

Mr.Rajaram Patil,

Senior manager - Application,

Thermo Fischer Scientifics,

SID division,

Povai, Mumbai

E-Mail - *******.*****@*************.***,************@**********.***

Mobile – 919*********.

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