Development Project

Praveen Kumar Suryadevara

E-mail: *****.***********@*****.***

Phone: 206-***-**** (Cell)

206-***-**** (Home)

Visa Status: Permanent US Resident

Summary: Experienced organic and medicinal chemist seeking a position in pharmaceutical industry to Synthesize compounds using the experience gained in synthesis, scale up, purification and SAR development of novel chemical entities (NCEs) targeting cancer and anti-infectious diseases.

Highlights

• Experienced in discovery and development of novel chemical entities

• Through knowledge in the multistep organic synthesis of new compounds and modified using existing methods

• Highly motivated individual with successfully performed research in academic and applied

• Developed cost effective synthetic routes for scale up lead compounds

• Involved in multi-disciplinary project and demonstrated the ability to take project further level

• Capable of using modern chromatographic and purification techniques

• Supervise undergraduate and graduate students

• Strong communication and presentation skills to demonstrate timely updates and future strategies

• Self-motivated, easy going team member

Experience

Postdoctoral Research Scientist-Anti-cancer drug discovery (June 2010 to Present)

Chemical Biology and therapeutics, St. Jude Children’s Research Hospital, Memphis, TN.

Advisor: Prof. R. Kiplin Guy, Chairman and Member

- Synthesis of ATM inhibitors against Cancer

- Structure based drug design, library development, and parallel and large scale synthesis

Postdoctoral Research Scientist-Anti-infective agents (May 2005 to May 2010)

Department of Chemistry, University of Washington, Seattle, WA.

Advisor: Prof. Michael H. Gelb

- Synthesis of novel and potent anti-parasitic agents

- SAR Studies, Hit-lead optimization and ADMET

Research Scholar (Ph.D programme) (Jan 2000 to Mar 2005)

Indian Institute of Chemical Technology, Hyderabad, India

Organic Chemistry & Methodology development

• Thesis title: Studies on some bioactive natural products and development of new synthetic methodologies using Lewis acids as catalysts.

- Synthesis of (-)-carinol analogs as enzyme inhibitors

- Discovered bismuth triflate catalysed cost effective synthesis of tetrahydrochromanoquinolines

- Synthesis of amino alcohols from epoxides using tungstophosphoric acid as reusable catalyst

Education

Ph. D., (Jan 2000 – Mar 2005)

Kakatiya University, Indian Institute of Chemical Technology, India

Organic Chemistry, Medicinal Chemistry & Synthetic methodology

Masters in Organic Chemistry. (June 1997 – April 1999)

Nagarjuna University, Bapatla Engineering College, India

Organic Chemistry & Spectroscopy

Scientific skills

• Experienced with analytical instruments (HPLC, UPLC, HPTLC, NMR, IR, MS)

• Parallel Synthesis, Library development, Microwave chemistry and Lewis acid catalysis

• Experienced in Heterocyclic chemistry

• Expert in large scale synthesis of lead compounds (1g-50g)

• Skilled in making salts of lead compounds to Improve ADMET properties

• Self-motivated personal with strong commitment to develop useful materials for organization

Computer skills

• Diploma in computers (MS-Office), Windows and Mac;

• Type writing (30 wpm); SciFinder, Chem draw

Publications

1. Pharmacological Characterization, Structural Studies, and In Vivo Activity of Anti-Chagas Disease Lead Compounds Derived from Tipifarnib. Buckner, F. S.; Bahia, M.; Praveen Suryadevara, et al. Anti-microbial Agents Chemotherapy 2012 (Revision).

2. Novel C-9, 9 -O-acyl esters of (-)-Carinol as Free-radical Scavengers and Xanthine oxidase enzyme inhibitors: Synthesis and Biological evaluation. Praveen Kumar Suryadevara, Med. Chem. 2011 (Under revision).

3. Structurally simple Inhibitors of Lanosterol 14 -Demethylase Are Efficacious In a Rodent Model of Acute Chagas Disease. Praveen Kumar Suryadevara,. J. Med. Chem. 2009, 52, (12), 3703-3715.

4. 2-Oxo-tetrahydro-1,8-naphthyridine-Based Protein Farnesyltransferase Inhibitor as Antimalarials. Olepu,S Praveen Kumar Suryadevara Bio. Med. Chem. Lett. 2008, 18, 494-498.

5. Second generation Tetrahydroquinoline Protein Farnesyltransferas Inhibitors as Anti- Malarials. Bendale, P., Olepu, S., Praveen Kumar Suryadevara, J. Med. Chem. 2007, 50, 19, 4585-4605.

6. Tungstophosphoric acid (H3PW12O40) an Efficient and Reusable Heterogenous Catalyst for the Regioselective ring opening of Epoxides with Amines. Babu, K.S., Raju, B. C., Rao, A. S., Praveen Kumar, Syn. Comm. 2005, 35, 911-917.

7. Bismuth Triflate catalyzed One Pot Synthesis of Chromanoquinolines. Babu, K.S., Raju, B. C., Rao, A. S., Praveen Kumar, S., Rao, J. M. J. Chem. Res. (S) 2004, 421-423.

8. A Simple, Effective and Highly Selective Cleavage of 3-Methylbut- 2- enyl(prenyl) Ethers Using p-Toulenesulfonic Acid. Babu, K.S., Raju, B. C., Srinivas, P. V., Rao, A. S., Praveen Kumar, S. Chem. Lett. 2003, 32, 8, 704-705.

9. A New and Convenient Method for Quantitative Estimation of Chrysophanol, an Antioxidant in the Rhizomes of Rheum emodi Roxb. Praveen Kumar, S. Journal of Planar Chromatograph Modern TLC. 2002, 15, 128-131.

10. Free Radical Scavenging Active Components from Cedrus deodara. Tiwari, A. K., Srinivas, P. V., Praveen Kumar, S. J. Agric. Food Chem. 2001, 49, 4042.

11. Rao, J. M., Babu, K. S., Tiwari, A. K., Babu, T. H., Srinivas, P. V., Suryadevara, P. K., Sastry, B. S., Ali, A. Z. and Yadav, J. S. Intestinal alpha-glucosidase inhibitors and a process for the isolation and use thereof. PCT Int. Appl. World Patent EP1986670, 05-Nov-2008.

12. Rao, J. M., Babu, K. S., Tiwari, A. K., Babu, T. H., Srinivas, P. V., Suryadevara, P. K., Sastry, B. S., Ali, A. Z. and Yadav, J. S. Intestinal alpha-glucosidase inhibitors and a process for the isolation and use thereof. PCT Int. Appl. World Patent (WO/2007/09639), 30-Aug-2007.

References:

Prof. R. Kiplin Guy Prof. Micheal H. Gelb

Chairman and Member Harry Catherine Jayne Bond Professor

Dept. of Chemical Biology University of Washington

Email: ***.***@******.*** Email: ****@****.**********.***

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