Care .Net Development Home Experience Project

MICHEL REMY CORBOZ

*** ***** ******

Green Brook, NJ 08812

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RESPIRATORY SCIENTIST

Extensive, diverse experience focusing on discovery and development of

respiratory drugs within major pharmaceutical companies. Broad knowledge

and expertise in respiratory pharmacology and physiology and their

implementation into relevant animal models of human disease. Excellent

written and verbal communication skills with 50 publications in peer-

reviewed journals. Additional experience and expertise in cardiovascular

and neurophysiology.

Professional Experience

YOURENCORE, Princeton, NJ 2012

Independent Consultant

. Provide consulting services focusing on discovery and development of

respiratory drug and early development.

. Broad knowledge and expertise in design and conduct of respiratory animal

models.

. Highly regarded and selected for peer reviews.

. Extensive experience in writing scientific papers.

MERCK, Kenilworth, NJ 2009 - 2011

In-Vivo Group

Principal Scientist

. Evaluated new inhaled drugs and formulations in rodents (in vivo).

. Established a guinea pig model for cardiovascular measurement (blood

pressure and heart rate). Assessment of bronchodilatory drugs.

. Established an isolated lung preparation to study intratracheal

deposition and lung retention of drugs.

. Developed the rat model of lipopolysaccharide (LPS)-induced pulmonary

inflammation model (neutrophilic lung inflammation).

. Developed relevant end-points of human asthma and COPD in animals

including biomarker strategies for target engagement.

SCHERING-PLOUGH, Kenilworth, NJ 1997 - 2009

Allergy and Immunology Group

Principal Scientist (2001 - 2009)

. Discovered new oral drugs including targets such as ?2C-adrenoceptor

agonist. Organized, presented and documented scientific data to senior

management and the executive committee.

. Conceived and championed a project since basic research to clinical

recommendation for two indications (respiratory and neuropathic pain).

. Chair of Discovery meeting in area of Respiratory Pharmacology (next

generation of nasal decongestant) and CNS (neuropathic pain).

. Member of Early Development Team in area of Respiratory Pharmacology that

advanced compounds in GLP toxicology testing and Phase I trials.

. In charge of the New Drug Recommendation Document; Active participant in

the writing of the preclinical biology sections of the Investigator New

Drug (IND) and Investigator Brochures (IB).

. Involved in many respiratory programs which led to clinical

recommendation of several compounds.

. Developed techniques using different airway preparations (nasal mucosa,

trachea, bronchi and isolated lung, in vivo) with increasing

physiological complexity.

. Discovered new oral and topical drugs for nasal congestion. Developed

methods to evaluate compound efficacy against key end points of nasal

congestion. Established an in vitro human bioassay for screening.

Developed techniques to assess nasal constrictor/vasodilatory effects of

drugs in rodent, primate and human tissues.

. Developed in vitro method to measure airway gland secretions (Hillock

technique).

MICHEL REMY CORBOZ

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Principal Scientist, (Continued)

. Established isolated lung and tissue preparations with electrical field

stimulation to study neural mechanism in the airways.

. Explored the feasibility of a pulmonary hypertension ex-vivo model for

COPD and a rodent model for rhinosinusitis.

. Established techniques to measure CNS and cardiovascular effects in rats.

Techniques included mydriasis, blood pressure and heart rate measurements

in conscious animals (normal and spontaneously hypertensive rat).

. Developed method to measure hyperventilation-induced bronchoconstriction

(in vivo).

. Published over 25 manuscripts on in vitro and in vivo animal models of

nasal congestion, asthma, COPD and pharmacology, including review

articles (see accompanying attachment).

. Invited speaker to International Symposia on the mechanism of nasal

congestion.

Associate Principal Scientist (1997 - 2000)

. Team member for tachykinin antagonist project and for histamine

antagonist project that discovered potent and selective tachykinin and

histamine antagonists. Preclinical biologist on these two projects.

. Published numerous articles (12) in this area. Received Presidential

Award for Outstanding Scientific Achievement from Schering-Plough for

work in the tachykinin field.

UNIVERSITY OF SOUTH ALABAMA, Mobile, AL 1996 - 1997

Instructor (1996 - 1997)

Research Associate (1996)

. Established an in vivo model for visualization (intravital microscopy) of

tracheal circulation.

. Team member for evaluating airway submucosal glands and mucus secretion.

. Manuscripts (11) were published on mucus secretion and tracheal

circulation.

. Teaching (see accompanying attachment).

Education

. Postdoctorat, Pulmonary Physiology, Department of Physiology, College of

Medicine, Mobile, AL, USA

. PhD (Highest Honors), Pulmonary Physiology, Laboratory of Physiology,

Faculty of Medicine, University J. Fourier of Grenoble, France

. MS, Animal Physiology, Laboratory of Physiology, University J. Fourier

Grenoble, France

. BS, Sciences of Nature and Life, University J. Fourier Grenoble, France

Professional Development and Training

Teaching

. Lectured course on pulmonary physiology, McKinley School, Newark, NJ

(1998-2006)

. Lectured course on pulmonary physiogy to undergraduate and graduate

students, University of South Alabama (1994-1997)

. Lectured laboratory on pulmonary physiogy to medical students, University

of South Alabama (1992-1997)

. Lectured course and lectured laboratory on neurophysiogy and pulmonary

physiogy to college students, University J. Fourier Grenoble, France

(1990-1991)

Student training

. Summer Intern Program (200*-****-****)

. Post-Doctoral Student (2000-2001)

MICHEL REMY CORBOZ

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Manuscript review for numerous journals

. American Journal of Physiology

. Anatomical Record

. British Journal of Pharmacology

. Critical Care Medicine

. Experimental Lung Research

. Journal of Pharmacology and Experimental Therapeutics

. Microvascular Research

. Naunyn-Schmiedeberg 's Archives of Pharmacology

. Respiratory Research

Invited Speaker

. Pulmonary Research Group - Spring 2006 Symposium, Upper Airway Disease:

Clinical and Research Perspectives, May 4th 2006, Allergy and Asthma

Center, John Hopkins, Baltimore, MD, USA

. IX International Da Vinci Society Meeting on Airway Circulation, Pulm.

Pharmacol. & Therap. September 23-25th 2005, Camogli, Italy

. VIII International Da Vinci Society Meeting on Airway Circulation, Pulm.

Pharmacol. & Therap. September 25-27th 2003, Nimes, France

. University of South Alabama, Nasal Mucosa, January 21th 2002, Mobile, AL,

USA

AFFILIATIONS

American Physiological Society

American Thoracic Society

Da Vinci Society

Microcirculatory Society

New Jersey Thoracic Society

Pulmonary Research Group

ACHIEVEMENTS and Awards

Presidential Award for Outstanding Group Achievement (1998)

MICHEL REMY CORBOZ

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Articles and Monographs

1. CORBOZ M.R, M.A. RIVELLI, C. CORELL, R. CHAPMAN

Role of nitric oxide and arginase on muscarinic-induced contractility in

allergen-challenged Brown Norway rat trachea. In Preparation.

2. CORBOZ M.R, J. PALAMANDA, M.A. RIVELLI, C. MORGAN, G.B. VARTY, C.W.

BOYCE, K.D. McCORMICK, J.C. HUNTER

Side-effect and pharmacokinetic profiles of the ?2C-adrenoceptor agonist

N-[3,4-Dihydro-4-(1H-imidazol-4-ylmethyl)-2H-1,4-Benzoxazin-6-yl]-N-

methyl-N'-methylurea (Compound B). Will be Submitted to Pharmacology.

3. CORBOZ M.R, M.A. RIVELLI, H. SHAH, C.W. BOYCE, K.D. McCORMICK, R.W.

CHAPMAN, J.C. HUNTER

Role of ?2-adrenoceptors in electrical field stimulation-induced

contraction of pig nasal mucosa and pharmacologic characterization of a

novel ?2C-adrenoceptor agonist . Am. J. Rhinol. Allergy 26: 1-7, 2012.

4. CORBOZ M.R, M.A. RIVELLI, X. FERNANDEZ, S. GREENFEDER

The tachykinin NK3-receptor agonist [MePhe7]-neurokinin B potentiates

vagal stimulation-induced bronchoconstriction and produces

bronchoconstriction in the isolated perfused lung of non-sensitized and

ovalbumin-sensitized guinea pig. Exp. Lung Res. 38: 233-249, 2012.

5. CORBOZ, M.R., M.A. RIVELLI, K.D. MCCORMICK, Y. WAN, H. SHAH, S. UMLAND,

G. LIEBER, Y. JIA, R. McLEOD, C. MORGAN, G.B. VARTY, J. WU, K. FENG,

C.W. BOYCE, R.G. ASLANIAN, J. PALAMANDA, A. NOMEIR, W. KORFMACHER, J.C.

HUNTER, J.C. ANTHES, J.A. HEY

Pharmacological characterization of the novel ?2C-adrenoceptor agonist N-

[3,4-Dihydro-4-(1H-imidazol-4-ylmethyl)-2H-1,4-Benzoxazin-6-yl]-N-ethyl-

N'-methylurea (Compound A). J. Pharmacol. Exp. Therap. 337: 256-266,

2011.

6. SANOU S.D., M. CORBOZ, G. BENCHETRIT, D. ANGLADE, GRIMBERT F.

Characteristiques de la filtration capillaire pulmonaire pendant une

augmentation du debit cardiaque associee a une vasodilatation. Int. J.

Biol. Chem. Sci. 4: 1278-1293, 2010.

7. TING P., J. LEE J., M. ALBANESE, J. WU, R. ASLANIAN, L. FAVREAU, C.

NARDO, W. KORFMACHER, R. WEST, S. WILLIAMS, J. ANTHES, M. RIVELLI, M.

CORBOZ, J. HEY.

The synthesis and structure-activity relationship of 4-benzimidazolyl-

piperidinylcarbonyl-piperidine analogs as histamine H3 antagonists.

Bioorganic & Medicinal Chemistry Letters 20: 5004-5008, 2010.

8. MINGO G.G., M.R. CORBOZ, B.G. SALISBURY, K.D. MCCORMICK, C.W. BOYCE, G.

MUKHOPADHVAY, R.L. MCLEOD

Alpha-2c adrenergic receptors contribute to basal nasal patency in the

anesthetized cat. Pharmacology 85: 259-263, 2010.

9. PALAMANDA J., H. MEI, R. MORRISON, R.L. MCLEOD, K. MCCORMICK, M. CORBOZ,

X. XU, W. KORFMACHER, L. BROSKE, A.A. NOMEIR

Pharmacokinetics of pseudoephedrine in rats, dogs, monkeys and its

pharmacokinetic-pharmacodynamic relationship in a feline model of nasal

congestion. Drug Metabolism Letters 4: 56-61, 2010.

10. CORBOZ M.R, M.A. RIVELLI, S.P. ECKEL, J.C. ANTHES

Bronchoconstrictor effects of the tachykinin NK3-receptor agonists

[MePhe7]-neurokinin B and senktide in the isolated guinea pig lung. Exp.

Lung Res. 36: 509-21, 2010.

MICHEL REMY CORBOZ

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11. PHILLIPS J.E., L. JI, M. RIVELLI, R.W. CHAPMAN, M.R. CORBOZ

Three-dimensional imaging and morphometric analysis of rodent paranasal

sinus cavities from X- ray computed tomography. Can. J. Vet. Med. 73: 205-

211, 2009.

12. CORBOZ M.R, J.E. PHILLIPS, L. de GARAVILLA

Introduction to pulmonary research group symposium upper airway disease:

Clinical and research perspectives. Pulm. Pharmacol. & Therap. 21: 431-

432, 2008.

13. CORBOZ M.R, M.A. RIVELLI, G.G. MINGO, R.L. McLEOD, L.M. VARTY, Y. JIA,

M. CARTWRIGHT, J.A. HEY

Mechanism of decongestant activity of ?2-adrenoceptor agonists. Pulm.

Pharmacol. & Therap. 21: 449-454, 2008.

14. CORBOZ M.R, X. FERNANDEZ, J.A. HEY

Increased blocking activity of combined tachykinin NK1- and NK2-receptor

antagonists on hyperventilation-induced bronchoconstriction in the

guinea pig. Pulm. Pharmacol. & Therap. 21: 67-72, 2008.

15. CORBOZ M.R, J.C. MUTTER, M.A. RIVELLI, G.G. MINGO, R.L. McLEOD, L.M.

VARTY, Y. JIA, M. CARTWRIGHT, J.A. HEY

?2-Adrenoceptor agonists as nasal decongestant. Pulm. Pharmacol. Ther.

20:149-56, 2007.

16. BERLIN M., P.C. TING, D.W. VACCARO, R. ASLANIAN, K.D. McCORMICK, J.F.

LEE, M.M. ALBANESE, M.W. MUTAHI, J.J. PIWINSKI, N.-Y. SHIH, L. DUGUMA,

D.M. SOLOMON, W. ZHOU, R. SHER, L. FAVREAU, M. BRYANT, W.A. KORFMACHER,

C. NARDO, R.E WEST, J.C. ANTHES, S.M. WILLIAMS, R.-L. WU, H.S. SHE, M.A.

RIVELLI, M.R. CORBOZ, J.A. HEY

Reduction of CYP450 inhibition in the 4-[(1H-imidazol-4-

yl)methyl]piperidine series of histamine H3 receptor antagonists.

Bioorganic Medicinal Chemistry Letters. 16: 989-994, 2006.

17. VACCARO D.W., R. SHER, M. BERLIN, N.-Y. SHIH, R. ASLANIAN, J.H.

SCHWERDT, K.D. McCORMICK, J.J. PIWINSKI, R.E WEST, J.C. ANTHES, S.M.

WILLIAMS, R.-L. WU, H.S. SHE, M.A. RIVELLI, J.C. MUTTER, M.R. CORBOZ,

J.A. HEY, L. FAVREAU

Novel histamine H3 receptor antagonists based on the 4-[(1H-imidazol-4-

yl)methyl]piperidine scaffold. Bioorganic Medicinal Chemistry Letters

16: 395-399, 2006.

18. CORBOZ M.R, M.A. RIVELLI, L.M. VARTY, J.C. MUTTER, M. CARTWRIGHT, C.A.

RIZZO, S.P. ECKEL, J.C. ANTHES, J.A. HEY

Pharmacological characterization of postjunctional ?2-adrenoceptors in

human nasal mucosa. Am. J. Rhinol. 19: 495-502, 2005.

19. CORBOZ M.R, L.M. VARTY, M.A. RIVELLI, J.C. MUTTER, G. MINGO, R.L.

McLEOD, R.W. EGAN, J.A. HEY

Effects of ?2-adrenoceptor agonists in nasal mucosa. Arch. Physiol.

Biochem. 111: 335-336, 2003.

20. CORBOZ M.R, L.M. VARTY, C.A. RIZZO, J.C. MUTTER, M.A. RIVELLI,, Y.

WAN, S.P. UMLAND, H. QIU, J. JAKWAY, K. McCORMICK, M.Y. BERLIN, J.A. HEY

Pharmacological characterization of ?2-adrenoceptor-mediated responses

in pig nasal mucosa. Auton. Autacoid Pharmacol. 23: 208-219, 2003.

21. CORBOZ M.R., X. FERNANDEZ, C.A. RIZZO, S. TOZZI, M.E. MONAHAN, J.A. HEY

Increased blocking activity of combined tachykinin NK1- and NK2-receptor

antagonists on tachykinergic bronchomotor responses in the guinea pig.

Auton. Autacoid Pharmacol. 23: 79-93, 2003.

MICHEL REMY CORBOZ

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22. RIZZO C.A., J. ANTHES, M.R. CORBOZ, R. CHAPMAN, N.-Y. SHIH, G.A.

REICHARD, K.J. NG, J.A. HEY

Development and potential utility of dual and triple NK receptor

antagonists. Curr. Topics Med. Chem. 3: 1410-1422, 2003.

23. PHILLIPS J.E., J.A. HEY, M.R. CORBOZ

Tachykinin NK3 and NK1 receptor activation elicits secretion from

porcine airway submucosal glands. Br. J. Pharmacol. 138: 254-260, 2003.

24. ANTHES J.C., R.C. CHAPMAN, C. RICHARD, S. ECKEL, M. CORBOZ, J.A. HEY,

X. FERNANDEZ, S. GREENFEDER, R. McLEOD, S. SHERING, C. RIZZO, Y.

CRAWLEY, N.-Y. SHIH, J. PIWINSKI, G. REICHARD, P. TING, N. CARRUTHERS,

F.M. CUSS, M. BILLAH, W. KREUTNER, R.W. EGAN

SCH 206272: a potent, orally active tachykinin NK1, NK2, and NK3

receptor antagonist. Eur. J. Pharmacol. 450(2): 191-202, 2002.

25. PHILLIPS J.E., J.A. HEY, M.R. CORBOZ

Effects of ion transport inhibitors on MCh-mediated secretion from

porcine airway submucosal glands. J. Appl. Physiol. 93: 873-881, 2002.

26. PHILLIPS J.E., J.A. HEY, M.R. CORBOZ

Automated measurement of airway gland secretions by the Hillocks

technique. Computer Methods and Programs in Biomedicine 68: 215-222,

2002.

27. JIA Y., S.I. APONTE, C. WANG, M.A. RIVELLI, R. YANG, C. RIZZO, M.R.

CORBOZ, T. PRIESTLEY, J.A. HEY

Nociceptin inhibits capsaicin-induced tachykinin release in isolated

guinea pig lung and Ca2+ response in nodose ganglia cells. Br. J.

Pharmacol. 135: 764-770, 2002.

28. TROUT L., M.R CORBOZ, S.T. BALLARD

Mechanism of substance P-induced bicarbonate and liquid secretion across

porcine bronchial epithelium. Am. J. Physiol. (Lung Cell. Mol.

Physiol.) 181: L639-L645, 2001.

29. CORBOZ M.R, X. FERNANDEZ, R.W. EGAN, J.A. HEY

Inhibitory activity of nociceptin/orphanin FQ on capsaicin-induced

bronchoconstriction in the guinea-pig. Life Sciences 69(10): 1203-1211,

2001.

30. GREENFEDER S., S. SEHRING, N. McHUGH, M. CORBOZ, M. RIVELLI, J.C.

ANTHES, M. BILLAH, R.W. EGAN, R.W. CHAPMAN

Tryptase-induced airway microvascular leakage in guinea pigs. Eur. J.

Pharmacol. 419: 261-267, 2001.

31. RIZZO C.A., L.M. RUCK, M.R. CORBOZ, S.P. UMLAND, Y. WAN, H. SHAH, J.

JAKWAY, L. CHENG, K. McCORMICK, R.W. EGAN, J.A. HEY

Postjunctional ?2c-adrenoceptor contractility in human saphenous vein.

Eur. J. Pharmacol. 413: 263-269, 2001.

32. CORBOZ M.R., S. T. BALLARD, H. GAO, J.N. BENOIT, S.K INGLIS, A.E.

TAYLOR

Differential effects of furosemide on porcine bronchial arterial and

airway smooth muscle. J. Appl. Physiol. 89: 1360-1364, 2000.

33. CORBOZ M.R, M.A. RIVELLI, R.W. EGAN, D. TULSHIAN, J. MATASI, A.B.

FAWZI, L. BENBOW, A. SMITH-TORHAN, H. ZHANG, J.A. HEY

Nociceptin inhibits capsaicin-induced bronchoconstriction in isolated

guinea pig lung. Eur. J. Pharmacol. 402: 171-179, 2000.

MICHEL REMY CORBOZ

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34. MCLEOD R.L., G.G. MINGO, C. HERCZKU, M.R. CORBOZ, S. J. RAMOS, F.

DEGENNARO-CULVER, O. PEDERSEN, J.A. HEY

Changes in nasal resistance and nasal geometry using pressure and

acoustic rhinometry in a feline model of nasal congestion. Am. J.

Rhinol. 13: 375-383, 1999.

35. CORBOZ M.R, M.A. RIVELLI, S.J. RAMOS, C.A. RIZZO, J.A. HEY

Tachykinin NK1 receptor-mediated vasorelaxation in human pulmonary

arteries. Eur. J. Pharmacol. 350: R1-R3, 1998.

36. CORBOZ M.R, S.T. BALLARD

Intravital microscopy: airway circulation. In: Methods in Pulmonary

Research. Edited by S. Uhlig and A.E. Taylor. Published by Birkhauser

Publisher (Boston), USA, 93-107, 1998.

37. INGLIS S.K, M.R CORBOZ, S.T. BALLARD

Effect of anion secretion inhibitors on mucin content of airway

submucosal gland ducts. Am. J. Physiol. 274 (Lung Cell. Mol. Physiol.

18): L762-L766, 1998.

38. ANGLADE D.J., M. CORBOZ, A. MENOUAR, J.C. PARKER, S. SANOU, S. BAYAT,

G. BENCHETRIT, F. GRIMBERT

Flow vs venous pressure effects on filtration coefficient in oleic acid-

injured lung. J. Appl. Physiol. 84: 1011-1023, 1998.

39. MENAOUAR A., D.J. ANGLADE, P. BAUSSAND, A. PELLOUX, M. CORBOZ, F.

GRIMBERT

Mechanism of chlorine gas-induced lung injury. Eur. Respir. J. 10: 1100-

1107, 1997.

40. CORBOZ M.R, S. T. BALLARD, S.K INGLIS, A.E. TAYLOR

Vasodilatory effect of furosemide on rat tracheal arterioles and

venules. Am J. Respir. Crit. Care Med. 156: 478-483, 1997.

41. INGLIS S.K, M.R CORBOZ, S. T. BALLARD, A.E. TAYLOR

Effect of anion transport inhibition on mucus secretion by airway

submucosal glands. Am. J. Physiol. 272 (Lung Cell. Mol. Physiol. 16):

L372-L377, 1997.

42. INGLIS S.K, M.R CORBOZ, S.T. BALLARD, A.E. TAYLOR

In situ visualization of bronchial submucosal glands and their secretory

response to acetylcholine. Am J. Physiol. 272 (Lung Cell. Mol. Physiol.

16): L203-L210, 1997.

43. CORBOZ M.R, S. T. BALLARD, S.K INGLIS, A.E. TAYLOR

Tracheal microvascular responses to inhibition of nitric oxide synthesis

in anesthetized rats. Am J. Respir. Crit. Care Med. 154: 1382-1386,

1996.

44. GRIMBERT F., A. MENAOUAR, D. ANGLADE, S, SANOU, M. CORBOZ

Filtration and capillary permeability. In: Clinical Microcirculation.

Edited by M. Vayssairat and P. Carpentier. Published by Masson (Paris),

15-24, 1996.

45. INGLIS S.K, M.R CORBOZ, S.T. BALLARD, A.E. TAYLOR

Regulation of ion transport across porcine distal bronchi. Am J.

Physio1. 270 (Lung Cell. Mol. Physiol. 14): L289-L297, 1996.

46. CORBOZ M.R, S. T. BALLARD, S.K INGLIS, A.E. TAYLOR

Tracheal microvascular responses to ?-adrenergic stimulation in

anesthetized rats. Am J. Respir. Crit. Care Med. 153: 1093-1597,1996.

47. CORBOZ M., S. SANOU, F. GRIMBERT

Capillary pressure estimates from arterial and venous occlusion in

intact dog lung. Eur. Respir. J. 8: 1122-1129,1995.

MICHEL REMY CORBOZ

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48. BALLARD S.T., J.D. FOUNTAIN, S.K INGLIS, M.R CORBOZ, A.E. TAYLOR

Chloride secretion across distal airway epithelium: Relationship to

submucosal gland distribution. Am J. Physiol. 268 (Lung Cell. Mol.

Physiol. 12): L526-L531, 1995.

49. CORBOZ M.R, S.T. BALLARD, A.E. TAYLOR

Distribution of functional adrenergic receptor subtypes in the

microcirculation of rat trachea. Am J. Respir. Crit. Care Med. 151 (5):

1589-1596, 1995.

50. GRIMBERT F., M. CORBOZ, S. SANOU, D. MARTIN, G. BENCHETRIT

Lymph flow and protein content as an index of microvascular filtration.

In: Progress in Lymphology-xm. Edited by R. V Cluzan, A.P. Pecking, F.M.

Lokiec. Published by Excerpta Medica, Elsevier, The Netherlands, 153-

157, 1992.

51. CORBOZ M.

Etude experimentale des pressions d'occlusion arterielle et veineuse

dans la circulation pulmonaire. Doctoral dissertation in Biology,

University Joseph Fourier, Grenoble, France, 1992.

MICHEL REMY CORBOZ

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Abstracts

1. CORBOZ M.R., S. FATHALLA.

The role of lung vasculature on postmortem bronchoconstriction in non-

sensitized and ovalbumin-sensitized guinea pigs. Am. J. Respir. Crit.

Care Med. 183: A2885, 2011.

2. CORBOZ M.R., S. FATHALLA, A. HOUSE, R.W. CHAPMAN, J.C. ANTHES.

Effect of arginase on muscarinic-induced contractility in isolated

bronchi and trachea of non-challenged and allergen-challenged guinea

pig. Am. J. Respir. Crit. Care Med. 183: A2583, 2011.

3. CORBOZ M.R., M.A. RIVELLI, G. Lieber, Y. Jia, R.L. McLeod, H. Shah, S.P.

Umland, C.W. Boyce, J. Wu, K.D. McCormick, J.A. Hey

Pharmacological characterization of the ?2C-adrenoceptor agonist

Compound A in binding, in vitro and in vivo assays. Am. J. Respir. Crit.

Care Med. 181: A4216, 2010.

4. CORBOZ M.R., M.A. RIVELLI, K.D. McCORMICK, J.E. PHILLIPS, J.C. ANTHES.

Role of ?-adrenoceptors in electrical field stimulation-induced

contraction of isolated pig nasal mucosa. Am. J. Respir. Crit. Care Med.

181: A4217, 2010

5. CORBOZ M.R., M.A. RIVELLI, J.E. PHILLIPS, R.W. CHAPMAN, J.C. ANTHES.

Role of nitric oxide and arginase on muscarinic-induced contractility in

isolated trachea of non-challenged and allergen-challenged Brown Norway

rat. Am. J. Respir. Crit. Care Med. 181: A2833, 2010

6. McLeod R.L., G.G Mingo, Y. Crawley, M.R. Corboz, Y. Jia, K.D. McCormick,

J.A. Hey

Characterization of the ?2c adrenergic agonist Compound A in

experimental animal models of nasal congestion. Am. J. Respir. Crit.

Care Med. 181: A4210, 2010

7. CORBOZ M.R., M.A. RIVELLI, S. SKEANS, K. McCORMICK, R. CHAPMAN, J.E.

PHILLIPS, J.C. ANTHES.

Vasodilatory and secretagogue roles of the prostaglandin D2 (PGD2)

receptor in nasal mucosa and airways of different species. Am. J.

Respir. Crit. Care Med. 179: A5699, 2009.

8. CORBOZ M.R., M.A. RIVELLI, A. DESAI-MERCHANT, M. ANAND, K.SMITH, J.E.

PHILLIPS, R. CHAPMAN, J.C. ANTHES

Effects of two days cigarette smoke exposure in isolated perfused rat

lung and pulmonary inflammation. Am. J. Respir. Crit. Care Med. 179:

A2027, 2009.

9. CORBOZ M.R., M.A. RIVELLI, G. MINGO, G. MUKHOPADHYAY, B. SALISBURY,R.L.

McLEOD, J.C. ANTHES

Binding, in vitro and in vivo decongestant activities of the standard

decongestant pseudoephedrine. Am. J. Respir. Crit. Care Med. 177: A625,

2008.

10. CORBOZ M.R., M.A. RIVELLI, J.C. ZIMMER, J.C. ANTHES

Pharmacological characterization of the ?-adrenoceptors in dog nasal

mucosa. Am. J. Respir. Crit. Care Med. 177: A626, 2008.

11. CORBOZ M.R., M.A. RIVELLI, G. MINGO, R.L. McLEOD

Effects of the selective ?1-adrenoceptor agonist phenylephrine in nasal

contractile bioassays and congestion model. Am. J. Respir. Crit. Care

Med. 175: A200, 2007.

MICHEL REMY CORBOZ

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12. CORBOZ M.R., M.A. RIVELLI, D.Y. KONG

Effect of ascorbic acid on ?-adrenoceptor agonists-induced contractions

in pig nasal mucosa and human saphenous vein. Am. J. Respir. Crit. Care

Med. 175: A199, 2007.

13. PHILLIPS J.R., L. JI, M.R. CORBOZ

Volume quantification of mouse, rat, and guinea pig paranasal sinus

cavities by CT imaging and computer assisted three-dimensional

reconstruction. Am. J. Respir. Crit. Care Med. 175: A671, 2007.

14. CORBOZ M.R., M.A. RIVELLI, J.C. MUTTER, G. MINGO, R.L. McLEOD, J.A.

HEY

Nasal contractility and decongestant effects of ?2-adrenoceptor

agonists. Am. J. Respir. Crit. Care Med., 2006.

15. JIA Y., G. DIAZ, M. CORBOZ, J.A. HEY

?-Adrenoceptor-mediated contractions of capacitance and resistance

vessels in porcine nasal mucosa explants. Am. J. Respir. Crit. Care

Med., 2006.

16. CORBOZ M.R., J.C. MUTTER, M.A. RIVELLI, J.A. HEY

Effect of the tachykinin NK1-receptor agonist [Met-OMe11]Substance P and

the calcitonin gene-related peptide-receptor agonist CGRP in dog, pig,

monkey and human nasal mucosa. Am. J. Respir. Crit. Care Med. A340,

2005.

17. CORBOZ M.R., V. JOGUPARTHI, J.C. MUTTER, P. WANG, J.A. HEY

Effect of neuropeptide Y and calcitonin-gene related peptide in pig

nasal mucosa. FASEB J. 18: A248, 2004.

18. CORBOZ M.R., J.C. MUTTER, C.A. RIZZO, J.A. HEY

?1- And ?2-adrenoceptor agonist responses in monkey nasal mucosa. Am. J.

Respir. Crit. Care Med. 169: A821, 2004.

19. CORBOZ M.R., M.A. RIVELLI, X. FERNANDEZ, J.A. HEY

The tachykinin NK3 agonist (N-Me-Phe7) neurokinin B potentiates vagal

stimulation-induced bronchoconstriction in the isolated guinea pig lung.

Am. J. Respir. Crit. Care Med. 167: A149, 2003.

20. CORBOZ M.R., J.C. MUTTER, L.M. RUCK, G. MINGO, R.L. McLEOD, S.P.

UMLAND, Y. WAN, J. JAKWAY, H. QIU, K.D. McCORMICK, J.A. HEY

Binding, in vitro and in vivo decongestant activities of ?-adrenergic

receptor agonists ST-91 and SK&F 35886. Am. J. Respir. Crit. Care Med.

167: A218, 2003.

21. CORBOZ M.R., M.A. RIVELLI, C.A. RIZZO, J.A. HEY

?1- and ?2-Adrenoceptors mediate vasoconstriction in human nasal mucosa.

Am. J. Respir. Crit. Care Med. 167: A425, 2003.

22. PHILLIPS J.E., J.A. HEY, M.R. CORBOZ

Effects of ion transport inhibitors on methacholine mediated secretion

from porcine airway submucosal glands. Am. J. Respir. Crit. Care Med.

167: A424, 2003.

MICHEL REMY CORBOZ

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23. VARTY, L.M., J.E. PHILLIPS, M.R. CORBOZ, Y. JIA, J.A. HEY

Differential ?2- and ?1-adrenoceptor real-time vasomotor contractions in

isolated porcine nasal mucosa. Am. J. Respir. Crit. Care Med. 167: A425,

2003.

24. CORBOZ M.R., C.A. RIZZO, X. FERNANDEZ, S. TOZZI, M.E. MONAHAN, J.A. HEY

Increased activity of combined NK1/NK2 blockade on tachykinin-induced

constriction in isolated bronchus, isolated lung and in vivo guinea

pigs. Am. J. Respir. Crit. Care Med. 165: B40, 2002.

25. CORBOZ M.R., J.C. MUTTER, M.A. RIVELLI, L.M. RUCK, C.A. RIZZO, G.

MINGO, R.L. McLEOD, Y. WAN, S.P. UMLAND, M.Y. BERLIN, J.A. HEY

Pharmacological characterization of ?-adrenergic receptor agonists

oxymetazoline and PGE-6201204 in binding, in vitro bioassays and in an

in vivo decongestant model. Am. J. Respir. Crit. Care Med. 165: A326,

2002.

26. CORBOZ M.R., M.A. RIVELLI, S. GREENFEDER, J.A. HEY

Tachykinin NK-3 receptor agonist produces bronchoconstriction in the

isolated guinea-pig lung. Am. J. Respir. Crit. Care Med. 165: A721,

2002.

27. PHILLIPS J.E., J.A. HEY, M.R. CORBOZ

Effects of neurokinin agonists and antagonists on submucosal gland

secretion from porcine airways. Am. J. Respir. Crit. Care Med. 165:

A722, 2002.

28. JIA Y., X. WANG, M.A. RIVELLI, M.R. CORBOZ, R.L. McLEOD, T. PRIESTLEY,

R.W. EGAN, J.A. HEY

Nociceptin/Orphanin FQ inhibits capsaicin-induced guinea pig airway

contraction through the activation of an inward-rectifier potassium

channel. Am. J. Respir. Crit. Care Med. 165: A719, 2002.

29. CORBOZ M.R., M.A. RIVELLI, C.A. RIZZO, J.A. HEY

Chloride channels mediate tachykinin NK-1 receptor agonist-induced

relaxation in human pulmonary arteries. FASEB J. 16: A71, 2002.

30. MUTTER J., M. RIVELLI, L.M. RUCK, C.A. RIZZO, J.A. HEY, M.R. CORBOZ.

Pharmacological characterization of ?1- and ?2- adrenoceptor agonist

responses in canine turbinate mucosa. FASEB J. 16: A127, 2002.

31. CORBOZ M.R., X. FERNANDEZ, R.W. EGAN, J.A. HEY

Nociceptin inhibits capsaicin-induced bronchoconstriction in the guinea-

pig. Am. J. Respir. Crit. Care Med. 163: A626, 2001.

32. PHILLIPS J.E., J.A. HEY, M.R. CORBOZ

Amiloride increases methacholine-induced tracheal submucosal gland fluid

flux in porcine tracheal epithelia. Am. J. Respir. Crit. Care Med. 163:

A406, 2001.

33. JIA Y., S.I. APONTE, M.A. RIVELLI, M.R. CORBOZ, J.H. CRONA, Z.X. DONG,

T. PRIESTLEY, J.A. HEY

Nociceptin inhibits capsaicin-induced tachykinin release in isolated

guinea pig lungs. Am. J. Respir. Crit. Care Med. 163: A826, 2001.

34. CORBOZ M.R., M.A. RIVELLI, C.A. RIZZO, J.A. HEY

Tachykinin NK-1 receptor agonist-induced relaxation in human pulmonary

arteries is not mediated by potassium channels. FASEB, 2001

35. RUCK L.M., C.A. RIZZO, M.R. CORBOZ, R. YANG, M. RIVELLI, J. MUTTER,

J.A. HEY

Pharmacological characterization of the ?2-adrenergic agonist responses

in porcine turbinate mucosa. FASEB, 2001

MICHEL REMY CORBOZ

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36. CORBOZ M.R., S.I. APONTE, M.A. RIVELLI, C.A. RIZZO, J.A. HEY

Differential role of tachykinin NK-1 and NK-2 receptors on vascular tone

in human pulmonary arteries. Am. J. Respir. Crit. Care Med. 161: A410,

2000.

37. RUCK L.M., C.A. RIZZO, J.A. HEY, R.W. EGAN, S.P. UMLAND, Y. WAN, H.

SHAH, J.JAKWAY, L. CHENG, J. SHORTALL, M.R. CORBOZ

Pharmacological characterization of the ?-2c adrenergic receptor in

human saphenous vein. FASEB J. 14: A1315, 2000.

38. RIVELLI M.A., M.R. CORBOZ, X. FERNANDEZ, J.A. HEY

Increased activity of combined NK1/NK2 blockade on tachykinin-induced

bronchoconstriction in isolated lung and in vivo in the guinea pigs. Am.

J. Respir. Crit. Care Med. 159: A281, 1999.

39. FERNANDEZ X., M.R. CORBOZ, J.A. HEY

Combination of NK1 and NK2 antagonists produces an increased blockade of

hyperventilation-induced bronchoconstriction in guinea pigs. Am. J.

Respir. Crit. Care Med. 159: A281, 1999.

40. CORBOZ M.R., S.I. RAMOS, M.A. RIVELLI, C.A. RIZZO, J.A. HEY

Mechanism of tachykinin NK-1 receptor agonist-induced relaxation in

human pulmonary arteries. Am. J. Respir. Crit. Care Med. 159: A572,

1999.

41. CORBOZ M.R., S.I. RAMOS, M.A. RIVELLI, C.A. RIZZO, J.A. HEY

Characterization of neurokinin NK-l

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