Yaxin (Jason) Huang

Address:

*** ******* **., *** *

Central, SC, 29630

Tel: 864-***-**** (cell)

Fax: 864-***-****

Email: ohz65a@r.postjobfree.com

Objective:

Seeking an organic synthetic position in pharmaceutical industry: structure-based drug design and new drug discovery.

Highlights and skills:

 Six years’ experience of multi-step syntheses of small organic molecules and asymmetric organometallic catalysis with biologically active organic compounds

 Capability to work independently with synthetic route design.

 Six years of lab-teaching experience enables excellent presentation and communication skills.

 Characterization of small organic compounds using NMR, GC/MS, LC/MS, HPLC, chiral HPLC, IR, UV/Vis on daily basis.

Education:

Ph.D. (Organic Chemistry) (expected graduation date) Dec, 2010

Clemson University

B.S. (Applied Chemistry) Jun, 2004

China Agricultural University

Research Experience:

Graduate Research (Aug 2004 - Present): Working with Dr. Karl Dieter in developing new methodologies in small substituted N,O-heterocycles synthesis.

• Synthesis of enantioenriched substituted cycloamidines.

• Conjugated addition to N-carbamoyl-2-pyridones and other 2-pyridones using organolithium and organocopper reagents.

• Cross-coupling reactions of alkenyl halides with amines, Buchwald–Hartwig type reactions involving palladium(Pd) catalysts.

• Stereo- and chemoselective opening of (E)-3-(1-propenyl)oxiranemethanol and its derivatives using titanium tetrachloride (TiCl4) and other reagents.

• Asymmetric allylic substitution of 2-[(tert-Butyldimethylsiloxy)methyl]-3-(trans-2-methylvinyl)oxirane using organolithium(Li), magnesium(Mg), and zinc(Zn) cuprates.

• Synthesis of enantioenriched substituted 5- and 6-membered lactones.

• Asymmetric synthesis of sex pheromones for insects.

Undergraduate Research (Sep 2002-Mar 2003): Worked with Dr. Min Wang and his research group. Participated in the project of capillary gas chromatographic separation of enantiomers of 2-phenyl-1-cyclopropanecarboxylate.

• Group member (Nov 2001-Feb 2002): Conducted research on the project of the synthesis of BINAP and application of BINAP-metal complex catalysts in asymmetric reduction.

Teaching Experience:

• Teaching Assistant (Aug 2004-Aug2010): Taught undergraduate level labs for General Chemistry, Organic Chemistry One &Two. Excellent feedback from the students.

Publications:

• Dieter, R. K., Huang.Y., Guo, F. “Regio- and Stereoselectivity in the Reactions of Organometallic reagents with 2,3-Epoxy- α, β -Enoates”, J. Org. Chem. Submitted.

• Dieter, R. K.; Huang, Y. “Conjugate Addition of Organometallic Reagents to 2-Pyridones”, Work completed, manuscript planned.

• Dieter, R. K.; Huang, Y. “Stereo- and Chemoselective Opening of (E)-3-(1-Propenyl)oxiranemethanol and its Derivatives using Titanium Tetrachloride (TiCl4)”, work completed, manuscript planned.

Conference Presentations:

• Blakemore, J. D.; Guo, F.; Huang, Y.; Dieter, R. K. “Toward the Synthesis of Enantioenriched and Highly Substituted δ –Lactones.” Abstracts of Papers, 233rd ACS National Meeting, Chicago, IL, United States, March 25-29, (2007)

• Dieter, R. K.; Huang, Y.. “The Chemo-, Regio- and Stereoselective Reactions of δ, γ- Epoxy-α, β-Enoates.” Abstracts, 59th Southeast Regional Meeting of the American Chemical Society, Greenville, SC, United States, October 24-27 (2007),

Awards and Honors:

• Excellent Academic Scholarship for 3 consecutive years Prize for Distinguished Student Representative in College of Science of China Agricultural University.

• Privilege to enter the Graduate Program in China Agricultural University, exempted from entrance examination.

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