Project Design

RESUME

BHUSHAN MOHAN MAHAJAN

Present address

B/4, 406, Nandan Apartment

Ramdev Nagar, Satellite

Ahmedabad

Contact No.: 090********/088********

E-mail: *****************@*****.**.**

Permanent address

100, ‘Matoshri’

Swaminarayan Housing Soc.

Market Yard, Parola Road Dhule – 424 001,

Maharashtra, INDIA.

¬¬¬¬¬

Career objectives:

To seek a challenging position in the field of research and development that can provide me a platform to exploit my experience, skills and knowledge to contribute my share of responsibilities.

Area of Interest: Research and Development/IPR/API-RA

Achievements and awards:

• Project Fellow, University Grants Commission, New Delhi, India from September 2008 to October 2010 in the Major Research Project entitled ‘QSAR, design and synthesis of some lipid lowering agents.’

Work Experience:

1. Designation and Organization:

Senior Research Associate: Piramal Discovery Solutions (Formerly known as O2h), Ahmedabad (November 2010 to till date).

Job profile:

• To work in allocated project and execute them within stipulated time.

• To carry out the literature search for novel compounds/known methods using commercial and noncommercial databases.

• To conduct novelty and prior art search using literature.

• To design synthetic route for targeted compound(s) using literature resources as well as organic chemistry intellects.

• Reaction set up, monitoring, optimization and purification of synthesized compounds, intermediate, drugs, etc.

• To characterize the synthesized compounds using spectroscopic techniques like IR, Mass, LCMS, HPLC, NMR etc.

• To isolate, characterize and predict the byproduct/impurities generated during the reaction.

• To carry out synthesis of desired compound with quantity ranging from mg to gm level.

• To optimize process chemistry and operations for yield and quality improvement; cost reduction, productivity enhancement; technology transfer from lab to plant.

• Troubleshooting during the trials and/or scale up reactions.

• Waste management – waste minimization and recovery of useful by-products from effluent and solvent recoveries.

• To respond to the queries raised by client and present the status of project in meetings.

• Actively participate in the project operations like scheme preparations, chemical calculations (using Excel), chemical search (involving various local and international suppliers); chemical procurement and preparing project management/reporting documents.

• To assist seniors/team members/group leaders in project status/updates/meetings.

2. Designation and organization:

Research Fellow: Department of Pharmaceutical Chemistry, L M College of Pharmacy, Ahmedabad (September 2008 to October 2010).

Job Profile:

• To carry out drug designing based on traditional as well as modern (Computational) approaches like QSAR, Pharmacophore generation, Docking, Virtual screening, etc.

• Actively involved in LEAD identification and optimization process.

• To carry out synthesis, characterization and biological evaluation of targeted molecule.

• To generate the Structure Activity Relationship (SAR) study based on the biological activity results.

• To submit/present the status report in front of project sanctioned authorities.

• To help post graduate students to complete their project related work.

• To deliver lectures, conduct practicals and examination of undergraduate/post graduate students.

3. Designation and organization:

• Lecturer: Sigma Institute of Pharmacy, Vadodara (May 2007 to August 2008).

Job profile:

• Prime duties are to take lectures on Medicinal Chemistry, Organic Chemistry, Drug Design.

• To conduct practicals for undergraduate students as a part of their university prerequisite.

• To conduct the examination as per university circular/schedule.

• To manage/arrange conference, meetings, preceding, scientific fair, science competition, etc. among the students.

• To motivate/appreciate/aware students to take part in above events.

• To carry out administrative work.

Technical Skills:

• Appreciable knowledge about Intellectual Property Rights (IPR) including patents, copyright, trademark, etc.

• Able to conduct prior art searches including patent and non-patent literature by using commercial (SciFinder, Discovery Gate, Beilstein, Reaxys, etc.) and non-commercial databases (USPTO, Espacenet, WIPO, IPO, Google patents, Patent Lens, etc).

• Good handling on almost all softwares necessary for structural drawing and structure search.

• Expert in literature search using offline (chemical abstracts, etc.) and online databases

• Extensive exposure on various carbon-carbon and carbon-nitrogen coupling reactions like Suzuki, Heck, Sonagashira, Buchwald, etc.

• Performed various protection and deprotection reactions, hydrogenations, condensations and many of the known organic functional group transformations.

• Experience in handling hazardous reagents like n-butyl lithium, cyanides, hydrides, Raney Ni, Pd-C, Pd(OH)2, etc.

• Having appreciable knowledge about synthesis of heterocycles and chemistry of heterocyclic compounds.

• Synthesized many structurally diverse compounds of the scale of 100 mg to 100 g during the course of research work with synthetic steps ranging from 3-14.

• Able to carry out different purification techniques like chromatography, recrystallisation, solvent trituration, acid-base-amine purification, solvent extraction, etc.

• Expertise in carrying out reactions at very low temperature and in inert environment.

• Able to work individually/collaboratively with at least two different projects.

• Expertise in ligand design for diverse therapeutic targets and optimizing it with computational Drug Design with full working knowledge of most of the CADD softwares including Discovery Studio 2.1 (Accelrys Inc., USA) and Autodock.

Academic Profile:

Master of Pharmacy : First Class (69.74%), June 2007, R C Patel College of (Pharmaceutical Chemistry) Pharmacy, Shirpur, Dist. Dhule Maharashtra, INDIA

Bachelor of Pharmacy : First Class (60.23%), May 2005 A R A College of

Pharmacy, Dhule, Maharashtra, INDIA

Publications:

1. Chhabria M.T., Brahmkshatriya P.S., Mahajan B.M., Darji U.B. and Shah G.B. Chem Bio Drug Design (Status: Accepted).

2. Chhabria M.T., Mahajan B.M. and Brahmkshatriya P.S. Med. Chem. Res., Published online, September, 2010.

3. Chhabria M.T., Mahajan B.M. Expert Opin. Ther. Patents, 2009, 19(8), 1083-1173.

4. Bari S.B., Mahajan B.M. Res. J. Chem. Environ. Sci. 2008, 12(3), 85-89.

5. Bari S.B., Mahajan B.M. Indian J. Pharm. Edu. Res., 2008, 42(1), 3-11.

Personal Profile:

• Date of Birth : June 30, 1984

• Marital Status : Married

• Nationality : Indian

• Language Proficiency : English, Hindi, Marathi, Gujarati

• Interests : Reading, Music, Sports, Internet surfing and browsing

Declaration

I hereby declare that all the information furnished above is true to the best of my knowledge.

Date: 13rd Feb. 2012 Name: Bhushan M Mahajan

Place: Ahmedabad

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