Project Manager, clinica data manager

Liping Deng Wang MS, PMP

**** **** ***, ******, ** 08820

732-***-****(H); 848-***-****(Mobile)

Skills

eDC, eCRF (PhaseForward, InForm), Encoding

Oraccle DB, SQL

MS Office applications, MSPS

Six Sigma

Cross functional project management

Professional Experience

Project Management, Merck & Co., Inc, Dec., 2006 to July 2011

• Project resource and cost management

- Led the functional area resource planning; was responsible for oncology and neuroscience franchises with 9 therapeutic areas

- Managed the team on project resource and cost estimation

- Acted as primary contact in the project team in providing the key resource and cost information to support the management on strategic planning and decision making

- Managed the project change and control processes to ensure the project progresses within budget

- Led the team on schedule shift assessment (FPE date shift) and developed the guideline in project scheduling to minimize the schedule risk

- Coordinated with functional areas to ensure the timely operational planning and execution in resource allocation and deliverables in responding to the monthly portfolio and project scope changes as reported in Book of Business

• Merck drug development average cost estimation for internal benchmarking (Lean Six Sigma Green Belt project)

- Defined and developed the project scope and strategy

- Led the cross functional collaborations to define the project scope and estimate the resource and costs of the H, M amd L benchmarking projects

- Established the internal benchmarking library for easy access and quick reference on the development average costs

- Applied Six Sigma methodologies (DMADV) and practiced throughout the entire project process

- Was certified as Six Sigma Green Belt.

Clinical Data Management, Merck & Co., Inc, Oct. 1997 to Dec. 2006

• Protocol review, CRF design and study readiness

- Led the protocol review and CRF design with clinical and IT teams

- Led the UAT activity in data collection tool and application development

- Developed the data management and handling guideline for the responsible studies

- Provided data collection and data entry field training at trial sites to ensure data entry quality and consistency

• Clinical data review and management for phase I-IV studies

- Performed data review and data validation for clinical data integrity and legitimacy

- Led the weekly cross-functional data management meeting in reviewing the status and progresses on trial data collection and management

- Collaborated with functional areas and IT to ensure timely resolution for the identified data issues and discrepancies

- Led the cross functional collaboration on final data review and database lock

- Supported CSR

- Supervised 4 contractors

• Auto encoding optimization and the biannual MedDRA implementation

- Analyzed the manually encoded terms and provided to IT the encoding mappings (verbatim to dictionary) with frequencies to optimize the encoding matches and to increase the auto encoding rate

- Developed the project plan for the bi-annual MedDRA upgrade and managed the implementation

• Project management for system subscription of Merck electronic dictionary data

- Managed the project team to deliver the system subscriptions of the Merck standard dictionary data.

- Developed standard and security code to ensure the proper data sharing

- Established service level agreement (SLA) to ensure the data steward and data security

Molecular Pharmacology, Merck & Co., Inc, Sept, 1993 to Oct, 1997

• Utilized molecular biology techniques to study the structure-function relationship of G protein coupled receptor (GPCR)

• Cloned receptor mutant and optimized the receptor protein expression and characterization

• Developed receptor binding assays for lead compound selection of Obesity targets (Beta 3 adrenergic receptor)

• Screened target lead using highthrouput technology

Columbia University at NYC, Dept of Medicine, July, 1989 to Dec. 1992

• Studied the structure-function relationship of lipoprotein (CETP)

• Characterized mutant to identify active ligand binding site

• Developed system for large scale protein expression and quantization

University of Illinois at Urbana-Champaign, Biotechnology Center, June, 1986 to Sept., 1988.

• Synthesis of oligonucleotides and peptides

• N-terminal sequencing of Peptide and protein

• HPLC purification of the synthetic oligonucleotides and peptides

• Amino acid composition Analysis.

Language

Fluent in Chinese writing and speaking

Education

M.S. Biochemistry University of Illinois at Urbana-Champaign, IL, May, 1989

B.S. Chemistry Southwestern University at Chongqing, China. Sept., 1978 to Aug., 1982

Professional Certification Certified Project Management Professional (PMP) by PMI, Dec., 2007

Activities

Manager of Huaxia Edison Dance Troupe

Write grant proposal to County and State Art council for funding

Team promotion and contract negotiation

General management on staffing and budgeting.

Publication

Wang, S; Deng, L.; Brown, L. B.; Agellon, L. B.; Tall, A. R. (1991) "Structure-Function Study of Human Cholesteryl Ester Transfer Protein by Linker Insertion Scanning Mutagenesis"

Biochemistry Vol.30 3484-3490.

Wang, S.;Deng,L.; Milne, R.W.; Tall, A.R. (1992); "Identification of A Sequence Within the C- terminal 26 Amino Acids of Cholesteryl Ester Transfer Protein Responsible for Binding a Neutralizing Antibody and Necessary for Neutral Lipid Transfer activity" J. Biol.Chem. Vol.267,p17487-17490.

Stevenson, S. C.; Wang, S; Deng, L.; Tall, A. R. "Human Plasma Cholesteryl Ester Transfer Protein

Consists of A Mixture of Two Forms Reflecting Variable Glycosylation at Asparagine 341"

Biochemistry Vol.30, p3484-3490.

Wang, S.; Wang, X.; Deng, L.; Rassart, E.; Milne, R.W.; Tall, A.R.;"Point Mutagenesis of C-terminal

Amino Acids of Cholesteryl Ester Transfer Protein: Opposite Faces of an Amphipathic Helix Important

for Cholesteryl Ester Transfer or For Binding Neutralizing Antibody" J. Biol.Chem. Vol.268,p1955- 1959.

Wang, S., Kussie, p., Deng, L. and Tall, A.R.(1995) "Defective Binding of Neutral Lipids by a Carboxyl

Terminal Deletion Mutant to Cholesteryl Ester Transfer Protein: Evidence for Involvement of the C-

terminus in a Neutral Lipid Binding Site." J. Biol. Chem. Vol. 270, p612-618.

Candelore, M.R.; Deng, L.; Tota, L.M.; Kelley, L.J.; Cascieri, M.A.; Strader, C.D.(1996)”

Phamacological Characterization of a Recently Described Human 3-Adrenergic Receptor Mutant”

Endocrinology Vol.137, No.6,p2638-2641.

Deng, L., Fournier, C., Tota, L. M., Cascieri, M. A., Underwood,D., Strader, C.D. and Canderlore, M. R

(1996)"S190 in the Human B1-Adrenergic Receptor is not Responsible for Stereoselective Ligand

Binding." Poster, IBC Symposium of G-Protein Coupled Receptors, Philadelphia, PA

Michael H. Fisher, Angela M. Amend, Thomas J. Bach, Jeanne M. Barker, Edward J. Brady, Mari R.

Candelore, Dayna Carroll, Margaret A. Cascieri, Shuet-Hing Lee Chiu, Liping Deng, Michael J. Forrest,

Bonnie Hegarty-Friscino, Xiao-Ming Guan, Gary J. Hom, Jennifer E. Hutchins, Linda J. Kelly, Robert J.

Mathvink, Joseph M. Metzger, Randall R. Miller, Hyun O. Ok, Emma R. Parmee, Richard Saperstein,

Catherine D. Strader, Ralph A. Stearns, G. Marie Thompson, Laurie Tota, Pasquale P.Vicario, Ann E.

Weber, John W. Woods, Matthew J. Wyvratt, Peter T. Zafian, & D. Euan MacIntyre (1998)

“STIMULATION OF METABOLIC RATE AND UCP1 IN RHESUS MONKEYS BY A HUMAN b3

AGONIST”, J Clin Invest. Vol 101(11) p2387-2393,

Parmee, E.R.; Ok, H.O.; Candelore, M.R.; Tota,L. Deng, L.; Strader, C.D.; Wyvratt,M. J.; Fisher, M.;

Weber, A.E.(1998) “Discovery of L755,507: A Subnanomolar Human 3 Adrenergic Receptor Agonist”

Bioorg Med Chem Lett. Vol.8(9) p1107-1112.

Naylor EM, Colandrea VJ, Candelore MR, Cascieri MA, Colwell LF Jr, Deng L, Feeney WP, Forrest MJ, Hom GJ, MacIntyre DE,Strader CD, Tota L, Wang PR, Wyvratt MJ, Fisher MH, Weber AE (1998)”3-Pyridylethanolamines: potent and selective human beta 3 adrenergic receptor agonists”

Bioorg Med Chem Lett Vol. 8(21):p3087-92

Weber AE, Ok HO, Alvaro RF, Candelore MR, Cascieri MA, Chiu SH, Deng L, Forrest MJ, Hom GJ,

Hutchins JE, Kao J, MacIntyre DE, Mathvink RJ, McLoughlin D, Miller RR, Newbold RC, Olah TV,

Parmee ER, Perkins L, Stearns RA, Strader CD, Szumiloski J, Tang YS, Tota L, Fisher MH(1998) “3-

Pyridyloxypropanolamine agonists of the beta 3 adrenergic receptor with improved pharmacokinetic

properties” Bioorg Med Chem Lett Vol.8(16)p2111-2116

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