Patent Agent/Technical Specialist

Feng Tian

***** ****** ***** **. #* Phone: 858-***-****

San Diego, CA 92130 E-mail: ***********@*****.***

Objective

Seeking a patent agent/technology specialist position to utilize both my knowledge of patent prosecution and my expertise in organic/pharmaceutical chemistry

Summary

* USPTO registered patent agent (USPTO registration number: 65278)

* Filed patent as an inventor by proposing and refining Markush structures

* Provided key recommendations for scientists qualified as inventors

* Prepared invention disclosure for novel discoveries

* Analyzed competitors’ patents/patent applications to find patentable chemical entities

* Proposed patent strategies for novel drug discovery projects

* Versatile project management skills and strong leadership skills

* Extensive technical knowledge of chemistry, biology, pharmacology, and public/proprietary database exploitation

* Excellent written and verbal communication skills

Professional Experience

Consultant

October 2009 - present, San Diego, CA

* Provided expert opinions on IP strategies available to startup companies focusing on innovative drug designs.

Research Scientist/Senior Research Scientist/Scientific Investigator

March 2001 – May 2009, Metabasis Therapeutics Inc., San Diego, CA

* Project leader: Initiated and led the medicinal chemistry effort focusing on the discovery of novel, liver-targeting glucokinase (GK) activators for the treatment of type 2 diabetes. As the GK project leader, managed a team of 4-12 scientists at different stages of the project from conception to POC studies. Wrote monthly and quarterly report to upper management. Established and implemented the strategies to gain substantial intellectual property protection through patent filing. Leading inventor of the final patent (WO/2009/023718).

* Scientist: Optimized potency and pharmacokinetic properties of prior hit structures based on biological assays and computer-assisted drug design. Designed and synthesized novel compounds and prodrugs thereof to improve oral bioavailability profiles and expand intellectual property protection. Initiated and optimized synthetic processes for clinical compounds. Conducted literature/patent search on structures or topics using both SciFinder and Crossfire Beilstein.

Research Associate

The Scripps Research Institute, San Diego, CA

* Designed and synthesized novel inhibitors for fucosyltransferase, a target for inflammation.

Research Assistant

Michigan State University, East Lansing, MI

* Synthesized potent inhibitors for myo-inositol 1-phosphate synthase and 3-dehydroquinate synthase.

* Developed novel methodology for butane 2,3-bisacetal protection of trans-1,2-diols.

* Developed novel methodology for the synthesis of cyclic phosphinic acid.

Education

Ph.D. in Organic Chemistry, Michigan State University, East Lansing, MI

B.S. and M.S. in Chemistry, Peking University, Beijing, China

Publication and Patent

1. A Tandem Decarboxylation and Inverse Electron-demand Diels–Alder Reaction of Amino-thiophenecarboxylic Acids with 1,3,5-Triazines

Dang, Q.; Carruli, E; Tian, F.; Dang, F.; Gibson, T.; Li, W.; Bai, H.; Chung, M.; Hecker, S.J. Tetrahedron Lett. 2009, 50, 2874–2876.

2. Novel Activators of Glucokinase (WO/2009/023718)

Tian, F.; Dang, Q.; Prasad, G. S.; Li, W.; Bookser, B. C.; Raffaele, N. B.; Erion, M. D.

3. myo-Inositol-1-phosphate Synthase Inhibition: In-Vivo Study in Rats

Einat, H.; Tian, F.; Belmaker, R.H.; Frost, J.W. Journal of Neural Transm. 2008, 115, 55-58.

4. Synthesis and Evaluation of Transition-state Analogue Inhibitors of ?-1,3-Fucosyltransferase

Michell, M.L.; Tian, F.; Lee, L.V.; Wong, C.-H. Angew. Chem. Int. Ed. 2002, 41, 3041-3044.

5. myo-Inositol 1-phosphate Synthase: Does a Single Active-site Amino Acid Catalyze Multiple Proton Transfers?

Tian, F.; Migaud, M.E.; Frost, J.W. J. Am. Chem. Soc. 1999, 121, 5795-5796.

6. Inhibitor Ionization as a Determinant of Binding to 3-Dehydroquinate Synthase

Tian, F.; Montchamp, J.-l.; Frost, J. W. J. Org. Chem. 1996, 61, 7373-7381.

7. Butane 2,3-Bisacetal Protection of Vicinal Diequatorial Diols

Montchamp, J.-l.; Tian, F.; Hart, M.E.; Frost, J.W. J. Org. Chem. 1996, 61, 3897-3899.

8. Double Arbuzov Reaction of in Situ Generated Bis(trimethylsiloxy)phosphine with Dielectrophiles: Methodology for the Synthesis of Cyclic Phosphinic Acids

Montchamp, J.-l.; Tian, F.; Frost, J.W. J. Org. Chem. 1995, 60, 6076-6081.

Presentation

1. Discovery Of a Second Generation FBPase Inhibitor, MB07803, with Reduced Metabolism and Improved Oral Bioavailability

Dang, Q.; van Poelje, P.D.; Lemus, R.H.; Tian, F.; Li, H.; Potter, S.; Fujitaki, J.; Linemeyer, D.; Erion, M.D. 235th ACS National Meeting, March 2008, MEDI-21.

2. myo-Inositol 1-phosphate Synthase: A Model of Enzyme Efficiency and Enzyme Opportunism?

Tian, F.; Arthur, J.C.; Peng, J.; Migaud, M.E.; Frost, J.W. 217th ACS National Meeting, March 1999, ORGN-457.

3. Synthesis and Evaluation of Amine- and Mercaptan-containing Inhibitors of 3-Dehydroquinate Synthase

Tian, F.; Frost, J.W. 217th ACS National Meeting, March 1999, ORGN-457.

References

Available upon request

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