research scientist; Lab manager; organic synthesis; oligonucleotides;

Chaofeng Dai, Ph. D.

**** ******* **. *. *** I, Atlanta, GA 30341-5655; 1-404-***-****; ********.***@*****.***

Objective

To obtain a R&D position in pharmaceutical or biotechnology industry that takes advantage of my extensive experience in synthetic organic chemistry and medicinal chemistry.

Qualification summary

• Solid background in modern synthetic and mechanistic organic chemistry

• Extensive experience in multi-steps synthesis of complex natural products

• Expertise in bioconjugate chemistry especially for DNA and protein labeling

• Good understanding of SAR and expertise in optimizing candidate efficacy

• Outstanding skills in compound purification and characterization

• Long-lasting leadership experience in large academic and medium industrial teams

• Strong ability to multi-task project management skills in academia and CRO industry

• Excellent verbal and written communication skills with multi-disciplinary team members

Education

• Ph. D. (09/2002-01/2007), Synthetic Organic Chemistry

Department of Chemistry, Xiamen University, Xiamen, Fujian, China

• M. S. (09/1999-07/2002), Synthetic Organic Chemistry

Department of Chemistry, Lanzhou University, Lanzhou, Gansu, China

• B. Sc. (09/1995-07/1999), Organic Chemistry

Department of Chemistry, Lanzhou University, Lanzhou, Gansu, China

Skills

• More than 10 years’ experience in organic synthesis and medicinal chemistry: asymmetric total synthesis of natural products; design, synthesis and SAR studies of anticancer and antibacterial agents; peptide chemistry: solution phase synthesis of cyclic peptide; phosphoramidite chemistry and solid phase DNA synthesis, purification and post synthesis modification; modified thymidine triphosphate analogues for enzymatic DNA synthesis; boronic acid chemistry: design, synthesis and binding tests of boron-containing small molecules as fluorescent sensors; bioconjugate chemistry especially copper free click chemistry for DNA and protein labeling; micro-scale and low temperature reactions; handling of air sensitive reagents.

• Leadership: served as a lab manager helping PI to run a research lab of around 20 members, advised graduate students in designing synthetic routes and troubleshooting, led several natural product synthesis projects.

• Structural determination: hands on experience with spectroscopic techniques (UV-VIS, Fluorescence, IR, NMR), GC-MS and LC-MS for structural determination of organic compounds.

• Separation techniques: hands on experience with both analytical and preparative HPLC.

• Professional software knowledge: Microsoft Office (Word, Excel, PowerPoint), Chemical drawing software (ISIS Draw, ChemDraw); Literature search software (SciFinder, Beilstein, Reaxys)

Working and Research Experience

• Group leader: Bioduro Co. Ltd., Beijing, China 03/2007-12/2007

Led a group of 5 members in conducting multi-step synthesis for clients-mostly world-leading pharmaceutical companies including Merck, GSK, Roche, and Novartis, within clients’ tight timeline on a scale ranging from milligrams to several hundred grams.

• Postdoctoral Research Associate Georgia State University, Atlanta, GA, 12/2007-present.

• Successfully designed and synthesized MS-tag and fluorescent dye labeled boronolectin as new imaging agents targeting cancer and microbial pathogens.

• Accomplished synthesis of fluorescent sensors and development of an LC-MS method for the recognition and quantitative analysis of molecules of biological importance.

• Developed strained alkyne-modified phosphoramidite for solid phase DNA synthesis and post synthesis modification

• Conducted synthesis of boronic acid-modified thymidine triphosphate for enzymatic DNA incorporation and aptamer SELEX.

• Graduate Research Assistant, Xiamen University, Xiamen, China, 09/2002-01/2007.

• Total synthesis of marine natural product hapalosin and three hapalosin C-9 analogues

• Total synthesis of deoxymelleumin A and deoxymelleumin B

• Graduate Research Assistant, Lanzhou University, Lanzhou, China, 09/1999-07/2002.

• Studies on synthesis and bioactivity evaluation of fused five or six-membered heterocyclic compounds (triazole, oxadiazole, thiadiazole, diazine, thiazine et. al)

Selected Publications (10 of 20)

1. Chen, W.; Wang, D.; Dai, C.; Hamelberg, D.; Wang, B. Clicking 1,2,4,5-Tetrazine and Cyclooctynes with Tunable Reaction Rates. Chem. Commun., 2012, 48, 1736-1738.

2. Dai, C.; Cazares, ..; Wang, L.; Chu, Y.; Wang, S..; Troyer, D.; Semmes,O.; Drake, R.; Wang, B. Using Boronolectin in MALDI-MS Imaging for the Histological Analysis of Cancer Tissue Expressing the Sialyl Lewis X Antigen. Chem. Commun. 2011, 47, 103**-*****.

3. Peng, H; Cheng, Y.; Dai, C.; King, A.; Predmore, B.; Lefer, D.; Wang, B. A Fluorescent Probe for Fast and Quantitative Detection of Hydrogen Sulfide in Blood Angew. Chem. Int. Ed. 2011, 50, 9672-9675.

4. Wang, L.; Dai, C.; Wang, S.; Wang, B. Facile and Complete Derivatization of Azide for Sensitive Detection Using LC-MS. Chem. Commun. 2011, 47, 103**-*****.

5. Cheng, Y.; Dai, C.; Peng, H.; Zheng, S.; Jin, S.; Wang, B. Design, Synthesis, and DNA Incorporation of Boronic Acid-modified TTPs. Chem. Asian J. 2011, 6, 2747-2752.

6. Dai, C.; Wang, L.; Sheng, J.; Peng, H.; Draganov, A.; Huang, Z.; Wang, B. The First Chemical Synthesis of Boronic Acid-modified DNA through Copper-free Click Reaction Chem. Commun., 2011, 47, 3598–3600.

7. Dai, C.; Draganov, A.; Wang, B. A novel metal-free synthesis of 6H-isoindolo[2,1-α]indol-6-one Heterocycl. Commun. 2010, 16, 245-247.

8. Dai, C.; Cheng, Y.; Cui, J.; Wang, B. Click reactions and boronic acids: applications, issues, and potential solutions. Molecules 2010, 15, 5768-5781.

9. Yang, X.; Dai, C.; Molina, A.; Wang, B. Boronic acid-modified DNA that changes fluorescent properties upon carbohydrate binding. Chem. Commun. 2010, 46, 1073-1075.

10. Dai, C.; Cheng, F.; Xu, H.; Ruan, Y.; Huang, P. Diversity-Oriented Asymmetric Synthesis of Hapalosin: Construction of Three Small C-9/ C-4/ C-3-Modified Hapalosin Analogues Libraries. J. Comb. Chem. 2007, 9, 386-394.

Patent

Dai, C.; Cazares, L.; Wang, L.; Chu, Y.; Wang, S.; Troyer, D.; Semmes,O.; Drake, R.; Wang, B. Boronolectin Conjugates and Methods of use for the Histological Analysis of Cancer Tissue using Maldi-Ms Imaging, US Provisional Patent Application No. 61/509,675, July 2011.

Selected Presentations (3 of 10)

1. Dai, C.; Cazares, L.; Wang, L.; Chu, Y.; Wang, S.; Troyer, D.; Semmes,O.; Drake, R.; Wang, B. The First MALDI-MS Imaging Agent for the Histological Analysis of Cancer Tissue Expressing the Sialyl Lewis X Antigen. Pittcon Conference, Orlando, FL March, 2012.

2. Wang, L.; Dai, C.; Wang, S.; Wang, B. A Novel LC-MS Method For Sensitive Detection of Inorganic Azide by Employing a Strain Promoted Click Chemistry. Pittcon Conference, Orlando, FL March, 2012.

3. Dai, C.; Wang, L.; Sheng, J.; Peng, H.; Draganov, A.; Huang, Z.; Wang, B. Method for the Chemical Scale Synthesis of Boronic Acid-modified DNA-aptamers through Copper free Click Reaction. 239th ACS National Meeting, San Francisco, CA, United States, March, 2010.

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