High School Research
Resume:
Jyoti R. Tibrewala, Ph.D.
Apt #123S
Arlington, VA 22202
*****@****.***.***
Highlight of Skills
* Proficient in use of analytical and preparative HPLC to identify and separate complex mixtures.
* Skilled at numerous characterization techniques, including NMR, UV-Vis, fluorescence spectrophotometry, and mass spectrometry.
* Experienced in conventional and microwave-assisted organic synthesis techniques.
* Fluent user of many computer programs, including ChemDraw, Origin, MestreNova, EndNote, KinetAsyst and the Microsoft Office suite.
* Excellent oral and written communication skills.
Education
* Ph.D., Chemistry, Princeton University, Princeton, NJ, 2010
* M.A., Chemistry, Princeton University, Princeton, NJ, 2006
* S.B., Chemistry, Massachusetts Institute of Technology, Cambridge, MA, 2004
Research Experience
2010-Present
Research Staff Member
Institute for Defense Analyses
Alexandria, VA
* Reviewed military test proposals requiring knowledge of diverse areas including chemistry, biology, physics, and engineering.
* Provided scientific advisory support to the Office of the Secretary of Defense – Director, Operational Test & Evaluation (OSD/DOT&E).
* Cultivated working relationships with Service test agencies, Service research laboratories, and contractors to facilitate test planning, data sharing, and reporting.
* Prepared and presented technical memoranda and briefings to OSD/DOT&E.
* Maintained a SECRET security clearance.
2004-2010
Research Assistant
Princeton University
Princeton, NJ
Adviser: Prof. John T. Groves
* Synthesized and evaluated new metalloporphyrin catalysts for therapeutic use in peroxynitrite decomposition.
* Extensive experience in reaction optimization, size-exclusion chromatography, analytical and preparative HPLC, UV-Vis and stopped-flow spectrophotometry.
* Regularly performed large-scale syntheses of metalloporphyrin catalysts for use in rodent models of diabetes and in small animal toxicology studies.
* Developed a method for microwave-assisted porphyrin synthesis.
* Served as the group EHS representative for 5 years.
* Taught Organic Chemistry I & II undergraduate laboratories.
* Mentored 2 summer undergraduate students and 1 senior thesis student.
2002-2004
Undergraduate Researcher
MIT
Cambridge, MA
Adviser: Prof. Stephen J. Lippard
* Synthesized and evaluated fluorescent sensors for transition metals and nitric oxide.
* Learned organic synthesis, fluorometry, dry box techniques, and LC-MS.
2004, 1999
Summer Intern
Brookhaven National Laboratory (BNL)
Upton, NY
* Studied pressure-induced changes in bone mineral content using a diamond anvil cell, ruby fluorescence spectroscopy, and FTIR microspectroscopy.
* Characterized a series of mineral compounds postulated to be the earliest phase of bone mineralization.
2002
Summer Fellow
BNL
Upton, NY
* Studied phytoremediation of lead-contaminated soils by corn plants using x-ray absorption microspectroscopy and FTIR microspectroscopy.
* Mentored 1 summer high school student.
2002
Student Intern
Northeastern University
Boston, MA
* Studied catalytic behavior of bioimprinted myoglobin toward styrene oxidation in organic solvents by GC-MS.
2001
Student Intern
Ortec International, Inc.
New York, NY
* Prepared a matrix of collagen sponges of various levels of denaturation and cross-linking.
* Characterized novel compositions by wet tensile testing and trypsin digestion.
* Used lyophilization to prepare films of collagen for nativity testing by FTIR spectroscopy.
* Gained experience with use of multi-well plate readers and SpectraMax software.
Awards
* First Place, Catalysis Society of Metropolitan NY Spring Symposium, Poster Contest, 2009
* 2007/2008 Merck-Patchett Summer Fellowship
* Honorable Mention, Princeton Research Symposium, Poster Contest, 2007
* US Department of Energy (DOE) Summer Undergraduate Laboratory Internship (SULI), 2004
* MIT Undergraduate Research Opportunities Program John Reed Fund, 2003
* National Society of Collegiate Scholars, 2002-present
* US DOE Energy Research Undergraduate Laboratory Fellowship (ERULF), 2002
* MIT Student-Alumni Externship
o Northeastern University, Prof. Patricia A. Mabrouk, Chemistry Department, 2002
o Ortec International, Inc., Dr. Mel Silberklang, VP Research and Development, 2001
Publications
* Tibrewala, J.; Groves, J.T. “Enhanced Rate of Peroxynitrite Decomposition by a Next-Generation Metalloporphyrin Catalyst,” manuscript in preparation.
* Obrosova, I.G.; Drel, V.R.; Oltman, C.L.; Mashtalir, N.; Tibrewala, J.; Groves, J.T.; Yorek, M.A. “Role of Nitrosative Stress in Early Neuropathy and Vascular Dysfunction in Streptozotocin-Diabetic Rats,” American Journal of Physiology: Endocrinology and Metabolism, 2007, 293, E1645-E1655.
* Drel, V.R.; Pacher, P.; Vareniuk, I.; Pavlov, I.; Ilnytska, O.; Lyzogubov, V.V.; Tibrewala, J.; Groves, J.T.; Obrosova, I.G. “A Peroxynitrite Decomposition Catalyst Counteracts Sensory Neuropathy in Streptozotocin-Diabetic Mice.” European Journal of Pharmacology, 2007, 569, 48-58.
* Vareniuk, I.; Pavlov, I.A.; Drel, V.R.; Lyzogubov, V.V.; Ilnytska, O.; Bell, S.R.; Tibrewala, J.; Groves, J.T.; Obrosova, I.G. “Nitrosative Stress and Peripheral Diabetic Neuropathy in Leptin-Deficient (ob/ob) Mice.” Experimental Neurology, 2007, 205, 425-436.
* Clark, M.A.; Duffy, K.; Tibrewala, J.; Lippard, S.J. “Synthesis and Metal-Binding Properties of Chelating Fluorescein Derivatives.” Organic Letters, 2003, 5, 2051-2054.
* Miller, L.M.; Tibrewala, J.; Carlson, C.S. “Examination of Bone Chemical Composition in Osteoporosis Using Fluorescence-Assisted Infrared Microspectroscopy.” Cellular and Molecular Biology, 2000, 46, 1035-1044.
Oral Presentations
* Tibrewala, J.R. “Therapeutic Applications of Biomimetic Catalysis: Synthetic Porphyrins to Decompose Peroxynitrite,” invited award lecture, Catalysis Society of Metropolitan New York, November 2009.
* Tibrewala, J.R. “Infrared Microspectroscopy of Bone,” BNL CSSP Seminar Series, Upton, NY, 1999.
Poster Presentations
* Tibrewala, J.R.; Groves, J.T. “Therapeutic Applications of Biomimetic Catalysis: Synthetic Porphyrins to Decompose Peroxynitrite,” Gordon Research Conference: Metals in Medicine, Andover, NH, 2010.
* Tibrewala, J.R.; Groves, J.T. “Therapeutic Applications of Biomimetic Catalysis: Synthetic Porphyrins to Decompose Peroxynitrite,” Catalysis Society of Metropolitan New York Spring Symposium, Princeton, NJ, 2009.
* Tibrewala, J.R.; Groves, J.T. “Design, Synthesis, and Evaluation of New Metalloporphyrin Drug Candidates,” Princeton Research Symposium, Princeton, NJ, 2007.
* Tibrewala, J.R.; Datta, A.; Groves, J.T. “Improving Methodology for the Synthesis and Characterization of Water Soluble Metalloporphyrins,” Gordon-Kenan Graduate Research Seminar: Bioinorganic Chemistry, Ventura, CA, 2007.
* Tibrewala, J.R.; Liu, Z.X.; Miller, L.M. “The Effects of Pressure on Bone Mineral and Applications to Understanding Osteoporosis,” US DOE SULI Poster Session, Upton, NY, 2004.
* Tibrewala, J.R.; Waide, S.L.; Miller, L.M. “Correlating the Organic Composition of Corn with the Uptake of Lead from Soil,” US DOE ERULF Poster Session, Upton, NY, 2002.
Affiliations & Professional Activities
* Princeton Research Symposium (PRS), graduate student-run campus-wide research symposium
o Publicity Coordinator (2008)
* Princeton Chemistry Graduate Student Organization (GSO)
o Hosted 2006-2007 GSO Seminar Speaker, Prof. Stephen J. Lippard, MIT
* American Chemical Society, member, 2005-present
o Washington Section, member, 2010-present
o Princeton Section, member, 2005-2010
* Chemical Biology Group at Princeton (journal club), member, 2005-2010
* Princeton Graduate and Research Organization for Women in Chemistry (GROW), member, 2004-present
* Princeton University Alumni Association, 2006-present
o Princeton Alumni Schools Committee, 2010-present
* MIT Alumni Association, member, 2004-present
o MIT Educational Council, member, 2010-present
* Association of MIT Alumnae, member, 2004-present
* The Tech, MIT student newspaper, 2000-2007
o Advisory Board (2006-2007)
o Chairman (2003-2004)
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