Supervisor Supply Chain

Location:

Knoxville, TN, 37902

Salary:

$110,000

Posted:

September 13, 2011

Contact this candidate

Resume:

James E. Phillips

Pfizer, Inc. *** Smith St.

Eastern Point Road Groton, CT 06340

Groton, CT 06320

860-***-**** Home: 860-***-****

Mobile: 860-***-****

*****.*********@******.***

*****.*.*********@*****.***

OBJECTIVE

To obtain a challenging and exciting process research/pilot plant position in the southeastern United States mirroring the positive work experience I enjoy as a process research chemist at Pfizer, Inc.

RESEARCH EXPERENCE

September 2002 - Present

Promoted to Scientist Aug. 2005

Development - Active Pharmaceutical Ingredient (D-API) Group

Pfizer, Inc., Groton Central Research and Development

(2002-2007) Supervisor: Dr. David B. Ripin (Currently Science Director, Clinton Foundation)

(2007-2009) Supervisor: Dr. Stephane Caron (Sr. Director)

(2009-2010) Supervisor: Dr. Juan Colberg (Director)

(2010-2011) Supervisor: Dr. Nicholas Thomson (Director)

The D-API group is responsible for providing material, 10-100 kilograms, for all post-Proof of Concept (POC) studies. Responsibilities include the design and scale up of multi-step syntheses that are used to prepare the Phase II-III regulatory API under cGMP conditions. The finalized processes are transferred to the Pfizer pilot plant facility for manufacturing, requiring extensive collaboration with engineering, safety and supply chain colleagues. Further, D-API research is charged with the responsibility of meeting ambitious cost of goods targets, reaction design within narrow engineering and safety protocols, impurity identification and purging, and finally documentary support of regulatory filings in the EU, US, Japan and other emerging markets.

- Succeeded in redesign and implementation of numerous API pilot plant manufacturing processes (Bosutinib, Latanoprost, Sulopenem) with an emphasis on cost reduction, yield maximization and enhanced purity profiles.

- Well known among my peers and management to possess superior knowledge of reaction mechanisms with an expertise in process research.

- Broad experience with metal catalyzed transformations; Suzuki, Sonogashira, Glaser, Wacker, Ullman, Heck, Pauson-Khand, Negishi, Stille.

- Presented research to the D-API group quarterly.

- Selected to participate in a cross discipline secondment with Pfizer’s Structure Elucidation NMR Group.

- Participated in the design and rollout of a site wide electronic notebook.

- Participated in the design and implementation of Pfizer’s Lab of the Future prototype. This initiative leverages cutting edge technology to automate reaction steps and data collection, to mimic manufacturing conditions, and reduce the research laboratory footprint.

- Interface between reaction engineering scientists, analytical support and pilot plant management to insure the manufacturing process proceeded without interruption. The D-API research chemist is ultimately responsible for the success of the run.

- Largest published production run: 35 kg peracetic acid oxidation of a thioacetate in a 300 gal. tank.

- Attended yearly Scientific Update conferences.

April 1997-September 2002

Promoted to Senior Associate Scientist Aug. 1999.

Research - Active Pharmaceutical Ingredient (R-API) Group

Pfizer, Inc.

(1997-2002) Supervisor: Dr. Shane Eisenbeis (Associate Research Fellow)

Research - Active Pharmaceutical Ingredient was responsible for providing World Wide Medicinal Chemistry with bulk intermediates, standard samples, impurities, metabolites and material for use in exploratory toxicology studies. accountable for all API deliveries up to POC. R-API focus is speed of delivery in a high attrition environment based on a fit for purpose approach.

Responsibilities also included performing the spectroscopic analysis and identification of the synthesized compounds using a variety of methods (NMR, LCMS, GCMS, IR).

James E. Phillips

- Performed a variety of reactions such as alkylations, reductions, oxidations, metal mediated couplings, nucleophilic and electrophilic rearrangements, and cryogenic synthesis up to 22-liter scale.

- Championed the wider use of retro-synthetic analysis at the associate level. These initiatives served to provide a greater range of approaches for many synthetic problems.

- Collaborated in the design and management of a high pressure reaction facility capable of performing the full spectrum of hetero and homogeneous hydrogenations and carbonylations.

- Excelled with an initiative aimed at supplying discovery colleagues with advanced intermediates. My individual productivity through the life of the program consistently surpassed my peers.

- Helped transform R-API from a service group to a full fledged research organization.

- Attended yearly American Chemical Society meetings culminating with follow up reports to my peers.

RESEARCH EXPERENCE (Continued)

August 1994 – April 1997

Graduate Student; Organic Chemistry

University of New Hampshire

Research Advisor: Dr. Charles K. Zercher

Dr. Zercher’s laboratory synthesized novel compounds designed to probe the mechanistic pathways of various metallocenes at different oxidation states.

- Completed several multi-step syntheses of target molecules for mechanistic studies.

- Taught undergraduate advance chemistry laboratories.

- Presented research in formal department meetings and poster sessions.

- Compiled and defended graduate research thesis entitled: “Zirconocene Mediated Rearrangement of Diallyl Ketals.”

PUBLICATIONS

Execution of Performic Acid Oxidation on Multikilogram Scale. Organic Process Research & Development (2007), 11(4), 762-765.

Synthesis and Purification of 6-Ethoxy-4-oxo-1,4dihydro-[1,5]naphthyridine-3-carboxylic Acid Benzylamine. Organic Process Research & Development (2003), 7(6), 873-878.

A Practical Large Scale Synthesis of 9-(hydroxymethyl)-fluorene-4-carboxylic acid. Synthetic Communications (2001), 31(22), 3533-3536.

Synthesis of Azepino[3,4b]indoles via the Plancher Rearrangement. Tetrahedron Letters, 2010, 51(33), 4303-4305.

Route Development and Bulk Synthesis of CP-865,569. Organic Process Research & Development (2007), 11(4), 754-761.

EDUCATION

May 1992 B.S. Chemistry, University of New Hampshire, Durham, New Hampshire.

April 1997 M.S. Chemistry, University of New Hampshire, Durham, New Hampshire.

AFFILIATIONS

- American Chemical Society

REFERENCES

- Dr. Brian Marquez (NMR Secondment Supervisor: May-Dec. 2009)

Work: 860-***-****

- Dr. Juan Colberg (Supervisor: 2009-2010)