Anand Ramakrishnan_PhD_MBA_Resume

ANAND RAMAKRISHNAN, Ph.D., M.B.A.

*** ******* ****. *****, *************, NY 13027

Tel: 817-***-**** (Home)

315-***-**** (Cell)

E-mail: ********@*****.***

PROFILE

A highly motivated bioanalytical scientist with a strong technical and business background and over five years of industry experience seeks challenging scientific and/or managerial position in the biopharmaceutical or related industry.

EXPERTISE

• Development, validation, and implementation of biosensor based assays for biologics

• Analytical support for biologics process development and investigations

• Development of analytical training programs and technology transfer activities

• Analytical project management

INDUSTRY EXPERIENCE

Scientist-II (07/2007-onwards): Process Analytical Sciences (PAS), Bristol Myers Squibb Company,

Syracuse, NY. Responsibilities include, biosensor method development and qualification, process analytical support, write technical reports, manage analytical projects, staff training, technology

transfer and support regulatory filing.

Project Management Activities

• Led analytical sub-team to support process improvements and regulatory filing. The inter-disciplinary project comprised representatives from process development, manufacturing sciences, QA, technical services, and QC.

Technical Activities

• Developed and implemented extended characterization analytical methods for biomolecules and critical reagents using the T100 biosensor.

Scientist-II (04/2007-07/2007): Analytical Biochemistry, Bristol Myers Squibb Company, Syracuse, NY.

Quality & Compliance Activities

• Subject matter expert (SME) on biosensor assays as part of an inter-disciplinary team that consisted of representatives from QC and third party manufacturing (TPM). The team was responsible for investigating problems in critical biological assays before the EU launch of Orencia®.

Team Development Activities

• Developed an extended staff training program, on biosensor method development and validations. Drafted pre-training protocols and post-training summaries. Successfully trained five junior analysts to date.

Customer Service & Operational Activities

• Supported critical reagent qualification activities including planning, inventory control, preparation/purification, document review, and testing. Designed and implemented testing protocols for over ten different in-house critical reagents.

Scientist-I (03/2003-03/2007): Analytical Biochemistry, Bristol Myers Squibb Company, Syracuse, NY.

Method Development & Validation Activities

• Developed, validated, and implemented biosensor (BIAcore 3000) based kinetic, thermodynamic, and potency assays to aid physical characterization of interactions between biomolecules and immobilized receptors. The methods were implemented for in-process sample testing and regulatory submissions.

• Developed a capillary electrophoresis (CE) method using the Beckman PACE/MDQ system for determination of molar ratios of neutral and amino monosaccharides in fermentation and purification samples. The method is currently in use for in-process sample testing.

Regulatory Filing Support & Other Activities

• Led an extended characterization (biosensor assays) team to support Orencia FDA post marketing commitments. The team comprised senior management representatives from BMS-Syracuse, NY and scientists from BMS-Hopewell, NJ. Successful project completion ensured an on-time US launch of Orenica in 2Q 2006.

• Lead scientist for additional testing of abatacept drug substance (manufactured at Lonza Biologics, NH and at Syracuse, NY) for binding to B7 receptors, in response to questions from the Swiss Agency for Therapeutic Products (Swissmedic). Successful project completion provided data to support regulatory filing in the EU and in Switzerland.

• Subject Matter Expert (SME) on biosensor assays for FDA (08/05), Health Canada (03/06) and EMEA (07/06) on-site audits.

Scientist (08/2002-03/2003): Pharmacokinetics, Metabolism and Bioanalytical Group, NeoPharm, Inc., Waukegan, IL.

Technical Activities

• Developed a chromatographic method for the analysis of Gemcitabine in mouse plasma

to support a liposome based formulation.

EDUCATION

Masters of Business Administration (2007)

Whitman School of Management-Syracuse University

Major: Marketing and New Product Development

Ph.D. in Chemical Engineering (2002)

University of Mississippi

MS in Chemical Engineering (2000)

University of Mississippi

M.Sc. (Tech.) in Bioprocess Technology (1997)

Department of Chemical Technology, University of Bombay, Bombay, India

Specialization: Downstream Processing

BS in Pharmaceutical Sciences & Technology (1995)

Department of Chemical Technology, University of Bombay, Bombay, India

ACHIEVEMENTS & AWARDS

• Member Beta Gamma Sigma Honor Society (May 2008)

• Bristol-Myers Squibb Technical Operations Achievement Award (October 2006):

For contribution to the Syracuse Abatacept Product Approval

• Bristol-Myers Squibb Triumph DOC Award (July 2006): For contribution to the Orencia (Abatacept) Lonza sBLA Approval

• Bristol-Myers Squibb IMPACT Spot Plus Award (May 2006): For contribution to the

Lonza Extended Characterization for Orencia

PUBLICATIONS

Over 20 peer-reviewed publications and over 25 presentations on the applications of the fractal modeling technique for describing Antigen-Antibody, Cell-Receptor, DNA Hybridization kinetics, etc. Selected publications listed below:

1. Butala, H.D., Doke, A.M., Ramakrishnan, A., Sadana, A. & Vo-Dinh, T. (2006)

Biosensor Surface Phenomenon, in Encyclopedia of Surface & Colloid Science, Second Edition, 2, pp. 990-1003, Taylor & Francis, NY.

2. Ramakrishnan, A. & Sadana, A. A Kinetic Study of Analyte-Receptor Binding and

Dissociation for Surface Plasmon Resonance Biosensor Applications, in Proceedings IEEE Sensors 2002, Vol. 1, paper 38.1, June 11-14, 2002, Orlando, Florida.

3. Ahmad, A., Ramakrishnan, A., McLean, M.A., Li, D.R., Rock, M.T., Karim, A. & Breau,

A.P. (2002) Use of Optical Biosensor Technology to Study the Immunological Cross-Reactivity of Different Sulfonamide Drugs. Analytical Biochemistry, 300(2), 177-184.

4. Ramakrishnan, A. & Sadana, A. (2002) Biosensors an Emerging Tool in Bioanalytical

Research: A Kinetic Analysis of the Analyte-Receptor Interactions in Biosensors, in Methods for Affinity Based Separations for Enzymes and Proteins, (ed. M.N. Gupta) Chapter 11, pp. 195-216. Birkhauser Verlag, Berlin.

5. Ramakrishnan, A. & Sadana, A. (2000) Economics of Bioseparation Processes in

Handbook of Bioseparations, (ed. S. Ahuja) Chapter 18, pp. 667-685. Academic Press, New York.

6. Ramakrishnan, A. & Sadana, A. (1998) Antigen-Antibody Binding Kinetics for

Biosensor Applications: A Single and A Dual-Fractal Analysis of the Influence of the Fractal Dimension on the Binding Rate Coefficient. Journal of Colloid & Interface Science, 208(2), 455-467.

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