Medicinal Chemist

Aniz K Roy M.Pharm (Pharmaceutical Chemistry)

Address: Piramal Life Sciences Ltd., NCE-Medicinal Chemistry Group, 1 Nirlon

Complex, Off Western Express Highway, Goregoan ((E), Mumbai 400063.

Email: ****.*.***@*****.*** , Mobile :+919*********

Career Objective

To pursue excellence in the field of Synthetic Medicinal Chemistry and to be an active

member of a team involved in the Discovery of Novel Molecules of therapeutic

importance and lead optimization

Strengths

Research expertise in the field of Synthetic organic chemistry, Medicinal chemistry,

Heterocyclic chemistry, Drug Discovery, New Chemical Entities (NCEs).

Design and multi step synthesis of NCEs and their biological evaluation for anti cancer

activities. Development of new synthetic methodologies, Total synthesis of bioactive

natural products. Expertise in scientific literature search from various search engines and

databases viz. Science Directs, Reaxys, PubMed, Thomson Pharma, Integrity prous,

chemsketch.

Interpretation of Patent Laws prevalent in US / Europe. Patent evaluation - Reading and

verifying patents. Identifying areas and inventions eligible for obtaining protection of

intellectual property and exploring opportunities for invalidation of lucrative patents.

Educational Background

M Pharmacy (Pharmaceutical chemistry) from C.L.Baid Metha college of

pharmacy,Chennai,Tamilnadu DR.MGR.medical University 2008 - 2010 – 72.50%

B Pharmacy in JSS College of pharmacy, ooty, Tamilnadu DR.M.G.R medical

university 2003 - 2008 – 57%

Higher Secondary School Certificate (HSC) Tamilnadu state board (76.75%)

Secondary School Certificate (SSC) Tamilnadu state board (83%)

Industrial Experience:

Spic Pharmaceutical Limited, Maraimalai Nagar, Chennai from 15/07/2010 to

4/08/2010

Current Position

Trainee Research Scientist: Drug Discovery, New Chemical Entities-Medicinal

Chemistry department. Piramal Life Sciences Ltd. Mumbai. October. 2010 to till date.

Research Projects:

Design and synthesis of novel Dual Kinase (IGF1R and EGFR) inhibitors for cancer

Research activities

Design, synthesis, characterization and biological evaluation of NCEs for cancer .

Designing of new molecules to improve potency, selectivity and Pharmacokinetic

properties.

Establishing Structure Activity Relationship (SAR) studies, translate potency into

efficacy and reduce toxicity.

Designing route for synthesis of compounds and solve synthetic problems; also design

routes, which are amenable for parallel synthesis.

HIT identification, Lead identification, and Lead optimization from target based and

compound based approaches.

Seminar and training :

International Conference and Indo-Canadian Satellite Symposium on Feb 2007, JSS

college of pharmacy, Ooty, Tamilnadu, India.

International Conference on herbal drug research Dec 2009, JSS college of pharmacy,

Ooty , Tamilnadu, India

Technical Skills

Synthetic

Handled organometallic reactions like Suzuki reactions. Mitsunobu reaction, Protection

and deprotection reactions for different functional group, Different oxidation and

reduction reactions and Resolution of stereoisomer.

Purification

Expert in various isolation and purification techniques viz. silica gel Column

Chromatography, HPLC, Combiflash ISCO (Flash purification System).

Structure Elucidation

Expertise in structure elucidation of organic compounds using various spectral data.

Spectroscopic techniques such as 1H NMR, IR, MS, and UV spectroscopy

Computer Proficiency

Expertise in using different routinely used computer software’s such as MS-Office,

Chem-Draw, ISIS draw

Instruments handled

Handling of LC-MS, Single Quadrupole agilent .HPLC Shimadzu.

.

Personal Details

Date of Birth : 27 June 1984

Sex : Male

Languages known : English, Tamil

Nationality : Indian

Permanent address : 21/25, Kizhakanam vilai, Palliyadi post, Kanyakumari

District, Tamil Nadu, 629169

Phone: +91-04651- 269275

Reference

Dr. Prashant Kharkar

Research Scientist, Post doctorate fellow,

Nycomed Pharma Ltd. Andheri.

Email: ****************@*****.***

.

Research Summary

Project Title: Synthesis of Amino-Pyrimidine Derivatives substituted with Uracil and its

characterization by using IR spectra, NMR spectra, MASS spectra and its evaluation on

in-vitro Anti-microbial activity and in-vitro cytotoxicity studies using vero and HeLa cell

line.

Abstract: synthesis of aminopyrimidine derivatives from chalcones by using aromatic

aldehydes and its substitution with uracil derivatives gives good response against

microbials and invitro cytotoxicity

Role on the project:

Literature search on amino-pyrimidine derivatives. Synthesized 15 molecules. Analyses

of NMR spectra, Mass spectra, IR spectra. Physiochemical properties such as melting

point, thin layer chromatography

Declaration:

I hereby declare that the above mentioned details are true to the best of my knowledge

and belief.

Aniz K Roy

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