TUMUL SRIVASTAVA, Ph.D.

*-******* *******, ***** **** Email: jwa65t@r.postjobfree.com

Hulang Road, KS Link Road, Mobile: +919*********, +919*********

Kadma, Jamshedpur, 831005

PROFILE

• 5 years of doctoral experience in solid and solution phase organic synthesis

• 5 years of postdoctoral experience in peptide based vaccine research

• Experience in medicinal chemistry involving lead identification and optimization

• 15 publications in peer reviewed international journals

• Leadership skills-supervisory experience with post-doctoral fellows and student interns

• Managerial skills-experience of laboratory supplies ordering, equipments purchasing and their maintenance through co-ordination with different departments.

• Successfully worked in culturally diverse work environment

• Excellent written and oral communication skills

• Trustworthy, meticulous, hard working and dynamic

WORK EXPERIENCE

Research Fellow July 2006-April 2010 Beckman Research Institute of City of Hope National Medical Centre, Duarte, CA, USA

Research Associate II May 2005-July 2006 Beckman Research Institute of City of Hope National Medical Centre, Duarte, CA, USA

Senior Research Fellow May 2003-March 2005 Central Drug Research Institute, Lucknow, India

Research Fellow March 2000- April 2003 Central Drug Research Institute, Lucknow, India

PROFESSIONAL SKILLS

• Expertise in solution and solid phase small heterocyclic molecules synthesis

• Expertise in solution and solid phase peptides and oligonucleotides synthesis

• Expertise in synthesis of Microspheres, an advanced drug carrier molecules used for better drug delivery

• Technical and operational proficiency with analytical techniques such as MALDI-MS, analytical and preparative HPLC, UV-Visible spectrophotometer and Polarimeter

• Operational expertise with Peptide synthesizer and Gene assembler.

• Knowledge of spectroscopic techniques such as IR and NMR

• Proficient in use of chemistry application software and databases

RESEARCH EXPERIENCE

May 2005 – April 2010; Beckman Research Institute of City of Hope National Medical Centre, Duarte, CA, USA.

• Synthesized and characterized IE2, UL28, US3, US32 and UL99 peptide libraries to find an affective CMV vaccine.

• Synthesized and characterized p53, MITF, BCL-XL, Wilms Tumor, Survivin, Neutrophil Elastase and Proteinase 3 peptide libraries in the search of a better cancer vaccine.

• Synthesized fusion peptides with PADRE peptide and/or Tetanus toxin for evaluating immunogenicity of the epitope in a mouse model.

• Microsphere preparation of fusion peptides for the better drug delivery of the same in mouse.

Mar 2000 – April 2005; Central drug Research Institute, Lucknow, India.

• Synthesized and characterized thiazolidine 4-carboxylic acid derivatives as antifungal agents.

• Synthesized and characterized 4-Thiazolidinones as antifungal and antituberculosis agent.

• Developed two new time efficient methodologies to synthesize 4-thiazolidinones.

• Developed a novel method towards optically pure amino alcohols.

EDUCATION

Ph.D. 2005 Organic Chemistry Central Drug Research Institute, Lucknow, India

M.Sc. 1998 1st Division Organic Chemistry Lucknow University, Lucknow, India

B.Sc. 1996 1st Division Physics & Chemistry Lucknow University, Lucknow, India

AWARDS AND HONORS

• Senior Research Fellowship awarded by Council of Scientific and Industrial Research, Govt. of India (2003-2005)

• Research Fellowship awarded by Central Drug Research Institute, Govt. of India (2000- 2003)

• GATE (Graduate Aptitude Test in Engineering) qualified in (1999)

• Gold medal in Chemistry awarded by Lucknow Christian Degree College (1996)

• Bronze medal in B.Sc. awarded by Lucknow Christian Degree College (1993-1996)

PUBLICATIONS

1. CD154 expression is associated with neutralizing antibody titer levels post-Influenza vaccination in stem cell transplant patients and healthy adults.

Biol. Blood Marrow Transplant, 2010, in press. A. Seidel, D. Smith, E. Yung, L. Aquino, Tumul Srivastava, V. Pullarkat, R. Spieberger, S. J. Forman and D. J. Diamond.

2. Modified vaccinia Ankara expressing survivin combined with gemcitabine generates specific antitumor effects in a murine pancreatic carcinoma model.

Cancer Immunology & Immunotherapy, 2010, in press. H. Ishizaki, E. R. Manuel, G-Y Song, Tumul Srivastava, S. Sun, D. J. Diamond and J Ellenhorn.

3. Heterologous prime/boost immunization with p53-based vaccines combined with toll-like receptors stimulation enhances tumor regression.

J. Immunother., 2010, 33(6) : 609-617. H. Ishizaki, G-Y Song, Tumul Srivastava, K. D. Carroll, V. Shahabi, E. R. Manuel, D. J. Diamond and J Ellenhorn.

4. Modified H5 promoter improves stability of insert genes while maintaining immunogenicity during extended passage of genetically engineered MVA vaccines.

Vaccine, 2010, 28(6): 1547-1557. Z. Wang, J. Martinez, W. Zhou, C. La Rosa, Tumul Srivastava, A. Dasgupta, R. Rawal, Z. Li, W. J. Britt, D. J. Diamond.

5. Mamu-A01/K(b) transgenic and MHC Class I knockout mice as a tool for HIV vaccine development.

Virology, 2009, 387(1): 16-28. L. Jinliang; Tumul Srivastava, R. Rawal, E. Manuel, D. Isbell, W. Tsark, C. La Rosa, Z. Wang, P. A Barry, K. D Hagen, J. Longmate, D. J Diamond.

6. A novel approach to evaluate the immunogenicity of viral antigens of clinical importance in HLA transgenic murine models.

Immunology letters, 2008, 120: 108-116. A. Krishnan, Z. Wang, Tumul Srivastava, R. Rawal, P. Manchanda, D. J. Diamond, C. La Rosa.

7. A fusion protein of HCMV IE1 exon4 and IE2 exon5 stimulates potent cellular immunity in an MVA vaccine vector.

Virology, 008, 377: 379-390. Z. Wang, W. Zhou, Tumul Srivastava, C. La Rosa, A. Mandarino, S. J. Forman, J. A. Zaia, W. J. Britt, D. J. Diamond.

8. Functional characterization of BK virus-specific cytotoxic CD4 T-cells in seropositive healthy adults.

Viral Immunology, 2007, 20(3): 379-388. W Zhou, M Sharma, J Martinez, Tumul Srivastava, D. J Diamond, WA Knowles, S. F Lacey.

9. An MVA vaccine overcomes tolerance to human p53 in mouse and man.

Cancer Immunology & Immunotherapy, 2007, 56: 1193-1205. G-Y Song, G Gibson, W. Haq, ECC Huang, Tumul Srivastava, M Hollstein, P Daftarian, Z Wang, D. J. Diamond, and J Ellenhorn.

10. Cross-reactive CTL recognize two HLA-A*02-restricted epitopes within the BK virus and JC virus VP1 polypeptides are frequent in immunocompetent individuals.

Virology, 2006, 350: 128-136. M. C. Sharma, W. Zhou, J. Martinez, L. Krymskaya, Tumul Srivastava, W. Haq, D. J. Diamond and S. F. Lacey.

11. Synthesis and biological evaluation of 4-thiazolidinone derivatives as potential antimycobacterial agents.

Arkivoc, 2005, (ii): 120-130. Tumul Srivastava, A. K. Gaikwad, W. Haq, S. Sinha and S. B. Katti.

12. An expeditious synthesis of thiazolidinones and metathiazanones.

J. Chem. Research(S), 2004, 2004(5): 368-369. R. K. Rawal, Tumul Srivastava, W. Haq and S. B. Katti.

13. A facile and simple method for the reduction of N-protected amino acids and peptides to the corresponding amino alcohols.

J. Chem. Research(S), 2003, 2003(8): 516-517. Tumul Srivastava, T. K. Srivastava, W. Haq and S. B. Katti.

14. Crystal structure of 2-(4-Chlorophenyl)-3-cyclohexylthiazolidin-4-one.

Acta crystallographica, 2003, E59(8): o1239-o1240. A. Sharon, Tumul Srivastava, S. B. Katti and P. R. Maulik.

15. Carbodiimide mediated synthesis of 4-thiazolidinone by one pot three-component condensation. Tetrahedron, 2002, 58(38): 7619-7624. Tumul Srivastava, W. Haq and S. B. Katti.

REFERENCES

1. Don J. Diamond, Ph.D.

Director, Translational Vaccine Research

Beckman Research Institute of City of Hope National Medical Center,

Duarte, CA, USA, 91010

Phone: 001-626-***-**** x63450, Email: jwa65t@r.postjobfree.com

2. S. B. Katti, Ph.D.

Scientist G, Medicinal & Process Chemistry Division,

Central Drug Research Institute,

Lucknow, UP, India, 226001

Phone: +91-522*******, Email: jwa65t@r.postjobfree.com

3. Joshua D. I. Ellenhorn, M.D.

Chief, Division of General and Oncologic Surgery

City of Hope National Medical Center,

Duarte, CA, USA, 91010

Phone: 001-626-***-****, Email: jwa65t@r.postjobfree.com

4. Simon F. Lacey, Ph.D.

Director, Clinical Immunobiology Correlative Studies Laboratory,

Beckman Research Institute of City of Hope National Medical Center,

Duarte, CA, USA, 91010

Phone: 001-626-***-****, Email: jwa65t@r.postjobfree.com

5. Anindya Dasgupta, Ph.D.

Research scientist, Biosciences,

Unilever R&D,

64 Whitefield Main Road,

Bangalore, India, 560066

Phone: +91-803*******, Email: jwa65t@r.postjobfree.com

6. Zhongde Wang, Ph.D.

Manager of Production, GenPhar Inc.

600 Seacoast Pkwy,

Mt Pleasent, SC, USA, 29466.

Phone: 001-843-***-****, Email: jwa65t@r.postjobfree.com

Contact this candidate