CDC service fellow

Shih-Houng Young, PhD

Pathology and Physiology Research Branch

Health Effects Laboratory Division

National Institute for Occupational Safety and Health

Morgantown, West Virginia, WV 26505

(O)304-***-**** ext 5; (c) 304-***-****

Office e-mail ******@***.***

Home e-mail: **************@*****.***

EDUCATION

Ph.D. Environmental Health Sciences (Industrial Hygiene), 1998. University of Alabama at Birmingham, Birmingham, Alabama

M.S./Applied Chemistry 1984. National Tsing Hua University, Hsinchu, Taiwan, ROC

B.S. / Chemistry 1982. National Tsing Hua University, Hsinchu, Taiwan, ROC

SUMMARY OF QUALIFICATIONS

• Extensive knowledge of public health, epidemiology, environmental health, industrial hygiene, and toxicology. Strong background in Chemistry.

• 12 years of experience in toxicology research in both academia and industry.

• In-depth understanding of the biology and chemistry of the major cell-wall component-(1->3)-β-glucan and its role in pulmonary inflammation in animal model.

• Extensive experience as a toxicology researcher in both reviewing and summarizing pertinent literature and in scientific writing and publishing. Excellent written communication and oral presentation skills.

GOVERNMENT/INDUSTRY EXPERIENCE

CDC Service Fellow 2004-present

Pathology and Physiology Research Branch, NIOSH

Morgantown, WV 26505

DUTIES AND RESPONSIBILITIES

• Studied the toxicology of 1->3-beta-glucans, published 12 papers on this subject and edited a book entitled Toxicology of 1->3-beta-glucans/Glucans as a marker for fungal exposure.

• Developed a new flow cytometry research project to assess white blood cell responses to different toxins and provide a quick and simple way to evaluate the nature of animal responses (such as inflammation, allergy, immune or fibrosis responses) and predict responses upon further stimulation to known stimulants such as LPS or listeria.

• Performed multiple and collaborative work on welding fume, residual oil fly ash, single/multi- walled carbon nanotubes, respirable crystalline silica, moon dust, and cerium oxide with and outside of NIOSH.

Research Scientist 2002-2004

MB Research Lab

In Vitro Toxicology

Spinnerstown, PA

DUTIES AND RESPONSIBILITIES

• Was in charge of developing and validating a SBIR project: Flow cytometry-based Local Lymph Node Assay with a set of known sensitizers, sensitizing irritants and non-sensitizers. Outcome of this project provided an alternative method for traditional radioactive LLNA assay and obtained additional information which helped to differentiate between irritant or irritating sensitizer.

• Planned and executed various toxicology assays according to OECD, FDA, EPA guidelines in a GLP lab for client.

NRC Associate Fellow (1999-2002)

Engineering Control &Technology Branch/ Pathology and Physiology Research Branch,Morgantown, WV 26505

DUTIES AND RESPONSIBILITIES

• Developed animal (rat, mouse) models of particle (1->3-beta-glucans) inhalation, pulmonary infection, and allergic asthma.

Senior Industrial Safety Specialist (1984-1992)

Industrial Safety and Environmental Protection Section, Chung Shan Institute of Science and Technology (CSIST)

Taoyuan, Taiwan, ROC

• Organizes, administers, implements a comprehensive Occupational Safety and Health audit and compliance program for CSIST, which cover its 20,000 + employee in 11 campuses around Taiwan.

• Was in charge of conducting accident investigation & analysis.

• Reviews and evaluates workplace practices and procedures and perform Safety audit

• Reviews construction plans and designs drawings for compliance with appropriate codes and regulations

• Coordinate and conduct occupational safety and health education and training.

• Recognize toxic effect of workplace exposure, establishes data collection plans, recommend proper control measurements.

PROFESSIONAL MEMBERSHIPS

SOT (Society of Toxicology) 2006-Present

AIHA (American Industrial Hygiene Association) 1992 - 2007

ACGIH (American Conference of Governmental Industrial Hygienists) 1992 – 1998

CERTIFICATES

Safety Program Auditing, International Loss Control Institute, Atlanta GA 1992

Modern Safety Management, International Loss Control Institute, Atlanta GA 1992

Certificated Industrial Safety Specialist Examination Yuan, Taiwan ROC 1992

PUBLICATIONS

Book Chapter

Young, S.-H., and Castranova, V. (2005), “Animal Model of (1->3)-β-Glucan-induced Pulmonary Inflammation in Rats”, In Toxicology of 1->3-Beta-Glucans, Glucans as a Marker for Fungal Exposure (S.-H. Young and V. Castranova, eds.), pp. 65-93. Taylor and Francis, New York.

Editorship

“Toxicology of 1->3-beta-Glucans” edited by Shih-Houng Young and Vincent Castranova, Taylor and Francis (2005).

Journal Papers

1. Murray AR, Kisin E, Tkach A, Mercer R, Young S, Fadeel B, Kagan VE, Shvedova AA [2011]. Factoring-in aggregation of SWCNT and nanofibers for better prediction of the specific features of their toxicity versus asbestos. Part Fibre Toxicol. [Submitted]

2. Xiaoqing He, Shih-Houng Young, Diane Schwegler-Berry, William Chisholm, Joseph Fernback, and Qiang Ma, Multi-walled carbon nanotubes induce fibrogenic response by stimulating reactive oxygen species production, activating NF-ĸB signaling, and promoting fibroblast-to-myofibroblast transformation, accepted by Chemical Research in Toxicology on Nov. 14, 2011.

3. L.M. Sargent*, A.F. Hubbs, S-H Young, M.L. Kashon, C.Z Dinu, J.L. Salisbury, S.A.Benkovic, D.T. Lowry, A.R. Murray, E.R. Kisin, K. J. Siegrist, L. Battelli, J. Mastovich, J.L. Sturgeon, K.L. Bunker, A.A. Shvedova, and S.H. Reynolds, Single-Walled Carbon Nanotube-induced Mitotic Disruption, submitted to Mutation Research.

4. James M. Antonini, Patti C. Zeidler-Erdely, Shih-Houng Young, Jenny R. Roberts, Aaron Erdely, Systemic Immune Cell Response after Lung Treatment with Welding Fumes that Contained Different Levels of Manganese, submitted to Journal of Immunotoxicology.

5. Xiaoqing He, Shih-Houng Young, Joseph E. Fernback, Qiang Ma, Single-walled carbon nanotube induce fibrogenic effect by distributing mitochondrial oxidative stress and activating NF-ĸB signaling, submitted to Particle and Fibre Toxicology.

6. Kan H, Wu ZX, Young SH, Chen BT, Cumpston JL, Chen F, Castranova V, Pulmonary exposure to ultrafine titanium dioxide enhances cardiac protein phosphorylation and neurotransmitter synthesis in nodose ganglia in rat, Nanotoxicology, 2011, DOI: 10.3109/17435390.2011.611915.

7. Rajendran Sellamuthu, Christina Umbright, Jenny R. Roberts, Rebecca Chapman, Shih-Houng Young, Diana Richardson, Howard Leonard, Walter McKinney, Bean Chen, David Frazer, Shengqiao Li, Michael Kashon and Pius Joseph, Blood gene expression profiling detects silica exposure and toxicity, Toxicological Sciences accepted on May 12, 2011.

8. Alexey V. Tkach, Galina V. Shurin, Michael R. Shurin, Elena R. Kisin, Ashley R. Murray, Shih-Houng Young, Alexander Star, Bengt Fadeel, Valerian E. Kagan, Anna A. Shvedova, Direct effects of carbon nanotubes on dendritic cells induce immune suppression upon pulmonary exposure, accepted by ACS Nano on June 7, 2011.

9. Shih-Houng Young, Jean. M. Cox-Ganser, Elizabeth S. Shogren, Michael G. Wolfarth, Shengqiao Li, James M. Antonini, Vincent Castranova, Ju-Hyeong Park, Pulmonary Inflammation Induced by Office Dust and the Relation to 1 3-β-Glucan Using Different Extraction Techniques. Toxicological and Environmental Chemistry 2011, 93(4), 806-823.

10. Patti C. Zeidler-Erdely, Lori A. Battelli, Sam Stone, Bean T. Chen, David G. Frazer, Shih-Houng Young, Aaron Erdely, Michael L. Kashon, Ronnee Andrews, James M. Antonini, Short-term inhalation of stainless steel welding fume causes sustained lung toxicity but no tumorigenesis in lung tumor susceptible A/J mice, Inhalation Toxicology 2011, 23(2), 112-120.

11. Aaron Erdely, Angie Liston, Rebecca Salmen, Tracy Hulderman, Shih-Houng Young, Patti C. Zeidler-Erdely, Vincent Castranova, Petia P. Simenonova, Identification of systemic markers from a single carbon nanotube exposure, , Journal of Occupational Medicine 2011 Jun;53(6 Suppl):S80-6.

12. Young S-H, Antonini JM, Roberts J. Pre-exposure to Repeated Low Doses of Zymosan Increases the Susceptibility to Pulmonary Infection in Rats. Exp Lung Res 35, 570-590, 2009.

13. Jenny Roberts, Shih-Houng Young, Vincent Castranova, James Antonini. The Soluble Nickel Component of Residual Oil Fly Ash Alters Pulmonary Host Defense in Rats, J. of Immunotoxicology,2009 Mar;6(1):49-61.

14. Jinshun Zhao, Linda Bowman, Xingdong Zhang, Val Vallyathan, Shih-Houng Young, Vincent Castranova and Min Ding. Titanium Dioxide (TiO2) Nanoparticles Induce JB6 Cell Apoptosis through Activation of the Caspase-8/Bid and Mitochondrial Pathways. Journal of Toxicology & Environmental Health Part A, 72:1141-9, 2009.

15. A.R. Murray, E. Kisin, S. Leonard, S-H. Young, C. Kommineni, V. E. Kagan, V. Castranova, A.A. Shvedova, Oxidative Stress and Inflammatory Response in Dermal Toxicity of Single Walled Carbon Nanotubes. Toxicology 2009 Mar 29;257(3):161-71.

16. Shih-Houng Young, James M. Antonini, Jenny R. Roberts, Single Pre-exposure to a High Dose of Zymosan Enhances Lung Defense Mechanisms and Accelerates the Pulmonary Clearance of a Bacterial Pathogen in Rats. Experimental Lung Research 2008, 34, p559-578.

17. Shih-Houng Young, James M. Antonini, Jenny R. Roberts, Aaron D. Erdely, Patti C. Zeidler-Erdely, Performance Evaluation of Cytometric Bead Assays for the Measurement of Lung Cytokines in Two Rodent Models. Journal of Immunological Methods (331) p 59-68, 2008.

18. Patti C Zeidler-Erdely, Michael L Kashon, Lori A Battelli, Shih-Houng Young, Aaron Erdely, Jenny R Roberts, Steven H Reynolds and James M Antonini. Pulmonary inflammation and tumor induction in lung tumor susceptible A/J and resistant C57BL/6J mice exposed to welding fume. Particle and Fibre Toxicology 2008, 5:12.

19. Shih-Houng Young, Gary R. Ostroff, Patti C. Zeidler-Erdely, Jenny R. Roberts, James M. Antonini, Vincent Castranova. A Comparison of the Pulmonary Inflammatory Potential of Different Components of Yeast Cell Wall. Toxicology and Environmental Health part A, (70) p.1116-1124, 2007.

20. Porter DW, Wolfarth M, Young S-H, Rao MK, Meighan T, Barger M, Andrew ME, Huffman LJ. “PGJ2 Inhibition of LPS-Induced Inflammatory Mediator Expression from Rat Alveolar Macrophages”. J. Tox. Environ. Health Part A. 70, p. 1967-76, 2007.

21. Li Z., Hulderman T, Salman, R., Chapman, R., Leonard, S. Young, S-H., Shvedova, AA., Luster, M., Simeonova, P. “Cardiovascular Effects of Pulmonary Exposure to Single-Wall Carbon Nanotubes” Environ. Health Perspect, 2007, 115(3): 377-82.

22. Kagan VE, Rao KMK, Young S-H, Meighan T, Murray AR, Tyurina YY, Castranova V, Shvedova AA. Pulmonary effects of single walled carbon nanotubes: inflammatiory response, oxidative stress/signaling, recognition by macrophages. 2007, Nanotechnology-Toxicological issues and Environmental Safety, p. 65-75.

23. Shvedova AA, Kisin ER, Murray A, Gorelik O, Arepalli S, Castranova V, Young S-H, Gao F, Tyurina YY, Oury T, Kagan VE. Vitamin E deficiency enhances pulmonary inflammatory response and oxidative stress Induced by single-walled carbon nanotubes in C57B6/L mice. Toxicology and Applied Pharmacology, (221), p. 339-348, 2007.

24. Roberts JR, Young S-H, Castranova V, Antonini JM. Soluble metals in Residual Oil Fly Ash alter lung immune response to bacterial infection in rats. Toxicology and Applied Pharmacology , (221) p. 306-319, 2007.

25. Shih-Houng Young, Jenny R. Roberts, James M. Antonini. Pulmonary Exposure to 1 3-β-Glucan Alters Adaptive Immune Responses in Rats. Inhalation Toxicology, 18:865-874, 2006.

26. Solano-Lopez C, Zeidler-Erdely PC, Hubbs AF, Reynolds SH, Roberts JR, Taylor MD, Young SH, Castranova V, Antonini JM. Welding Fume Exposure and Associated Inflammatory and Hyperplastic Changes in the Lungs of Tumor Susceptible A/J Mice. Tox. Path. (2006), 34:364-372.

27. Antonini, J. M., Leonard, S. S., Roberts, J. R., Solano-Lopez, C., Young, S. H., Shi, X., and Taylor, M. D. (2005). Effect of stainless steel manual metal arc welding fume on free radical production, DNA damage, and apoptosis induction. Mol Cell Biochem 279, 17-23.

28. Roberts JR, Young S, Antonini JM, Castranova V [2005]. Soluble nickel associated with residual oil fly ash increases susceptibility to pulmonary infection in rats Toxicologist 2005 Mar; 84(Suppl 1):295-296.

29. Shih-Houng Young, Victor A. Robinson, Mark Barger, Micheal Whitmer, Dale W. Porter, David.G. Frazer and Vincent Castranova, Exposure to particulate 1->3-beta-glucans induce greater pulmonary toxicity than soluble 1->3-beta-glucans in rats Toxicology and Environmental Health part A, (66) p25-38, 2003.

30. Shih-Houng Young, Victor A. Robinson, Mark Barger, Robert R. Jacobs, David G. Frazer and Vincent Castranova, Partially Opened Triple-helix is the Biologically Active form of Particulate 1->3-beta-Glucans which Induced Pulmonary Inflammation in rats. Toxicology and Environmental Health part A, (66) 551-563, 2003.

31. Shih-Houng Young, Victor A. Robinson, Mark Barger, Patti Zeidler, Dale Porter, David G. Frazer and Vincent Castranova, Modified Endotoxin Responses In Rats Pre-Treated With 1->3-beta-Glucan Zymosan A), Toxicology and Applied Pharmacology, (178) p.172-179, 2002.

32. Shih-Houng Young, Victor A. Robinson, Mark Barger, Dale W. Porter, David G. Frazer and Vincent Castranova, Acute Inflammation And Recovery In Rats After Intratracheal Instillation of A 1->3- -Glucan (Zymosan A). Journal of Toxicology and Environmental Health part A (64):311-325, 2001.

33. Shih-Houng Young, Jianping Ye, David G. Frazer, Xianglin Shi and Vincent Castranova, Molecular Mechanism of Tumor Necrosis Factor- Production in 1->3- -Glucan (Zymosan) Activated Macrophages, J. Biol. Chem. (276) p.20781-7, 2001.

34. Jianping Ye, Patti Zeidler, Shih-Houng Young, Anthony Martinez, Victor A Robinson, William Jones, Paul Baron, Xianglin Shi and Vincent Castranova, Activation of MAP kinase p38 and ERK is Involved in Glass Fiber-induced TNF- Production in macrophages. J. Biol. Chem. (276) p5360-5367 (2001).

35. Shih-Houng Young, Wen-Ji Dong and Robert R. Jacobs, Observation of a partially opened triple-helix conformation in 1->3- -glucan by fluorescence resonance energy transfer spectroscopy. J. Biol. Chem. (275) p.11874-9, 2000.

36. Shih-Houng Young and Robert R. Jacobs, Sodium hydroxide-induced conformational change in Schizophyllan detected by the fluorescence dye, aniline blue, Carbohydr. Res., 310 (1998) p.91-99.

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