Patent Professional / Scientific Advisor

Prasad Dande, Ph.D.

Scientist, Author, Facilitator – Nanotechnology, Biotechnology, & Pharmaceuticals

Contact: *** ***** ****, **** ***, Evanston, IL-60201

Tel: 312-***-****; E-mail: ******@*****.***

Summary

Prolific inventor, author, & scientist with demonstrated technical writing track record in the nanotechnology, biotechnology, & pharmaceutical industries. Track record of significant achievements in multiple research areas, technologies, and industries. Detail oriented, organized, multi-tasker with project management experience and a broad knowledge base. Accurately performs challenging tasks with precision and attention to detail, personally committed to achieving high client satisfaction. Excellent verbal and written communicator, analytical thinker, and teamplayer, and with outgoing personality who enjoys forming professional relationships and collaborations.

My specific areas of expertise include, but are not limited to biotechnology, nanotechnology, medical devices, and bioabsorbable materials. I am seeking to translate my broad knowledge base, communication skills, and technical writing abilities to a career in scientific communications. I will use my communication skills, technical writing abilities, and in-depth understanding of pharmaceutical / biotechnology industry to be a productive member of your team.

Experience

2007 – present Associate Research Investigator – Abbott Laboratories Chicago, IL

• Designed novel nanomaterials, bioactive entities, and formulation systems.

• Headed IP effort to generate intellectual property coverage of Abbott nanotechnology discoveries. Six provisional applications have been filed. These are some of the first Abbott patent applications in this field.

• Conducted literature / patent database [Scifinder, chemical abstracts, etc.] searches. Identified key loophole in competitor’s claims and identified chemical entities that enabled Abbott to file a focused provisional application. An entity claimed in this application is now a development lead.

• Drafted provisional applications and provided scientific advisory support in patent prosecution.

2005 – 2007 Scientist, Intellectual Property - Saoirse Corporation Cambridge, MA

• Designed novel nanomaterials, searched literature for prior-art and freedom-to-practice, and drafted provisional patent applications as warranted.

• Drafted one major and three ancillary provisional applications in the areas of nanoparticle formulation, targeted drug delivery, and diagnostics.

• Collated information relevant to company’s technology via literature / patent [Scifinder, Chemical Abstracts, etc.] searches and developed in-house knowledge database.

• Conducted prior art searches, evaluated provisional applications and provided scientific advisory support in all stages of application drafting.

• Organized in-house IP committee and helped develop long term IP strategy.

2001 – 2005 Scientist, Chemistry - Isis Pharmaceuticals Carlsbad, CA

• Designed & synthesized novel bioactive entities in oncology, antivirals / antiinfectives, metabolic diseases, and antisense / siRNA therapeutics.

• Drafted twenty records of invention (internal provisional applications) to record significant scientific discoveries. Assisted in drafting of eight provisional patent applications.

• Collated information relevant to company’s technology via literature / patent database [Scifinder, chemical abstracts, etc.] searches and maintained departmental database.

• Identified key loophole in competitor’s filing allowing Isis scientists to develop a novel solid-phase chemistry for oligonucleotide conjugation strategy. This technology was subsequently used not only within Isis but also licensed to its partners, and was the basis for a pre-clinical study.

• Author and inventor on key patent claiming a major innovation in carbohydrate synthesis. This application, when granted, will enable Isis pharmaceuticals to own the rights to practice the only known stereo-selective synthesis of 4’-Thio RNA, a key component of RNAi therapeutics. This technology has already resulted in significant cost savings in both material and manufacturing costs.

• Conducted prior art searches, evaluated provisional applications and provided scientific advisory support in all stages of patent application drafting.

• Inventor on six key patent applications in chemistry, molecular biology, and nucleic acid therapeutics.

Relevant Experience, Skills, & Achievements

• 7 years R&D, and technical writing experience in the discovery and technology industry.

• Responsible for the identification / development of three development candidates, over $ 2.0 million in milestone payments, and two successful research initiatives.

• Extensively published author (14 research articles) and inventor (inventor on 8 published patent applications).

• Experienced public speaker (20 presentations at national and international symposia).

• Skilled communicator with excellent interpersonal skills, and outgoing personality who enjoys forming productive working relationships.

• Intellectual property / technical writing experience specializing in organic and medicinal chemistry, protein chemistry, nanotechnology, RNAi, material sciences, biotechnology and pharmaceuticals.

Education

• University of California, Berkeley, CA - Post-doctoral fellow, Polymer Chemistry

• University of Nebraska, Omaha, NE - Ph.D., Pharmaceutical Sciences

• University of Bombay, Bombay, India - B.S., Pharmaceutical Sciences

Selected Patents

1. Bhat, B., Prakash, T. P., Dande, P., Allerson, C., Griffey, R. H., Swayze, E.E. Conjugated double-stranded RNA compositions for use in gene modulation. U.S. Pat. Appl. Publ. (2008)

2. Swayze, E.E.; Robinson, D. E., Jr.; Jefferson, E. A. C.; Dande, P.; Prakash, T. P.; Allerson, C.; Bhat, B. Preparation of conjugated pyrrolidinyl cholesterol RNA duplexes for attaching conjugates to oligomeric compounds for modulating gene expression. PCT Int. Appl. (2006)

3. Bhat, B.; Swayze, E.; Allerson, C.; Dande, P.; Prakash, T. P.; Griffey, R. H. Chimeric gapped short interfering nucleic acids for inhibition of gene expression by RNA interference. PCT Int. Appl. (2005)

4. Bhat, B.; Swayze, E.; Prakash, T. P.; Allerson, C.; Dande, P.; Griffey, R. H. Positionally modified short interfering nucleic acids for inhibition of gene expression by RNA interference. PCT Int. Appl. (2005)

5. Bhat, B.; Dande, P.; Prakash, T. P.; Allerson, C.; Swayze, E. E.; Griffey, R. H. Preparation of antisense 4'-thionucleosides-containing oligoribonucleotides duplexes for use in the RNA interference pathway of gene modulation. PCT Int. Appl. (2005)

6. Bhat, B.; Bhat, N.; Dande, P.; Eldrup, A. B.; Olsen, D. B.; MacCoss, M. Carbocyclic nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase. PCT Int. Appl. (2003)

7. Bhat, B.; Dande, P.; Bhat, N.; Eldrup, A. B. Double-stranded oligonucleotides containing carbocyclic nucleosides for use in gene modulation. PCT Int. Appl. (2003)

8. Carroll, S. S.; Olsen, D. B.; Durette, P. L.; Bhat, B.; Dande, P.; Eldrup, A. B. Preparation of nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase. PCT Int. Appl. (2003)

Selected Publications

1. Dande, P.; Thazha, P.; Sioufi, N.; Jarres, R.; Gauss, H.; Berdeja, A.; Swayze, E.; Griffey, R.; Bhat, B. Improving RNA Interference in Mammalian Cells by 4'-Thio-modified siRNA: Effect on siRNA Activity and Nuclease Stability When Used in Combination with 2'-O- Alkyl Modifications. Journal of Medicinal Chemistry (2006), 49(5), 1624-1634.

2. Thazha, P.; Allerson, C. A.; Dande, P.; Vickers, T. A.; Sioufi, N.; Jarres, R .; Baker, B. F .; Swayze, E. E.; Griffey, R. H . ; Bhat, B. Positional Effects of Chemical Modifications on siRNA Activity in Mammalian Cells. Journal of Medicinal Chemistry (2005), 48(13), 4247- 4253.

3. Eldrup, A. B.; Prhavc, M.; Brooks, J.; Bhat, B.; Thazha, P.; Song, Q.; Bera, S.; Bhat, N.; Dande, P.; Cook, P. D.; Bennett, C. F.; Carroll, S. S.; Ball, R. G.; Bosserman, M.; Burlein, C.; Colwell, L. F.; Fay, J. F.; Flores, O. A.; Getty, K.; LaFemina, R. L.; Leone, J.; MacCoss, M.; McMasters, D. R.; Tomassini, J. E.; Von Langen, D.; Wolanski, B.; Olsen, D. B. Structure-Activity Relationship of Heterobase-Modified 2'-C-Methyl Ribonucleosides as Inhibitors of Hepatitis C Virus RNA Replication. Journal of Medicinal Chemistry (2004), 47(21), 5284-5297

4. Varadarajan, S.; Shah, D.; Dande, P.; Settles, S.; Chen, F. X.; Fronza, G.; Gold, B.. (2003) DNA Damage and Cytotoxicity Induced by Minor Groove Binding Methyl Sulfonate Esters. Biochemistry, 42(48), 143**-*****

5. Li, Z.; Huang, L.; Dande, P.; Gold, B.; Stone, M. P. (2002) Structure of a Tethered Cationic 3-Aminopropyl Chain Incorporated into an Oligodeoxynucleotide: Evidence for 3'- Orientation in the Major Groove Accompanied by DNA Bending. J. Am. Chem. Soc.,124(29), 8553-8560.

6. Francis, Matthew B.; Goh, Sarah L.; Dande, Prasad; Padilla De Jesus, Omayra L.; Fréchet, Jean M. J. (2001) DNA-dendrimer conjugates for drug delivery. Polymeric Materials Science and Engineering, 84, 12-13

7. Soto, Ana Maria; Kankia, Besik I.; Dande, Prasad; Gold, Barry; Marky, Luis A. (2001) Incorporation of a cationic aminopropyl chain in DNA hairpins: thermodynamics and hydration. Nuc. Acd. Res., 29(17), 3638-3645

8. Kelly. J., Inga, A., Chen, F. X., Dande, P., Shah, D., Monti, P., Aprile, A., Burns, P. A., Scott, G., Abbondolo, A., Gold, B., and Fronza, G. (1999) Relationship between DNA methylation and mutational analysis induced by sequence selective minor groove methylating agents. J. Biol. Chem. 274, 183**-*****.

9. Vennerstorm, J. L., Nuzum, E. O., Miller, R. E., Dorn, A., Gerena, L., Dande, P., Ellis, W. Y., Ridley, R. G. and Milhous, W. K. (1999) 8-aminoquinolines active against blood stage Plasmodium falciparum in vitro inhibit hematin polymerization. Antimicrob. Agents. and Chemother. 43, 598-602.

10. Heystek, L. E., Zhou, H. Q., Dande, P. and Gold, B. (1998) Control over localization of positive charge in DNA: The effect on duplex DNA and RNA stability. J. Am. Chem. Soc.120, 121**-*****.

11. Dande, P., Liang, G., Chen, F.-X., Roberts, C., Nelson, M.G., Hashimoto, H., Switzer, C. and Gold, B. (1997) The regioselective effect of zwitterionic DNA substitutions on DNA alkylation: Evidence for strong side chain orientational preference. Biochemistry 36, 6024- 6032.

Contact this candidate