D.V.M, PH.D, MB(ASCP)
Resume:
SCIENTIFIC & CLINICAL RESEARCH & QUANTITATIVE ANALYSIS
Dedicated and motivated professional with years of collaborative research experience in the fields of cancer, molecular, and cellular biology. Strong background conducting advanced studies and developing strategic plans to address theoretical, practical, and experimental design initiatives. Comfortable writing scientific manuscripts and grants, presenting data in formal settings, compiling accurate documentation, and directing postdoctoral fellows, medical residents, graduate students, and technical personnel. 18 publications in peer review journals.
AREAS OF EXPERTISE
Research & Development
Experimental Design
Advanced Studies
Molecular Biology
Cancer Biology Virology
Biotechnology
Analysis & Planning
Data Management
Records & Reporting Computer Programming
Program Coordination
Project Management
Training & Instruction
Professional Presentations
PROFESSIONAL EXPERIENCE
NORTHWESTERN UNIVERSITY - Chicago, IL 2003-2012
Research Assistant Professor – Department of Surgery 2008-2012
Lead role in the identification and validation of novel cancer targets for breast cancer treatment
Developed biological strategies to determine compounds that inhibited breast cancer cell tumorogenesis
Closely examined infertility regiments on breast cancer cell proliferation
Instructed a Molecular Biology Laboratory course for the “Master in Biotechnology” program
Conducted research for independent projects, managed lab operations, and supervised lab assistants
Research Assistant Professor – Department of Biochemistry 2004-2007
Identified and cloned novel cytokine receptors produced in the placenta (PLP-E)
Created curriculum and taught a laboratory course for the Biotechnology programs
Performed research and directed a team of postdoctoral research associates and technical assistants
Research Assistant Professor – Department of Pediatrics 2003-2004
Worked in the Children’s Memorial Institute of Education and Research
Managed projects with the goal of elucidating the molecular mechanisms of HIV-1 virus reproduction
UNIVERSITY OF NEBRASKA MEDICAL CENTER - Omaha, NE 1998-2003
Instructor
Develop and validate novel treatment approaches for advanced prostate cancer
Studied molecular mechanisms associated with transdifferentiated prostate cancer cells
Investigated transcriptional regulation prostate specific phosphatase
Taught courses Molecular Biology for graduate students in the School of Pharmacology
INSTITUTE OF AGRICULTURAL BIOTECHNOLOGY – Moscow, Russia 1994-1996
Leading Researcher
Worked within the Department of Genetic Engineering of Animals
Led research projects utilizing ribozymes and antisense RNAs to prevent lentiviral infections
LICENSES AND CERTIFICATIONS
ASCP BOARD OF CERTIFICATION 2012
TECHNOLOGIST IN MOLECULAR BIOLOGY MB(ASCP)
NRI SCHOOL – WASHINGTON, DC 2001
COMPUTER PROGRAMMING
EDUCATION
INSTITUTE OF AGRICULTURAL BIOTECHNOLOGY – Moscow, Russia 1994
Ph.D. – Molecular Biology & Virology
MOSCOW ACADEMY OF VETERINARY SCIENCE – Moscow, Russia 1986
D.V.M.
MOSCOW ACADEMY OF VETERINARY SCIENCE – Moscow, Russia 1986
M.S. - Biophysics
POST DOCTORAL TRAINING
UNIVERSITY OF NEBRASKA MEDICAL CENTER – Omaha, NE 1996-1998
Post Doctoral Fellow – Department of Biochemistry & Molecular Biology
PROFESSIONAL MEMBERSHIPS
AMERICAN SOCIETY FOR CLINICAL PATHOLOGY
PROFESSIONAL ACHIEVEMENTS
2008-2012
Results of my work led to the discovery of novel mechanisms that contribute to the biologic aggressiveness of breast cancer as well as identifying potential therapeutic targets and clinical markers of cancer prognosis.
2004-2007
Results of proteomics array breakdown, cDNA library screening, EST databases analysis and outcome of protein-protein interaction directed to the identification of novel hematopoietic cytokine expressed in the placenta.
2003-2004
My effort on establishing and validating results for genome-wide screening in yeast system led to the identification of two novel anti-HIV apoptosis related cellular factors and demonstrated that expression discovered proteins in mammalian cell culture are able to suppress virus reproduction and prevent HIV-induced apoptosis.
1996-2003
Successfully initiated a technologically advanced project aimed at characterizing novel tissue for specific regulatory elements of prostate specific phosphatase and demonstrating specificity of its expression in cell culture and in transgenic animals. Results of my efforts led to the discovery of molecular mechanisms and transdifferention carcinoma cells into neuroendocrine phenotype trough cell exposition to a variety pharmacological agents and steroids. Initiated and successfully advanced a novel approach by utilizing signal transduction inhibitors to maximize treatment selectivity while minimizing toxicity and effectiveness treatment of prostate cancer patients.
SELECTED PUBLICATIONS
1. Zelivianski, S., Cooley,A., Kall, R., Jeruss, J., CDK4-Mediated phosphorylation inhibits Smad3 activity incyclin D overexpressing breast cancer cells. Mol. Cancer Res. 2010, 8(10):1375-87.
2. Cooley A, Zelivianski S*, Jeruss JS. Impact of cyclin E overexpression on Smad3 activity in breast cancer cell lines. Cell Cycle. 2010, 9(24), 4900-7 (*equal contribution).
3. Zelivianski, S., Liang, D., Chen, M., Mirkin, B.L., and Zhao, R., Y. Suppressive effect of elongation factor 2 on apoptosis induced by HIV-1 viral protein R. Apoptosis 2006, 11(4), 377-388.
4. Zelivianski, S., Glowacki, R., Lin, M.-F. Transcriptional activation of the human prostatic acid phosphatase gene by NF- B via a novel hexanucleotide-binding site. Nucl. Acid Res. 2004, 32(12), 3566-3580.
5. Zelivianski, S., Spellman, M., Kellerman, M., Kakitelashvilli, V., Xia-Wei Zhou, X.-W., Taylor, R., Davis, T., Hauke, R., and Lin M.-F. MAPK/ERK inhibitor PD98056 enhances Docetaxel-induced apoptosis of human prostate cancer cells. Int. J. of Cancer 2003, 107 (3), 478-485.
6. Zelivianski, S., Igawa, T., Lim, S., Taylor, R., and Lin, M.-F. Identification and characterization of regulatory elements of the human prostatic acid phosphatase promoter. Oncogene 2002, 21, 3696-3705.
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