SCIENTIFIC & CLINICAL RESEARCH & QUANTITATIVE ANALYSIS

Dedicated and motivated professional with years of collaborative research experience in the fields of cancer, molecular, and cellular biology. Strong background conducting advanced studies and developing strategic plans to address theoretical, practical, and experimental design initiatives. Comfortable writing scientific manuscripts and grants, presenting data in formal settings, compiling accurate documentation, and directing postdoctoral fellows, medical residents, graduate students, and technical personnel. 18 publications in peer review journals.

AREAS OF EXPERTISE

Research & Development

Experimental Design

Advanced Studies

Molecular Biology

Cancer Biology Virology

Biotechnology

Analysis & Planning

Data Management

Records & Reporting Computer Programming

Program Coordination

Project Management

Training & Instruction

Professional Presentations

PROFESSIONAL EXPERIENCE

NORTHWESTERN UNIVERSITY - Chicago, IL 2003-2012

Research Assistant Professor – Department of Surgery 2008-2012

Lead role in the identification and validation of novel cancer targets for breast cancer treatment

Developed biological strategies to determine compounds that inhibited breast cancer cell tumorogenesis

Closely examined infertility regiments on breast cancer cell proliferation

Instructed a Molecular Biology Laboratory course for the “Master in Biotechnology” program

Conducted research for independent projects, managed lab operations, and supervised lab assistants

Research Assistant Professor – Department of Biochemistry 2004-2007

Identified and cloned novel cytokine receptors produced in the placenta (PLP-E)

Created curriculum and taught a laboratory course for the Biotechnology programs

Performed research and directed a team of postdoctoral research associates and technical assistants

Research Assistant Professor – Department of Pediatrics 2003-2004

Worked in the Children’s Memorial Institute of Education and Research

Managed projects with the goal of elucidating the molecular mechanisms of HIV-1 virus reproduction

UNIVERSITY OF NEBRASKA MEDICAL CENTER - Omaha, NE 1998-2003

Instructor

Develop and validate novel treatment approaches for advanced prostate cancer

Studied molecular mechanisms associated with transdifferentiated prostate cancer cells

Investigated transcriptional regulation prostate specific phosphatase

Taught courses Molecular Biology for graduate students in the School of Pharmacology

INSTITUTE OF AGRICULTURAL BIOTECHNOLOGY – Moscow, Russia 1994-1996

Leading Researcher

Worked within the Department of Genetic Engineering of Animals

Led research projects utilizing ribozymes and antisense RNAs to prevent lentiviral infections

LICENSES AND CERTIFICATIONS

ASCP BOARD OF CERTIFICATION 2012

TECHNOLOGIST IN MOLECULAR BIOLOGY MB(ASCP)

NRI SCHOOL – WASHINGTON, DC 2001

COMPUTER PROGRAMMING

EDUCATION

INSTITUTE OF AGRICULTURAL BIOTECHNOLOGY – Moscow, Russia 1994

Ph.D. – Molecular Biology & Virology

MOSCOW ACADEMY OF VETERINARY SCIENCE – Moscow, Russia 1986

D.V.M.

MOSCOW ACADEMY OF VETERINARY SCIENCE – Moscow, Russia 1986

M.S. - Biophysics

POST DOCTORAL TRAINING

UNIVERSITY OF NEBRASKA MEDICAL CENTER – Omaha, NE 1996-1998

Post Doctoral Fellow – Department of Biochemistry & Molecular Biology

PROFESSIONAL MEMBERSHIPS

AMERICAN SOCIETY FOR CLINICAL PATHOLOGY

PROFESSIONAL ACHIEVEMENTS

2008-2012

Results of my work led to the discovery of novel mechanisms that contribute to the biologic aggressiveness of breast cancer as well as identifying potential therapeutic targets and clinical markers of cancer prognosis.

2004-2007

Results of proteomics array breakdown, cDNA library screening, EST databases analysis and outcome of protein-protein interaction directed to the identification of novel hematopoietic cytokine expressed in the placenta.

2003-2004

My effort on establishing and validating results for genome-wide screening in yeast system led to the identification of two novel anti-HIV apoptosis related cellular factors and demonstrated that expression discovered proteins in mammalian cell culture are able to suppress virus reproduction and prevent HIV-induced apoptosis.

1996-2003

Successfully initiated a technologically advanced project aimed at characterizing novel tissue for specific regulatory elements of prostate specific phosphatase and demonstrating specificity of its expression in cell culture and in transgenic animals. Results of my efforts led to the discovery of molecular mechanisms and transdifferention carcinoma cells into neuroendocrine phenotype trough cell exposition to a variety pharmacological agents and steroids. Initiated and successfully advanced a novel approach by utilizing signal transduction inhibitors to maximize treatment selectivity while minimizing toxicity and effectiveness treatment of prostate cancer patients.

SELECTED PUBLICATIONS

1. Zelivianski, S., Cooley,A., Kall, R., Jeruss, J., CDK4-Mediated phosphorylation inhibits Smad3 activity incyclin D overexpressing breast cancer cells. Mol. Cancer Res. 2010, 8(10):1375-87.

2. Cooley A, Zelivianski S*, Jeruss JS. Impact of cyclin E overexpression on Smad3 activity in breast cancer cell lines. Cell Cycle. 2010, 9(24), 4900-7 (*equal contribution).

3. Zelivianski, S., Liang, D., Chen, M., Mirkin, B.L., and Zhao, R., Y. Suppressive effect of elongation factor 2 on apoptosis induced by HIV-1 viral protein R. Apoptosis 2006, 11(4), 377-388.

4. Zelivianski, S., Glowacki, R., Lin, M.-F. Transcriptional activation of the human prostatic acid phosphatase gene by NF- B via a novel hexanucleotide-binding site. Nucl. Acid Res. 2004, 32(12), 3566-3580.

5. Zelivianski, S., Spellman, M., Kellerman, M., Kakitelashvilli, V., Xia-Wei Zhou, X.-W., Taylor, R., Davis, T., Hauke, R., and Lin M.-F. MAPK/ERK inhibitor PD98056 enhances Docetaxel-induced apoptosis of human prostate cancer cells. Int. J. of Cancer 2003, 107 (3), 478-485.

6. Zelivianski, S., Igawa, T., Lim, S., Taylor, R., and Lin, M.-F. Identification and characterization of regulatory elements of the human prostatic acid phosphatase promoter. Oncogene 2002, 21, 3696-3705.

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