Bioinformatics Scientist

Keyur Talsania

*** **** ** *******, ** -*****

Contact: 856-***-****

Email: *****.********@*****.***

EXPERIENCE

Research Assistant/Bioinformatician: March 2011– Current

Thomas Jefferson University, Philadelphia, PA

Conduct Multivariate analysis to analyze rat whole genome gene expression data of affymetrix arrays to find out the difference of expression of different levels of lead exposure with comparison of gender and time of exposure.

Use Genespring, Partek, Multi experiment viewer (MeV) and R/ Bioconductor to carry out Gene expression and Chip- Chip data analysis.

Use IPA, Genego and David pathway analysis and functional annotation, Cytoscape to construct network of Genes of interest.

Analyze DNA Methylation Promoter arrays of Human and rat.

Research Associate, Biostatistics: November 2009 – March 2011

Jackson State University, Jackson, MS

Developed Genetic Data Analysis structure and analyze different types of genetic data such Haplotype Study, Population Genetics, QTL Analysis, DNA Microarray Analysis.

Worked with Gene expression data of affymetrix, illumina and agilent using Gene spring and Tm4 software suit.

Carried out DNA methylation data analysis of illunina arrays.

Worked on i2b2 (Informatics for Integrating Biology and the Bedside), integrate it with ETL tool Talend for Genetic, clinical data input and analyze them.

Conducted Power Analysis, Sample size calculation and randomization study using SAS and PASS.

Research Assistant: March 2008 – August 2008

Children Hospital of Philadelphia, Philadelphia, PA

Conducted genome-wide disease-association studies.

Used Single Nucleotide Polymorphisms (SNPs) and haplotype analysis on various diseases such as Type 1 Diabetes, Berylliosis and Tuberculosis .

Used Bioinformatics tools, language Java and statistical software SAS to prepare study of ‘SKDM HLA Tool: A Comprehensive HLA and Disease Associations Analysis Software'.

Used Software PLINK and MS Excel to perform the statistical tests for Association, LD and Epistasis to find out the Localization of Chronic Beryllium Disease susceptibility to multiple regions with in the MHC.

ACADEMIC BACKGROUND

University of Sciences, Philadelphia, PA, January 2009

Master of Science: Bioinformatics

Sikkim Manipal University, Gujarat, India June 2006 Master of Science: Bioinformatics

M.G. Science Institute, Gujarat, India June 2004

Bachelor of Science: Chemistry

SKILLS

Programming Experience: C, Perl, Java.

Databases: MySQL, PostgreSQL, Microsoft Excess, Oracle.

Scripts: HTML, PHP, XML.

Software : R / Bioconductor, SAS, Cytoscape, Partek, Genespring, Mev, Genego, IPA.

Operating System : Windows 9x, DOS, NT, XP, Vista, Windows7, Linux Fedora, Ubuntu, Unix, Mac ox.

ACADEMIC PROJECT

University of Sciences in Philadelphia, PA, USA. January 2008 – May 2008

Scripting Experience.

Built an application that can scan an input bacterial nucleotide sequence for ribosome binding sites using neural network approach and Hidden Markov Model. .

Scanned the bacterial nucleotide sequences from NCBI and convert them as input for neural network using Perl and Shell Script.

Constructed Joone Neural Engine to scan the sequence and obtain results.

Microarray Data Manipulation. June 2008 – May 2008

Used DNA microarray data to perform statistical analysis using different Statistical methods.

Used GeneSpring – analytical software to visualize and manipulate gene expression data.

Query the KEGG pathway database using SQL.

Sikkim Manipal University, Gujarat, India. January 2006 – May 2006

Worked on a project on Protein comparisons to conduct various studies to compare specific Rice proteins to Human proteins. Jan 06 – May 06

Used Protein BLAST and CLUSTAL-W to query protein sequences.

PUBLICATION

Stathis Kanterakis, Eleni Magira, Kenneth D Rosenman, Milton Rossman, Keyur Talsania and Dimitri S Monos. SKDM HLA Tool: A Comprehensive HLA and Disease Associations Analysis Software.(Hum Immunol. 2008 Jul 1)

Eleni Magira, Chryssa papasteriades, Marilyn Spyropoulou, Keyur Talsania , Michalis Toubis, Charis Roussos, Dimitri Monos. Susceptibility to Pulmonary Tuberculosis in a Greek population is associated with the presence of the HLA-A R114 residue. (Submitted to The Lancet)

ABSTRACT

Incorporating analytical function into a customized data retrieval system. (Submit and accept in 12th RCMI International symposium on health disparities )

Profiles as tool for collaboration among researchers. (Submit and accept in 12th RCMI International symposium on health disparities )

Collaborative Model of Data Sharing among Major Research Entities: Lessons from RCMI Translational Research Network (RTRN) and Jackson Heart Study (JHS). S(ubmit and accept in The APHA 138th Annual Meeting )

CERTIFICATION

Health Insurance Portability and Accountability Act (HIPPA)

Protecting Human Research Participants (PHRP)

Collaborative Institutional Training Initiative (CITI)

References available upon request.

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