Scientist/Chemist

BHAGWAT BHALCHANDRA VISHNU

Mobile No.: 008**-*********; E-Mail: hvlwvz@r.postjobfree.com

CAREER PRÉCIS

 Over 12 years of functional experience in managing research activities, coordinating team. Progressive research work in domain of synthetic and Medicinal Chemistry

 Professional approach towards research, proactive attitude, mentoring skills and adaptive nature

 Focused on analyzing research activities and incessant literature review to refine research processes

 Actively involved in motivating, training and guiding doctoral students in their research fields

Please refer to Annexure – I, for Knowledge Purview, Publications & Presentations

SCHOLASTICS

 Ph.D. (Chemistry) - University of Pune - 2000

 M.Sc. (Organic Chemistry) - University of Pune - 1989

 B.Sc. (Chemistry) - Pune University - 1987

EMPLOYMENT RECITAL

School of Pharmacy, National Taiwan University, Taipei, Taiwan since Oct’03

Post Doctoral Fellow (Medicinal Chemistry)

National Taiwan University, Taipei, Taiwan Nov’02 – Sept’03

Post Doctoral Fellow (Chemistry of Fullerene Compounds)

Agharkar Research Institute, Pune, India Sept’00 – Sept’02

Research Associate (Phytochemistry of Medicine Plants)

National Chemical Laboratory, Pune, India Sept’96 – Sept’00

Doctoral Researcher

National Chemical Laboratory, Pune, India Jan’92 – Sept’96

Research Fellow (JRF and SRF)

Hoechst India Ltd., Mumbai, India Dec’90 – Sept’91

Research Assistant (Organic Chemistry)

Sudarshan Chemical Pvt. Ltd., Pune, India Aug’89 – Dec’90

Analytical Chemist

PROFICIENCY FORTE

 Planning and organising research activities; resolving procedural problems to achieve efficiency, optimization within set time frame as appropriate to research objectives

 Setting up, calibrating, operating and maintaining a variety of laboratory equipment as specified by the requirements of the research study

 Ensuring appropriate procedures and standards for research activities

 Monitoring the research progress and taking necessary actions for the non conformities

 Characterizing all lab prepared compounds, documentation of data, project management, literature updates and report presentations

 Motivating team and imparting continuous on job training for accomplishment for greater research efficiency

 Mentoring students in research programs and guiding students for proposals, projects & schemes.

 Encourage discussions and enhance team spirit for cooperation and sharing information pertaining to team goal

RESEARCH ASSIGNMENTS

 Present work: Reduction of hERG binding affinity of ligand in antidepressant research, in order to reduce cardiac side effects

 Synthesis of antidepressant agent: Synthesized Heterocyclic compounds showed nM activity, which is under Patent filling. Its Chiral (R & S) isomer synthesis was also attempted.

 Chiral separation of anti-depressant: Chiral separation of enantiomers in gram scale using chiral HPLC.

 Anticancer drug design: Synthesis of quinazoline related derivative

 Monitored synthesis of histone deacetylase (HDAc) inhibitors: Synthesis, structural modification, characterization of products and investigation (synthesis of heterocyclic compounds)

 Synthesis of special Donor-Acceptor System of fullerene compounds, multiple adduct synthesis (using Bingel reaction).

 Two projects on medicinal plants:

• Isolation of active anti-diarrhoeal compound from a medicinal plant

• Isolation and characterization of one compound from a medicinal plant, which showed moderate anti-inflammatory activity.

 Gas permeation studies in polyarylates and dispersed polymeric systems

 Synthesis of monomers, additives (liquid crystalline compounds, metal complexes), polymers, Polyarylate Membranes

 Additive dispersed membrane preparation. Determination of their physical properties. Gas permeation studies. Correlation of gas permeability and selectivity with physical properties of membrane.

 Multi-step (15-18 steps) target molecule synthesis: Anti-HIV indolizidine alkaloid, (+)-castanospermine (derivatives) and (-) slaframine alkaloid, attempted using PET (Photo Induced Electron Transfer) Reaction

 Bulk scale resolution of enantiomers of anti-cancer compound using L- tartaric acid derivatives

 Testing of raw, intermediate and finished products

 Raw materials sampling; purity testing of raw materials, intermediate compounds, finished products using instrumental methods & chemical analysis (like Volumetric Titrations and Gravimetric analysis)

ACADEMIC AWARDS

 Council of Scientific and Industrial Research (CSIR) Fellowship Award entailing:

• Junior Research Fellowship Award (1992-1993)

• Senior Research Fellowship Award (1994-1996)

• Eligibility Award of Lecturer in Chemistry

• Award of Excellence for Poster Presentation: 2008 PST Medicinal Chemistry Symposium, April 25-27, 2008, Nan-Tou County.

• Travel Tour Award for 6th International Symposium for Chinese Medicinal Chemists (ISCMC), July 28th, 2008, Shanghai, China.

PERSONAL VITAE

Date of Birth : 5th September, 1965

Present Address : 3F, No. 11, Ln. 104, Guojhong Rd., Yonghe city, Taipei county 234, Taiwan (ROC)

Contact : 008**-*********.

Permanent Address : C/o. Waman V. Bhagwat, 1302, Sadashiv Peth, Shrikrishneshwar Housing Society, Near Godbole Hospital, Pune – 411030, Maharashtra, India, Contact: 020-********.

SOME NEEDED INFORMATION

Relevant Experience : 12 – 14 years after M. Sc.

Total Experience : 20 years after M. Sc.

Notice Period : 1 month

Current Location : Taipei, Taiwan

ANNEXURE – I

KNOWLEDGE PURVIEW

 Medicinal Chemistry:

• Rational drug design according to Traditional Medicinal Chemistry and Computer Modelling (like High Throughput Screening & Fragment Base Drug Design) used as a supportive tool for the discovery in anticancer research

 Organic Synthetic Chemistry:

• Multi-step synthesis: purification, identification, structure elucidation by spectroscopic techniques like TLC, IR, UV, GC, NMR, HPLC, Mass Techniques

• Chiral enantiomer separation in gram scale using semi-preparative Chiral column

• Air-sensitive reactions and reagents handling

• Derivatization of fullerene using Bingel reaction

• Large scale resolution of enantiomers

• Synthesis of organoselenium and organosilicone compounds

 Polymer Membranes:

• Synthesis of monomers and polymers by solution and interfacial techniques

• Synthesis of new polyarylates and their structure elucidation

• Preparation of dense membranes (such as homogeneous & additive dispersed) and measurement of their physical properties for membrane characterization (like density, viscosity, WAXD, DSC, TGA, SEM, Polarized Light Microscopy), gas permeation and selectivity properties of polymer membranes for various gases

• Commercial membrane casting (small scale) and Spiral Modular Process

• Composite membrane preparation

 Phytochemistry:

• Plant drying, powdering; identification of active fraction or compounds by further fractionation and purification using Pharmacological screening, structure elucidation of isolated compounds by physical methods like MP, IR, NMR, Mass Spectroscopy, GC and HPLC techniques

PUBLICATIONS

 Patent related to anti-depression agent is under filling process.

 “Simple, rapid and efficient method of enantiomer separation using semi-preparative HPLC column” (working paper).

 Paper related to patent work (anti-depression work) will be published after patent filling.

 “Specific Stabilization of DNA Triple Helices by Indolo [2, 1-b] Quinazolin-6, 12-Dione Derivatives”

; Bioorganic & Medicinal Chemistry Letters 2007, 17, 1769-1772. Grace Shiahuy Chen, Bhalchandra V. Bhagwat, Pei-Yin Liao, Hui-Ting Chen, Shwu-Bin Lin and Ji-Wang Chern

 “The Barrier Effect of Liquid Crystalline Compound on Gas Permeation Properties of Polysulfone and Polycarbonate Membranes.” B. V. Bhagwat, S. G. Joshi, D. G. Panse, C. R. Rajan, J. Gadgil; (Manuscript shortly communicating to Journal of Scientific and Industrial Research)

 “The Effect of Liquid Crystalline Compound Addition on Gas Transport through Polysulfone and Polycarbonate”; B. V. Bhagwat, S. G. Joshi, D. G. Panse, C. R. Rajan, J. Gadgil;(Working paper).

 “Polyarylates based on Trifluoromethyl Terephthalic Acid: Synthesis and Gas Permeation Studies” B. V. Bhagwat, S. G. Joshi, U. K. Kharul, C. R. Rajan; (Manuscript in progress).

 “Anti-Inflammatory Activity of 5-Hydroxy-6, 7, 8-Trimethoxy Flavone, Alnetin, from the Inflorescence of Thelepaepale Ixiocephala”; D. G. Naik, B. V. Bhagwat, A. Misar, A. M. Mujumdar (Manuscript is ready to communicate for Planta Medica Journal)

PRESENTATIONS

 Posters Presentation:

• “A New Non-Carbohydrate Approach for the Total Synthesis of (+)-Castanospermine”; B. V. Bhagwat and G. Pandey*; IUPAC, (P-Tue-18), Bangalore (1994).

• “Synthesis and Studies on Specific Stabilization of DNA Triple Helices by Indolo [2,1-b] Quinazolin-6, 12-Dione Derivatives”; Bhalchandra V. Bhagwat, Grace Shiahuy Chen, Hui-Ting Chen, Pei-Yin Liao, Ji-Wang Chern*; American Association for Cancer Research- Chemistry in Cancer Research, A Vital Partnership, B19,San Diego, California, USA (February 4-7, 2007).

• “Synthesis of 9- Substituted Tryptanthrin Derivatives and their activity against Different Cancer Cell Lines”; Bhalchandra V. Bhagwat, Grace Shiahuy Chen, Meng-Ling Chen, pei-Yun Liao and Ji-Wang Chern*; ACS, 234th National Meeting & Exposition, Boston, Technical Program/ Medicinal Chemistry Session: 348, (2007).

• “Design and Synthesis of Quinazoline Derivatives as Potent and Selective 5HT2 Antagonist”; Bhalchandra V. Bhagwat, Grace Shiahuy Chen, Ji-Wang Chern*; 2008 PST Medicinal Chemistry Symposium, Nan-Tou County, Taiwan (April 25-27, 2008).

• “Design and Synthesis 2, 6-Dihydro-3H-Imidazo [1,2-c] Quinazolin-5-One Derivative as Potent Antidepressant Agents”; Bhalchandra V. Bhagwat, Grace Shiahuy Chen, Ji-Wang Chern*; 6th International Symposium for Chinese Medicinal Chemists (ISCMC), Shanghai, China (July 28th, 2008).

 Oral Presentation:

• “Synthesis and Studies of 9-Substituted Tryptanthrin Derivatives against Cancer Cell Lines”; B.V.Bhagwat; 2007 TPA Medicinal Chemistry Symposium, Sito, Taiwan (May, 2007).

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