Engineering High School

Padmini Kavuru

***** *** ***** **, *** #***

Tampa, FL 33613

Email: hcezxr@r.postjobfree.com

Contact: 813-***-****

Objective

Seeking for a position in a goal oriented organization where my knowledge, skills and extensive experience will be used for the full advancement and growth of the organization.

Education

•Pursuing Ph. D in Crystal engineering and solid-state chemistry, University of South Florida under Dr. Michael J. Zaworotko’s supervision. (2009-Present, Graduation by Summer 2012)

•Master degree in Inorganic Chemistry (Thesis title: Crystal Engineering of Nutraceuticals), University of South Florida under Dr. Michael J. Zaworotko’s supervision (2007-2008)

•Master degree in Physical Chemistry, Kakatiya University, Warangal, India (2000-2002)

•Bachelor degree of Science in Chemistry, Singareni Women’s College, Kothagudem, India (1997-2000)

•Bachelor degree of Education in Physical Sciences, IASE, Hyderabad, India (Jan 2003-Dec 2003)

Skills

•Sound knowledge in Supramolecular Chemistry and Crystal Engineering

•Screening of new forms such as polymorphs, hydrates, solvates, salts and cocrystals of Nutraceuticals/APIs

•Well acquainted with Cambridge Structural Database (CSD) software

• Experienced in techniques such as: PXRD, TGA, DSC, UV-VIS, FT-IR, HPLC, AAS, various crystallization techniques and basic knowledge in solving crystal structures by Single-crystal X-ray diffraction

•Proficient in most common chemistry related software (ChemDraw, ChemSketch, ISIS/Draw), Microsoft Excel, Word, and PowerPoint

•Ability to handle multiple tasks, working under pressure, good analytical and problem solving skills

Work Experience

Graduate Research Associate (2007-Present):

Design and synthesize novel crystalline forms including cocrystals and other crystalline forms (polymorphs, solvates and hydrates) of natural products (Nutraceuticals) and APIs utilizing supramolecular chemistry and crystal engineering strategies.

Past and current projects:

a)Crystal engineering of Quercetin and Hesperetin and the effect of cocrystallization on the solubility and bioavailability (2007-2008)

b)Multi-component crystalline forms of polyphenols and phenolic acids: Structure-property relationship between solubility-melting point, solubility of API- solubility of cocrystal former and solubility-crystal packing (2009-2010)

c)Design and synthesis of novel forms of Hydrochlorothiazide: Novel crystal forms and their solubility studies (2009-2011)

d)Ionic cocrystals: New crystalline forms of LiNO3 with zwitterions (2010-2011)

e) Pharmaco-kinetic studies of cocrystals (2011-present)

f)Dissolutions of cocrystals utilizing HPLC, UV-VIS and AAS

Graduate Teaching Associate (2007-Present):

Laboratory Instructor for Undergraduates at University of South Florida for General Chemistry I & II and Organic I & II labs

Chemistry Faculty: Jan’04-April’06 (India)

•Worked as an instructor for Chemistry at Singareni Women’s Junior college, Kothagudem, India.

•Worked as an instructor for Physics and Chemistry at Goutham concept school for high school.

Academic Publications

•“2:1 Cocrystals of Homochiral and Achiral Amino Acid Zwitterions with Li+ Salts: Water Stable Zeolitic Metal-Organic Materials (LiZMOMs) and Diamondoid Metal-Organic Materials (LiDMOMs)”. Tien Teng Ong, Padmini Kavuru, Thanhha Nguyen, Ryan Cantwell, Lukasz Wojtas, Michael J. Zaworotko. J Am Chem Soc. 2011, 133 (24), 9224-7.

•“Hierarchy of Supramolecular Synthons: Persistent Hydrogen Bonds Between Carboxylates and Weakly Acidic Hydroxyl Moieties in Cocrystals of Zwitterions”. Padmini Kavuru, Dalia Aboarayes, Kapildev K Arora, Heather D Clarke, Alyssa Kennedy, Lissette Marshall, et al. Crystal Growth & Design, 2010, 10 (8), 3568-3584.

•“Structure Stability Relationships in Cocrystal Hydrates: Does the Promiscuity of Water Make Crystalline Hydrates the Nemesis of Crystal Engineering?” Heather D. Clarke, Kapildev K. Arora, Heather Bass, Padmini Kavuru, Tien Teng Ong, Twarita Pujari, Lukasz Wojtas and Michael J. Zaworotko. Crystal Growth & Design, 2010, 10 (5), 2152–2167.

•“Cocrystals of Quercetin with Improved Solubility and Oral Bioavailability”. Adam J. Smith, Padmini Kavuru, Lukasz Wojtas, Michael J. Zaworotko, R. Douglas Shytle. Molecular Pharmaceutics, 2011, 8 (5), 1867-1876.

•“Hierarchy of Supramolecular Synthons: Supramolecular Homosynthons vs. Supramolecular Heterosynthons in Cocrystals of Polyphenols”. Padmini Kavuru, Heather Bass, Łukasz Wojtas and Michael J. Zaworotko. Crystal Growth & Design. (Manuscript in progress).

Patent Applications:

•“Nutraceutical Cocrystal Compositions”. Michael J. Zaworotko, Heather Clarke, Arora Kapildev, Padmini Kavuru, Roland Douglas Shytle, Twarita Pujari, Lissette Marshall, Tien Teng Ong. PCT Int. Appl. 2008, WO 200-***-**** A2, filed June 6th 2008.

•“Cocrystals of Lithium Salts as Fine-tunable Platforms for Utility as Porous Materials and Active Pharmaceutical Ingredients “.Michael J. Zaworotko, Roland Douglas Shytle, Tien Teng Ong, Padmini Kavuru, Ryan N. Cantwell, Thanhha Nguyen. (Pending)

Research Presentations

• “Designing cocrystals of p-Coumaric acid and Hydrochlorothiazide through crystal engineering approach”. Padmini Kavuru, Lukasz, Wojtas, Michael J. Zaworotko. AAPS Workshop on Emerging Oral Delivery Strategies and Technologies to Enable Biopharmaceutical Performance of BCS II, III and IV Molecules. April 12-13, 2011.

•“Crystal Engineering Nutraceuticals: Use of Caffeic acid as a Cocrystal Former”. Heather Bass, Padmini Kavuru, Michael J. Zaworotko. Florida Annual Meeting and Exposition (FAME), May 14, 2010.

•"Crystal Engineering of Nutraceuticals", Padmini Kavuru, Michael J. Zaworotko., ACS 4th Annual MIM (Meeting In Miniature), March 31, 2007.

Membership:

•American Chemical Society member (ACS)

•American Association of Pharmaceutical Scientists (AAPS)

References and official documents are promptly available upon request.

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