Manager Project

CURRICULUM VITAE

K.K. SREE GANESH Mobile No. : 097********

Email ID: ************@*****.***

OBJECTIVE

To work in a globally competitive environment on challenging assignments that shall yield the twin benefits of the job satisfaction and steady paced professional growth firm.

EXPERIENCE PROFILE

Presently working as Junior Manager in Common Resource Analytical Advanced Instruments (CRAAI) Analytical R&D, IPDO for Dr. Reddy’s Laboratories Ltd., Hyderabad since July-2007 to till date.

Worked in Research & Development (Synthesis), Center of Excellence (COE), API, Dr. Reddy’s Laboratories Ltd., Hyderabad from Jan-2007 to June-2007.

PRESENT EXPERIENCE

Organization : Dr.Reddy’s Laboratories Ltd., IPDO, Bachupally.

Designation : Junior Manager

KEY ROLES & RESPONSIBILITIES

Isolation of drug process related impurities, degradants, Chiral, potential impurities and intermediates by using Preparative and Flash Chromatography.

Characterization of the isolated compounds by UV, IR, Mass, Proton, Carbon, 2D NMR, XRD and Thermal Techniques.

Developing HPLC methods and mass compatible methods.

Performing dissolutions and evaluating sink conditions for ER, DR, MR formulations using USP Type III and IV dissolution apparatus.

Evaluating intrinsic solubility of drugs prior to preformulation drug design by using intrinsic dissolution.

Preparing Certificate of Analysis for the isolated and characterized impurities.

Preparation of SOP’s for the chromatography and dissolution apparatuses.

Maintaining GLP compliance in the working area.

PREVIOUS EXPERIENCE

Organization : Dr.Reddy’s Laboratories Ltd., IPDO, Bachupally.

Designation : Senior Executive

KEY ROLES & RESPONSIBILITIES

Synthesis and Optimization of Active Pharmaceutical Ingredient.

Purification of synthesized compounds by recrystallization, Fractional distillation, Liquid-Liquid extractions, TLC and column chromatography.

Maintaining lab record note book and ensure lab compliance.

INSTRUMENTS HANDLED

Handling of HPLC, UPLC, TLC, preparative HPLC and Flash Chromatography.

USP Type I, II, III & IV and Intrinsic dissolution apparatus.

UV & FT-IR Spectrophometer.

PROFESSIONAL ACHEIVEMENTS

Isolated 96 impurities and unambiguously structural elucidation and conformation done for

41 impurities and synthesized compounds.

Isolated a conjugated estrogen impurity for addressing a deficiency for USFDA DMF filling.

Isolated eight isomers by chiral method to address USFDA deficiency.

USFDA deficiency came for pseudophedrine HCL to revalidate the method by Ephedrone Impurity. Ephedrone is highly unstable impurity. Ephedrone is prepared by synthetic way for online method validation.

Isolated six unknown impurities of Dexlansoprazole formed during stability study for USFDA DMF filling.

Isolated four unknown impurities of Esomeprazole for method validation for DMF filling.

Isolated three impurities of Sirolimus for DMF filling.

Isolated three impurities of Atrovastatin for method validation to address deficiency from USDFA.

To address an USFDA deficiency a discriminating method was developed by USP Type III dissolution apparatus for Fluoxetine HCl.

To address an USFDA deficiency a discriminating method was developed by USP Type IV dissolution apparatus for Azacytidine.

Screened several polymorphs and batches of Irbesartan by intrinsic dissolution and found the suitable form for formulation scale up process.

Developed a single mass compatible method for Esomeprazole degradants.

PUBLISHED MANUSCRIPT

1) Bandaru.Venkata Subbaiah a*, K.K.Sree Ganesh a, G.Vamsi krishna a, K.Vyas a, R. Vasu Dev b, K. Subramanyam Reddyc .Isolation and characterization of degradant impurities in dipyridamole formulation. J Pharm Biomed Anal. 2012 Mar 5;61:256-64.

2) Satheesh .B ab*, Sree Ganesh .K.K a, Saravanan.D b. Simultaneous RP-HPLC Quantification of Desloratadine and Montelukast sodium in a Tablet Formulation. Res. J. Chem. Environ., Volume 15, No. ( 2 ) June (2011) Pages 815-818.

ACCEPTED MANUSCRIPT

1) L Kalyanaraman ab*, K.K. Sree Ganesh a, R Mohan Kumar c, R Pichai b, S Narasimhan c, K. Vyas a .An NMR and LC-MS based Mixture Analysis approach for structural elucidation of antimicrobial derivatives of Calophyllolide. Journal of Liquid Chromatography & Related Technologies.

2) Satheesh.B 1, 2*, Sree Ganesh .K.K 1, Saravanan.D 2. Identification, isolation & characterization of an unknown impurity of vernicline. Scientia Pharmaceutica.

MANUSCRIPT UNDER REVIEW

1) Satheesh.B 1, 2*, Sree Ganesh .K.K 1, Saravanan.D 2. Simultaneous determination of Tadalafil and its related compounds in pharmaceutical dosage forms by UPLC. Journal of Liquid Chromatography & Related Technologies.

2) L Kalyanaraman *, K.K. Sree Ganesh , R Mohan Kumar §, R Pichai , S Narasimhan §,

K. Vyas . Electrophilic aromatic substitution reactions of calophyllolide. Journal of Natural

products research.

3) L Kalyanaraman *, K.K. Sree Ganesh , R Mohan Kumar §, R Pichai , S Narasimhan §,

K. Vyas . Characterization of a bioactive derivative of Calophyllolide by 2D NMR and LC-MS/MS. Natural product communication.

4) B. Venkata Subbaiah a *, K.K.Sree Ganesha, Lakkireddy Prakasha, K. Subramanyam Reddyc . Preparative isolation and UPLC-ToF MS identification of eight degradants from stressed tablets of Esomeprazole. Journal of Liquid Chromatography & Related Technologies.

5) Satheesh. B a, b *, Sree Ganesh .K.K b, Saravanan. D a, Ramakant. K.Gundu b and Sivananthan Sivaraman b.Quantification of Flupirtine and its related compounds in pharmaceutical dosage forms by UPLC. Journal of Liquid Chromatography & Related Technologies.

6) Satheesh. B a, b *, Sree Ganesh .K.K b, Saravanan. D a, Ramakant. K.Gundu b and Sivananthan Sivaraman b. Simultaneous determination of Ilaprazole and its related compounds in pharmaceutical dosage forms by UPLC. Journal of Liquid Chromatography & Related Technologies.

ACADEMIC PROFILE

M.Sc., Tech. Pharmaceutical Chemistry from BITS Pillani, Rajasthan (2007-2010) with aggregate of CGPA 8.9 (work intergrated course).

B.Sc., Bio-Chemistry from Bharathidhasan University (2003-2006) with the aggregate of 69%.

HSC from R.C.Hr.Sec.School (2003) with the aggregate of 75%.

SSLC from R.C.Hr.Sec.School (2001) with the aggregate of 78%.

PROJECT WORK

Title : “Synthesis and characterization of an advanced key intermediate of

Ritanovir and Lopinavir”

Place : Dr.Reddy’s Laboratories Ltd., IPDO, Bachupally, Hyderabad.

PERSONAL STRENGTHS

Quick learning and adopting capabilities

Good leadership qualities and excellent communication skills

Ability to work in a team as well as acting upon own initiative

Discipline and positive attitude with high sense of responsibility

Optimistic and high degree of patience to understand the chemistry and to act upon

Flexible to work according to the organization requirements

TECHNICAL SKILLS

Familiar with Chem-Draw and SciFinder applications.

Good command over Ms-Office: Word, Power Point, Excel etc.

Installation of softwares and hardware tools.

PERSONAL PROFILE

Name : K.K.Sree Ganesh

Date of birth : 01-05-1986

Father Name : G.Kalyanaraman

Martial Status : Single

Nationality : Indian

Religion : Hindu

Languages Known : Tamil, English and Telugu

Address for Correspondence : LIG. 193, Road No.2 (Pent House),

Phase-I, KPHB Colony,

Hyderabad-500072,

Andhra Pradesh, India.

DECALARATION

I hereby declare that the information furnished above is true and correct to the best of my knowledge.

Place : (K.K.Sree Ganesh)

Date : Signature

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