scientist
Resume:
Yaquan Sun (Permanent Resident)
West Chester, PA 19380
*********@*******.***
610-***-****(cell)
OBJECTIVE: Seeking a scientist position in organic synthesis/medicinal chemist position at industry
EDUCATION
• Postdoctoral Research Associate , Catholic University of American, Washington DC, 2003~2005
• Ph. D., Chemistry, Zhejiang University of Technology, Hangzhou, P.R. China, 2003
• B. A., Chemistry, Yancheng Teacher’s University, Yancheng, P.R. China, 1986.
SUMMARY OF SKILLS
• In-depth knowledge in organic theory, organic reactions, reaction mechanism and their applications.
• In-depth knowledge in chemical composition, structure, and properties of substances and chemical process and transformations undergone.
• Strong experience in organic synthesis, hetercyclo-compound synthesis, multistep synthesis, parallel synthesis,compound purification and characterize structure.
• Strong experience in optimizing multistep reaction process and provide the scale-up procedure.
• Strong experience in current Good Laboratory Practice (cGLP).
• Proficient in drug design by QSAR, characterization, synthesis and separation of drug metabolism product.
• Hands-on experience in using various laboratory instruments and techniques such as UV-Vis, HPLC, GC, 1D&2D NMR, FT-IR, UV, TLC, LC/MS.
• Language: Fluent in both English and Chinese.
EXPERIENCE
2005-Present: Research Scientist & Senior Scientist, Organic/Medicinal Synthesis Department, Othera Pharmaceuticals Inc.
Study on Drug Design and Synthesis
• Conduct research on drug design and synthesis of new drug target series compounds
• Optimized the process procedure of OT304 for cGLP
• Supervise manufacture of OT304 in 25 kg scale
• Optimization of process chemistry of OT730 and OT551 for cGLP
• Synthesis of metabolism product of drug candidate of OT551
• Synthesis of the intermediates of Othera drug candidates and optimize the chemical process
• In charge of maintaining NMR, IR
August 2003 – August 2005: Postdoctoral Research Associate, Department of Chemistry, The Catholic University of America
Study on drug design and synthesize new kind of β-blocker for treatment for Glaucoma
• Conduct research on drug design and synthesis
• Optimize chemical reaction procedure for process chemistry and chemical manufacture
• Work in pharmaceutical research and development for cGLP under FDA guideline
September 1998 – May 2003: Research Assistant, College of Pharmacy Science, Zhejiang University of Technology PR China
Study on Synthesis of 3,6-Dialkyl-s-Tetrazine Derivatives and its’ Structure - Activity Relationship of Anti-tumor
• Conducted research on structure-activity relationships of a new kind of s-tetrazine compounds for anticancer drug candidate.
• Created a protocol for green synthesis of chloroformate
• Find a way to make non-patent medicine-fluoxetine
AFFILIATIONS
• American Chemical Society (ACS)
PUBLICATIONS
(1) Synthesis and identification of the primary degradation products in a clinical ophthalmic formulation using NMR, MS, and a stability-indicating HPLC method for OT-551(submitted to ACS)
Yaquan Sun, Weixing Li, Marina Senko, Xiaowen Yang, Ghanshyam Patil (Submitted)
(2) Stability Indicating High Performance Liquid Chromatographic Assay for the Determination of OT-551.HCl in Bulk and in Formulations Marina Senko, Xiaowen Yang, Weixing Li, Yaquan Sun, Ghanshyam Patil (submitted to ACS)
(3) An eye drop solution formulation development of OT-551: A Topically Administered Therapeutic Candidate in Clinical Trials for the Treatment of Age-Related Macular Degeneration Asish Dutta, Marina Senko, Weixing Li, , Xiaowen Yang,Yaquan Sun, James Zhou, Ghanshyam Patil (submitted to ACS)
(4) An eye drop suspension formulation development of OT-551: A Topically Administered Therapeutic Candidate in Clinical Trials for the Treatment of Age-Related Macular Degeneration Marina Senko, Asish Dutta, Weixing Li, , Xiaowen Yang,Yaquan Sun, James Zhou, Ghanshyam Patil (submitted to ACS)
(5) Cyclodexin containing an eye drop solution formulation development of OT-551: A Topically Administered Therapeutic Candidate in Clinical Trials for the Treatment of Age-Related Macular Degeneration Asish Dutta, Marina Senko, Weixing Li, , Xiaowen Yang,Yaquan Sun, James Zhou, Ghanshyam Patil (submitted to ACS)
(6) “Convenient preparation of 3,6-dialkyl-1,6-dihydron-s-tetrazine” in Synthetic Communication, Vol.33 (16):2769~2775, 2003;
(7) “Crystal structure of N, N’-Diphenyl-3, 6-Diethyl-1, 4-Dihydro-S- tetrazine-1,4-Dicarboamide ” in Chinese Journal of Structure Chemsitry, Vol. 23(1):53~55, 2004;
(8) “Study on the catalytically rearrangement of 1,6-dihydro-S- detrained and its reaction, Ⅱ，reaction with diphosgene ” in Chinese Journal of Synthetic Chemistry, Vol. 10(5):400-404, 2002;
(9) “Crystal structure of N, N’-Diphenyl-3, 6-Dimethyl-1,4-Dihydro- S-tetrazine-1,4-Dicarboamide ” in Chinese Journal of Structure Chemistry, Vol. 21(6):663-666, 2002;
(10) “Synthesis and Crystal Structure of N, N’-Bis-m-Tolyl-3,6-Dimethyl- 1,4- Dihedron-s- Tetrazine-1, 4- Dicarbonamide” in Chinese Journal of Organic Chemistry, Vol. 23(5):483-487, 2003;
(11) “Synthesis and antitumor activity of s-tetrazine derivatives” in Bioorganic & Medicianl Chemistry Letters Vol. 14:11 77~1181, 2004;
(12) “Study on the Catalytically Rearrangement of 1,6-Dihydro-Tetrazine and It’s Reaction” in Chemical Journal Chinese Universities, Vol. 23(10):1877~1881, 2002;
(13) “The Crystal Structure of 10-(2’, 5 ’-Dimethoxybenzylidene)Anthrone” in Chinese Journal of Structure Chemistry, Vol. 22(6):653-656, 2003;
(14) “Preparation of chloroformates using bis (trichloromethyl)carbonte ” in Journal of Chemical Research,10:708~709, 2004;
(16) “Conformational control of spin state in iron (II) tripodal inidazole complexes” in Inorganica Chimica Acta (Inorg. Chime. Act) Vol 358(12) 3441-3448, 2005;
(17) “Synthesis and anti-tumor activity of N,N’-Bis(substitutedphenyl)-3,6-dialkyl-1,4-dihydro-s-stetrazine-1,4-dicarboxamide ” in Journal of Chemical Research, 2:91~93, 2005;
(18) “Primary Screen on Insect bioactivity of s- tetrazine ” in Chinese Journal of Synthetic Chemistry, Vol. 12(5):468-472, 2005;
(19) “Synthesis of 1-(2-pyridyl) peperazine” in Chinese Journal of Pharmaceutical Industry, Vol. 32(3):133-133, 2001;
(20) “Study on synthesis of 2-bromo-3,4-dihydro-N-hydroxyl-Naphthalinimine ” in Journal of Zhejiang University of Technology (Natural Science), Vol.29(3):272-274, 2001;
PRESENTATIONS
1st Chinese Excellence Doctorial Candidate’s Academia Meeting Shenzhen, Nov. 12-16 2002 Title: “Study on Synthesis, Mechanism, and Antitumor Activity of Dihydro-s-Tetrazine’s derivatives”
11th Chinese Catalytical Academia Meeting Hangzhou Oct. 15-20, 2002. Title: “Study on synthesis of 1, 6-dihydro-s- tetrazine and its reaction”
2nd Chinese Organic Academia & 1st Chinese Chembiology Academia Meeting Hangzhou, Nov. 11-15 2001. Title: “Study on the catalytically rearrangement of 1, 6-dihydro-S- tetrazine and its reaction, Ⅱ，reaction with diphosgene”
2nd Chinese Organic Academia & 1st Chinese Chembiology Academia Meeting Hangzhou, Nov. 11-15 2001. . Title: “Study on the Catalytically Rearrangement of 1, 6-Dihydro-Tetrazine and its Reaction”
REFERENCES
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