Synthetic organic/medicinal chemist.

SUMMARY

I am an exceptional researcher with a Ph.D. in Medicinal Chemistry with major focus on synthetic organic chemistry and more than three years of post-doctoral experience in the same. I have expertise in purification techniques like chromatography, dialysis and analytical techniques like HPLC, LC-MS, and characterization of organic compounds using MS, UV-VIS, IR, 1D and 2D NMR. I also have expertise in molecular biology techniques, protein expression and conducting biological assays, cellular uptake and in vitro metabolic studies.

EDUCATION

• Ph. D in Medicinal Chemistry from University of Rhode Island, Kingston RI (August 2008). Advisor: Dr. Keykavous Parang

• Master of Pharmaceutical Chemistry from Hamdard University, Delhi; INDIA (August 2004). Advisor: Dr. Mohd. Amir

• Bachelor of Pharmacy from Meeruth University, INDIA (May 2001).

SKILLS

• Synthetic organic chemistry: multi-step solution and solid phase synthesis of small molecules, peptides and heterocyclic compounds; structure activity relationship and rational drug design.

• Purification processes: recrystallization, dialysis, column chromatography (normal and reverse phase, size exclusion, ion-exchange, affinity column), preparative TLC, HPLC and FPLC.

• Characterization techniques: MS, MALDI, 1D and 2D NMR (1H, 13C, 31P, 11B) UV and FTIR.

• Analytical techniques: Analytical HPLC, TLC and LC-MS.

• Radiolabeled materials handling experience with 3H and 32P.

• Software expertise: Chem-office, Autodock, Sybyl, Gaussian, Surflex, FlexX, Discovery Studio.

• Biochemistry techniques: protein expression and purification, western blotting, gel electrophoresis, bacterial/cell culture; in vitro assays, cellular uptake and enzyme kinetic studies.

• Literature and database search. Biochemical data analysis

RESEARCH EXPERIENCE

Senior Researcher–W. Tjarks, Ohio State University Jan. 2011 to Present

• Synthesis of folate conjugates of Iodo-carboranyl amines and catalytic (radio)halogen exchange.

• In vitro metabolic studies using 3H-substituted carboranyl thymidine analogues.

Post-Doctoral Researcher–W. Tjarks, Ohio State University April 2009 to Dec. 2010

• Synthesis of carboranyl alkyl amines and N3-substituted carboranyl thymidine analogues.

• Isolation and purification of protein hTK1 using His-tagged Ni-affinity column.

• Biological screening of synthesized compounds in presence of hTK1 and enzyme kinetics studies.

Post-Doctoral Fellow–K. Parang, University of Rhode Island Sept. 2008 to Feb. 2009

• Synthesis of anti-HIV Nucleoside conjugates of polyglutamic acid

• Synthesis of Dextran conjugate of 5-flurodeoxyuridine for site specific drug delivery to the liver

Graduate Research–K. Parang, University of Rhode Island Sept. 2004 to Aug. 2008

• Synthesis of fatty acyl esters of nucleoside (FLT, AZT, 3TC and FTC) as anti-HIV agents.

• Solid phase synthesis of nucleosides, nucleotides and peptides.

• Bioconjugation of nucleosides on different polymers (cellulose sulfate and suramin, dextran).

• Peptides bioconjugation on dextran for site specific drug delivery.

• Synthesis of peptide prodrugs of FLT and AZT for targeted drug delivery as anti-HIV agents.

Hamdard University, INDIA Sept. 2003 to Aug. 2004

• Synthesis and biological evaluation indazol and pyrazol derivatives as anti-inflammatory agents.

MANAGEMENT SKILLS

• Mentored > 10 students and Post-docs: Supervised and mentored many undergraduates, graduates and post-docs with the concepts of medicinal chemistry and associated research work.

• Teaching Experience: Supervised and aided Pharm D. students of P1-P3 level for Pharmaceutical Technology lab, Medicinal chemistry lab and respective courses.

HONORS

• ACS Professional Development Scholarship 2012 (243rd ACS San Diego).

• YCC Leadership Development Award for January 2012, ACS Leadership Institute, Texas.

• ACS Professional Development Scholarship 2011 (242nd ACS Denver).

• William Potter Prize, 2005-2006, University of Rhode Island.

• Graduate research assistantship, 2004-2005, USAID-CONRAD.

• AICTE-Scholarship, 2002-2004, All India Council of Technical Education.

PROFESSIONAL PUBLICATIONS AND PRESENTATIONS

Patents

• Doncel, G. F., Parang, K., Agarwal, H. K. Substituted nucleoside derivatives with antiviral and antimicrobial properties. PCT Int. Appl. (2009), 96pp. CODEN: PIXXD2 WO 200-***-**** A2 20090115 Application: WO 2008-US69571 20080709.

Key Publications (total 15 publications)

1. Agarwal, H. K., Chhikara, B. S., Doncel, G. F., Parang. K. Synthesis and Anti-HIV Activities of Glutamate and Peptide Conjugates of Nucleoside Reverse Transcriptase Inhibitors. J. Med. Chem., 2012, 55, 2672-2687.

2. Tiwari, R., Toppino, A., Agarwal, H. K., Hua, T., Byun, Y., Gallucci, J, Hasabelnaby, S., Goudah, A., Darby, M. V., Barth, R. V., and Tjarks, W. Synthesis, Biological Evaluation, and Radioiodination of Halogenated Closo-Carboranyl Thymidine Analogues. Inorg. Chem., 2012, 51, 629-639.

3. Agarwal, H. K.*, Ricks, K. G., Buszek, B., Tjarks. W. Synthesis of closo-1,7-carboranyl alkyl amines. Tetrahedron Letters, 2011, 52, 5664-5667. (As corresponding author)

4. Agarwal, H. K., Loethan, K., Mandal, D., Gustavo, D. F., Parang, K. Synthesis and Biological Evaluation of Fatty Acyl Ester Derivatives of 2 , 3 -Didehydro-2 ,3 -Dideoxythymidine. Bioorg. Med. Chem. Lett. 2011, 7, 1917-1921.

Oral and poster presentations. Presented eleven times at national and local levels.

Reference: At linkedin Profile: http://www.linkedin.com/pub/hitesh-agarwal/b/737/238

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