Biochemist

Curriculum Vitae

Jason Michael Carte

Contact Information

**** ***** ****** *****

Athens, GA 30605

Phone: 912-***-****

E-mail: *******@***.***

Education

August 2006-December 2009 M.S. Biochemistry and Molecular Biology, The University of Georgia

August 2002-May 2006 B.S. Biology, minor in Chemistry, Georgia Southern University

Research Experience

I have spent the last three years investigating a recently discovered defense mechanism present in many prokaryotes that functions to protect the organisms against phages and other genome invaders known as the CRISPR-Cas system. I have identified and characterized a novel endoribonuclease, Cas6, from the hyperthermophilic archaeon Pyrococcus furiosus that cleaves long precursor RNAs into short, invader targeting CRISPR RNAs. I designed and optimized assay conditions that allow simultaneous detection of substrate binding and cleavage activity. In addition, I have determined several key catalytic features of the enzyme, including the requirements for substrate recognition as well likely catalytic amino acids. During my graduate career I also played an active role in training and mentoring a number of undergraduates and junior graduate students.

Publications

Carte, J, R. Wang, H. Li, R. Terns, and M Terns. Cas6 is an Endoribonuclease that Generates Guide RNAs for Invader Defense in Prokaryotes. Genes Dev 2008, December 15; (22)24: 3489-96.

Teaching Experience

Biology 1103L: Introduction to Cell and Molecular Biology lab for non-science majors. I designed assignments including quizzes, gave lectures, led class discussions, graded all assignments, and determined final grades.

Biology 1104L: Introduction to Organismal Biology lab for non-science majors. Same responsibilities as above.

Misc.

Winner, Harry Peck Research Award, Department of Biochemistry and Molecular Biology, University of Georgia, August 2009

Cas6 endoribonuclease and methods of use, patent pending

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