Assistant Medical
Resume:
AIDA GISEL HOWELL
Whitehouse Station, NJ 08889
908-***-**** (home), 908-***-**** (cell)
******@**********.***
Education: M.S. Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS, 1999. Thesis advisor: Andrew Parkinson.
M.S. Health Science, Purdue University, West Lafayette, IN, 1983.
B.S. Nuclear Medicine Technology, University of Puerto Rico, San Juan, PR, 1980.
Clinical Research Experience:
1) Served as liaison between Biophysica, KUMC and contract laboratories to discuss the FDA preclinical requirements for IND submission.
2) Collected, stored, analyzed and disposed of human radioactive urine.
3) Drew serial blood samples from breast and prostate cancer patients.
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4) Created charts to assess patient pain level. Collected data from patients on a monthly basis and assessed their drug response and progress.
5) Analyzed data from cancer patients and presented to Doctors and staff (KUMC) and contract laboratory personnel.
6) Review medical literature and journals to maintain staff informed of recent developments.
7) Wrote SOP for clinical studies to be conducted. For example, Wrote the SOP to investigate the gastric-emptying time of Parkinsonians’ patients using L-DOPA.
Computer Experience:
Knowledgeable in the use of Microsoft Word, Powerpoint, and Excel. Knowledgeable in Internet Explorer.
Work Experience:
10/00- 4/03 Research Associate (part time), Drug Discovery, Johnson and Johnson Pharmaceuticals, Raritan, NJ
Conducted receptor binding assays for alpha1 and alpha2 adrenergic receptors in support of drug discovery.
8/97- 12/99 Biology Instructor, University of San Diego, San Diego, CA
Taught Biology courses for Biology majors and non-major students. The non-major course was a survey review of Biology.
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The major course was a survey lab in which techniques, ranging
from the most basic (such as pipetting and weighing) to more complex (such as DNA isolation, cutting and identification) were taught.
7/95 - 8/96 Senior Research Assistant, Biophysica Foundation, San Diego, CA
Was in charge of the planning and execution of all in vivo and in vitro studies as well as the analysis and reporting of all data to the president of the company. Developed animal models to evaluate the effectiveness of our drug against human breast, ovary, lung, colon, prostate and kidney cancers. Studied the effect of our drug given concomitantly with other anti-cancer agents for the treatment of prostate cancer.
October, 1990 Consultant for Environmental Standard Company, Valley Forge, PA
Reviewed document about zinc disposition and accumulation of ground waters of Cayey, PR. Translated this document from English to Spanish and presented it in a public hearing in San Juan, PR.
01/89 - 08/89 Research Assistant, Pharmacology Department Wyeth-Ayerst Research, Princeton, NJ
Developed screening methods to evaluate the induction of Interleukin-1 by anti-inflammatory drugs in mice using Western Blot analysis and gel electrophoresis techniques.
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1986 - 1988 Graduate Student, Dept. of Pharmacology, Toxicology and Experimental Therapeutics, Univ. of Kansas Medical Center, Kansas City, KS
Conducted research to elucidate the role that alterations of the glucocorticoid receptor gene might play in the development of lung neoplasia. Demonstrated that both glucocorticoid receptor
mRNA isoforms (3.5 and 5.0 kD) are equally expressed in normal and cancerous lung cells.
1985 -1986 Research Assistant, Nuclear Medicine Department Univ. of Kansas Medical Center, Kansas City, KS
Participated in Phase II and III studies using Strontium-89 for palliative treatment of pain caused by metastatic bone tumors due to primary prostate and breast cancers. Studied patient response to treatment by evaluating forms on which patients logged their daily degree of physical activity, appetite and overall mental and physical state. Our study showed that
Strontium-89 reduced the amount of pain and improved the overall health of the patients. In addition, we observed that the earlier the intervention with Strontium-89 in the course of the patient’s disease, the faster these patients experience relief from pain.
Participated in the evaluation of the long-term effect of L-DOPA therapy on stomach emptying time and bowel transit time of food and drugs in Parkinsonian patients. Responsibilities included organization and supervision of eight technicians performing emptying time studies and blood and urine collection.
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1984 -1985 Technical Support, Biomedical Research Laboratories, Overland Park, KS
Preparation of estrogen and progesterone receptor material from rabbit uterus to be sold by the company as a standard for estrogen and progesterone receptor studies. Biodistribution studies in tumor-bearing rats and rabbits in the evaluation of an Iodine-123 estrogen derivative for the early diagnosis of mammary tumors. Development of a quality control program
that served over twenty scientific laboratories in the United States.
01-05 1983 Teaching Assistant, Anger Camera Laboratory
Purdue University, West Lafayette, IN
1981 -1982 Health Physics Technician, Radiation Safety Office
Purdue University, West Lafayette, IN
Monitored low and high energy isotopes in laboratories by conducting wipe tests and used Geiger Counter and "Cutie Pie" counter. Picked up and incinerated low level radioactive waste.
1980 -1983 Graduate Student, Health Science Department, Purdue Univ.
Biodistribution studies with Selenium-75 labeled estriol derivative for the early diagnosis of mammary tumors in rats
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Laboratory Experience:
1) Receptor binding assays for alpha1 and alpha2 adrenergic receptors
2) Isolation of estrogen and progesterone receptor material from rabbit uterus
- competitive binding assay - RIA
3) Expression of glucocorticoid receptor gene in mouse lung cells
- Northern blot analysis - autoradiography
- Southern blot analysis - hybridization
- nick translation - gel electrophoresis
- plasmid preparation - spectrometry
- mini preps - beta counting
3) Screening methods for the quantification of Interleukin-1 in mice
- Western blot analysis - gel electrophoresis
4) In vivo efficacy studies with anti-cancer drugs
- Cell culture of normal and cancer cells
- Handling of nude mice
- Induction of tumors in nude mice using human tumor cells (prostate, breast, ovary, kidney and non-small lung)
- Tumors passage using tumor fragments
5) Induction of mammary tumors in rats using dimethyl-benzanthracene (DMBA)
6) Biodistribution studies in rats and rabbits
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Supervised five to eight technicians and was responsible for their performance and well-being.
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