Quality Control Assurance
Resume:
Daniel J. Rabinowitz, M.S.
**** ***** *****, ********** **, 30004
E-mail: **********.**@*****.*** Phone: 561-***-****
Education
o Georgia State University – Atlanta, GA
M.S. in Analytical Chemistry 2006-2008
Thesis Topic: “Electrode Potentials of Substituted Anthraquinones”
The objective of MS research was to synthesize an anthraquinone derivative with a substitution group that would yield the least negative redox potential value and could undergo photo-induced electron transfer in DNA.
o Barry University – Miami Shores, FL
B.S. in Chemistry, 2004-2006
Research Topic:” Betacyanins from Bougainvillea spectabilis, natural food colorants and antioxidants”
The objective of BS research was to isolate and quantify the concentration of Betacyanins in the bracts of Bougainvillea spectabilis by using negative-ion exchange and HPLC analysis.
o Florida State University – Tallahassee, FL
Major: Chemistry, 2002-2004
Summary of Qualification and Experience
Daniel Rabinowitz obtained his M.S. degree from Georgia State University with a major in Analytical/Physical Chemistry. He has five years of laboratory experiences with analytical chemistry, microbiology, biochemistry, statistics, physical chemistry and instrumental analysis. In 2008, he joined the Nutritional Biomarkers Laboratory at CDC. He is currently involved in the analysis of vitamins (folate, methylmalonic acid and vitamin B12), iron status and inflammation indicators (ferritin, soluble transferrin receptor, C-reactive protein), electrolytes (sodium, potassium, chloride), and creatinine for NHANES and other studies to provide novel information on nutritional status.
Work/Research Experience
Associate Service Fellow/Researcher/Analytical Chemist (Feb 2012- current) Centers for Disease Control and Prevention, Nutritional Biomarkers, Branch, Division of Laboratory Sciences, Atlanta, GA 30341
o Assisted in research, development, validation and implementation of quantitating methylmalonic acid in serum.
o Proficient with and maintained the maintenance for the following instrumentation: Agilent HPLC, API-4000 MS/MS, Gilson, Tecan, Hamilton, Hitachi Mod PE, Thermo Vantage/Quantum, Perkin-Elmer Janus Multiprobe Instrument and GC-MS/MS.
o Independently worked on four routine projects: Folate Microbiological assay, Hitachi Modular PE, Methylmalonic acid and dried blood spot.
o Proficient in the analysis of biological samples from the National Health and Nationalization Examination Survey (NHANES).
o Communication with service technicians and team leads for trouble shooting instrument issues.
o Familiar with and successfully performed in proficiency programs (College of American Pathologists (CAP), United Kingdom National External Quality Assurance Survey (UKNEQAS), National Institute of Standards and Technology (NIST)) for four years.
o Participated in the training of scientists from international and national laboratories.
o Provided consultation to junior scientists at the University of Minnesota for dried blood spot and folate microbiological assay.
o Assisted in the preparation of large quality control pools.
o Set up and validated kit assays and new instrumentation.
o Adhered to CDC/NCEH/DLS and CLIA 88 (regulatory/quality) guidelines with regard to laboratory protocols and quality control.
o Adhered to the CDC/NCEH/DLS policy of treating all data as confidential.
o Responsible for ordering and taking inventory of the general laboratory supplies.
Technician Specialist (Aug 2009 – Feb 2012) Battelle Contractor, Nutritional Biomarkers Branch, Division of Laboratory Sciences, Centers for Disease Control and Prevention, Atlanta, GA 30341
o Fully responsible for four NHANES projects: folate by microbiologic assay, analysis of vitamin B12, ferritin/soluble transferrin receptor (sTfR) and sodium, potassium, chloride and creatinine by clinical analyzer.
o Conducted method validation experiments for the folate dried blood spot microbiologic assay and then applied this assay to 800 dried blood spot samples from the Lymphocytic Leukemia Study to measure hemoglobin-folate concentrations.
o Participated in providing laboratory training and consultation for the folate microbiological assay to five groups of scientist from national and international laboratories.
o Participated in the production and characterization of large quantities of quality control pools for methods such as folate LC-MS/MS, folate microbiologic assay, methylmalonic acid and for the ELISA assay.
Guest Researcher (ORISE fellow) (July 2008 – Aug 2009) Oak Ridge Institute for Science and Education, Nutritional Biomarkers Branch, Division of Laboratory Sciences, Centers for Disease Control and Prevention, Atlanta, GA 30341
o Utilized training acquired from team leader and manufacturer to conduct analysis of folate for NHANES and other studies by microbiologic assay and by LC-MS/MS.
o Imported laboratory data into laboratory information system database, LIMS.
o Successfully participated in proficiency testing exercises (UK NEQAS) and conducted internal calibration verification exercises using reference materials from NIST and NIBSC.
o Participated in the development and validation of the quantitation of hemoglobin-folate concentration in dried blood spots.
Graduate Student, Chemistry Department, Georgia State University, Atlanta, GA (Aug 2006 – May 2008)
Assistant
o Provided assistance to undergraduate chemistry students in weekly laboratory setting.
o Graded lab reports.
o Promoted safe laboratory practices.
Training courses (July 2008-– Present)
o Thermo TSQ basic and advanced user training (July 18-21, 2011).
o Hitachi Modular PE (July 11-16, 2010).
o API Instrument Systems and Analyst Software (Jan 27th 2009).
o Techniques on modern HPLC, Agilent HPLC 1100/2200 and Chemstation software (Dec 2-5, 2008).
o Gilson and Trilution software (Nov 6, 2008)
o Hamilton Starlet lab training on instrument operation, programming, maintenance and method script writing using Microlab Vector 4.0 Star software (Oct 18-19, 2008).
o All required safety courses for CDC and Battelle (July 2008 – Present)
Peer-Reviewed Publications
o Yu Cao, Daniel J. Rabinowitz, Dabney W. Dixon, and Thomas L. Netzel “Synthesis, Electrochemistry and Hydrolysis of Anthraquinone Derivatives” Synthetic Communications 2009, 39 (23), pp. 4230 – 4238.
Manuscript in preparation:
o Reham A. I. Abou-Elkhair, Daniel J. Rabinowitz, Dabney W. Dixon and Thomas L. Netzel “Synthesis and Electrochemistry of Anthraquinone and Their Nucleosides”.
Acknowledged of contribution:
o Christine M. Pfeiffer, Jeffery P. Hughes, Ramon A. Durazo-Arvizu, et.al “Changes in Measurement Procedure from a Radioassay to a Microbiological Assay Necessitate Adjustment of Serum and RBC Folate Concentrations in the U.S. Population from the NHANES 1988-2010” Journal of Nutrition 2012 May, 142(5), pp. 894-900.
o Christine M. Pfeiffer, Jeffery P. Hughes, David A. Lacher, et.al “Estimation of Trends in Serum and RBC Folate in the U.S. Population from Pre-to Post fortification Using Assay-Adjusted Data from the NHANES 1988-2010” Journal of Nutrition 2012 May, 142(5), pp. 886-893.
o Ekaterina Paliakov, Mindy Zhang, and Christine Pfeiffer, “Analysis of Serum Methylmalonic Acid by LC-MS/MS in Low Volume Samples” Mass Spectrometry Applications to the Clinical Lab San Diego, CA; January 2012.
o Christine M. Pfeiffer, Mindy Zhang, David A. Lacher, et.al “Comparison of Serum and Red Blood Cell Folate Microbiological Assays for National Population Surveys” Journal of Nutrition 2011 July, 141(7), pp. 1402-1409.
Analyzed patient samples for total folate
o “Vitamin B12 Deficiency in Resettled Bhutanese Refugees --- United State, 2008-2011” Morbidity and Mortality Weekly Report Match 25, 2011, 60(11); 343-346.
Analyzed patient samples for B12
o Reham A.I. Abou-Elkhair, Dabney W. Dixon and Thomas L. Netzel “Synthesis and Electrochemical Evaluation of Conjugates between 2’-Deoxyadenosine and Modified Anthraquinone: Probes for Hole Transfer Studies in DNA” Journal of Organic Chemistry 2009, 74 (13), pp. 4712-4719.
Electrochemical analysis of modified anthraquinone
Posters/Oral Presentations
Oral Presentations:
o D.J. Rabinowitz and A. Suarez, “Betacyanins from Bougainvillea spectabilis, natural food colorants and antioxidants” South Florida Academy of Sciences in Melbourne, FL; March 17, 2006.
Poster Presentations:
o Anand P Chokkalingam, Danielle Chun, Ling-I Hsu, Catherine Metayer, Daniel J Rabinowitz, Mindy Zhang, Joseph L Wiemels and Patricia A Buffler “Serological levels of folate at birth and risk of childhood acute lymphoblastic leukemia” American Associate for Cancer Research Chicago, IL; March 2012
o Daniel J. Rabinowitz, Ming Zhang, Neelima Paladugula, Donna L. LaVoie, and Christine M Pfeiffer “A Fresh Look at the Folate Microbiological Assay, Including Dried Blood Spots and Preanalytical Conditions for Whole Blood Samples” American Association of Clinical Chemistry Chicago, IL; July 19-23, 2009
o D.J. Rabinowitz, “Electrode Potentials of Substituted Anthraquinones” Biology and Chemistry Poster Day, Georgia State University; Atlanta, GA; February 23, 2008
o Reham A. I. Abou-Elkhair, Daniel Rabinowitz and Thomas L. Netzel. Synthesis of Water Soluble Anthraquinone - Deoxyadenosine Conjugates for Studies of their Electrochemical Properties and Laser Kinetics. Biology and Chemistry Poster Day, Georgia State University; Atlanta, GA; February 23, 2008
o Yu Cao, Daniel Rabinowitz, Dabney White Dixon, and Dr. Thomas L. Netzel. Preparation of Anthraquinone Derivatives for Application in DNA Synthesis. Biology and Chemistry Poster Day, Georgia State University; Atlanta, GA; February 23, 2008
o D.J. Rabinowitz and A. Suarez, “Betacyanins from Bougainvillea spectabilis, natural food colorants and antioxidants;” 231st American Chemical Society National Meeting; Atlanta, GA; March 23-25, 2006.
References provided upon request.
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