Patent Agent

Pancham Bakshi, Ph.D.

(U.S. Citizen)

Cell: 617-***-****; ***************@*****.***

Summary of Qualifications

1. Legal Skills

Registered to practice before USPTO (February 2008)

Serving as a scientific advisor in current position (+7 years)

Reviewing and analyzing scientific publications, prior art, patents, and patent applications

Performing patent validity analysis, patent portfolio management, diligence work, freedom-to-operate, chemical structure-based searches, and patentability assessments

Providing scientific, patent, bioinformatic databases, sequence databases, and drug databases (SciFinder, CAS, GenBank , EMBL, FDA Orange Book, USPTO etc.) searches

Working with attorneys in drafting and prosecution of patent applications, and responding to office actions

Assisting attorneys in understanding complex scientific principles

Preparation of scientific documents for patents, grants, and publications in peer-reviewed journal

2. Technical Skills

Ph.D. in Biochemical Technology

Performed research in interdisciplinary field of organic chemistry, medicinal chemistry, analytical chemistry, and biochemistry

In-depth research experience in Alzheimer’s disease (+10Y), oncology, diabetes and drug addiction

Expertise in structure-activity based design, organic synthesis, evaluation of chemical libraries, pharmacology, and drug discovery

Proficient in combinatorial synthetic chemistry, HT synthesis, nanotechnology (liposome synthesis & formulation), solution and solid phase synthesis of biopolymers (modified oligonucleotides, modified peptides, peptidomimetics), bioconjugates, small molecules, natural products, chiral compounds (synthesis using biocatalysts and biochemical transformation), wet chemistry, polymer chemistry and formulation

Specialized in analytical chemistry and instrumentation( NMR spectrum, Mass spectrum, Fluorescence and Circular Dichroism spectrum, Electron Paramagnetic Resonance spectrum, Ultraviolet and Visible Absorption spectrum and Fourier Transform Infrared spectrum), and bio-analytics (pharmacokinetics (PK) / pharmacodynamics (PD) assays (drug metabolism), quantitative biologically-based dose-response modeling and drug delivery)

Well versed with diverse in vivo and in vitro biochemical assays and molecular biology techniques (cell-based assays, cell-free assays, cell-toxicity assays, high-throughput screening, biotinylation, photolabeling techniques, activity based protein profiling, click-chemistry, immuno-precipitation assays, ELISA, Western blots, siRNA technique, Quantitative PCR, purification of tagged proteins, SILAC isotope labeling, and analysis of DNA/RNA sequence data) and pharmacological assays (in vivo testing of compounds in transgenic mouse model)

Well versed with both PC and Mac software and expert in Chemdraw, Endnote, Statistical analysis (Sigma plot, Excel spreadsheets, SigmaStat and SigmaXL) and Laboratory information Management System (LIMS)

Held key position as Head Medicinal Chemist in cross functional multidisciplinary translational research team in drug discovery projects

3. Ability to communicate orally to wide variety of technical and lay audiences

Presented Scientific data/research results in National and International meetings/conferences

Presented scientific data in in-house lab meetings

Presented papers in Journal clubs

Led and managed scientific professionals and collaborators

Instructed and trained research scientists, technicians, and support staff

4. Ability to communicate in writing

Prepared scientific documents for patents, grants, and publications

Reviewed papers of several Journals and grant proposals

Reviewed and edited scientific documents, research reports, and presentations of subordinates

Working with attorneys in drafting and prosecution of patent applications, and responding to office actions

*Education and Certifications*

UNITED STATES PATENT AND TRADEMARK OFFICE

Patent Bar exam and Admitted to USPTO Bar, 2008

HARVARD MEDICAL SCHOOL, BOSTON, MA

Postdoctoral fellowship in Neurology and Drug discovery, 2001 to 2004 (4 years)

CENTER FOR BIOCHEMICAL TECHNOLOGY / UNIVERSITY OF DELHI, Delhi, India 2001

Ph.D. in Biochemical Technology (Designing and Synthesis of Enkephalin Analogues and Their Physicochemical and Pharmacological Studies) with two fellowships

UGCCSIR (University Grants Commission Council of Scientific and Industrial Research) Research Fellow

GATE (Graduate Aptitude Test for Engineering) Research Fellow

UNIVERSITY OF DELHI, Delhi, India

Master of Science in Organic Chemistry, 1994

Bachelor of Science in Chemistry, with Honors, 1992

*Professional Experience*

ROSKAMP INSTITUTE /ARCHER PHARMACEUTICALS, Sarasota, Florida 2004 to Present

Senior Scientist II/ Scientific Advisor, Medicinal Chemistry and Drug Discovery

HARVARD MEDICAL SCHOOL, Boston, Massachusetts 2001 to 2004

Harvard Center for Neurodegeneration and Repair (HCNR)

Laboratory of Drug Discovery in Neurodegeneration (LDDN: 2002 to 2003)

Research Fellow in Neurology

UNIVERSITY OF TEXAS MEDICAL BRANCH, Galveston, Texas 2000 to 2001

Synthetic Organic Chemistry Core Laboratory (SOCCL)

Senior Research Associate

*Honors, Awards and Grants*

• CXCR2-antagonism: Novel therapeutic approach for Alzheimer’s disease (Source/Project Number/Role: Alzheimer’s Drug Discovery Foundation, Institute For the study of Aging/ ADDF 20100904/Principal Investigator (2010-2011))

• Epsilon cleavage, gamma-secretase and APP metabolism (Source/Project Number/Role: Academic research grant/ ARG2008/Principal Investigator (2008-2009))

• HCNR Sabbatical Postdoctoral Fellowship for pursuing high-throughput screening for identification of modulators of APP Processing, 2003.

• New Investigator Travel Award from Society for Biomolecular Screening to attend their IX conference in Portland, Oregon, 2003.

• Young Scientist Travel Fellowship for attending 8th International Conference on Alzheimer's Disease and Related Disorders in Stockholm, Sweden, 2002.

• Represented India at “Southwest Asian / Japanese Science and Cultural Exchange Program” in Tokyo, Japan, 1996.

• Graduate Aptitude Test for Engineering (GATE) Scholarship, India, 1995.

• Junior Research Fellowship from Council of Scientific and Industrial Research, India, 1995.

• Merit Scholarship from State (Delhi) administration for pursuing higher studies, 1987-1994.

*Selected Patents and Publications*

Mullan, M., Paris D., and Bakshi, P. Compounds for inhibiting beta-amyloid production and methods of identifying the compounds. (WO 2006/074419, PCT/US2006/000576).

Mullan, M., Paris D., and Bakshi, P. Compounds and combinations thereof for inhibiting Beta-amyloid production and methods of use thereof (WO 2008/006070, PCT/US2007/072959)

Mullan, M., Paris, D., and Bakshi, P. Compounds for inhibiting Beta-amyloid production (WO 2007/103683, PCT/US2007/062959)

Mullan, M., Paris, D., and Bakshi, P. Compounds for inhibiting Beta-amyloid production (Application number: US 20070191409A)

Mullan, M., Paris D., and Bakshi, P. Polyhydroquinoline compounds and dihydropyridine compounds for inhibiting beta-amyloid production (WO/2008/070875, PCT/US2007/087019).

Bakshi P, Margenthaler E, Jon Reed, Mullan M. Depletion of CXCR2 inhibits γ-secretase activity and amyloid- production in murine model of AD. Cytokine 2011 Feb; 53(2):163-9. Epub 2010 Nov 16.

Bakshi P, Chao Jin, Pierre Broutin, Beniam Berhane, Jon Reed, Mullan M. Structural optimization of a CXCR2-directed antagonist that indirectly inhibits γ-secretase and reduces Aβ. Bioorg Med Chem. 2009 Dec 1;17(23):8102-12. Epub 2009 Oct 3.

Bakshi, P., Margenthaler, E., Laporte,V., Crawford, F., and Mullan, M. “Novel Role of CXCR2 in Regulation of γ-Secretase Activity,” ACS Chem Biol. 2008 Dec 19; 3(12):777-89.

Paris D, Patel N, Quadros A, Linan M, Bakshi P, Ait-Ghezala G, Mullan M (2007).”Inhibition of Abeta production by NF-kappaB inhibitors”, Neurosci Lett. 415(1):11-6.

Ait-Ghezala G, Volmar CH, Frieling J, Paris D, Tweed M, Bakshi P, Mullan M (2007). “CD40 promotion of amyloid beta production occurs via the NF-kappaB pathway”, Eur J Neurosci. 25(6):1685-95.

Bakshi, P., Jun, G., Liao, Y.F., Ni, J., Stein, R., Yeh, L.A., and Wolfe, M.S. “A high-throughput screen to identify modulators of amyloid beta-protein precursor processing,” J. Biomol. Screen. Feb. 10(1): 1-12, 2005.

Bakshi, P. and Wolfe, M.S. “Stereochemical analysis of (hydroxyethyl) urea peptidomimetic inhibitors of gamma-secretase,” J. Med. Chem. Dec. 47(26): 6485-9, 2004.

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