Project Manager Development

Vladimir Babtsov

***** ******* **., ***. ***

Davie, FL 33324

********.*******@*****.***

Ph:954-***-****; Cell: 561-***-****

OBJECTIVE

Master of Science chemist with solid experience in organic synthesis and development of analytical methods.

Analytical procedures development, validation and method transfer using HPLC, TLC, GC/MS/FID/ECD, FTIR, UV, KF, wet chemistry

Validation protocols and STP writing

Synthesis, isolation and purification by preparative chromatography of different types of organic compounds

Reverse engineering of brand pharmaceutical products: tablets, ointments, creams, lotions

Development of NIR-based Process Analytical Technology method for wet granulation process

Microencapsulation processes development

Bacterial toxins isolation and purification

EXPERIENCE

Actavis Sunrise, FL

R&D Scientist 2010-present

Development and validation of HPLC analytical methods including API: Assay, Impurities; drug products: Assay, Impurities, Dissolution, BU/CU

Writing of STPs, validation protocols and reports

Reverse engineering of tablets

Analytical support of products development

Sancilio & Company, Ltd.- West Palm Beach, Florida

R&D Scientist 2010

Development and validation of analytical methods (HPLC, GC, AA, KF, titration) including Assay, Chromatographic Purity, Content Uniformity, etc. for different pharmaceuticals: tablets, soft gel capsules, polyvitamins.

Laboratory test procedures and validation protocols writing

Calculation spreadsheets development and validation

Analytical support of products development

TARO Pharmaceutical Industries - Haifa Bay, Israel

Senior Research & Development Chemist 2001-2009

Synthesis, isolation and purification of API impurities

Development and validation of analytical methods (HPLC, TLC, GC, UV, FTIR, automated titration, wet chemistry).

Reverse engineering of brand pharmaceutical products

NIR-based PAT for wet granulation process.

Tagra Biotechnologies - Misgav, Israel

Project Manager 1998 to 2001

Development of microencapsulation processes of vitamins, pigments, botanical extracts. Analytical methods development (stability, HPLC, GC, UV-vis).

Ascorbic acid derivatives synthesis.

Galil Aroma- Kiryat Shmona, Israel

Research & Development Chemist 1996 to 1998

Ambrox synthesis.

Analytical procedures development (HPLC, GC, UV).

MIGAL- Kiryat Shmona, Israel

Research & Development Chemist 1992 to 1996

Analytical methods development (HPLC, GC/MS/FID/ECD, UV, FTIR), preparative isolation and purification of botanical active principles (ginsenosides, eleutherosides) , pesticides analysis.

Institute of Applied Microbiology- Obolensk, Moscow region, Russia

Research & Development Chemist 1986 to 1991

Fermentation process optimization, bacterial endo-toxins isolation and purification.

EDUCATION

Organic Chemistry - Moscow Institute of Fine Chemical Technology, M.Sc., 1986

MAJOR ACCOMPLISHMENTS

Developed and validated according to FDA requirements dozens of analytical procedures for API assay, residual solvents, cleaning validation, etc.

Succeeded in reverse engineering of brand pharmaceutical products

A number of impurities of API were synthesized and chromatographically purified. Examples are: Hydroxymethyl Lotadine, Lactose ester of Ceterizine, impurity D (1,2-dihydroxy-3-(4-(2-methoxyethyl) phenoxy) propane) of Metroprolol

A number of halogen substituted polyphenolic compounds were synthesized (candidates as anti-cancer drugs)

Stabilized derivatives of Ascorbic acid were synthesized

A proprietary method of synthesis of scent Ambrox was developed

A proprietary method of microencapsulation was developed in pilot scale

A proprietary method of measurement of oxygen consumption by microorganisms was developed

PATENTS & PUBLICATIONS

Vladimir Babtsov, Yury Shapiro, Emma Kvitnitsky, "Method of Microencapsulation”, Tagra Biotechnologies Ltd

(Misgav, IL), No. 6932984 (2001)

Vladimir Babtsov, Yury Shapiro, Emma Kvitnitsky, Valery Belakhov, “ Stabilized Derivatives of Ascorbic Acid-3-Phosphate”, Tagra Biotechnologies Ltd. (Misgav, IL), No. 7045546 (2001)

Vladimir Babtsov, Svetlana Popova, “Method of Measurement of Oxygen Consumption by Microorganisms”, Institute of Applied Microbiology, Russia, No. 1479519 (1989)

ADDITIONAL QUALIFICATIONS

Languages

English, Russian, Hebrew

Software

Empower (Waters), HP Chemstation (Agilent HPLC, GC), Borwin (Jasco), TotalChro

Contact this candidate