Manager Development

RICHARD W. BOND, Ph.D.

*** ******* *******

Union, NJ 07083

Home: 908-***-**** *********@*****.*** Cell: 908-***-****

SUMMARY

Senior level Cell Biologist focused on assay and drug development. Experienced in mammalian cell culture and in designing in vitro assays and in vivo models. Broad experience in using molecular tools such as protein overexpression and knockdown to ensure target validation and in producing proteins for assays and crystallography. Broad knowledge of molecular tools such as PCR, vector design and sequencing. Involved in bringing four drugs into clinical development including two biologics. Collaborates effectively with cross-functional teams. Experienced manager who has worked on multiple teams in a matrix environment but still enjoys doing bench work.

PROFESSIONAL EXPERIENCE

MERCK RESEARCH LABS, Rahway, NJ 2011

External Scientific Lead, In Vitro Pharmacology

Designed, developed and implemented assays for research operating plans with outside partners. Validated quality, accuracy, and efficiency in data produced.

Accomplishments:

•Coordinated efforts between academic collaborator and CRO to find and validate PD biomarkers using chemical proteomics (SILAC and iTRAQ).

•Set up in vitro 3D cell culture assays to increase correlation with in vivo activity.

•Ensured accuracy of kinase specificity assays by determining Ki for compounds where IC50 was close to the enzyme concentration.

•Set up selectivity assays at site running primary assay to ensure rapid testing.

•Transferred and validated BaF3 cell lines expressing various kinases to enable analysis of cell based specificity of lead compounds.

SCHERING-PLOUGH (merged with Merck in 2009), Kenilworth, NJ 1995 – 2011

Senior Principal Scientist, Oncology (2002 – 2011)

Principal Scientist, Oncology (1995 – 2002)

Led drug development projects from target ID and validation to clinical development. Designed assays and molecular tools to drive project advancement. Produced and presented supporting data to leadership committees to ensure passage to next stage of development.

Accomplishments:

•Played an integral part in bringing four programs into clinical development including two biologics.

•Utilized multiple molecular tools including blocking ligands and soluble receptors to ensure effects are due to inhibiting the target of interest increasing the likelihood of success in the clinic.

•Developed biomarker assays in parallel enabling rapid establishment of several assays simultaneously with limited resources.

•Assisted many projects by personally producing key molecular reagents (knockdown /overexpression; wild type, mutant or tagged proteins) faster and with higher quality than outside vendors.

•Optimized transduction of Lentiviral vectors with fluorescent tags (GFP or RFP) to efficiently knockdown targets to increase validation.

•Designed cellular reporter assays to measure activation of various signaling pathways to monitor off target activities of compounds.

•Discovered that a contaminating kinase was affecting the activity measurements of a primary assay in high throughput screening saving time, money and effort.

•Met aggressive goals by using experience as a manager to keep associates focused on priorities in an open and collaborative manner.

•Volunteered for various departmental efforts including safety manager, interferon adenovirus early development team, cost savings team (saved over one million dollars), and summer teacher program.

EDUCATION

Postdoctoral Fellow, Anatomy and Neurobiology, Washington University Medical School, St. Louis, MO

PhD, Biochemistry, University of Illinois, Urbana, IL

BA, Chemistry, Southern Illinois University, Carbondale, IL

PROFESSIONAL DEVELOPMENT AND TRAINING

Management Excellence program and other management training programs, Schering-Plough, Kenilworth, NJ

ACHIEVEMENTS AND AWARDS

•Schering-Plough President’s Award: IGF1R Monoclonal Antibody Program

•Schering-Plough Impact Award: Structure of Farnesyl Transferase with Inhibitors

•Schering-Plough President’s Award: Farnesyl Transferase Inhibitor Program

•NIH fellowships at Washington University and University of Illinois

MEMBERSHIPS

•New Jersey Commission on Cancer Research grant review committee

•American Association for Cancer Research

•Society for Laboratory Automation and Screening

PUBLICATIONS

• Four US patents

• Twenty one peer reviewed publications

Contact this candidate